PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33887608-12 2021 The APE1-NRF2 network played a critical role in protecting esophageal cells against ROS and promoting cell survival under oxidative reflux conditions. Reactive Oxygen Species 84-87 NFE2 like bZIP transcription factor 2 Homo sapiens 9-13 33977953-8 2021 More importantly, we revealed that this anti-inflammatory effect is attributed to reduced ROS overproduction by the Nrf2 pathway, as pre-treatment with Nrf2 siRNA or an inhibitor of superoxide dismutase (SOD) or/and glutathione peroxidase (GPx) abolished hesperetin-induced NF-kappaB inactivation and reductions in inflammatory cytokine secretion. Reactive Oxygen Species 90-93 NFE2 like bZIP transcription factor 2 Homo sapiens 116-120 33892113-4 2021 Here, we show that exposure of triple-negative breast cancer (TNBC) cells to ionizing radiation (IR) upregulates Nrf2 expression and promotes its nuclear translocation in a reactive oxygen species (ROS)-dependent manner. Reactive Oxygen Species 198-201 NFE2 like bZIP transcription factor 2 Homo sapiens 113-117 33892113-6 2021 Mechanistically, we found that Nrf2 knockdown increases IR-induced ROS production and impedes DNA repair at least in part via inhibition of DNA-PK. Reactive Oxygen Species 67-70 NFE2 like bZIP transcription factor 2 Homo sapiens 31-35 33892113-8 2021 Collectively, these results demonstrate that IR-induced ROS production can activate Nrf2 signaling, which in turn counteracts the killing effect of irradiation. Reactive Oxygen Species 56-59 NFE2 like bZIP transcription factor 2 Homo sapiens 84-88 33865914-8 2021 In addition, it also activates the Nrf2-keap1-ARE cascade to stabilize the tau-mediated increased level of ROS. Reactive Oxygen Species 107-110 NFE2 like bZIP transcription factor 2 Homo sapiens 35-39 33992677-7 2021 TF footprinting analysis of our ATAC-seq experiments identified 5 TFs or TF families with evidence for ROS-responsive changes in DNA binding: NRF2, AP-1, p53, NFY, and SP/KLF. Reactive Oxygen Species 103-106 NFE2 like bZIP transcription factor 2 Homo sapiens 142-146 33977953-8 2021 More importantly, we revealed that this anti-inflammatory effect is attributed to reduced ROS overproduction by the Nrf2 pathway, as pre-treatment with Nrf2 siRNA or an inhibitor of superoxide dismutase (SOD) or/and glutathione peroxidase (GPx) abolished hesperetin-induced NF-kappaB inactivation and reductions in inflammatory cytokine secretion. Reactive Oxygen Species 90-93 NFE2 like bZIP transcription factor 2 Homo sapiens 152-156 33416106-0 2021 ROS-mediated hypomethylation of PRDX5 promotes STAT3 binding and activates the Nrf2 signaling pathway in NSCLC. Reactive Oxygen Species 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 79-83 32893669-0 2021 Cpt1a promoted ROS-induced oxidative stress and inflammation in liver injury via the Nrf2/HO-1 and NLRP3 inflammasome signaling pathway. Reactive Oxygen Species 15-18 NFE2 like bZIP transcription factor 2 Homo sapiens 85-89 33921908-9 2021 Genetic tools, such as small interfering RNA (siRNA) can down-regulate molecular pathways such as HIF-1alpha and Nrf2 to promote ROS levels, leading to CP sensitivity. Reactive Oxygen Species 129-132 NFE2 like bZIP transcription factor 2 Homo sapiens 113-117 33937072-8 2021 Although the nuclear factor erythroid-2 related factor 2 (Nrf2) pathway served an important role in protecting gastric cancer cells against the injury of ROS, it can not reverse LCT-3d-induced cell apoptosis. Reactive Oxygen Species 154-157 NFE2 like bZIP transcription factor 2 Homo sapiens 13-56 33898880-10 2021 Mechanistically, Mn-TCP bioceramics inhibited osteoclastogenesis and promoted the regeneration of osteoporotic bone defects by scavenging ROS via Nrf2 activation. Reactive Oxygen Species 138-141 NFE2 like bZIP transcription factor 2 Homo sapiens 146-150 33937072-8 2021 Although the nuclear factor erythroid-2 related factor 2 (Nrf2) pathway served an important role in protecting gastric cancer cells against the injury of ROS, it can not reverse LCT-3d-induced cell apoptosis. Reactive Oxygen Species 154-157 NFE2 like bZIP transcription factor 2 Homo sapiens 58-62 33834930-7 2021 Impaired autophagy also reduced the protective effect of astrocytes on neurons against ROS stress because of the decrease in the level of glutathione released by astrocytes, which could be improved by activating the NFE2L2/NRF2 (nuclear factor, erythroid derived 2, like 2) pathway. Reactive Oxygen Species 87-90 NFE2 like bZIP transcription factor 2 Homo sapiens 216-222 33728720-8 2021 This indicates that Nrf2 up-regulation is enhanced by reactive oxygen species production, rather than KGF, and by extracellular basic pH of the skin. Reactive Oxygen Species 54-77 NFE2 like bZIP transcription factor 2 Homo sapiens 20-24 33754307-1 2021 The transcription factor nuclear factor erythroid 2-like 2 (NEF2L2; NRF2) plays crucial roles in the defense system against electrophilic or oxidative stress by upregulating an array of genes encoding antioxidant proteins, electrophile/reactive oxygen species (ROS) detoxifying enzymes, and drug efflux transporters. Reactive Oxygen Species 236-259 NFE2 like bZIP transcription factor 2 Homo sapiens 25-58 33754307-1 2021 The transcription factor nuclear factor erythroid 2-like 2 (NEF2L2; NRF2) plays crucial roles in the defense system against electrophilic or oxidative stress by upregulating an array of genes encoding antioxidant proteins, electrophile/reactive oxygen species (ROS) detoxifying enzymes, and drug efflux transporters. Reactive Oxygen Species 236-259 NFE2 like bZIP transcription factor 2 Homo sapiens 60-66 33754307-1 2021 The transcription factor nuclear factor erythroid 2-like 2 (NEF2L2; NRF2) plays crucial roles in the defense system against electrophilic or oxidative stress by upregulating an array of genes encoding antioxidant proteins, electrophile/reactive oxygen species (ROS) detoxifying enzymes, and drug efflux transporters. Reactive Oxygen Species 236-259 NFE2 like bZIP transcription factor 2 Homo sapiens 68-72 33416106-12 2021 All these results suggested that the reactive oxygen species (ROS)-mediated hypomethylation of PRDX5 enhanced STAT3 binding affinity with the promoter region, and resulted in the promotion of cell migration and invasion, as well as in the activation of the Nrf2 signaling pathway in NSCLC. Reactive Oxygen Species 37-60 NFE2 like bZIP transcription factor 2 Homo sapiens 257-261 33416106-12 2021 All these results suggested that the reactive oxygen species (ROS)-mediated hypomethylation of PRDX5 enhanced STAT3 binding affinity with the promoter region, and resulted in the promotion of cell migration and invasion, as well as in the activation of the Nrf2 signaling pathway in NSCLC. Reactive Oxygen Species 62-65 NFE2 like bZIP transcription factor 2 Homo sapiens 257-261 33305700-4 2021 After 24 h, the cellular reactive oxygen species and malondialdehyde concentrations significantly increased, while the superoxide dismutase activity decreased; translocation of Nrf2 from the cytosol to the nucleus as well as downstream protein expression of Nrf2-regulated genes heme oxygenase-1 and Bcl-2 was inhibited. Reactive Oxygen Species 25-48 NFE2 like bZIP transcription factor 2 Homo sapiens 258-262 33451022-7 2021 The nuclear factor erythroid 2 related factor 2 (NRF2) pathway is known to be activated by arsenite via ROS production. Reactive Oxygen Species 104-107 NFE2 like bZIP transcription factor 2 Homo sapiens 4-47 33444090-7 2021 Under ICH pathological conditions, such as overproduction of reactive oxygen species (ROS), Nrf2 is translocated into the nucleus where it up-regulates the expression of several anti-oxidative phase II enzymes such as heme oxygenase-1 (HO-1). Reactive Oxygen Species 61-84 NFE2 like bZIP transcription factor 2 Homo sapiens 92-96 33444090-7 2021 Under ICH pathological conditions, such as overproduction of reactive oxygen species (ROS), Nrf2 is translocated into the nucleus where it up-regulates the expression of several anti-oxidative phase II enzymes such as heme oxygenase-1 (HO-1). Reactive Oxygen Species 86-89 NFE2 like bZIP transcription factor 2 Homo sapiens 92-96 33451022-7 2021 The nuclear factor erythroid 2 related factor 2 (NRF2) pathway is known to be activated by arsenite via ROS production. Reactive Oxygen Species 104-107 NFE2 like bZIP transcription factor 2 Homo sapiens 49-53 33186670-10 2021 Nrf2 can strongly influence the NSCs function and fate determination by reducing levels of reactive oxygen species in benefit of NSC survival and neurogenesis. Reactive Oxygen Species 91-114 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 33520087-7 2021 More importantly, berbamine increased the intracellular reactive oxygen species (ROS) level through the downregulation of antioxidative genes such as Nrf2, HO-1, SOD2, and GPX-1. Reactive Oxygen Species 81-84 NFE2 like bZIP transcription factor 2 Homo sapiens 150-154 32810525-1 2021 Nuclear factor-erythroid 2-related factor 2 (NRF2) is a master regulator of a series of cytoprotective genes, which protects cells from stress conditions such as reactive oxygen species (ROS) and electrophiles. Reactive Oxygen Species 162-185 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 32780286-13 2021 Moreover, novel non-ROS-related proteins were part of these forming functional hybrids, such as the NOX5/sGC, NOX1,2/NOS2, NRF2/ENC-1 and MPO/SP-A modules. Reactive Oxygen Species 20-23 NFE2 like bZIP transcription factor 2 Homo sapiens 123-127 33277792-8 2021 In agreement with our data from hepatocytes, trehalose induced the nuclear translocation of NRF2 and the transcription of its downstream antioxidative genes, resulting in reduced cellular reactive oxygen species levels. Reactive Oxygen Species 188-211 NFE2 like bZIP transcription factor 2 Homo sapiens 92-96 32767140-6 2021 The observed increases in antioxidant capacity upon inhibition of TrxR in normal cells are in part dependent upon activation of the Nrf2 transcription factor, while exaggerated ROS levels in cancer cells can be explained by a non-oncogene addiction of cancer cells to TrxR1 due to their increased endogenous production of ROS. Reactive Oxygen Species 322-325 NFE2 like bZIP transcription factor 2 Homo sapiens 132-136 32810525-1 2021 Nuclear factor-erythroid 2-related factor 2 (NRF2) is a master regulator of a series of cytoprotective genes, which protects cells from stress conditions such as reactive oxygen species (ROS) and electrophiles. Reactive Oxygen Species 162-185 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 32810525-1 2021 Nuclear factor-erythroid 2-related factor 2 (NRF2) is a master regulator of a series of cytoprotective genes, which protects cells from stress conditions such as reactive oxygen species (ROS) and electrophiles. Reactive Oxygen Species 187-190 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 32810525-1 2021 Nuclear factor-erythroid 2-related factor 2 (NRF2) is a master regulator of a series of cytoprotective genes, which protects cells from stress conditions such as reactive oxygen species (ROS) and electrophiles. Reactive Oxygen Species 187-190 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 33091421-9 2020 Mechanistically, TRIM16 promoted the activation of protein kinase C (PKC)-interacting cousin of thioredoxin (PICOT), p-Akt and Nrf2, while knockdown of PICOT reversed TRIM16-mediated ROS resistance and decreased the expression of p-Akt and Nrf2. Reactive Oxygen Species 183-186 NFE2 like bZIP transcription factor 2 Homo sapiens 240-244 33375092-9 2020 More specifically, NRF2-mediated oxidative stress response and several toxicological gene classes related to reactive oxygen species metabolism were significantly modulated. Reactive Oxygen Species 109-132 NFE2 like bZIP transcription factor 2 Homo sapiens 19-23 33293849-5 2020 Conversely, low-level local ROS play an important role both as redox-signaling molecules in a wide spectrum of pathways involved in the maintenance of cellular homeostasis (MAPK/ERK, PTK/PTP, PI3K-AKT-mTOR), and regulating key transcription factors (NFkappaB/IkappaB, Nrf2/KEAP1, AP-1, p53, HIF-1). Reactive Oxygen Species 28-31 NFE2 like bZIP transcription factor 2 Homo sapiens 268-272 32918982-8 2020 Oxidative stress-induced intrinsic apoptosis was decreased by the high expression of Nrf2 and antioxidant genes, which improved mitochondrial function and ROS via activation of the PI3K-pAKT pathway by atorvastatin. Reactive Oxygen Species 155-158 NFE2 like bZIP transcription factor 2 Homo sapiens 85-89 33656904-10 2020 The Keap1-Nrf2-ARE system regulates many detoxification and antioxidant enzymes in cells after the exposure to reactive oxygen species and electrophiles. Reactive Oxygen Species 111-134 NFE2 like bZIP transcription factor 2 Homo sapiens 10-14 33287295-1 2020 Nuclear factor erythroid 2-related factor 2 (NRF2) is the key transcription factor triggered by oxidative stress that moves in cells of the antioxidant response element (ARE)-antioxidant gene network against reactive oxygen species (ROS) cellular damage. Reactive Oxygen Species 208-231 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 33287295-1 2020 Nuclear factor erythroid 2-related factor 2 (NRF2) is the key transcription factor triggered by oxidative stress that moves in cells of the antioxidant response element (ARE)-antioxidant gene network against reactive oxygen species (ROS) cellular damage. Reactive Oxygen Species 208-231 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 33287295-1 2020 Nuclear factor erythroid 2-related factor 2 (NRF2) is the key transcription factor triggered by oxidative stress that moves in cells of the antioxidant response element (ARE)-antioxidant gene network against reactive oxygen species (ROS) cellular damage. Reactive Oxygen Species 233-236 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 33287295-1 2020 Nuclear factor erythroid 2-related factor 2 (NRF2) is the key transcription factor triggered by oxidative stress that moves in cells of the antioxidant response element (ARE)-antioxidant gene network against reactive oxygen species (ROS) cellular damage. Reactive Oxygen Species 233-236 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 33343802-0 2020 Induction of HO-1 by 5, 8-Dihydroxy-4",7-Dimethoxyflavone via Activation of ROS/p38 MAPK/Nrf2 Attenuates Thrombin-Induced Connective Tissue Growth Factor Expression in Human Cardiac Fibroblasts. Reactive Oxygen Species 76-79 NFE2 like bZIP transcription factor 2 Homo sapiens 89-93 33343802-16 2020 These results suggested that DDF-induced HO-1 expression is, at least, mediated through the activation of the ROS-dependent p38 MAPK/Nrf2 signaling pathway in HCFs. Reactive Oxygen Species 110-113 NFE2 like bZIP transcription factor 2 Homo sapiens 133-137 33242180-0 2020 NRF2 level is negatively correlated with TGF-beta1-induced lung cancer motility and migration via NOX4-ROS signaling. Reactive Oxygen Species 103-106 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 33242180-6 2020 Notably, the levels of reactive oxygen species (ROS) that were elevated by TGF-beta1 treatment were higher in the NRF2-low A549 than those in control cells, and treatment with ROS scavenger blocked TGF-beta1-induced cell motility. Reactive Oxygen Species 23-46 NFE2 like bZIP transcription factor 2 Homo sapiens 114-118 33242180-6 2020 Notably, the levels of reactive oxygen species (ROS) that were elevated by TGF-beta1 treatment were higher in the NRF2-low A549 than those in control cells, and treatment with ROS scavenger blocked TGF-beta1-induced cell motility. Reactive Oxygen Species 48-51 NFE2 like bZIP transcription factor 2 Homo sapiens 114-118 33242180-6 2020 Notably, the levels of reactive oxygen species (ROS) that were elevated by TGF-beta1 treatment were higher in the NRF2-low A549 than those in control cells, and treatment with ROS scavenger blocked TGF-beta1-induced cell motility. Reactive Oxygen Species 176-179 NFE2 like bZIP transcription factor 2 Homo sapiens 114-118 32946993-9 2020 Nrf2 is an essential molecule in the maintenance of CSCs" stemness and self-renewal in response to different oxidative stresses such as chemotherapy-induced elevation of ROS. Reactive Oxygen Species 170-173 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 32946993-12 2020 The significant role of Nrf2 in the regulation of mitochondrial function and ROS levels suggests this molecule as a potential target to eradicate CSCs. Reactive Oxygen Species 77-80 NFE2 like bZIP transcription factor 2 Homo sapiens 24-28 33299528-3 2020 We previously reported that SUMOylation at lysine residue 110 is important for the ability of NRF2 to promote reactive oxygen species (ROS) clearance in hepatocellular carcinoma. Reactive Oxygen Species 110-133 NFE2 like bZIP transcription factor 2 Homo sapiens 94-98 33489797-12 2020 Conclusions: Our findings illustrate the mechanism of metformin-mediated Nrf2 degradation through posttranslational modifications (PTMs), which weakens the ROS defense system in NSCLC. Reactive Oxygen Species 156-159 NFE2 like bZIP transcription factor 2 Homo sapiens 73-77 33299528-3 2020 We previously reported that SUMOylation at lysine residue 110 is important for the ability of NRF2 to promote reactive oxygen species (ROS) clearance in hepatocellular carcinoma. Reactive Oxygen Species 135-138 NFE2 like bZIP transcription factor 2 Homo sapiens 94-98 33299528-6 2020 Mechanistically, NRF2 SUMOylation increased the antioxidant ability of NRF2 and reduced cellular ROS levels, mainly by transcriptionally activating Cat in KLK LUAD cells. Reactive Oxygen Species 97-100 NFE2 like bZIP transcription factor 2 Homo sapiens 17-21 32999020-3 2020 In the present study, we demonstrate that the accumulation of reactive oxygen species (ROS) late after DENV infection (>24 hpi) resulted from a disruption in the balance between oxidative stress and the Nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent antioxidant response. Reactive Oxygen Species 62-85 NFE2 like bZIP transcription factor 2 Homo sapiens 203-246 32999020-3 2020 In the present study, we demonstrate that the accumulation of reactive oxygen species (ROS) late after DENV infection (>24 hpi) resulted from a disruption in the balance between oxidative stress and the Nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent antioxidant response. Reactive Oxygen Species 62-85 NFE2 like bZIP transcription factor 2 Homo sapiens 248-252 32999020-3 2020 In the present study, we demonstrate that the accumulation of reactive oxygen species (ROS) late after DENV infection (>24 hpi) resulted from a disruption in the balance between oxidative stress and the Nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent antioxidant response. Reactive Oxygen Species 87-90 NFE2 like bZIP transcription factor 2 Homo sapiens 203-246 32999020-3 2020 In the present study, we demonstrate that the accumulation of reactive oxygen species (ROS) late after DENV infection (>24 hpi) resulted from a disruption in the balance between oxidative stress and the Nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent antioxidant response. Reactive Oxygen Species 87-90 NFE2 like bZIP transcription factor 2 Homo sapiens 248-252 32999020-5 2020 Impairment of the Nrf2 regulator by the NS2B3 complex inhibited the antioxidant gene network and contributed to the progressive increase in ROS levels, along with an increased virus replication and inflammatory or apoptotic gene expression. Reactive Oxygen Species 140-143 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22 33274001-6 2020 Besides, we found that delphinidin could significantly alleviate the reduction of Nrf2 protein levels and the accumulation of intracellular ROS levels in Nrf2 knockdown HepG2 cells. Reactive Oxygen Species 140-143 NFE2 like bZIP transcription factor 2 Homo sapiens 154-158 32620467-6 2020 Nrf2 binds effectively to antioxidant response elements (ARE) that mainly encodes majority of the phase II antioxidant enzymes as well as stress receptive proteins including glutathione S-transferase (GSH), heme oxygenase-1 (HO-1), peroxiredoxin I, all these act by cellular defense mechanism and removes the cytotoxic electrophiles along with the ROS that is reactive oxygen species. Reactive Oxygen Species 348-351 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 33228209-7 2020 The activation of the cellular NRF2 (nuclear factor erythroid 2 like 2) pathway and induction of cytoprotective genes accompanies an increase in ROS levels. Reactive Oxygen Species 145-148 NFE2 like bZIP transcription factor 2 Homo sapiens 31-35 33228209-7 2020 The activation of the cellular NRF2 (nuclear factor erythroid 2 like 2) pathway and induction of cytoprotective genes accompanies an increase in ROS levels. Reactive Oxygen Species 145-148 NFE2 like bZIP transcription factor 2 Homo sapiens 37-70 33204402-8 2020 Similarly, Nrf2 inhibitor ML385 partly blocked the regulation of antioxidative genes and ROS overproduction by CA in PA-treated HepG2 cells. Reactive Oxygen Species 89-92 NFE2 like bZIP transcription factor 2 Homo sapiens 11-15 32858502-0 2020 Emerging role of NRF2 in ROS-mediated tumor chemoresistance. Reactive Oxygen Species 25-28 NFE2 like bZIP transcription factor 2 Homo sapiens 17-21 32858502-3 2020 The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is a master regulator of neutralizing cellular ROS and restoring redox balance. Reactive Oxygen Species 123-126 NFE2 like bZIP transcription factor 2 Homo sapiens 25-68 32858502-3 2020 The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is a master regulator of neutralizing cellular ROS and restoring redox balance. Reactive Oxygen Species 123-126 NFE2 like bZIP transcription factor 2 Homo sapiens 70-74 32858502-4 2020 Understanding the role of NRF2 in ROS-mediated chemoresistance can be helpful in the development of chemotherapy strategies with better efficiency. Reactive Oxygen Species 34-37 NFE2 like bZIP transcription factor 2 Homo sapiens 26-30 32858502-5 2020 In this review, we sum up the roles of ROS in the development of chemoresistance to classical chemotherapy agents including cisplatin, 5-fluorouracil, gemcitabine, oxaliplatin, paclitaxel, and doxorubicin, and how to overcome ROS-mediated tumor chemoresistance by targeting NRF2. Reactive Oxygen Species 39-42 NFE2 like bZIP transcription factor 2 Homo sapiens 274-278 32858502-6 2020 Finally, we propose that targeting NRF2 might be a promising strategy to resist ROS-driven chemoresistance and acquire better efficacy in cancer treatment. Reactive Oxygen Species 80-83 NFE2 like bZIP transcription factor 2 Homo sapiens 35-39 32620467-6 2020 Nrf2 binds effectively to antioxidant response elements (ARE) that mainly encodes majority of the phase II antioxidant enzymes as well as stress receptive proteins including glutathione S-transferase (GSH), heme oxygenase-1 (HO-1), peroxiredoxin I, all these act by cellular defense mechanism and removes the cytotoxic electrophiles along with the ROS that is reactive oxygen species. Reactive Oxygen Species 360-383 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 32558263-6 2020 Transcription of HMOX1 and other NFE2L2-dependent genes is increased in response to electrophilic and reactive oxygen species (ROS). Reactive Oxygen Species 102-125 NFE2 like bZIP transcription factor 2 Homo sapiens 33-39 32558263-6 2020 Transcription of HMOX1 and other NFE2L2-dependent genes is increased in response to electrophilic and reactive oxygen species (ROS). Reactive Oxygen Species 127-130 NFE2 like bZIP transcription factor 2 Homo sapiens 33-39 33080927-2 2020 Following an oxidative insult, NRF2 orchestrates an antioxidant program, leading to increased glutathione levels and decreased reactive oxygen species (ROS). Reactive Oxygen Species 127-150 NFE2 like bZIP transcription factor 2 Homo sapiens 31-35 33128166-6 2021 The effects of LED anti-inflammation response are dependent on the mechanism of inhibiting ROS level and regulating NF-kappaB signaling pathways by increasing Nrf2 expression in the cells. Reactive Oxygen Species 91-94 NFE2 like bZIP transcription factor 2 Homo sapiens 159-163 33532592-7 2021 Moreover, SDT reduced levels of the labile iron pool and ferritin expression via the reactive oxygen species (ROS)-nuclear factor erythroid 2-related factor 2 (Nrf2)-FPN1 pathway. Reactive Oxygen Species 85-108 NFE2 like bZIP transcription factor 2 Homo sapiens 115-158 33532592-7 2021 Moreover, SDT reduced levels of the labile iron pool and ferritin expression via the reactive oxygen species (ROS)-nuclear factor erythroid 2-related factor 2 (Nrf2)-FPN1 pathway. Reactive Oxygen Species 110-113 NFE2 like bZIP transcription factor 2 Homo sapiens 115-158 33080927-2 2020 Following an oxidative insult, NRF2 orchestrates an antioxidant program, leading to increased glutathione levels and decreased reactive oxygen species (ROS). Reactive Oxygen Species 152-155 NFE2 like bZIP transcription factor 2 Homo sapiens 31-35 33082834-12 2020 Serum levels of EPA and DHA had a strong negative relationship with the level of ROS, whereas the ROS level had a strong negative relationship with the levels of KEAP1-NRF2. Reactive Oxygen Species 98-101 NFE2 like bZIP transcription factor 2 Homo sapiens 168-172 32860873-4 2020 Among other pathways, HO-1 expression is stimulated by the Nrf2/Keap1 system which senses electrophilic compounds including alkylating agents and reactive oxygen species (ROS) such as superoxide or hydrogen peroxide. Reactive Oxygen Species 146-169 NFE2 like bZIP transcription factor 2 Homo sapiens 59-63 32860873-4 2020 Among other pathways, HO-1 expression is stimulated by the Nrf2/Keap1 system which senses electrophilic compounds including alkylating agents and reactive oxygen species (ROS) such as superoxide or hydrogen peroxide. Reactive Oxygen Species 171-174 NFE2 like bZIP transcription factor 2 Homo sapiens 59-63 32811277-3 2020 Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) pathway is the cellular mechanism to combat increased reactive oxygen species (ROS). Reactive Oxygen Species 149-172 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 32696316-9 2020 ROS induction is required for LO-mediated cell death and NRF2-dependent induction of TXNRD1. Reactive Oxygen Species 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 57-61 32663513-3 2020 Nuclear factor erythroid 2 related factor 2 (Nrf2) is a significant regulator of redox balance that has been shown to improve kidney disease by eliminating ROS. Reactive Oxygen Species 156-159 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 32663513-3 2020 Nuclear factor erythroid 2 related factor 2 (Nrf2) is a significant regulator of redox balance that has been shown to improve kidney disease by eliminating ROS. Reactive Oxygen Species 156-159 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 32663513-4 2020 To date, researchers have found that the use of Nrf2-activated compounds can effectively reduce ROS, thereby preventing or retarding the progression of various types of AKI. Reactive Oxygen Species 96-99 NFE2 like bZIP transcription factor 2 Homo sapiens 48-52 32686580-2 2020 To mitigate the deleterious effects of ROS, cells activate the transcription factor NFE2L2/NRF2, which is constitutively degraded through its partner KEAP1. Reactive Oxygen Species 39-42 NFE2 like bZIP transcription factor 2 Homo sapiens 84-90 32686580-2 2020 To mitigate the deleterious effects of ROS, cells activate the transcription factor NFE2L2/NRF2, which is constitutively degraded through its partner KEAP1. Reactive Oxygen Species 39-42 NFE2 like bZIP transcription factor 2 Homo sapiens 91-95 32686580-3 2020 The inactivation of KEAP1 by ROS results in the upregulation of NFE2L2, which leads to the upregulation of critical detoxifying molecules that serve to keep ROS at tolerable levels in order to maintain cell viability. Reactive Oxygen Species 29-32 NFE2 like bZIP transcription factor 2 Homo sapiens 64-70 32686580-3 2020 The inactivation of KEAP1 by ROS results in the upregulation of NFE2L2, which leads to the upregulation of critical detoxifying molecules that serve to keep ROS at tolerable levels in order to maintain cell viability. Reactive Oxygen Species 157-160 NFE2 like bZIP transcription factor 2 Homo sapiens 64-70 32811277-3 2020 Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) pathway is the cellular mechanism to combat increased reactive oxygen species (ROS). Reactive Oxygen Species 149-172 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 32811277-3 2020 Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) pathway is the cellular mechanism to combat increased reactive oxygen species (ROS). Reactive Oxygen Species 174-177 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 32811277-3 2020 Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) pathway is the cellular mechanism to combat increased reactive oxygen species (ROS). Reactive Oxygen Species 174-177 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 32811277-9 2020 A relevant reason for increased ROS was further explained with the decreased levels of transcription factor Nrf2. Reactive Oxygen Species 32-35 NFE2 like bZIP transcription factor 2 Homo sapiens 108-112 32854194-7 2020 HA disrupted antioxidant networks by decreasing the levels of nuclear factor erythroid 2-related factor 2 (NRF2), leading to ROS accumulation and fibrotic responses, as evidenced by NRF2 activation and knockdown. Reactive Oxygen Species 125-128 NFE2 like bZIP transcription factor 2 Homo sapiens 62-105 32428544-4 2020 In many cell types, the transcription factor, nuclear factor erythroid 2-related factor 2 (Nrf2) and antioxidant response element (ARE) protect against oxidative stress by suppressing ROS. Reactive Oxygen Species 184-187 NFE2 like bZIP transcription factor 2 Homo sapiens 46-89 32428544-4 2020 In many cell types, the transcription factor, nuclear factor erythroid 2-related factor 2 (Nrf2) and antioxidant response element (ARE) protect against oxidative stress by suppressing ROS. Reactive Oxygen Species 184-187 NFE2 like bZIP transcription factor 2 Homo sapiens 91-95 32428544-6 2020 Moreover, we found that decreased ROS accumulation induced by TBHQ didn"t depend on mitochondrial derived ROS production, indicating that Nrf2 activation alleviated cisplatin induced oxidative stress and apoptosis through mitochondrial-independent ROS production. Reactive Oxygen Species 34-37 NFE2 like bZIP transcription factor 2 Homo sapiens 138-142 32428544-8 2020 In conclusion, Nrf2 activation protects auditory hair cells from cisplatin-induced ototoxicity through suppressing the total cellular ROS levels which arise from sources other than mitochondria. Reactive Oxygen Species 134-137 NFE2 like bZIP transcription factor 2 Homo sapiens 15-19 32729622-3 2020 Here, we demonstrate that knockout of NRF2 in cells results in hypersensitivity to ionizing radiation (IR) in the presence or absence of reactive oxygen species (ROS). Reactive Oxygen Species 137-160 NFE2 like bZIP transcription factor 2 Homo sapiens 38-42 32729622-3 2020 Here, we demonstrate that knockout of NRF2 in cells results in hypersensitivity to ionizing radiation (IR) in the presence or absence of reactive oxygen species (ROS). Reactive Oxygen Species 162-165 NFE2 like bZIP transcription factor 2 Homo sapiens 38-42 32729622-4 2020 Under ROS scavenging conditions, induction of DNA double-strand breaks (DSBs) increases the NRF2 protein level and recruits NRF2 to DNA damage sites where it interacts with ATR, resulting in activation of the ATR-CHK1-CDC2 signaling pathway. Reactive Oxygen Species 6-9 NFE2 like bZIP transcription factor 2 Homo sapiens 92-96 32729622-4 2020 Under ROS scavenging conditions, induction of DNA double-strand breaks (DSBs) increases the NRF2 protein level and recruits NRF2 to DNA damage sites where it interacts with ATR, resulting in activation of the ATR-CHK1-CDC2 signaling pathway. Reactive Oxygen Species 6-9 NFE2 like bZIP transcription factor 2 Homo sapiens 124-128 32937821-4 2020 NRF2, a master regulator of inflammatory signaling, might play a role in the regulation of bone metabolism via anti-inflammatory signaling and decreased reactive oxygen species (ROS) levels. Reactive Oxygen Species 153-176 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 32937821-4 2020 NRF2, a master regulator of inflammatory signaling, might play a role in the regulation of bone metabolism via anti-inflammatory signaling and decreased reactive oxygen species (ROS) levels. Reactive Oxygen Species 178-181 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 32937821-7 2020 In addition to direct impact on OCs and OBs, the activity of NRF2 on myeloma cells and mesenchymal stromal cells influences the inflammatory stress/ROS level in these cells, which has an impact on OCs, OBs, and osteocytes. Reactive Oxygen Species 148-151 NFE2 like bZIP transcription factor 2 Homo sapiens 61-65 32854194-7 2020 HA disrupted antioxidant networks by decreasing the levels of nuclear factor erythroid 2-related factor 2 (NRF2), leading to ROS accumulation and fibrotic responses, as evidenced by NRF2 activation and knockdown. Reactive Oxygen Species 125-128 NFE2 like bZIP transcription factor 2 Homo sapiens 107-111 32784474-3 2020 We found that, in aging human (h)LECs, a progressive decline of nuclear factor erythroid 2-related factor 2 (Nrf2)/ARE (antioxidant response element)-mediated antioxidant genes was connected to Bmal1-deficiency, leading to accumulation of reactive oxygen species (ROS) and cell-death. Reactive Oxygen Species 239-262 NFE2 like bZIP transcription factor 2 Homo sapiens 64-107 32589943-4 2020 This results in ROS generation, which through NRF2 drives HCC through cell-autonomous and non-autonomous mechanisms. Reactive Oxygen Species 16-19 NFE2 like bZIP transcription factor 2 Homo sapiens 46-50 32784474-3 2020 We found that, in aging human (h)LECs, a progressive decline of nuclear factor erythroid 2-related factor 2 (Nrf2)/ARE (antioxidant response element)-mediated antioxidant genes was connected to Bmal1-deficiency, leading to accumulation of reactive oxygen species (ROS) and cell-death. Reactive Oxygen Species 239-262 NFE2 like bZIP transcription factor 2 Homo sapiens 109-113 32784474-3 2020 We found that, in aging human (h)LECs, a progressive decline of nuclear factor erythroid 2-related factor 2 (Nrf2)/ARE (antioxidant response element)-mediated antioxidant genes was connected to Bmal1-deficiency, leading to accumulation of reactive oxygen species (ROS) and cell-death. Reactive Oxygen Species 264-267 NFE2 like bZIP transcription factor 2 Homo sapiens 64-107 32784474-3 2020 We found that, in aging human (h)LECs, a progressive decline of nuclear factor erythroid 2-related factor 2 (Nrf2)/ARE (antioxidant response element)-mediated antioxidant genes was connected to Bmal1-deficiency, leading to accumulation of reactive oxygen species (ROS) and cell-death. Reactive Oxygen Species 264-267 NFE2 like bZIP transcription factor 2 Homo sapiens 109-113 32801466-11 2020 These results suggest that ESG suppressed PM-induced inflammation by decreasing ROS accumulation through the Nrf2 pathway. Reactive Oxygen Species 80-83 NFE2 like bZIP transcription factor 2 Homo sapiens 109-113 32742329-4 2020 The levels of reactive oxygen species (ROS) are regulated by Nrf2 and its suppressor protein Kelch-like ECH-associated protein 1 (Keap1). Reactive Oxygen Species 14-37 NFE2 like bZIP transcription factor 2 Homo sapiens 61-65 32742329-4 2020 The levels of reactive oxygen species (ROS) are regulated by Nrf2 and its suppressor protein Kelch-like ECH-associated protein 1 (Keap1). Reactive Oxygen Species 39-42 NFE2 like bZIP transcription factor 2 Homo sapiens 61-65 32407842-0 2020 Excessive reactive oxygen species induce apoptosis via the APPL1-Nrf2/HO-1 antioxidant signalling pathway in trophoblasts with missed abortion. Reactive Oxygen Species 10-33 NFE2 like bZIP transcription factor 2 Homo sapiens 65-69 32727915-4 2020 In a cohort of patients with ADPKD, reactive oxygen species (ROS) frequently accumulated, and their production correlated negatively with NRF2 abundance and positively with disease severity. Reactive Oxygen Species 36-59 NFE2 like bZIP transcription factor 2 Homo sapiens 138-142 32727915-4 2020 In a cohort of patients with ADPKD, reactive oxygen species (ROS) frequently accumulated, and their production correlated negatively with NRF2 abundance and positively with disease severity. Reactive Oxygen Species 61-64 NFE2 like bZIP transcription factor 2 Homo sapiens 138-142 32589628-10 2020 We found that the ROS levels were significantly increased after downregulation of si-Nrf2 compared with the control group. Reactive Oxygen Species 18-21 NFE2 like bZIP transcription factor 2 Homo sapiens 85-89 32716865-11 2020 Moreover, HT-induced reactive oxygen species (ROS) generation is sensitized by transcription factor NF-E2 related factor 2 (Nrf2) and activates the cellular expression of antioxidants and autophagy gene. Reactive Oxygen Species 21-44 NFE2 like bZIP transcription factor 2 Homo sapiens 100-122 32716865-11 2020 Moreover, HT-induced reactive oxygen species (ROS) generation is sensitized by transcription factor NF-E2 related factor 2 (Nrf2) and activates the cellular expression of antioxidants and autophagy gene. Reactive Oxygen Species 21-44 NFE2 like bZIP transcription factor 2 Homo sapiens 124-128 32716865-11 2020 Moreover, HT-induced reactive oxygen species (ROS) generation is sensitized by transcription factor NF-E2 related factor 2 (Nrf2) and activates the cellular expression of antioxidants and autophagy gene. Reactive Oxygen Species 46-49 NFE2 like bZIP transcription factor 2 Homo sapiens 100-122 32716865-11 2020 Moreover, HT-induced reactive oxygen species (ROS) generation is sensitized by transcription factor NF-E2 related factor 2 (Nrf2) and activates the cellular expression of antioxidants and autophagy gene. Reactive Oxygen Species 46-49 NFE2 like bZIP transcription factor 2 Homo sapiens 124-128 32605589-0 2020 BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer. Reactive Oxygen Species 14-17 NFE2 like bZIP transcription factor 2 Homo sapiens 64-68 32605589-11 2020 Ubiquitination/degradation of Nrf2 inhibited the activity of ARE to increase accumulation of reactive oxygen species (ROS), thereby inhibiting the phosphorylation levels of AktSer473 and mTORSer2448. Reactive Oxygen Species 93-116 NFE2 like bZIP transcription factor 2 Homo sapiens 30-34 32605589-11 2020 Ubiquitination/degradation of Nrf2 inhibited the activity of ARE to increase accumulation of reactive oxygen species (ROS), thereby inhibiting the phosphorylation levels of AktSer473 and mTORSer2448. Reactive Oxygen Species 118-121 NFE2 like bZIP transcription factor 2 Homo sapiens 30-34 32605589-13 2020 BDH2 regulates intracellular ROS levels to mediate the PI3K/Akt/mTOR pathway through Keap1/Nrf2/ARE signalling, thereby inhibiting the growth of GC. Reactive Oxygen Species 29-32 NFE2 like bZIP transcription factor 2 Homo sapiens 91-95 32585931-3 2020 HCC overcomes the problem generated by ROS increase by increasing the antioxidant machinery, in which key mechanisms involve glutathione, nuclear factor erythroid 2-related factor 2 (Nrf2), and hypoxia-inducible transcription factor (HIF-1alpha). Reactive Oxygen Species 39-42 NFE2 like bZIP transcription factor 2 Homo sapiens 138-181 32585931-3 2020 HCC overcomes the problem generated by ROS increase by increasing the antioxidant machinery, in which key mechanisms involve glutathione, nuclear factor erythroid 2-related factor 2 (Nrf2), and hypoxia-inducible transcription factor (HIF-1alpha). Reactive Oxygen Species 39-42 NFE2 like bZIP transcription factor 2 Homo sapiens 183-187 32469262-1 2021 The levels of reactive oxygen species (ROS) are tightly controlled and regulated by Nuclear Factor Erythroid-2-Like 2 (Nrf2) transcription factor, which is the main regulator of antioxidant responses and its suppressor protein Kelch-like ECH-associated protein 1 (Keap1). Reactive Oxygen Species 14-37 NFE2 like bZIP transcription factor 2 Homo sapiens 84-117 32555166-0 2020 Sodium butyrate inhibits high cholesterol-induced neuronal amyloidogenesis by modulating NRF2 stabilization-mediated ROS levels: involvement of NOX2 and SOD1. Reactive Oxygen Species 117-120 NFE2 like bZIP transcription factor 2 Homo sapiens 89-93 32469262-1 2021 The levels of reactive oxygen species (ROS) are tightly controlled and regulated by Nuclear Factor Erythroid-2-Like 2 (Nrf2) transcription factor, which is the main regulator of antioxidant responses and its suppressor protein Kelch-like ECH-associated protein 1 (Keap1). Reactive Oxygen Species 14-37 NFE2 like bZIP transcription factor 2 Homo sapiens 119-123 32469262-1 2021 The levels of reactive oxygen species (ROS) are tightly controlled and regulated by Nuclear Factor Erythroid-2-Like 2 (Nrf2) transcription factor, which is the main regulator of antioxidant responses and its suppressor protein Kelch-like ECH-associated protein 1 (Keap1). Reactive Oxygen Species 39-42 NFE2 like bZIP transcription factor 2 Homo sapiens 84-117 32469262-1 2021 The levels of reactive oxygen species (ROS) are tightly controlled and regulated by Nuclear Factor Erythroid-2-Like 2 (Nrf2) transcription factor, which is the main regulator of antioxidant responses and its suppressor protein Kelch-like ECH-associated protein 1 (Keap1). Reactive Oxygen Species 39-42 NFE2 like bZIP transcription factor 2 Homo sapiens 119-123 32336035-1 2020 The transcription factor, nuclear factor E2-related factor 2 (Nrf2), is highly sensitive to oxidative burst products, including reactive oxygen species (ROS) and reactive nitrogen species. Reactive Oxygen Species 128-151 NFE2 like bZIP transcription factor 2 Homo sapiens 26-60 32142889-2 2020 Nuclear factor erythroid 2 [NF-E2]-related factor 2 (NRF2) is a transcription factor of a variety of antioxidant and cytoprotective enzymes, so that Nrf2 serves as a hero which reduces the levels of damaging ROS in the cell. Reactive Oxygen Species 208-211 NFE2 like bZIP transcription factor 2 Homo sapiens 53-57 32142889-2 2020 Nuclear factor erythroid 2 [NF-E2]-related factor 2 (NRF2) is a transcription factor of a variety of antioxidant and cytoprotective enzymes, so that Nrf2 serves as a hero which reduces the levels of damaging ROS in the cell. Reactive Oxygen Species 208-211 NFE2 like bZIP transcription factor 2 Homo sapiens 149-153 32142889-5 2020 Moreover, Dicer was found to be regulated by ROS/NRF2 interaction to contribute to activation of DNA damage repair mechanism. Reactive Oxygen Species 45-48 NFE2 like bZIP transcription factor 2 Homo sapiens 49-53 32526964-6 2020 In addition, BAI activated antioxidative system nuclear factor-erythroid 2-related factor-2 (NRF2) and heme oxygenase 1 (HMOX1), leading the reduction of BaP-induced ROS production. Reactive Oxygen Species 166-169 NFE2 like bZIP transcription factor 2 Homo sapiens 48-91 32526964-6 2020 In addition, BAI activated antioxidative system nuclear factor-erythroid 2-related factor-2 (NRF2) and heme oxygenase 1 (HMOX1), leading the reduction of BaP-induced ROS production. Reactive Oxygen Species 166-169 NFE2 like bZIP transcription factor 2 Homo sapiens 93-97 32336035-1 2020 The transcription factor, nuclear factor E2-related factor 2 (Nrf2), is highly sensitive to oxidative burst products, including reactive oxygen species (ROS) and reactive nitrogen species. Reactive Oxygen Species 128-151 NFE2 like bZIP transcription factor 2 Homo sapiens 62-66 32336035-1 2020 The transcription factor, nuclear factor E2-related factor 2 (Nrf2), is highly sensitive to oxidative burst products, including reactive oxygen species (ROS) and reactive nitrogen species. Reactive Oxygen Species 153-156 NFE2 like bZIP transcription factor 2 Homo sapiens 26-60 32336035-1 2020 The transcription factor, nuclear factor E2-related factor 2 (Nrf2), is highly sensitive to oxidative burst products, including reactive oxygen species (ROS) and reactive nitrogen species. Reactive Oxygen Species 153-156 NFE2 like bZIP transcription factor 2 Homo sapiens 62-66 32424161-3 2020 We address this paradox by identifying the constitutive activation of the NRF2 master antioxidant response in Neoaves (~95% of bird species), providing an adaptive mechanism capable of counterbalancing high ROS levels. Reactive Oxygen Species 207-210 NFE2 like bZIP transcription factor 2 Homo sapiens 74-78 32536875-8 2020 As a counter balance of excessive ROS, nuclear factor erythroid 2 related factor 2 (Nrf2), a redox-sensitive cell-protective transcription factor, will be highlighted as a potential therapeutic target for antioxidant defenses. Reactive Oxygen Species 34-37 NFE2 like bZIP transcription factor 2 Homo sapiens 39-82 32536875-8 2020 As a counter balance of excessive ROS, nuclear factor erythroid 2 related factor 2 (Nrf2), a redox-sensitive cell-protective transcription factor, will be highlighted as a potential therapeutic target for antioxidant defenses. Reactive Oxygen Species 34-37 NFE2 like bZIP transcription factor 2 Homo sapiens 84-88 32369110-2 2020 Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway inhibition participates in hyperglycemia-induced ROS accumulation. Reactive Oxygen Species 187-190 NFE2 like bZIP transcription factor 2 Homo sapiens 44-87 32369110-2 2020 Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway inhibition participates in hyperglycemia-induced ROS accumulation. Reactive Oxygen Species 187-190 NFE2 like bZIP transcription factor 2 Homo sapiens 89-93 32509156-4 2020 Besides, it was also expounded that nuclear factor-erythroid 2 (NF-E2)-related factor 2/BTB domain and CNC homolog 1 (Nrf2/Bach1) might be involved in the regulation of HO-1 and the quantum effect of photon altered ROS generation. Reactive Oxygen Species 215-218 NFE2 like bZIP transcription factor 2 Homo sapiens 36-87 32509156-4 2020 Besides, it was also expounded that nuclear factor-erythroid 2 (NF-E2)-related factor 2/BTB domain and CNC homolog 1 (Nrf2/Bach1) might be involved in the regulation of HO-1 and the quantum effect of photon altered ROS generation. Reactive Oxygen Species 215-218 NFE2 like bZIP transcription factor 2 Homo sapiens 118-122 32278282-10 2020 Moreover, it demonstrates that canagliflozin stimulates the expression of HO-1 in vascular SMCs via the ROS-Nrf2 pathway, and that the induction of HO-1 contributes to the cellular actions of canagliflozin. Reactive Oxygen Species 104-107 NFE2 like bZIP transcription factor 2 Homo sapiens 108-112 32317087-3 2020 In this study, Nrf2 overexpression attenuated CK2 downregulation-induced ROS production and senescence markers including SA-beta-gal staining and activation of p53-p21Cip1/WAF1 in human breast (MCF-7) and colon (HCT116) cancer cells. Reactive Oxygen Species 73-76 NFE2 like bZIP transcription factor 2 Homo sapiens 15-19 32370041-5 2020 The most effective extracts, Xylopia parviflora, Echinops giganteus, and Dichrostachys glomerata, showed a concentration-dependent ROS-scavenging activity, which involved Nrf2 translocation into the nucleus. Reactive Oxygen Species 131-134 NFE2 like bZIP transcription factor 2 Homo sapiens 171-175 32320383-0 2020 Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells. Reactive Oxygen Species 46-69 NFE2 like bZIP transcription factor 2 Homo sapiens 36-42 32320383-8 2020 The increased ROS level also increased transcription factor nuclear factor, erythroid 2 like 2 (NFE2L2, Nrf2) and the autophagy of NPCs, both of which attenuated the pyroptosis. Reactive Oxygen Species 14-17 NFE2 like bZIP transcription factor 2 Homo sapiens 104-108 32346399-11 2020 In contrast, silencing of both Keap1 and Nrf2 restored ROS production, cell death, and inflammatory reactions. Reactive Oxygen Species 55-58 NFE2 like bZIP transcription factor 2 Homo sapiens 41-45 32320383-8 2020 The increased ROS level also increased transcription factor nuclear factor, erythroid 2 like 2 (NFE2L2, Nrf2) and the autophagy of NPCs, both of which attenuated the pyroptosis. Reactive Oxygen Species 14-17 NFE2 like bZIP transcription factor 2 Homo sapiens 60-94 32320383-9 2020 In summary, ROS induces the pyroptosis of NPCs through the NLRP3/ PYCARD pathway, and establishes negative regulation by increasing autophagy and NFE2L2. Reactive Oxygen Species 12-15 NFE2 like bZIP transcription factor 2 Homo sapiens 146-152 32320383-8 2020 The increased ROS level also increased transcription factor nuclear factor, erythroid 2 like 2 (NFE2L2, Nrf2) and the autophagy of NPCs, both of which attenuated the pyroptosis. Reactive Oxygen Species 14-17 NFE2 like bZIP transcription factor 2 Homo sapiens 96-102 32293500-9 2020 Pharmacological or siRNA-mediated inhibition of the PERK/NRF2 pathway synergistically enhanced BIX-01294-induced apoptosis, with suppressed HO-1 expression, increased p38 phosphorylation, and elevated ROS generation, indicating that activated PERK/NRF2 signaling suppressed ROS-induced apoptosis in KG1 cells. Reactive Oxygen Species 201-204 NFE2 like bZIP transcription factor 2 Homo sapiens 57-61 32255482-10 2020 Knockdown of Nrf2 led to an abnormal elevation of ROS, and the antioxidant NAC could increase Nrf2 activation, indicating that ROS and Nrf2 act within a negative feedback loop. Reactive Oxygen Species 50-53 NFE2 like bZIP transcription factor 2 Homo sapiens 13-17 32255482-10 2020 Knockdown of Nrf2 led to an abnormal elevation of ROS, and the antioxidant NAC could increase Nrf2 activation, indicating that ROS and Nrf2 act within a negative feedback loop. Reactive Oxygen Species 127-130 NFE2 like bZIP transcription factor 2 Homo sapiens 13-17 32255482-10 2020 Knockdown of Nrf2 led to an abnormal elevation of ROS, and the antioxidant NAC could increase Nrf2 activation, indicating that ROS and Nrf2 act within a negative feedback loop. Reactive Oxygen Species 127-130 NFE2 like bZIP transcription factor 2 Homo sapiens 94-98 32255482-10 2020 Knockdown of Nrf2 led to an abnormal elevation of ROS, and the antioxidant NAC could increase Nrf2 activation, indicating that ROS and Nrf2 act within a negative feedback loop. Reactive Oxygen Species 127-130 NFE2 like bZIP transcription factor 2 Homo sapiens 94-98 32293500-9 2020 Pharmacological or siRNA-mediated inhibition of the PERK/NRF2 pathway synergistically enhanced BIX-01294-induced apoptosis, with suppressed HO-1 expression, increased p38 phosphorylation, and elevated ROS generation, indicating that activated PERK/NRF2 signaling suppressed ROS-induced apoptosis in KG1 cells. Reactive Oxygen Species 274-277 NFE2 like bZIP transcription factor 2 Homo sapiens 57-61 32293500-13 2020 CONCLUSIONS: PERK/NRF2 signaling plays a key role in protecting LSCs against ROS-induced apoptosis, thus conferring resistance to G9a inhibitors. Reactive Oxygen Species 77-80 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22 32273683-13 2020 Pretreatment of bladder cancer cells with ROS scavengers abolished NRF2 expression and nuclear translocation, indicating that miconazole activates the noncanonical p62-KEAP1-NRF2 pathway, which is regulated by ROS production. Reactive Oxygen Species 210-213 NFE2 like bZIP transcription factor 2 Homo sapiens 174-178 32318339-4 2020 Further mechanism studies revealed that silencing FEN1 in combination with low doses of ATO might increase intracellular ROS and reduce glutathione (GSH) levels, by reducing the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2); elevating ROS leaded to apoptosis and p38 and JNK pathway activating. Reactive Oxygen Species 265-268 NFE2 like bZIP transcription factor 2 Homo sapiens 248-252 32032580-11 2020 In line with in vivo evidence, NRF2 silencing in HaCaT cells significantly decreased cell survival rate in response to BLM due to suppressed expression of antioxidative genes and increased intracellular levels of reactive oxygen species (ROS). Reactive Oxygen Species 213-236 NFE2 like bZIP transcription factor 2 Homo sapiens 31-35 32032580-11 2020 In line with in vivo evidence, NRF2 silencing in HaCaT cells significantly decreased cell survival rate in response to BLM due to suppressed expression of antioxidative genes and increased intracellular levels of reactive oxygen species (ROS). Reactive Oxygen Species 238-241 NFE2 like bZIP transcription factor 2 Homo sapiens 31-35 32023790-2 2020 Nuclear factor (erythroid-derived 2)-like 2(Nrf2) is responsible for gene expression of antioxidant enzymes to protect cells from oxidative stress by reactive oxygen species(ROS) production. Reactive Oxygen Species 150-173 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 32023790-2 2020 Nuclear factor (erythroid-derived 2)-like 2(Nrf2) is responsible for gene expression of antioxidant enzymes to protect cells from oxidative stress by reactive oxygen species(ROS) production. Reactive Oxygen Species 150-173 NFE2 like bZIP transcription factor 2 Homo sapiens 44-48 32023790-2 2020 Nuclear factor (erythroid-derived 2)-like 2(Nrf2) is responsible for gene expression of antioxidant enzymes to protect cells from oxidative stress by reactive oxygen species(ROS) production. Reactive Oxygen Species 174-177 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 32023790-2 2020 Nuclear factor (erythroid-derived 2)-like 2(Nrf2) is responsible for gene expression of antioxidant enzymes to protect cells from oxidative stress by reactive oxygen species(ROS) production. Reactive Oxygen Species 174-177 NFE2 like bZIP transcription factor 2 Homo sapiens 44-48 32070709-9 2020 Pre-treatment of cells with these derivatives strongly inhibited H2O2 induced decrease of cell viability, reduced the production of ROS and MDA, promoted antioxidase activities, and further upregulated the expression of Nrf2 and its target genes. Reactive Oxygen Species 132-135 NFE2 like bZIP transcription factor 2 Homo sapiens 220-224 32023790-14 2020 Taken together, these results implicate that B cell cytotoxicity by substitutes should be lower than BPA and Nrf2 can prevent B cells from BPA- or BPA substitutes-induced cytotoxicity via ROS production. Reactive Oxygen Species 188-191 NFE2 like bZIP transcription factor 2 Homo sapiens 109-113 32238837-7 2020 Because reactive oxygen species inhibit glomerular insulin signalling in diabetes and Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway is one of the most important intrinsic antioxidative systems, we evaluated whether linagliptin increased Nrf2 in podocytes. Reactive Oxygen Species 8-31 NFE2 like bZIP transcription factor 2 Homo sapiens 175-179 32238837-7 2020 Because reactive oxygen species inhibit glomerular insulin signalling in diabetes and Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway is one of the most important intrinsic antioxidative systems, we evaluated whether linagliptin increased Nrf2 in podocytes. Reactive Oxygen Species 8-31 NFE2 like bZIP transcription factor 2 Homo sapiens 294-298 32273683-12 2020 Miconazole-induced generation of reactive oxygen species (ROS) promoted NRF2 activation. Reactive Oxygen Species 33-56 NFE2 like bZIP transcription factor 2 Homo sapiens 72-76 32273683-12 2020 Miconazole-induced generation of reactive oxygen species (ROS) promoted NRF2 activation. Reactive Oxygen Species 58-61 NFE2 like bZIP transcription factor 2 Homo sapiens 72-76 32273683-13 2020 Pretreatment of bladder cancer cells with ROS scavengers abolished NRF2 expression and nuclear translocation, indicating that miconazole activates the noncanonical p62-KEAP1-NRF2 pathway, which is regulated by ROS production. Reactive Oxygen Species 42-45 NFE2 like bZIP transcription factor 2 Homo sapiens 67-71 32273683-13 2020 Pretreatment of bladder cancer cells with ROS scavengers abolished NRF2 expression and nuclear translocation, indicating that miconazole activates the noncanonical p62-KEAP1-NRF2 pathway, which is regulated by ROS production. Reactive Oxygen Species 42-45 NFE2 like bZIP transcription factor 2 Homo sapiens 174-178 31661353-4 2020 The levels of reactive oxygen species (ROS) are tightly controlled and regulated by Nrf2 and its suppressor protein Kelch-like ECH-associated protein 1 (Keap1). Reactive Oxygen Species 14-37 NFE2 like bZIP transcription factor 2 Homo sapiens 84-88 31372933-3 2020 NRF2, the master regulator of redox balance, has been shown to protect against kidney disease through its negation of reactive oxygen species (ROS). Reactive Oxygen Species 118-141 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 31372933-3 2020 NRF2, the master regulator of redox balance, has been shown to protect against kidney disease through its negation of reactive oxygen species (ROS). Reactive Oxygen Species 143-146 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 31372933-4 2020 However, many kidney diseases exhibit high levels of ROS as a result of decreased NRF2 protein levels and transcriptional activity. Reactive Oxygen Species 53-56 NFE2 like bZIP transcription factor 2 Homo sapiens 82-86 31372933-5 2020 Many studies have tested the strategy of using NRF2 inducing compounds to alleviate ROS to prevent or slow down the progression of kidney diseases. Reactive Oxygen Species 84-87 NFE2 like bZIP transcription factor 2 Homo sapiens 47-51 32121537-6 2020 Thus, PERK-mediated NRF2 activation encompasses a PERK-ATF4-dependent control of NRF2 expression that contributes to the NRF2 protective response engaged during ER stress-induced ROS production. Reactive Oxygen Species 179-182 NFE2 like bZIP transcription factor 2 Homo sapiens 20-24 32121537-6 2020 Thus, PERK-mediated NRF2 activation encompasses a PERK-ATF4-dependent control of NRF2 expression that contributes to the NRF2 protective response engaged during ER stress-induced ROS production. Reactive Oxygen Species 179-182 NFE2 like bZIP transcription factor 2 Homo sapiens 81-85 32121537-6 2020 Thus, PERK-mediated NRF2 activation encompasses a PERK-ATF4-dependent control of NRF2 expression that contributes to the NRF2 protective response engaged during ER stress-induced ROS production. Reactive Oxygen Species 179-182 NFE2 like bZIP transcription factor 2 Homo sapiens 81-85 32167099-6 2020 Activated Nrf2 up-regulated antioxidant enzyme activities (superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px)) and inhibited ROS and MDA production. Reactive Oxygen Species 153-156 NFE2 like bZIP transcription factor 2 Homo sapiens 10-14 32111036-8 2020 SP treatment enhanced the nuclear translocation of nuclear factor erythroid 2-related factor (Nrf2) with upregulated antioxidant enzymes and suppressed reactive oxygen species (ROS)-mediated oxidative stress in the lung tissues of LPS-induced ALI model and TNF-alpha-stimulated NCI-H292 cells. Reactive Oxygen Species 152-175 NFE2 like bZIP transcription factor 2 Homo sapiens 51-92 32111036-8 2020 SP treatment enhanced the nuclear translocation of nuclear factor erythroid 2-related factor (Nrf2) with upregulated antioxidant enzymes and suppressed reactive oxygen species (ROS)-mediated oxidative stress in the lung tissues of LPS-induced ALI model and TNF-alpha-stimulated NCI-H292 cells. Reactive Oxygen Species 152-175 NFE2 like bZIP transcription factor 2 Homo sapiens 94-98 32111036-8 2020 SP treatment enhanced the nuclear translocation of nuclear factor erythroid 2-related factor (Nrf2) with upregulated antioxidant enzymes and suppressed reactive oxygen species (ROS)-mediated oxidative stress in the lung tissues of LPS-induced ALI model and TNF-alpha-stimulated NCI-H292 cells. Reactive Oxygen Species 177-180 NFE2 like bZIP transcription factor 2 Homo sapiens 51-92 32106613-5 2020 In line of principle, the controlled activation of NRF2 might reduce the risk of cancer initiation and development in normal cells by scavenging reactive-oxygen species (ROS) and by preventing genomic instability through decreased DNA damage. Reactive Oxygen Species 145-168 NFE2 like bZIP transcription factor 2 Homo sapiens 51-55 32106613-5 2020 In line of principle, the controlled activation of NRF2 might reduce the risk of cancer initiation and development in normal cells by scavenging reactive-oxygen species (ROS) and by preventing genomic instability through decreased DNA damage. Reactive Oxygen Species 170-173 NFE2 like bZIP transcription factor 2 Homo sapiens 51-55 31313842-2 2020 We show that NRF2 activation stimulates cell growth and markedly reduces reactive oxygen species (ROS) generation, whereas miR-29b-1-5p overexpression increases ROS generation and reduces cell proliferation. Reactive Oxygen Species 73-96 NFE2 like bZIP transcription factor 2 Homo sapiens 13-17 31313842-2 2020 We show that NRF2 activation stimulates cell growth and markedly reduces reactive oxygen species (ROS) generation, whereas miR-29b-1-5p overexpression increases ROS generation and reduces cell proliferation. Reactive Oxygen Species 98-101 NFE2 like bZIP transcription factor 2 Homo sapiens 13-17 32130657-8 2020 This suggests that an ROS-rich microenvironment drives the selection, survival, and growth of cells with high NRF2 activity. Reactive Oxygen Species 22-25 NFE2 like bZIP transcription factor 2 Homo sapiens 110-114 32121537-5 2020 In addition, NRF2 activation is late and largely driven by reactive oxygen species (ROS) generated during late protein synthesis recovery, contributing to protecting against cell death. Reactive Oxygen Species 59-82 NFE2 like bZIP transcription factor 2 Homo sapiens 13-17 32121537-5 2020 In addition, NRF2 activation is late and largely driven by reactive oxygen species (ROS) generated during late protein synthesis recovery, contributing to protecting against cell death. Reactive Oxygen Species 84-87 NFE2 like bZIP transcription factor 2 Homo sapiens 13-17 32111854-1 2020 Diesel exhaust particles (DEP) are known to generate reactive oxygen species in the respiratory system, triggering cells to activate antioxidant defence mechanisms, such as Keap1-Nrf2 signalling and autophagy. Reactive Oxygen Species 53-76 NFE2 like bZIP transcription factor 2 Homo sapiens 179-183 31661353-4 2020 The levels of reactive oxygen species (ROS) are tightly controlled and regulated by Nrf2 and its suppressor protein Kelch-like ECH-associated protein 1 (Keap1). Reactive Oxygen Species 39-42 NFE2 like bZIP transcription factor 2 Homo sapiens 84-88 31678283-5 2019 However, Nrf2 signaling protects malignant cells from ROS damage against tumor growth and chemoresistance. Reactive Oxygen Species 54-57 NFE2 like bZIP transcription factor 2 Homo sapiens 9-13 31548295-5 2020 Moreover, the nuclear factor erythroid 2-related factor 2 (Nrf2) plays a key protective role in IDH1-mutated cells by prompting GSH synthesis and reactive oxygen species scavenging. Reactive Oxygen Species 146-169 NFE2 like bZIP transcription factor 2 Homo sapiens 14-57 31548295-5 2020 Moreover, the nuclear factor erythroid 2-related factor 2 (Nrf2) plays a key protective role in IDH1-mutated cells by prompting GSH synthesis and reactive oxygen species scavenging. Reactive Oxygen Species 146-169 NFE2 like bZIP transcription factor 2 Homo sapiens 59-63 31475364-7 2019 We conclude that Res inhibits ROS production by activating the Nrf2 pathway, thereby inhibiting activation of NF-kappaB and proliferation and migration of RA-FLSs, to induce apoptosis. Reactive Oxygen Species 30-33 NFE2 like bZIP transcription factor 2 Homo sapiens 63-67 31546024-4 2019 Mechanistically, NRF2 SUMOylation promoted de novo serine synthesis in HCC by enhancing the clearance of intracellular reactive oxygen species (ROS) and up-regulating phosphoglycerate dehydrogenase (PHGDH). Reactive Oxygen Species 119-142 NFE2 like bZIP transcription factor 2 Homo sapiens 17-21 31546024-4 2019 Mechanistically, NRF2 SUMOylation promoted de novo serine synthesis in HCC by enhancing the clearance of intracellular reactive oxygen species (ROS) and up-regulating phosphoglycerate dehydrogenase (PHGDH). Reactive Oxygen Species 144-147 NFE2 like bZIP transcription factor 2 Homo sapiens 17-21 31319135-9 2019 These data suggest a possibility for activation of Nrf2-independent ROS detoxification pathways by either ALA or marliolide. Reactive Oxygen Species 68-71 NFE2 like bZIP transcription factor 2 Homo sapiens 51-55 31347718-5 2019 Fortunately, OS preconditioning can increase the expression of superoxide dismutase, catalase, NQO1, and heme oxygenase 1 through the nuclear factor erythroid 2-related factor 2 pathway, thereby decreased the intracellular reactive oxygen species (ROS) levels, relieved the damage of ROS to mitochondria, DNA and cell membrane, enhanced the anti-OS ability of BMSCs, and promoted the survival of BMSCs under OS. Reactive Oxygen Species 223-246 NFE2 like bZIP transcription factor 2 Homo sapiens 134-177 31347718-5 2019 Fortunately, OS preconditioning can increase the expression of superoxide dismutase, catalase, NQO1, and heme oxygenase 1 through the nuclear factor erythroid 2-related factor 2 pathway, thereby decreased the intracellular reactive oxygen species (ROS) levels, relieved the damage of ROS to mitochondria, DNA and cell membrane, enhanced the anti-OS ability of BMSCs, and promoted the survival of BMSCs under OS. Reactive Oxygen Species 248-251 NFE2 like bZIP transcription factor 2 Homo sapiens 134-177 31586142-2 2019 The nuclear factor erythroid 2-related factor 2 (Nrf2) - antioxidant response elements (ARE) (Nrf2-ARE) signaling pathway plays a crucial role in protecting liver cells from ROS, inducing enzymes such as phase II metabolizing enzymes and antioxidant enzymes. Reactive Oxygen Species 174-177 NFE2 like bZIP transcription factor 2 Homo sapiens 4-47 31319135-1 2019 Nuclear factor erythroid 2-like 2 (Nrf2) is a key transcription factor responsible for the induction of cytoprotective genes when a cell is exposed to reactive oxygen species (ROS). Reactive Oxygen Species 151-174 NFE2 like bZIP transcription factor 2 Homo sapiens 0-33 31319135-1 2019 Nuclear factor erythroid 2-like 2 (Nrf2) is a key transcription factor responsible for the induction of cytoprotective genes when a cell is exposed to reactive oxygen species (ROS). Reactive Oxygen Species 151-174 NFE2 like bZIP transcription factor 2 Homo sapiens 35-39 31319135-1 2019 Nuclear factor erythroid 2-like 2 (Nrf2) is a key transcription factor responsible for the induction of cytoprotective genes when a cell is exposed to reactive oxygen species (ROS). Reactive Oxygen Species 176-179 NFE2 like bZIP transcription factor 2 Homo sapiens 0-33 31319135-1 2019 Nuclear factor erythroid 2-like 2 (Nrf2) is a key transcription factor responsible for the induction of cytoprotective genes when a cell is exposed to reactive oxygen species (ROS). Reactive Oxygen Species 176-179 NFE2 like bZIP transcription factor 2 Homo sapiens 35-39 31828114-8 2019 Knockdown of Nrf2 in K562/G01 cells enhanced the intracellular ROS level, suppressed cell proliferation, and increased apoptosis in response to imatinib treatments. Reactive Oxygen Species 63-66 NFE2 like bZIP transcription factor 2 Homo sapiens 13-17 31507082-1 2019 Sigma-1 receptor (S1R) regulates reactive oxygen species (ROS) accumulation via nuclear factor erythroid 2-related factor 2 (NRF2), which plays a vital role in ferroptosis. Reactive Oxygen Species 33-56 NFE2 like bZIP transcription factor 2 Homo sapiens 80-123 31507082-1 2019 Sigma-1 receptor (S1R) regulates reactive oxygen species (ROS) accumulation via nuclear factor erythroid 2-related factor 2 (NRF2), which plays a vital role in ferroptosis. Reactive Oxygen Species 33-56 NFE2 like bZIP transcription factor 2 Homo sapiens 125-129 31507082-1 2019 Sigma-1 receptor (S1R) regulates reactive oxygen species (ROS) accumulation via nuclear factor erythroid 2-related factor 2 (NRF2), which plays a vital role in ferroptosis. Reactive Oxygen Species 58-61 NFE2 like bZIP transcription factor 2 Homo sapiens 80-123 31507082-1 2019 Sigma-1 receptor (S1R) regulates reactive oxygen species (ROS) accumulation via nuclear factor erythroid 2-related factor 2 (NRF2), which plays a vital role in ferroptosis. Reactive Oxygen Species 58-61 NFE2 like bZIP transcription factor 2 Homo sapiens 125-129 31586142-2 2019 The nuclear factor erythroid 2-related factor 2 (Nrf2) - antioxidant response elements (ARE) (Nrf2-ARE) signaling pathway plays a crucial role in protecting liver cells from ROS, inducing enzymes such as phase II metabolizing enzymes and antioxidant enzymes. Reactive Oxygen Species 174-177 NFE2 like bZIP transcription factor 2 Homo sapiens 49-53 31586142-2 2019 The nuclear factor erythroid 2-related factor 2 (Nrf2) - antioxidant response elements (ARE) (Nrf2-ARE) signaling pathway plays a crucial role in protecting liver cells from ROS, inducing enzymes such as phase II metabolizing enzymes and antioxidant enzymes. Reactive Oxygen Species 174-177 NFE2 like bZIP transcription factor 2 Homo sapiens 94-98 31067610-10 2019 Conclusion: The activation of nuclear factor E2-related factor 2 (Nrf2)-HO-1 inhibited ROS expression and subsequently attenuated autophagy and cell apoptosis after HG injury was decreased. Reactive Oxygen Species 87-90 NFE2 like bZIP transcription factor 2 Homo sapiens 66-70 30759236-10 2019 Genetic or pharmacologic blockade of NRF2 not only disrupted ROS homeostasis (mean [SD] ROS levels increased by 317 [42.1]%, P = .001, in IDH1R132C and by 286. Reactive Oxygen Species 61-64 NFE2 like bZIP transcription factor 2 Homo sapiens 37-41 30759236-13 2019 CONCLUSIONS: IDH1 mutation reprograms ROS homeostasis in cancer cells, which leads to dependency on the NRF2 antioxidant pathway for ROS scavenging. Reactive Oxygen Species 38-41 NFE2 like bZIP transcription factor 2 Homo sapiens 104-108 30759236-13 2019 CONCLUSIONS: IDH1 mutation reprograms ROS homeostasis in cancer cells, which leads to dependency on the NRF2 antioxidant pathway for ROS scavenging. Reactive Oxygen Species 133-136 NFE2 like bZIP transcription factor 2 Homo sapiens 104-108 31569690-3 2019 Herein, we demonstrated that higher doses of SFN (>6 muM) activated death signaling by overstimulation of Nrf2/ARE (antioxidant response element)-mediated Kruppel-like factor (Klf9) repression of Prdx6 expression, which increased reactive oxygen species (ROS) load and cell death. Reactive Oxygen Species 230-253 NFE2 like bZIP transcription factor 2 Homo sapiens 106-110 31569690-3 2019 Herein, we demonstrated that higher doses of SFN (>6 muM) activated death signaling by overstimulation of Nrf2/ARE (antioxidant response element)-mediated Kruppel-like factor (Klf9) repression of Prdx6 expression, which increased reactive oxygen species (ROS) load and cell death. Reactive Oxygen Species 255-258 NFE2 like bZIP transcription factor 2 Homo sapiens 106-110 31265839-9 2019 Moreover, knockdown of Nrf2 significantly blocked the SIRT6-mediated protection effect against Ang II-induced apoptosis and reactive oxygen species generation. Reactive Oxygen Species 124-147 NFE2 like bZIP transcription factor 2 Homo sapiens 23-27 31540482-7 2019 In addition, GSH significantly decreased LPS-induced ROS generation, which was associated with an activation of nuclear factor erythroid-derived 2-related factor 2 (Nrf2)/ heme oxygenease-1 (HO-1) signaling pathway. Reactive Oxygen Species 53-56 NFE2 like bZIP transcription factor 2 Homo sapiens 112-163 31540482-7 2019 In addition, GSH significantly decreased LPS-induced ROS generation, which was associated with an activation of nuclear factor erythroid-derived 2-related factor 2 (Nrf2)/ heme oxygenease-1 (HO-1) signaling pathway. Reactive Oxygen Species 53-56 NFE2 like bZIP transcription factor 2 Homo sapiens 165-169 31260654-5 2019 However, some Nrf2 inducers could be exerting cytoprotective and chemosensitizing roles through a simple integrated mechanism in which the cellular level of reactive oxygen species is controlled, thus inhibiting the oxidative damage in non-target tissues and the tumor chemoresistance mediated by NF-kappaB or HIF-1alpha. Reactive Oxygen Species 157-180 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 30401882-8 2019 Taken together, we identified high STEAP1 transcript levels leading to reduced ROS production that prevented apoptosis via the NRF2 pathway in CRC cells as a pathological mechanism in CRC. Reactive Oxygen Species 79-82 NFE2 like bZIP transcription factor 2 Homo sapiens 127-131 31326116-10 2019 Overall, these results demonstrated that miR-152-3p protected neurons from OGD/R-induced apoptosis and ROS production by reinforcing Nrf2/ARE antioxidant signaling through targeting and inhibiting PSD-93, findings that suggest miR-152-3p is a potential target for neuroprotection during ischemic stroke. Reactive Oxygen Species 103-106 NFE2 like bZIP transcription factor 2 Homo sapiens 133-137 31091354-5 2019 T3 -dependent protective mechanisms include (i) the reactive oxygen species (ROS)-dependent activation of transcription factors nuclear factor-kappaB (NF-kappaB), AP-1, signal transducer and activator of transcription 3, and nuclear factor erythroid-2-related factor 2 (Nrf2) upregulating the expression of protective proteins. Reactive Oxygen Species 52-75 NFE2 like bZIP transcription factor 2 Homo sapiens 225-268 31229571-11 2019 These results suggest that heat shock-generated ROS were involved in induction of cellular defense molecules Prxs, GSH and G6PD through Nrf2 activation. Reactive Oxygen Species 48-51 NFE2 like bZIP transcription factor 2 Homo sapiens 136-140 31091354-5 2019 T3 -dependent protective mechanisms include (i) the reactive oxygen species (ROS)-dependent activation of transcription factors nuclear factor-kappaB (NF-kappaB), AP-1, signal transducer and activator of transcription 3, and nuclear factor erythroid-2-related factor 2 (Nrf2) upregulating the expression of protective proteins. Reactive Oxygen Species 52-75 NFE2 like bZIP transcription factor 2 Homo sapiens 270-274 31091354-5 2019 T3 -dependent protective mechanisms include (i) the reactive oxygen species (ROS)-dependent activation of transcription factors nuclear factor-kappaB (NF-kappaB), AP-1, signal transducer and activator of transcription 3, and nuclear factor erythroid-2-related factor 2 (Nrf2) upregulating the expression of protective proteins. Reactive Oxygen Species 77-80 NFE2 like bZIP transcription factor 2 Homo sapiens 225-268 31091354-5 2019 T3 -dependent protective mechanisms include (i) the reactive oxygen species (ROS)-dependent activation of transcription factors nuclear factor-kappaB (NF-kappaB), AP-1, signal transducer and activator of transcription 3, and nuclear factor erythroid-2-related factor 2 (Nrf2) upregulating the expression of protective proteins. Reactive Oxygen Species 77-80 NFE2 like bZIP transcription factor 2 Homo sapiens 270-274 31382215-3 2019 Here, we show that combination therapy targeting the generation of ROS through NADPH oxidase inhibition and the endogenous antioxidant system through nuclear factor erythroid 2-related factor 2 (Nrf2) activation prevents excessive ROS accumulation, mitochondrial depolarisation and neuronal death during in vitro seizure-like activity. Reactive Oxygen Species 67-70 NFE2 like bZIP transcription factor 2 Homo sapiens 195-199 31302408-14 2019 Nrf2 short-term pharmacological activation attenuates age-related impairment of endothelium-dependent and reactive oxygen species (ROS)-induced vasodilation in different rat and human vascular territories by upregulation of Nrf2-related signaling and decreased oxidative stress. Reactive Oxygen Species 131-134 NFE2 like bZIP transcription factor 2 Homo sapiens 224-228 31382215-3 2019 Here, we show that combination therapy targeting the generation of ROS through NADPH oxidase inhibition and the endogenous antioxidant system through nuclear factor erythroid 2-related factor 2 (Nrf2) activation prevents excessive ROS accumulation, mitochondrial depolarisation and neuronal death during in vitro seizure-like activity. Reactive Oxygen Species 231-234 NFE2 like bZIP transcription factor 2 Homo sapiens 150-193 31382215-3 2019 Here, we show that combination therapy targeting the generation of ROS through NADPH oxidase inhibition and the endogenous antioxidant system through nuclear factor erythroid 2-related factor 2 (Nrf2) activation prevents excessive ROS accumulation, mitochondrial depolarisation and neuronal death during in vitro seizure-like activity. Reactive Oxygen Species 67-70 NFE2 like bZIP transcription factor 2 Homo sapiens 150-193 31382215-3 2019 Here, we show that combination therapy targeting the generation of ROS through NADPH oxidase inhibition and the endogenous antioxidant system through nuclear factor erythroid 2-related factor 2 (Nrf2) activation prevents excessive ROS accumulation, mitochondrial depolarisation and neuronal death during in vitro seizure-like activity. Reactive Oxygen Species 231-234 NFE2 like bZIP transcription factor 2 Homo sapiens 195-199 31423010-8 2019 Nrf2-mediated FPN1 downregulation promoted intracellular iron accumulation and reactive oxygen species. Reactive Oxygen Species 79-102 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 31470592-2 2019 The NRF2-NQO1 axis represents a protective mechanism against ROS. Reactive Oxygen Species 61-64 NFE2 like bZIP transcription factor 2 Homo sapiens 4-8 31455352-13 2019 We also found that cardamonin inhibited the Nrf2-dependent ROS scavenging system which further increased intracellular ROS levels. Reactive Oxygen Species 59-62 NFE2 like bZIP transcription factor 2 Homo sapiens 44-48 31455352-13 2019 We also found that cardamonin inhibited the Nrf2-dependent ROS scavenging system which further increased intracellular ROS levels. Reactive Oxygen Species 119-122 NFE2 like bZIP transcription factor 2 Homo sapiens 44-48 31467925-0 2019 Nrf2-Heme Oxygenase-1 Attenuates High-Glucose-Induced Epithelial-to-Mesenchymal Transition of Renal Tubule Cells by Inhibiting ROS-Mediated PI3K/Akt/GSK-3beta Signaling. Reactive Oxygen Species 127-130 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 31456942-6 2019 Mechanistically, we show that SIRT5 contributes to cisplatin resistance in ovarian cancer by suppressing cisplatin-induced DNA damage in a reactive oxygen species (ROS)-dependent manner via regulation of the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway. Reactive Oxygen Species 164-167 NFE2 like bZIP transcription factor 2 Homo sapiens 208-251 31456942-6 2019 Mechanistically, we show that SIRT5 contributes to cisplatin resistance in ovarian cancer by suppressing cisplatin-induced DNA damage in a reactive oxygen species (ROS)-dependent manner via regulation of the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway. Reactive Oxygen Species 164-167 NFE2 like bZIP transcription factor 2 Homo sapiens 253-257 31467925-9 2019 Conclusion: The present study suggests that Nrf2-HO-1 signaling has an inhibitory role in the regulation of EMT through the modulation of ROS-mediated PI3K/Akt/GSK-3beta activity, highlighting Nrf2-HO-1 and GSK-3beta as potential therapeutic targets in diabetic nephropathy. Reactive Oxygen Species 138-141 NFE2 like bZIP transcription factor 2 Homo sapiens 44-48 31467925-9 2019 Conclusion: The present study suggests that Nrf2-HO-1 signaling has an inhibitory role in the regulation of EMT through the modulation of ROS-mediated PI3K/Akt/GSK-3beta activity, highlighting Nrf2-HO-1 and GSK-3beta as potential therapeutic targets in diabetic nephropathy. Reactive Oxygen Species 138-141 NFE2 like bZIP transcription factor 2 Homo sapiens 193-197 30623427-1 2019 Induction of reactive oxygen species (ROS), an important process for the cytotoxicity of various acute myeloid leukemia (AML) therapies including hypomethylating agents (HMAs), concurrently activates the NF-E2-related factor 2 (Nrf2) antioxidant response pathway which in turn results in induction of antioxidant enzymes that neutralize ROS. Reactive Oxygen Species 13-36 NFE2 like bZIP transcription factor 2 Homo sapiens 204-226 31382550-7 2019 In particular, we describe how ROS impact various signaling pathways of autophagy, including mTORC1-ULK1, AMPK-mTORC1-ULK1, and Keap1-Nrf2-p62, as well as selective autophagy including mitophagy and pexophagy. Reactive Oxygen Species 31-34 NFE2 like bZIP transcription factor 2 Homo sapiens 134-138 30623427-1 2019 Induction of reactive oxygen species (ROS), an important process for the cytotoxicity of various acute myeloid leukemia (AML) therapies including hypomethylating agents (HMAs), concurrently activates the NF-E2-related factor 2 (Nrf2) antioxidant response pathway which in turn results in induction of antioxidant enzymes that neutralize ROS. Reactive Oxygen Species 13-36 NFE2 like bZIP transcription factor 2 Homo sapiens 228-232 30623427-1 2019 Induction of reactive oxygen species (ROS), an important process for the cytotoxicity of various acute myeloid leukemia (AML) therapies including hypomethylating agents (HMAs), concurrently activates the NF-E2-related factor 2 (Nrf2) antioxidant response pathway which in turn results in induction of antioxidant enzymes that neutralize ROS. Reactive Oxygen Species 38-41 NFE2 like bZIP transcription factor 2 Homo sapiens 204-226 30623427-1 2019 Induction of reactive oxygen species (ROS), an important process for the cytotoxicity of various acute myeloid leukemia (AML) therapies including hypomethylating agents (HMAs), concurrently activates the NF-E2-related factor 2 (Nrf2) antioxidant response pathway which in turn results in induction of antioxidant enzymes that neutralize ROS. Reactive Oxygen Species 38-41 NFE2 like bZIP transcription factor 2 Homo sapiens 228-232 30623427-1 2019 Induction of reactive oxygen species (ROS), an important process for the cytotoxicity of various acute myeloid leukemia (AML) therapies including hypomethylating agents (HMAs), concurrently activates the NF-E2-related factor 2 (Nrf2) antioxidant response pathway which in turn results in induction of antioxidant enzymes that neutralize ROS. Reactive Oxygen Species 337-340 NFE2 like bZIP transcription factor 2 Homo sapiens 204-226 30623427-1 2019 Induction of reactive oxygen species (ROS), an important process for the cytotoxicity of various acute myeloid leukemia (AML) therapies including hypomethylating agents (HMAs), concurrently activates the NF-E2-related factor 2 (Nrf2) antioxidant response pathway which in turn results in induction of antioxidant enzymes that neutralize ROS. Reactive Oxygen Species 337-340 NFE2 like bZIP transcription factor 2 Homo sapiens 228-232 31346356-2 2019 Nrf2 induces the expression of metabolic detoxification and antioxidant enzymes to eliminate reactive oxygen species (ROS). Reactive Oxygen Species 93-116 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 31047916-4 2019 Using the Caenorhabditis elegans (C. elegans) nematode model, we observed that EGCG activated SKN-1 (the functional ortholog of Nrf2 in C. elegans), as shown by the increased skn-1 mRNA level, induction of the gene gst-4, and enhanced SKN-1-mediated oxidative stress resistance that were indicated by elevation of total antioxidant ability and reductions in reactive oxygen species and malondialdehyde. Reactive Oxygen Species 358-381 NFE2 like bZIP transcription factor 2 Homo sapiens 128-132 31316111-6 2019 A classic NRF2 activator, tert-butylhydroquinone (tBHQ), significantly decreased ROS levels and calcium deposition in VSMCs by promoting the nuclear translocation of NRF2 and upregulating P62 and KEAP1 expression. Reactive Oxygen Species 81-84 NFE2 like bZIP transcription factor 2 Homo sapiens 10-14 31316111-7 2019 In contrast, silencing NRF2 and P62 with siRNAs increased the levels of ROS and calcium deposition in VSMCs. Reactive Oxygen Species 72-75 NFE2 like bZIP transcription factor 2 Homo sapiens 23-27 31336817-8 2019 Furthermore, prodigiosin promoted Nrf2 protein level and inhibited ROS in Nrf2 knocked down HepG2 cells. Reactive Oxygen Species 67-70 NFE2 like bZIP transcription factor 2 Homo sapiens 74-78 31029719-7 2019 ROS generation was partially mediated by CYPs induction and downregulation of NRF2-pathway through KEAP1 overexpression. Reactive Oxygen Species 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 78-82 31346356-2 2019 Nrf2 induces the expression of metabolic detoxification and antioxidant enzymes to eliminate reactive oxygen species (ROS). Reactive Oxygen Species 118-121 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 30758914-10 2019 ALA treatment decreased ROS production in UPM-exposed fibroblasts via the Nrf2, HO-1, and NQO-1 pathways. Reactive Oxygen Species 24-27 NFE2 like bZIP transcription factor 2 Homo sapiens 74-78 31242588-3 2019 During physical exercise, the reactive oxygen species (ROS) are increased; therefore, if the endogenous and exogenous antioxidant defenses are unable to control the elevation of ROS, the resulting OS triggers the activation of the transcriptional factor Nrf2 to induce the antioxidant response. Reactive Oxygen Species 30-53 NFE2 like bZIP transcription factor 2 Homo sapiens 254-258 31242588-3 2019 During physical exercise, the reactive oxygen species (ROS) are increased; therefore, if the endogenous and exogenous antioxidant defenses are unable to control the elevation of ROS, the resulting OS triggers the activation of the transcriptional factor Nrf2 to induce the antioxidant response. Reactive Oxygen Species 55-58 NFE2 like bZIP transcription factor 2 Homo sapiens 254-258 31242588-3 2019 During physical exercise, the reactive oxygen species (ROS) are increased; therefore, if the endogenous and exogenous antioxidant defenses are unable to control the elevation of ROS, the resulting OS triggers the activation of the transcriptional factor Nrf2 to induce the antioxidant response. Reactive Oxygen Species 178-181 NFE2 like bZIP transcription factor 2 Homo sapiens 254-258 31293646-0 2019 Nuclear Nrf2 Activity in Laryngeal Carcinoma is Regulated by SENP3 After Cisplatin-Induced Reactive Oxygen Species Stress. Reactive Oxygen Species 91-114 NFE2 like bZIP transcription factor 2 Homo sapiens 8-12 31293646-1 2019 Nuclear factor erythroid 2-related factor 2 (Nrf2) is a nuclear transcription factor that is activated by reactive oxygen species (ROS). Reactive Oxygen Species 106-129 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 31293646-1 2019 Nuclear factor erythroid 2-related factor 2 (Nrf2) is a nuclear transcription factor that is activated by reactive oxygen species (ROS). Reactive Oxygen Species 106-129 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 31293646-1 2019 Nuclear factor erythroid 2-related factor 2 (Nrf2) is a nuclear transcription factor that is activated by reactive oxygen species (ROS). Reactive Oxygen Species 131-134 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 31293646-1 2019 Nuclear factor erythroid 2-related factor 2 (Nrf2) is a nuclear transcription factor that is activated by reactive oxygen species (ROS). Reactive Oxygen Species 131-134 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 31293646-9 2019 Our data identified intranuclear activation of Nrf2 is triggered by cisplatin-induced ROS development through the activity of SENP3. Reactive Oxygen Species 86-89 NFE2 like bZIP transcription factor 2 Homo sapiens 47-51 30878937-3 2019 Lung cells silenced for Nrf2 (shNrf2) demonstrated diverse susceptibility to various PM extracts; water extracts containing high levels of dissolved metals exhibited higher capacity to generate mitochondrial reactive oxygen species (ROS) and hence increased oxidative stress levels. Reactive Oxygen Species 233-236 NFE2 like bZIP transcription factor 2 Homo sapiens 24-28 30758914-13 2019 ALA treatment inhibited this increase via the Nrf2 pathway, suggesting that ALA may have a protective effect against rhinitis caused by ROS expression induced by exposure to UPM. Reactive Oxygen Species 136-139 NFE2 like bZIP transcription factor 2 Homo sapiens 46-50 30047218-10 2019 CONCLUSION: These results indicate that the RPS extract suppresses MS transfer stimulated by ROS generated following UVB exposure through the activation of Nrf2 signaling. Reactive Oxygen Species 93-96 NFE2 like bZIP transcription factor 2 Homo sapiens 156-160 31360690-17 2019 The inhibition of ROS by treatment with N-acetylcysteine, a radical scavenger, abrogated Z-ajoene-induced expression of NQO1 as well as activation of ERK and Nrf2, suggesting that Z-ajoene augments the Nrf2-dependent antioxidant defense via ROS generation and ERK activation. Reactive Oxygen Species 18-21 NFE2 like bZIP transcription factor 2 Homo sapiens 158-162 31360690-17 2019 The inhibition of ROS by treatment with N-acetylcysteine, a radical scavenger, abrogated Z-ajoene-induced expression of NQO1 as well as activation of ERK and Nrf2, suggesting that Z-ajoene augments the Nrf2-dependent antioxidant defense via ROS generation and ERK activation. Reactive Oxygen Species 18-21 NFE2 like bZIP transcription factor 2 Homo sapiens 202-206 31360690-18 2019 Conclusions: Z-ajoene induces NQO1 expression in MCF-10A cells through ROS-mediated activation of Nrf2. Reactive Oxygen Species 71-74 NFE2 like bZIP transcription factor 2 Homo sapiens 98-102 30215291-4 2019 Urolithin A also reduced intracellular reactive oxygen species, which may be partially due to activation of the Nrf2-mediated antioxidative response. Reactive Oxygen Species 39-62 NFE2 like bZIP transcription factor 2 Homo sapiens 112-116 30737796-5 2019 Ultimately, resveratrol-enriched grape peel extract significantly augmented the antioxidant response in vitro, possibly by attenuating the accumulation of intracellular reactive oxygen species via the Nrf2 signaling pathway. Reactive Oxygen Species 169-192 NFE2 like bZIP transcription factor 2 Homo sapiens 201-205 30818202-0 2019 N-acetylcysteine attenuates PM2.5-induced apoptosis by ROS-mediated Nrf2 pathway in human embryonic stem cells. Reactive Oxygen Species 55-58 NFE2 like bZIP transcription factor 2 Homo sapiens 68-72 30962285-5 2019 Treatment of cardiomyocytes with TMP195 or TMP269, which are selective class IIa HDAC inhibitors, or shRNA-mediated knockdown of HDAC5 but not HDAC9 leads to stimulation of NRF2-mediated transcription in a reactive oxygen species-dependent manner. Reactive Oxygen Species 206-229 NFE2 like bZIP transcription factor 2 Homo sapiens 173-177 30818202-8 2019 Interestingly, scavenging of PM2.5-induced ROS by N-acetylcysteine (NAC) could block cell apoptosis and rescue the activity of Nrf2 signaling pathway. Reactive Oxygen Species 43-46 NFE2 like bZIP transcription factor 2 Homo sapiens 127-131 30818202-9 2019 In conclusion, we demonstrate that PM2.5 is toxic to hESCs by inhibition of ROS-mediated Nrf2 pathway activity. Reactive Oxygen Species 76-79 NFE2 like bZIP transcription factor 2 Homo sapiens 89-93 30807827-10 2019 iHAEs showed relatively high resistance to ROS stimulation, which can be attributed to the high SOD2 expression and up-regulation of Nrf2, HO-1 after x-rays exposure. Reactive Oxygen Species 43-46 NFE2 like bZIP transcription factor 2 Homo sapiens 133-137 31139208-8 2019 Thus, ROS, in particular H2O2, were found to be strong Nrf2 activators. Reactive Oxygen Species 6-9 NFE2 like bZIP transcription factor 2 Homo sapiens 55-59 30851366-6 2019 Additionally, transient Nrf2 knockdown enhanced CPT-induced ROS production and hTERT promoter activity. Reactive Oxygen Species 60-63 NFE2 like bZIP transcription factor 2 Homo sapiens 24-28 30692632-5 2019 The HBXIP-mediated reduction in NRF2-KEAP1 complexes promotes NRF2 accumulation and nuclear entry, which facilities the activation of antioxidant response element (ARE)-dependent signaling cascades, thereby reducing the accumulation of endogenous cellular reactive oxygen species (ROS). Reactive Oxygen Species 256-279 NFE2 like bZIP transcription factor 2 Homo sapiens 32-36 30924710-1 2019 Glyceollins are soybean-derived phytoalexins that induce the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling pathway, which is involved in the detoxification of carcinogens and the removal of reactive oxygen species (ROS). Reactive Oxygen Species 205-228 NFE2 like bZIP transcription factor 2 Homo sapiens 106-110 30924710-1 2019 Glyceollins are soybean-derived phytoalexins that induce the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling pathway, which is involved in the detoxification of carcinogens and the removal of reactive oxygen species (ROS). Reactive Oxygen Species 230-233 NFE2 like bZIP transcription factor 2 Homo sapiens 106-110 30924710-2 2019 Recent studies, however, have indicated that Nrf2 induction stimulates the development of pre-existing tumors and confers resistance to chemotherapy by elevating drug metabolism and by efficient scavenging of ROS produced by the Warburg effect, which is regulated, in turn, by the p53 tumor suppressor. Reactive Oxygen Species 209-212 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 30692632-5 2019 The HBXIP-mediated reduction in NRF2-KEAP1 complexes promotes NRF2 accumulation and nuclear entry, which facilities the activation of antioxidant response element (ARE)-dependent signaling cascades, thereby reducing the accumulation of endogenous cellular reactive oxygen species (ROS). Reactive Oxygen Species 256-279 NFE2 like bZIP transcription factor 2 Homo sapiens 62-66 30692632-5 2019 The HBXIP-mediated reduction in NRF2-KEAP1 complexes promotes NRF2 accumulation and nuclear entry, which facilities the activation of antioxidant response element (ARE)-dependent signaling cascades, thereby reducing the accumulation of endogenous cellular reactive oxygen species (ROS). Reactive Oxygen Species 281-284 NFE2 like bZIP transcription factor 2 Homo sapiens 32-36 30692632-5 2019 The HBXIP-mediated reduction in NRF2-KEAP1 complexes promotes NRF2 accumulation and nuclear entry, which facilities the activation of antioxidant response element (ARE)-dependent signaling cascades, thereby reducing the accumulation of endogenous cellular reactive oxygen species (ROS). Reactive Oxygen Species 281-284 NFE2 like bZIP transcription factor 2 Homo sapiens 62-66 31003475-9 2019 Augmented PMN-MDSC ROS upregulated Notch1 receptor expression in CTCs through the ROS-NRF2-ARE axis, thus priming CTCs to respond to ligand-mediated (Jagged1) Notch activation. Reactive Oxygen Species 19-22 NFE2 like bZIP transcription factor 2 Homo sapiens 86-90 31003475-9 2019 Augmented PMN-MDSC ROS upregulated Notch1 receptor expression in CTCs through the ROS-NRF2-ARE axis, thus priming CTCs to respond to ligand-mediated (Jagged1) Notch activation. Reactive Oxygen Species 82-85 NFE2 like bZIP transcription factor 2 Homo sapiens 86-90 30995787-1 2019 Reactive oxygen species (ROS) induce nuclear factor erythroid 2-related factor 2 (Nrf2) activation as an adaptive defense mechanism, determining the synthesis of antioxidant molecules, including heme-oxygenase-1 (HO-1). Reactive Oxygen Species 0-23 NFE2 like bZIP transcription factor 2 Homo sapiens 37-80 30995787-1 2019 Reactive oxygen species (ROS) induce nuclear factor erythroid 2-related factor 2 (Nrf2) activation as an adaptive defense mechanism, determining the synthesis of antioxidant molecules, including heme-oxygenase-1 (HO-1). Reactive Oxygen Species 0-23 NFE2 like bZIP transcription factor 2 Homo sapiens 82-86 30995787-1 2019 Reactive oxygen species (ROS) induce nuclear factor erythroid 2-related factor 2 (Nrf2) activation as an adaptive defense mechanism, determining the synthesis of antioxidant molecules, including heme-oxygenase-1 (HO-1). Reactive Oxygen Species 25-28 NFE2 like bZIP transcription factor 2 Homo sapiens 37-80 30995787-1 2019 Reactive oxygen species (ROS) induce nuclear factor erythroid 2-related factor 2 (Nrf2) activation as an adaptive defense mechanism, determining the synthesis of antioxidant molecules, including heme-oxygenase-1 (HO-1). Reactive Oxygen Species 25-28 NFE2 like bZIP transcription factor 2 Homo sapiens 82-86 30798127-5 2019 We show that administration of two NRF2 gene inducers namely the semi-synthetic triterpenoid Bardoxolone methyl, and the isothiocyanate sulfurophane, result in cardioprotection against doxorubicin toxicity comparable to dexrazoxane as evidenced by an increase in cell viability and a decrease in the production of reactive oxygen species. Reactive Oxygen Species 314-337 NFE2 like bZIP transcription factor 2 Homo sapiens 35-39 30826055-5 2019 By treating RAW cells with three compounds, we found that NRF2 was activated and its downstream antioxidant genes were upregulated, and the RANKL-induced intracellular ROS production and osteoclastogenesis were impaired. Reactive Oxygen Species 168-171 NFE2 like bZIP transcription factor 2 Homo sapiens 58-62 30821469-8 2019 The compound diminished ROS levels and increased cell viability and GSH content by activating the nuclear factor Nrf2. Reactive Oxygen Species 24-27 NFE2 like bZIP transcription factor 2 Homo sapiens 113-117 30701326-7 2019 RMS rapidly and efficiently brought back ROS levels by up-regulating the gene expression of antioxidant enzymes, miRNAs as well as of NRF2. Reactive Oxygen Species 41-44 NFE2 like bZIP transcription factor 2 Homo sapiens 134-138 30701326-8 2019 Silencing of NRF2 restrained the RMS ability to counteract RT-induced ROS accumulation, antioxidant enzyme and miRNA expression and was able to increase the abundance of gamma-H2AX, a biomarker of DNA damage, in RT-treated cells. Reactive Oxygen Species 70-73 NFE2 like bZIP transcription factor 2 Homo sapiens 13-17 30802714-11 2019 Treatment of JFD suppressed the activation of ERK and mTOR and activated the KEAP1/NRF2/ARE signaling axis, which is a predominant regulator of cytoprotective responses to oxidative stress, thereby lessening the damage caused by excess reactive oxygen species (ROS). Reactive Oxygen Species 236-259 NFE2 like bZIP transcription factor 2 Homo sapiens 83-87 30802714-11 2019 Treatment of JFD suppressed the activation of ERK and mTOR and activated the KEAP1/NRF2/ARE signaling axis, which is a predominant regulator of cytoprotective responses to oxidative stress, thereby lessening the damage caused by excess reactive oxygen species (ROS). Reactive Oxygen Species 261-264 NFE2 like bZIP transcription factor 2 Homo sapiens 83-87 30765703-3 2019 Here we show that the kinases Mst1 and Mst2 (Mst1/2) sense ROS and maintain cellular redox balance by modulating the stability of antioxidant transcription factor Nrf2. Reactive Oxygen Species 59-62 NFE2 like bZIP transcription factor 2 Homo sapiens 163-167 30765703-4 2019 Site-specific ROS release recruits Mst1/2 from the cytosol to the phagosomal or mitochondrial membrane, with ROS subsequently activating Mst1/2 to phosphorylate kelch like ECH associated protein 1 (Keap1) and prevent Keap1 polymerization, thereby blocking Nrf2 ubiquitination and degradation to protect cells against oxidative damage. Reactive Oxygen Species 14-17 NFE2 like bZIP transcription factor 2 Homo sapiens 256-260 30765703-4 2019 Site-specific ROS release recruits Mst1/2 from the cytosol to the phagosomal or mitochondrial membrane, with ROS subsequently activating Mst1/2 to phosphorylate kelch like ECH associated protein 1 (Keap1) and prevent Keap1 polymerization, thereby blocking Nrf2 ubiquitination and degradation to protect cells against oxidative damage. Reactive Oxygen Species 109-112 NFE2 like bZIP transcription factor 2 Homo sapiens 256-260 30765703-5 2019 Treatment with the antioxidant N-acetylcysteine disrupts ROS-induced interaction of Mst1/2 with phagosomes or mitochondria, and thereby diminishes the Mst-Nrf2 signal. Reactive Oxygen Species 57-60 NFE2 like bZIP transcription factor 2 Homo sapiens 155-159 30765703-7 2019 Thus, our results identify the Mst-Nrf2 axis as an important ROS-sensing and antioxidant mechanism during an antimicrobial response. Reactive Oxygen Species 61-64 NFE2 like bZIP transcription factor 2 Homo sapiens 35-39 30412705-8 2019 Because NRF2 regulates reactive oxygen species levels, additional studies investigated mechanisms of HbF regulation using a hemin-induced oxidative stress model. Reactive Oxygen Species 23-46 NFE2 like bZIP transcription factor 2 Homo sapiens 8-12 30597358-1 2019 Nrf2 and Bach1 are important transcriptional factors that protect against reactive oxygen species (ROS). Reactive Oxygen Species 74-97 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 30597358-1 2019 Nrf2 and Bach1 are important transcriptional factors that protect against reactive oxygen species (ROS). Reactive Oxygen Species 99-102 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 30277819-2 2019 Previous studies have shown that a regulatory connection exists between NRF2 and autophagy during reactive oxygen species-generated oxidative stress. Reactive Oxygen Species 98-121 NFE2 like bZIP transcription factor 2 Homo sapiens 72-76 30647407-10 2019 Our observations indicate that the c-Met-Nrf2-HO-1 pathway plays a vital role in relieving ROS-mediated oxidative stress of renal tumors. Reactive Oxygen Species 91-94 NFE2 like bZIP transcription factor 2 Homo sapiens 41-45 30569096-9 2019 In addition, Nrf2 silencing enhanced the effects of H2O2 by promoting ROS production and cell apoptosis. Reactive Oxygen Species 70-73 NFE2 like bZIP transcription factor 2 Homo sapiens 13-17 30529626-0 2019 Cordycepin sensitizes breast cancer cells toward irradiation through elevating ROS production involving Nrf2. Reactive Oxygen Species 79-82 NFE2 like bZIP transcription factor 2 Homo sapiens 104-108 30529626-5 2019 Importantly, cordycepin treatment down-regulated the expression levels of Nuclear factor erythroid 2-related factor (Nrf2) and a series of downstream genes, such as heme oxygenase-1 (HO-1), to enhance ROS in breast cancer cells exposed to irradiation. Reactive Oxygen Species 201-204 NFE2 like bZIP transcription factor 2 Homo sapiens 74-115 30529626-5 2019 Importantly, cordycepin treatment down-regulated the expression levels of Nuclear factor erythroid 2-related factor (Nrf2) and a series of downstream genes, such as heme oxygenase-1 (HO-1), to enhance ROS in breast cancer cells exposed to irradiation. Reactive Oxygen Species 201-204 NFE2 like bZIP transcription factor 2 Homo sapiens 117-121 30800209-8 2019 These data indicate that curcumin may induce ROS scavenging by upregulating Nrf2 and GSH, thus inhibiting HIF-1alpha stabilization to suppress CTGF expression to exhibit its protection on HCC. Reactive Oxygen Species 45-48 NFE2 like bZIP transcription factor 2 Homo sapiens 76-80 30445746-7 2018 Induction of ARE (antioxidant responsive element) and ROS (reactive oxygen species) mediated pathway by Nrf2 controls the activity of nuclear factor-kappaB (NF-kappaB). Reactive Oxygen Species 54-57 NFE2 like bZIP transcription factor 2 Homo sapiens 104-108 31079103-1 2019 BACKGROUND/AIMS: The Nrf2 signaling pathway plays a pivotal role in neutralizing excess reactive oxygen species formation and therefore enhancing the endogenous cellular protection mechanism. Reactive Oxygen Species 88-111 NFE2 like bZIP transcription factor 2 Homo sapiens 21-25 30248308-7 2018 Knocking down HO-1 or Nrf2 with the special siRNA also led to elevated ROS level and enhanced NTP-induced cell death. Reactive Oxygen Species 71-74 NFE2 like bZIP transcription factor 2 Homo sapiens 22-26 31298161-7 2019 NRF-2 mediated antioxidant mechanism always suppresses the formation of superoxide (O2-) as well as other reactive oxygen species (ROS). Reactive Oxygen Species 106-129 NFE2 like bZIP transcription factor 2 Homo sapiens 0-5 31298161-7 2019 NRF-2 mediated antioxidant mechanism always suppresses the formation of superoxide (O2-) as well as other reactive oxygen species (ROS). Reactive Oxygen Species 131-134 NFE2 like bZIP transcription factor 2 Homo sapiens 0-5 30444987-6 2019 Further, the treatment prevented MMPs loss by directly scavenging the ROS and restored the antioxidant enzyme network with normalization of heme oxygenase-1 (HO-1) expression by inhibiting nuclear translocation of Nrf2. Reactive Oxygen Species 70-73 NFE2 like bZIP transcription factor 2 Homo sapiens 214-218 30445746-7 2018 Induction of ARE (antioxidant responsive element) and ROS (reactive oxygen species) mediated pathway by Nrf2 controls the activity of nuclear factor-kappaB (NF-kappaB). Reactive Oxygen Species 59-82 NFE2 like bZIP transcription factor 2 Homo sapiens 104-108 29972223-3 2018 However, antioxidant AHR ligands inhibit reactive oxygen species generation via activation of nuclear factor-erythroid 2-related factor-2, which is a master switch for antioxidative signalling. Reactive Oxygen Species 41-64 NFE2 like bZIP transcription factor 2 Homo sapiens 94-137 30337853-9 2018 The reduced glutathione, a major small molecule antioxidant present in all mammalian cells, and produced by several downstream target genes of NRF2, counterbalances the mitochondrial reactive oxygen species (ROS) production. Reactive Oxygen Species 183-206 NFE2 like bZIP transcription factor 2 Homo sapiens 143-147 29722183-9 2018 Emerging evidences support a low-level laser stimulation mediated increase in "good" reactive oxygen species, able to activate redox sensitive signal transduction pathways such as Nrf-2, NF-kB, ERK which act as key redox checkpoints. Reactive Oxygen Species 85-108 NFE2 like bZIP transcription factor 2 Homo sapiens 180-185 30426047-4 2018 NRF2 is a transcription factor induced by ROS. Reactive Oxygen Species 42-45 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 30243728-0 2018 The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K. Reactive Oxygen Species 94-97 NFE2 like bZIP transcription factor 2 Homo sapiens 47-51 30337853-9 2018 The reduced glutathione, a major small molecule antioxidant present in all mammalian cells, and produced by several downstream target genes of NRF2, counterbalances the mitochondrial reactive oxygen species (ROS) production. Reactive Oxygen Species 208-211 NFE2 like bZIP transcription factor 2 Homo sapiens 143-147 29902531-3 2018 Nuclear factor-erythroid 2-related factor 2 (Nrf2) represents an important intracellular defense system that protects cells against oxidative insults caused by ROS. Reactive Oxygen Species 160-163 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 30227999-2 2018 Activation of nuclear transcription factor erythroid 2-related factor (Nrf2) by small molecules could eliminate ROS, and thus block the pathogenesis of oxidative stress-induced diseases. Reactive Oxygen Species 112-115 NFE2 like bZIP transcription factor 2 Homo sapiens 14-69 30227999-2 2018 Activation of nuclear transcription factor erythroid 2-related factor (Nrf2) by small molecules could eliminate ROS, and thus block the pathogenesis of oxidative stress-induced diseases. Reactive Oxygen Species 112-115 NFE2 like bZIP transcription factor 2 Homo sapiens 71-75 29894801-8 2018 Both ROS detection assays demonstrated an increase in the amount of ROS by CSE in ovarian cells, which was consistent with the results observed for the Keap1-Nrf2 pathway upon Western blot analysis. Reactive Oxygen Species 5-8 NFE2 like bZIP transcription factor 2 Homo sapiens 158-162 29894801-8 2018 Both ROS detection assays demonstrated an increase in the amount of ROS by CSE in ovarian cells, which was consistent with the results observed for the Keap1-Nrf2 pathway upon Western blot analysis. Reactive Oxygen Species 68-71 NFE2 like bZIP transcription factor 2 Homo sapiens 158-162 30009418-6 2018 Reactive oxygen species scavenging, antiinflammatory, and modulation of various molecular pathways such as Nrf2, NFkB, p-21 activated kinase 1 (PAK1), and p-smad2/3 signaling modulation have been implicated behind the claimed protection. Reactive Oxygen Species 0-23 NFE2 like bZIP transcription factor 2 Homo sapiens 107-111 29902531-3 2018 Nuclear factor-erythroid 2-related factor 2 (Nrf2) represents an important intracellular defense system that protects cells against oxidative insults caused by ROS. Reactive Oxygen Species 160-163 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 29902531-4 2018 Therefore, molecules with the capacities of inducing Nrf2, and preventing mitochondrial dysfunction can inhibit cell apoptosis, and thus are potential drug candidates for the therapy of ROS-mediated vascular diseases. Reactive Oxygen Species 186-189 NFE2 like bZIP transcription factor 2 Homo sapiens 53-57 30319732-9 2018 Autophagy and NRF2 form a positive feedback regulation loop to regulate reactive oxygen species (ROS) levels in ovarian cancer spheroid cells. Reactive Oxygen Species 72-95 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 30319732-9 2018 Autophagy and NRF2 form a positive feedback regulation loop to regulate reactive oxygen species (ROS) levels in ovarian cancer spheroid cells. Reactive Oxygen Species 97-100 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 30127006-3 2018 NRF2 plays a critical role in the innate immune system, limiting inflammation via reactive oxygen species (ROS) suppression and direct repression of the proinflammatory cytokines, IL-1beta and IL-6. Reactive Oxygen Species 82-105 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 30180849-7 2018 The Nrf2 activation of macrophages correlated with the reactive oxygen species induced by cancer cells derived lactate. Reactive Oxygen Species 55-78 NFE2 like bZIP transcription factor 2 Homo sapiens 4-8 30127006-3 2018 NRF2 plays a critical role in the innate immune system, limiting inflammation via reactive oxygen species (ROS) suppression and direct repression of the proinflammatory cytokines, IL-1beta and IL-6. Reactive Oxygen Species 107-110 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 29885333-13 2018 In untransformed cells, this sulforaphane induced inducible Nrf2 to decrease ROS and possibly malignant cell transformation. Reactive Oxygen Species 77-80 NFE2 like bZIP transcription factor 2 Homo sapiens 60-64 30112565-10 2018 WGS and LY294002 (PI3K inhibitor) both remarkably decreased the phosphorylation level of Akt (P < 0.05), down-regulated the protein level of Nrf2 (P < 0.05), increased the content of ROS (P < 0.05), up-regulated the protein level of cleaved Caspase-3 (P < 0.05), and induced apoptosis (P < 0.05). Reactive Oxygen Species 189-192 NFE2 like bZIP transcription factor 2 Homo sapiens 144-148 29969714-12 2018 Thus, there is a "Dr. Jekyll and Mr. Hyde" effect of ROS: ROS enhance sulforaphane"s ARE-regulated gene expression even as they also inhibit Nrf2 protein synthesis. Reactive Oxygen Species 53-56 NFE2 like bZIP transcription factor 2 Homo sapiens 141-145 29969714-12 2018 Thus, there is a "Dr. Jekyll and Mr. Hyde" effect of ROS: ROS enhance sulforaphane"s ARE-regulated gene expression even as they also inhibit Nrf2 protein synthesis. Reactive Oxygen Species 58-61 NFE2 like bZIP transcription factor 2 Homo sapiens 141-145 30203714-1 2018 Autoimmune rheumatic lesions are often characterised by the immune cell recruitment including B lymphocytes and the presence of reactive oxygen species (ROS), which increase antioxidant gene transcription via nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Reactive Oxygen Species 128-151 NFE2 like bZIP transcription factor 2 Homo sapiens 254-258 30203714-1 2018 Autoimmune rheumatic lesions are often characterised by the immune cell recruitment including B lymphocytes and the presence of reactive oxygen species (ROS), which increase antioxidant gene transcription via nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Reactive Oxygen Species 153-156 NFE2 like bZIP transcription factor 2 Homo sapiens 254-258 30203714-3 2018 In this study, we investigated whether B cell survival is regulated by Nrf2 via ROS-mediated Syk activation in WiL2-NS human B lymphoblast cells. Reactive Oxygen Species 80-83 NFE2 like bZIP transcription factor 2 Homo sapiens 71-75 29969714-0 2018 Dr. Jekyll and Mr. Hyde: Oxidizable phenol-generated reactive oxygen species enhance sulforaphane"s antioxidant response element activation, even as they suppress Nrf2 protein accumulation. Reactive Oxygen Species 53-76 NFE2 like bZIP transcription factor 2 Homo sapiens 163-167 29960846-3 2018 Nuclear factor erythroid 2-related factor 2 (Nrf2) has been reported to be activated by ROS through inactivation of its regulating protein, Kelch-like ECH-associated protein (Keap1), and to be the key mediator of phase I and phase II drug metabolizing enzymes, and phase III drug transporters. Reactive Oxygen Species 88-91 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 29701272-2 2018 The transcription factor NF-E2 p45-related factor 2 (NRF2, also called Nfe2l2), a master regulator of redox homoeostasis, has been reported to tightly control the expression of numerous ROS-detoxification genes and participates in drug resistance. Reactive Oxygen Species 186-189 NFE2 like bZIP transcription factor 2 Homo sapiens 25-51 29701272-2 2018 The transcription factor NF-E2 p45-related factor 2 (NRF2, also called Nfe2l2), a master regulator of redox homoeostasis, has been reported to tightly control the expression of numerous ROS-detoxification genes and participates in drug resistance. Reactive Oxygen Species 186-189 NFE2 like bZIP transcription factor 2 Homo sapiens 53-57 29701272-2 2018 The transcription factor NF-E2 p45-related factor 2 (NRF2, also called Nfe2l2), a master regulator of redox homoeostasis, has been reported to tightly control the expression of numerous ROS-detoxification genes and participates in drug resistance. Reactive Oxygen Species 186-189 NFE2 like bZIP transcription factor 2 Homo sapiens 71-77 29784660-6 2018 IL-6-driven ROS reduction is associated with an increase in the master antioxidant factor NRF2, which rapidly translocates to the mitochondria to decrease mitochondrial activity and stimulate mitophagy. Reactive Oxygen Species 12-15 NFE2 like bZIP transcription factor 2 Homo sapiens 90-94 30069011-4 2018 T-ALL cells treated with NS1619 and DHEA showed activation of the ROS-responsive transcription factor NRF2, indicating engagement of antioxidant pathways, as well as increased cleavage of OPA1, a mitochondrial protein that promotes mitochondrial fusion and regulates apoptosis. Reactive Oxygen Species 66-69 NFE2 like bZIP transcription factor 2 Homo sapiens 102-106 29960846-3 2018 Nuclear factor erythroid 2-related factor 2 (Nrf2) has been reported to be activated by ROS through inactivation of its regulating protein, Kelch-like ECH-associated protein (Keap1), and to be the key mediator of phase I and phase II drug metabolizing enzymes, and phase III drug transporters. Reactive Oxygen Species 88-91 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 29441509-1 2018 Nuclear factor erythroid 2-related factor 2 (NRF2), DJ1 and sulfiredoxin 1 (SRXN1) are transcription factors which protect cells from the oxidative damage caused by reactive oxygen species and, on the other hand, are associated with resistance to cancer treatments. Reactive Oxygen Species 165-188 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 29441509-1 2018 Nuclear factor erythroid 2-related factor 2 (NRF2), DJ1 and sulfiredoxin 1 (SRXN1) are transcription factors which protect cells from the oxidative damage caused by reactive oxygen species and, on the other hand, are associated with resistance to cancer treatments. Reactive Oxygen Species 165-188 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 29737559-4 2018 Most viruses cause oxidative stress and increase the activity of radicals and reactive oxygen species (ROS), subsequently, the cellular protection system activates the Nrf2 and increases the expression of cytoprotective genes. Reactive Oxygen Species 103-106 NFE2 like bZIP transcription factor 2 Homo sapiens 168-172 29901070-5 2018 Western blot analysis and RT-qPCR revealed that NRG1 regulates ERK pathway and the pivotal regulator of cellular redox status, nuclear factor E2-related factor 2 (NRF2), which maintains moderate reactive oxygen species (ROS) levels through a set of antioxidant response element (ARE)-containing genes. Reactive Oxygen Species 195-218 NFE2 like bZIP transcription factor 2 Homo sapiens 163-167 29901070-5 2018 Western blot analysis and RT-qPCR revealed that NRG1 regulates ERK pathway and the pivotal regulator of cellular redox status, nuclear factor E2-related factor 2 (NRF2), which maintains moderate reactive oxygen species (ROS) levels through a set of antioxidant response element (ARE)-containing genes. Reactive Oxygen Species 220-223 NFE2 like bZIP transcription factor 2 Homo sapiens 163-167 29901070-7 2018 Since the presence of NRG1 regulates redox homeostasis through NRF2, protecting PTC cells from the accumulation of ROS and ROS-induced cell death, NRG1 may thus prove to be a potential therapeutic target in the treatment of thyroid cancer. Reactive Oxygen Species 115-118 NFE2 like bZIP transcription factor 2 Homo sapiens 63-67 29901070-7 2018 Since the presence of NRG1 regulates redox homeostasis through NRF2, protecting PTC cells from the accumulation of ROS and ROS-induced cell death, NRG1 may thus prove to be a potential therapeutic target in the treatment of thyroid cancer. Reactive Oxygen Species 123-126 NFE2 like bZIP transcription factor 2 Homo sapiens 63-67 29737559-5 2018 However, in some cases, the activation of Nrf2 is not ROS-dependent, and is carried out directly via the ROS-independent pathway. Reactive Oxygen Species 54-57 NFE2 like bZIP transcription factor 2 Homo sapiens 42-46 29737559-5 2018 However, in some cases, the activation of Nrf2 is not ROS-dependent, and is carried out directly via the ROS-independent pathway. Reactive Oxygen Species 105-108 NFE2 like bZIP transcription factor 2 Homo sapiens 42-46 30123077-8 2018 Additionally, the Nrf2-mediated antioxidative response, which works against with bortezomib-induced autophagy, also protected cells against bortezomib-induced ROS production. Reactive Oxygen Species 159-162 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22 29792947-8 2018 In addition, silencing of Nrf2 increased apoptosis in cells treated with SFN/TRAIL; however, blockade of ROS generation inhibited apoptotic activity. Reactive Oxygen Species 105-108 NFE2 like bZIP transcription factor 2 Homo sapiens 26-30 30060630-7 2018 Nuclear factor erythroid 2-related factor-2 (Nrf2) is a transcription factor that mediates various antioxidant enzymes and regulates cellular ROS levels. Reactive Oxygen Species 142-145 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 30060630-7 2018 Nuclear factor erythroid 2-related factor-2 (Nrf2) is a transcription factor that mediates various antioxidant enzymes and regulates cellular ROS levels. Reactive Oxygen Species 142-145 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 30060630-18 2018 Thus, the use of bioactive substances such as CTP, which activates Nrf2 to reduce the cellular level of ROS and inhibit the adipogenic differentiation of hASCs, could be a new strategy for overcoming obesity. Reactive Oxygen Species 104-107 NFE2 like bZIP transcription factor 2 Homo sapiens 67-71 29941222-2 2018 Nuclear factor erythroid-2 related factor 2 (Nrf2) plays a critical role against ROS factors to conserve epithelial integrity. Reactive Oxygen Species 81-84 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 29941222-2 2018 Nuclear factor erythroid-2 related factor 2 (Nrf2) plays a critical role against ROS factors to conserve epithelial integrity. Reactive Oxygen Species 81-84 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 30123077-0 2018 Combined inhibition of autophagy and Nrf2 signaling augments bortezomib-induced apoptosis by increasing ROS production and ER stress in pancreatic cancer cells. Reactive Oxygen Species 104-107 NFE2 like bZIP transcription factor 2 Homo sapiens 37-41 30123077-9 2018 Finally, the dual inhibition of autophagy and Nrf2 signaling cooperatively enhanced bortezomib-induced apoptosis by elevating ROS levels and ER stress. Reactive Oxygen Species 126-129 NFE2 like bZIP transcription factor 2 Homo sapiens 46-50 30123077-10 2018 Together, these data demonstrate that activation of autophagy and the Nrf2 antioxidant system, which lowers intracellular ROS, are mechanistically how PC cells overcome bortezomib treatment. Reactive Oxygen Species 122-125 NFE2 like bZIP transcription factor 2 Homo sapiens 70-74 29582209-7 2018 Increased ROS levels were also observed, possibly attributed to the weakened anti-oxidative response evidenced by the underexpression of the Nrf2-regulated genes encoding HO-1 and NQO1. Reactive Oxygen Species 10-13 NFE2 like bZIP transcription factor 2 Homo sapiens 141-145 30037352-10 2018 We also found that exogenous mimic-microRNA-21 targeted putative microRNA-21 ROS-homeostatic target genes, e.g., KRIT1, NRF2 and SOD2, which were significantly downregulated. Reactive Oxygen Species 77-80 NFE2 like bZIP transcription factor 2 Homo sapiens 120-124 29549478-12 2018 MET was found to attenuate Raf-1-ERK1/2 signaling in HaCaT cells to suppress the expression and phosphorylation levels of Nrf2, which contributed to the intracellular generation of ROS and the pro-apoptotic effects of MET. Reactive Oxygen Species 181-184 NFE2 like bZIP transcription factor 2 Homo sapiens 122-126 29684504-5 2018 (4) Nrf2 functional regulation was able to regulate the redox status of nerves by changing the levels of target antioxidants and reactive oxygen species (ROS) at the same time, without altering the balance between them. Reactive Oxygen Species 129-152 NFE2 like bZIP transcription factor 2 Homo sapiens 4-8 29684504-5 2018 (4) Nrf2 functional regulation was able to regulate the redox status of nerves by changing the levels of target antioxidants and reactive oxygen species (ROS) at the same time, without altering the balance between them. Reactive Oxygen Species 154-157 NFE2 like bZIP transcription factor 2 Homo sapiens 4-8 29805077-6 2018 NRF2, an oxidant-defense transcription factor, directly controls TRPA1 expression, thus providing an orthogonal mechanism for protection against oxidative stress together with canonical ROS-neutralizing mechanisms. Reactive Oxygen Species 186-189 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 29621903-5 2018 We also found that Nrf2 knock-out caused high reactive oxygen species (ROS) stress, suppression of cell proliferation, increased apoptosis in vitro, and a decrease of tumour growth in vivo. Reactive Oxygen Species 46-69 NFE2 like bZIP transcription factor 2 Homo sapiens 19-23 29621903-5 2018 We also found that Nrf2 knock-out caused high reactive oxygen species (ROS) stress, suppression of cell proliferation, increased apoptosis in vitro, and a decrease of tumour growth in vivo. Reactive Oxygen Species 71-74 NFE2 like bZIP transcription factor 2 Homo sapiens 19-23 29549478-0 2018 Metformin Promotes HaCaT Cell Apoptosis through Generation of Reactive Oxygen Species via Raf-1-ERK1/2-Nrf2 Inactivation. Reactive Oxygen Species 62-85 NFE2 like bZIP transcription factor 2 Homo sapiens 103-107 29421853-7 2018 Application of CBE facilitated the nuclear translocation of Nrf2 against reactive oxygen species (ROS)-induced damage, which is essential for the coordinated induction of cytoprotective enzymes. Reactive Oxygen Species 73-96 NFE2 like bZIP transcription factor 2 Homo sapiens 60-64 29421853-7 2018 Application of CBE facilitated the nuclear translocation of Nrf2 against reactive oxygen species (ROS)-induced damage, which is essential for the coordinated induction of cytoprotective enzymes. Reactive Oxygen Species 98-101 NFE2 like bZIP transcription factor 2 Homo sapiens 60-64 29729523-6 2018 As functional implications, NRF2 silencing rendered ADR44P cells to retain higher levels of reactive oxygen species and to be sensitive to anticancer drug toxicity. Reactive Oxygen Species 92-115 NFE2 like bZIP transcription factor 2 Homo sapiens 28-32 29469959-2 2018 In the presence of reactive oxygen species, Keap1 (Kelch-ECH-associating protein-1) inhibitor complex undergoes conformational changes disrupting Keap1-Nrf2 binding and Nrf2 translocates into nucleus. Reactive Oxygen Species 19-42 NFE2 like bZIP transcription factor 2 Homo sapiens 152-156 29469959-2 2018 In the presence of reactive oxygen species, Keap1 (Kelch-ECH-associating protein-1) inhibitor complex undergoes conformational changes disrupting Keap1-Nrf2 binding and Nrf2 translocates into nucleus. Reactive Oxygen Species 19-42 NFE2 like bZIP transcription factor 2 Homo sapiens 169-173 29627441-10 2018 Therefore, we studied the effect of ROS-related signaling on Nrf2 by measuring the activation of AKT and members of the mitogen-activated protein kinase family, such as extracellular signal-regulated kinase (ERK1/2) and p38. Reactive Oxygen Species 36-39 NFE2 like bZIP transcription factor 2 Homo sapiens 61-65 29627441-14 2018 Taken together, our results suggest that AFN contributes to Nrf2 activation through ROS-mediated activation of the p38-AKT pathway in HaCaT cells. Reactive Oxygen Species 84-87 NFE2 like bZIP transcription factor 2 Homo sapiens 60-64 29710809-3 2018 B-Hydroxybutyrate, the most studied ketone body, has been shown to reduce the production of reactive oxygen species (ROS), improving mitochondrial respiration: it stimulates the cellular endogenous antioxidant system with the activation of nuclear factor erythroid-derived 2-related factor 2 (Nrf2), it modulates the ratio between the oxidized and reduced forms of nicotinamide adenine dinucleotide (NAD+/NADH) and it increases the efficiency of electron transport chain through the expression of uncoupling proteins. Reactive Oxygen Species 92-115 NFE2 like bZIP transcription factor 2 Homo sapiens 240-291 29518609-10 2018 Cells with Nrf2 knockdown or Cis treatment increased production of ROS, and ROS was markedly enhanced by a combination of Nrf2 knockdown and Cis. Reactive Oxygen Species 67-70 NFE2 like bZIP transcription factor 2 Homo sapiens 11-15 29518609-10 2018 Cells with Nrf2 knockdown or Cis treatment increased production of ROS, and ROS was markedly enhanced by a combination of Nrf2 knockdown and Cis. Reactive Oxygen Species 76-79 NFE2 like bZIP transcription factor 2 Homo sapiens 122-126 29538645-4 2018 Activation of Nrf2 with RTA 408 inhibited reactive oxygen species production, mitochondrial depolarization and cell death in an in vitro model of seizure-like activity. Reactive Oxygen Species 42-65 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 29413963-5 2018 Additionally, polysulfide may inhibit ROS production by simultaneously lessening the activation of NADPH oxidase and inducing nucleus translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) in RPT cells. Reactive Oxygen Species 38-41 NFE2 like bZIP transcription factor 2 Homo sapiens 196-200 29716554-1 2018 BACKGROUND: There is growing evidence that the transcription factor nuclear factor E2-related factor 2 (Nrf2) is the major participant in regulating antioxidants and pathways for detoxifying reactive oxygen species (ROS), as well as having a vital role in tumor proliferation, invasion, and chemoresistance. Reactive Oxygen Species 191-214 NFE2 like bZIP transcription factor 2 Homo sapiens 68-102 29716554-1 2018 BACKGROUND: There is growing evidence that the transcription factor nuclear factor E2-related factor 2 (Nrf2) is the major participant in regulating antioxidants and pathways for detoxifying reactive oxygen species (ROS), as well as having a vital role in tumor proliferation, invasion, and chemoresistance. Reactive Oxygen Species 191-214 NFE2 like bZIP transcription factor 2 Homo sapiens 104-108 29716554-1 2018 BACKGROUND: There is growing evidence that the transcription factor nuclear factor E2-related factor 2 (Nrf2) is the major participant in regulating antioxidants and pathways for detoxifying reactive oxygen species (ROS), as well as having a vital role in tumor proliferation, invasion, and chemoresistance. Reactive Oxygen Species 216-219 NFE2 like bZIP transcription factor 2 Homo sapiens 68-102 29716554-1 2018 BACKGROUND: There is growing evidence that the transcription factor nuclear factor E2-related factor 2 (Nrf2) is the major participant in regulating antioxidants and pathways for detoxifying reactive oxygen species (ROS), as well as having a vital role in tumor proliferation, invasion, and chemoresistance. Reactive Oxygen Species 216-219 NFE2 like bZIP transcription factor 2 Homo sapiens 104-108 29710809-3 2018 B-Hydroxybutyrate, the most studied ketone body, has been shown to reduce the production of reactive oxygen species (ROS), improving mitochondrial respiration: it stimulates the cellular endogenous antioxidant system with the activation of nuclear factor erythroid-derived 2-related factor 2 (Nrf2), it modulates the ratio between the oxidized and reduced forms of nicotinamide adenine dinucleotide (NAD+/NADH) and it increases the efficiency of electron transport chain through the expression of uncoupling proteins. Reactive Oxygen Species 92-115 NFE2 like bZIP transcription factor 2 Homo sapiens 293-297 29710809-3 2018 B-Hydroxybutyrate, the most studied ketone body, has been shown to reduce the production of reactive oxygen species (ROS), improving mitochondrial respiration: it stimulates the cellular endogenous antioxidant system with the activation of nuclear factor erythroid-derived 2-related factor 2 (Nrf2), it modulates the ratio between the oxidized and reduced forms of nicotinamide adenine dinucleotide (NAD+/NADH) and it increases the efficiency of electron transport chain through the expression of uncoupling proteins. Reactive Oxygen Species 117-120 NFE2 like bZIP transcription factor 2 Homo sapiens 240-291 29710809-3 2018 B-Hydroxybutyrate, the most studied ketone body, has been shown to reduce the production of reactive oxygen species (ROS), improving mitochondrial respiration: it stimulates the cellular endogenous antioxidant system with the activation of nuclear factor erythroid-derived 2-related factor 2 (Nrf2), it modulates the ratio between the oxidized and reduced forms of nicotinamide adenine dinucleotide (NAD+/NADH) and it increases the efficiency of electron transport chain through the expression of uncoupling proteins. Reactive Oxygen Species 117-120 NFE2 like bZIP transcription factor 2 Homo sapiens 293-297 29526395-2 2018 Extracellular signal regulated kinase (ERK)/nuclear factor erythroid-2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) is a ROS response pathway. Reactive Oxygen Species 124-127 NFE2 like bZIP transcription factor 2 Homo sapiens 44-87 29774099-3 2018 Furthermore, transient knockdown of nuclear factor-erythroid 2-related factor 2 (Nrf2), in the presence of CPT, increased the ROS" level and further shifted the cell cycle from early S phase to the G2/M phase, indicating that Nrf2 delayed the S phase in response to CPT. Reactive Oxygen Species 126-129 NFE2 like bZIP transcription factor 2 Homo sapiens 36-79 29774099-3 2018 Furthermore, transient knockdown of nuclear factor-erythroid 2-related factor 2 (Nrf2), in the presence of CPT, increased the ROS" level and further shifted the cell cycle from early S phase to the G2/M phase, indicating that Nrf2 delayed the S phase in response to CPT. Reactive Oxygen Species 126-129 NFE2 like bZIP transcription factor 2 Homo sapiens 81-85 29774099-3 2018 Furthermore, transient knockdown of nuclear factor-erythroid 2-related factor 2 (Nrf2), in the presence of CPT, increased the ROS" level and further shifted the cell cycle from early S phase to the G2/M phase, indicating that Nrf2 delayed the S phase in response to CPT. Reactive Oxygen Species 126-129 NFE2 like bZIP transcription factor 2 Homo sapiens 226-230 29271701-6 2018 Furthermore, RGO induced the nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated antioxidant enzyme heme oxygenase-1 (HO-1) expression, and effectively blocked the overproduction of TPA-induced reactive oxygen species. Reactive Oxygen Species 202-225 NFE2 like bZIP transcription factor 2 Homo sapiens 74-78 29526395-10 2018 Therefore, our results suggest that up-regulation of HO-1 in PA-treated neurons is a compensatory response to ROS increase and that increasing HO-1 expression by Nrf2 activation can prevent the process of ROS production in PA-treated neurons. Reactive Oxygen Species 205-208 NFE2 like bZIP transcription factor 2 Homo sapiens 162-166 29526395-2 2018 Extracellular signal regulated kinase (ERK)/nuclear factor erythroid-2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) is a ROS response pathway. Reactive Oxygen Species 124-127 NFE2 like bZIP transcription factor 2 Homo sapiens 89-93 29507103-2 2018 In this work, we apply this to transcription factor nuclear factor (erythroid-derived 2)-like 2 (NRF2) by cross-validating its position in a protein-protein interaction network (the NRF2 interactome) functionally linked to cytoprotection in low-grade stress, chronic inflammation, metabolic alterations, and reactive oxygen species formation. Reactive Oxygen Species 308-331 NFE2 like bZIP transcription factor 2 Homo sapiens 97-101 29507103-2 2018 In this work, we apply this to transcription factor nuclear factor (erythroid-derived 2)-like 2 (NRF2) by cross-validating its position in a protein-protein interaction network (the NRF2 interactome) functionally linked to cytoprotection in low-grade stress, chronic inflammation, metabolic alterations, and reactive oxygen species formation. Reactive Oxygen Species 308-331 NFE2 like bZIP transcription factor 2 Homo sapiens 182-186 29193391-8 2018 Moreover, knockdown of Nrf2 by siRNA abrogated the inhibitory effects of DHM on ROS generation and subsequent PA-induced pyroptosis. Reactive Oxygen Species 80-83 NFE2 like bZIP transcription factor 2 Homo sapiens 23-27 28494612-4 2018 We discuss the difference between biomarkers that are the result of a chemical reaction (such as lipid peroxides or oxidized proteins that are a result of the reaction of molecules with reactive oxygen species) and those that represent the biological response to stress, such as the transcription factor NRF2 or inflammation and inflammatory cytokines. Reactive Oxygen Species 186-209 NFE2 like bZIP transcription factor 2 Homo sapiens 304-308 29670684-7 2018 We propose that cotreatment increased ROS-induced cell cycle arrest and cellular apoptosis and inhibits melanoma growth by regulating the AKT-Nrf2 pathway in A375 cells which offers a possible therapeutic intervention strategy for the treatment of human melanoma. Reactive Oxygen Species 38-41 NFE2 like bZIP transcription factor 2 Homo sapiens 142-146 29243822-0 2018 Nrf2 promotes oesophageal cancer cell proliferation via metabolic reprogramming and detoxification of reactive oxygen species. Reactive Oxygen Species 102-125 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 29243822-11 2018 Metabolic reprogramming to glutathione metabolism, and ROS detoxification by activation of Nrf2, enhanced cancer progression and led to a poor clinical outcome in oesophageal cancer patients. Reactive Oxygen Species 55-58 NFE2 like bZIP transcription factor 2 Homo sapiens 91-95 29503744-6 2018 The regulation of ROS levels by the glutathione pathway and the Nrf2-Keap1-Cul3 trimeric complex will be discussed. Reactive Oxygen Species 18-21 NFE2 like bZIP transcription factor 2 Homo sapiens 64-68 29438305-1 2018 The Nrf2 (nuclear factor E2-related factor or nuclear factor (erythroid-derived 2)-like 2) transcription factor is a key player in cytoprotection and activated in stress conditions caused by reactive oxygen species (ROS) or electrophiles. Reactive Oxygen Species 191-214 NFE2 like bZIP transcription factor 2 Homo sapiens 4-8 29381356-8 2018 Our results suggest that astaxanthin activates the Nrf-2/HO-1 antioxidant pathway by generating small amounts of ROS. Reactive Oxygen Species 113-116 NFE2 like bZIP transcription factor 2 Homo sapiens 51-56 29061583-5 2018 Bioengineered NRF2-siRNA was able to significantly knock down NRF2 mRNA and protein levels in human OS 143B and MG63 cells, and subsequently suppressed the expression of NRF2-regulated oxidative enzymes [heme oxygenase-1 and NAD(P)H:quinone oxidoreductase 1] and elevated intracellular levels of reactive oxygen species. Reactive Oxygen Species 296-319 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 29416012-0 2018 ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells. Reactive Oxygen Species 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 35-39 29416012-5 2018 Next, we revealed that NRF2, a master regulator of antioxidants, was able to maintain low intracellular ROS levels of CICs, even though in the absence of oxidative stress. Reactive Oxygen Species 104-107 NFE2 like bZIP transcription factor 2 Homo sapiens 23-27 29416012-8 2018 A positive regulatory ROS-independent ER stress pathway (GRP78/p-PERK/NRF2 signaling) was identified to mediate the metabolic shift (Warburg effect) and stemness of CICs. Reactive Oxygen Species 22-25 NFE2 like bZIP transcription factor 2 Homo sapiens 70-74 29416012-10 2018 Our data show that NRF2 acting as a central node in the maintenance of low ROS levels and stemness associated properties of the CICs, which is significantly associated with the clinical outcome, but independent from ROS stress. Reactive Oxygen Species 75-78 NFE2 like bZIP transcription factor 2 Homo sapiens 19-23 29416012-10 2018 Our data show that NRF2 acting as a central node in the maintenance of low ROS levels and stemness associated properties of the CICs, which is significantly associated with the clinical outcome, but independent from ROS stress. Reactive Oxygen Species 216-219 NFE2 like bZIP transcription factor 2 Homo sapiens 19-23 28815354-0 2018 NF-E2-Related Factor 2 Suppresses Intestinal Fibrosis by Inhibiting Reactive Oxygen Species-Dependent TGF-beta1/SMADs Pathway. Reactive Oxygen Species 68-91 NFE2 like bZIP transcription factor 2 Homo sapiens 0-22 28815354-12 2018 Moreover, scavenging ROS by N-acetyl cysteine could inhibit the increasing expression of TGF-beta1 promoted by Nrf2 knockdown. Reactive Oxygen Species 21-24 NFE2 like bZIP transcription factor 2 Homo sapiens 111-115 28815354-13 2018 CONCLUSIONS: The results suggested that Nrf2 suppressed intestinal fibrosis by inhibiting ROS/TGF-beta1/SMADs pathway in vivo and in vitro. Reactive Oxygen Species 90-93 NFE2 like bZIP transcription factor 2 Homo sapiens 40-44 28801702-6 2018 Upon paeonol treatment, intracellular reactive oxygen species levels in aging MRC-5 cells were significantly decreased via regulation of nuclear translocation of Nrf2. Reactive Oxygen Species 38-61 NFE2 like bZIP transcription factor 2 Homo sapiens 162-166 29300356-3 2018 Meanwhile, the Keap1-Nrf2/ARE pathway, which removes ROS, is activated at increased ROS levels, and antioxidant compounds facilitates the dissociation of Nrf2. Reactive Oxygen Species 53-56 NFE2 like bZIP transcription factor 2 Homo sapiens 21-25 29300356-3 2018 Meanwhile, the Keap1-Nrf2/ARE pathway, which removes ROS, is activated at increased ROS levels, and antioxidant compounds facilitates the dissociation of Nrf2. Reactive Oxygen Species 84-87 NFE2 like bZIP transcription factor 2 Homo sapiens 21-25 29438305-1 2018 The Nrf2 (nuclear factor E2-related factor or nuclear factor (erythroid-derived 2)-like 2) transcription factor is a key player in cytoprotection and activated in stress conditions caused by reactive oxygen species (ROS) or electrophiles. Reactive Oxygen Species 216-219 NFE2 like bZIP transcription factor 2 Homo sapiens 4-8 29273513-8 2018 Notably, silencing of Nrf2 (siRNA transfection) significantly diminished zerumbone-mediated cytoprotective effects, as evidenced by impaired antioxidant genes, uncontrolled ROS/apoptotic DNA fragmentation and keratinocytes death, following UVA irradiation. Reactive Oxygen Species 173-176 NFE2 like bZIP transcription factor 2 Homo sapiens 22-26 29315210-11 2018 The pretreatment of T-47D cells with an ROS scavenger, N-acetyl-l-cysteine (NAC), attenuated the apoptosis and MMP disruption induced by isoaaptamine up to 90%, and these effects were mediated by the disruption of nuclear factor erythroid 2-related factor 2 (Nrf 2)/p62 pathway. Reactive Oxygen Species 40-43 NFE2 like bZIP transcription factor 2 Homo sapiens 214-257 29315210-11 2018 The pretreatment of T-47D cells with an ROS scavenger, N-acetyl-l-cysteine (NAC), attenuated the apoptosis and MMP disruption induced by isoaaptamine up to 90%, and these effects were mediated by the disruption of nuclear factor erythroid 2-related factor 2 (Nrf 2)/p62 pathway. Reactive Oxygen Species 40-43 NFE2 like bZIP transcription factor 2 Homo sapiens 259-264 29031566-3 2018 Here, we hypothesize that the transcription factor NRF2 whose physiological role is to protect cells from reactive oxygen species via the regulation of drug metabolism and antioxidant gene plays an important role in MM cells survival and proliferation. Reactive Oxygen Species 106-129 NFE2 like bZIP transcription factor 2 Homo sapiens 51-55 29155359-0 2018 4-Methylthio-3-butenyl isothiocyanate mediates nuclear factor (erythroid-derived 2)-like 2 activation by regulating reactive oxygen species production in human esophageal epithelial cells. Reactive Oxygen Species 116-139 NFE2 like bZIP transcription factor 2 Homo sapiens 47-90 29155359-4 2018 Reactive oxygen species (ROS) tended to increase when Het-1A cells were treated with MTBITC, and the increases in ROS and Nrf2 expression in the cells treated with MTBITC were completely abolished by treatment with N-acetyl-l-cysteine. Reactive Oxygen Species 0-23 NFE2 like bZIP transcription factor 2 Homo sapiens 122-126 29423117-6 2018 The neurogenic effect of ROS on stem cell behaviour was confirmed by the observations that the expression of neuronal markers in the paraquat-treated cells was suppressed by an antioxidant while further enhanced by knocking down Nrf2, a key transcription factor associated with antioxidant signaling. Reactive Oxygen Species 25-28 NFE2 like bZIP transcription factor 2 Homo sapiens 229-233 29033244-2 2017 Nrf2 is the master regulator of ROS balance. Reactive Oxygen Species 32-35 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 28815642-7 2017 The redox imbalance between NOX4 and Nrf2 was an important cause for the ROS overproduction that led to cell injury in HUVECs. Reactive Oxygen Species 73-76 NFE2 like bZIP transcription factor 2 Homo sapiens 37-41 28882558-5 2017 CA-mediated Nrf2/HO-1 activation reduced the level of reactive oxygen species and protected the hDPCs from H2O2-induced oxidative stress, which induces apoptosis. Reactive Oxygen Species 54-77 NFE2 like bZIP transcription factor 2 Homo sapiens 12-16 28807874-11 2017 In conclusion, induction of OSGIN1 by DHA is at least partially associated with increased ROS production, which activates PI3K/Akt/Nrf2 signaling. Reactive Oxygen Species 90-93 NFE2 like bZIP transcription factor 2 Homo sapiens 131-135 28009908-3 2017 Oxidative stress response assays have proven to be sensitive tools, but the mechanism by which water samples are inducing the oxidative stress response remains unclear because both electrophiles and reactive oxygen species (ROS) may activate the Nrf2-antioxidant response element (ARE) pathway. Reactive Oxygen Species 199-222 NFE2 like bZIP transcription factor 2 Homo sapiens 246-250 28849014-7 2017 Further experiments revealed that Zn supplementation inhibited the HG-induced production of ROS through activation of the Nrf2 antioxidant pathway. Reactive Oxygen Species 92-95 NFE2 like bZIP transcription factor 2 Homo sapiens 122-126 28954235-3 2017 This hyper-radiosensitivity is dependent on an immediate increase in the levels of reactive oxygen species (ROS) that also promotes autophagy and activation of the Keap1/Nrf2 antioxidant pathway. Reactive Oxygen Species 83-106 NFE2 like bZIP transcription factor 2 Homo sapiens 170-174 28954235-3 2017 This hyper-radiosensitivity is dependent on an immediate increase in the levels of reactive oxygen species (ROS) that also promotes autophagy and activation of the Keap1/Nrf2 antioxidant pathway. Reactive Oxygen Species 108-111 NFE2 like bZIP transcription factor 2 Homo sapiens 170-174 28954235-4 2017 Nrf2 activation initially protects HSCs from the detrimental effects of ROS, but protection is transient, and increased ROS levels return, promoting a long-term decrease in HSC self-renewal. Reactive Oxygen Species 72-75 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 28954235-4 2017 Nrf2 activation initially protects HSCs from the detrimental effects of ROS, but protection is transient, and increased ROS levels return, promoting a long-term decrease in HSC self-renewal. Reactive Oxygen Species 120-123 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 28009908-3 2017 Oxidative stress response assays have proven to be sensitive tools, but the mechanism by which water samples are inducing the oxidative stress response remains unclear because both electrophiles and reactive oxygen species (ROS) may activate the Nrf2-antioxidant response element (ARE) pathway. Reactive Oxygen Species 224-227 NFE2 like bZIP transcription factor 2 Homo sapiens 246-250 28874782-5 2017 DHC also activated nuclear-related factor-2 (Nrf2) which involves antioxidant enzymes like superoxide dismutase (SOD) and glutathione peroxidase (GPx), and significantly decreased oxidative stress and inflammation via down-regulated reactive oxygen species (ROS), NADPH oxidase (NOX2, NOX4), nuclear factor kappa-beta (NF-kB), and nitric oxide (NO), including matrix metalloproteinases-9 (MMP-9) levels. Reactive Oxygen Species 233-256 NFE2 like bZIP transcription factor 2 Homo sapiens 19-43 28416455-4 2017 The present study shows that luteolin activates inducible Nrf2 to inhibit Cr(VI)-generated reactive oxygen species (ROS) in normal BEAS-2B cells. Reactive Oxygen Species 91-114 NFE2 like bZIP transcription factor 2 Homo sapiens 58-62 28416455-4 2017 The present study shows that luteolin activates inducible Nrf2 to inhibit Cr(VI)-generated reactive oxygen species (ROS) in normal BEAS-2B cells. Reactive Oxygen Species 116-119 NFE2 like bZIP transcription factor 2 Homo sapiens 58-62 28416455-6 2017 By contrast, in cells that have been transformed by Cr(VI), Nrf2 is constitutively activated, and its target proteins, heme oxygenase 1 (HO-1), NAD(P)H:quinone oxidoreductase 1 (NQO1), and superoxide dismutase 1/2 (SOD1/SOD2) are all constitutively activated, and ROS levels are low. Reactive Oxygen Species 264-267 NFE2 like bZIP transcription factor 2 Homo sapiens 60-64 28874782-5 2017 DHC also activated nuclear-related factor-2 (Nrf2) which involves antioxidant enzymes like superoxide dismutase (SOD) and glutathione peroxidase (GPx), and significantly decreased oxidative stress and inflammation via down-regulated reactive oxygen species (ROS), NADPH oxidase (NOX2, NOX4), nuclear factor kappa-beta (NF-kB), and nitric oxide (NO), including matrix metalloproteinases-9 (MMP-9) levels. Reactive Oxygen Species 258-261 NFE2 like bZIP transcription factor 2 Homo sapiens 19-43 28874782-5 2017 DHC also activated nuclear-related factor-2 (Nrf2) which involves antioxidant enzymes like superoxide dismutase (SOD) and glutathione peroxidase (GPx), and significantly decreased oxidative stress and inflammation via down-regulated reactive oxygen species (ROS), NADPH oxidase (NOX2, NOX4), nuclear factor kappa-beta (NF-kB), and nitric oxide (NO), including matrix metalloproteinases-9 (MMP-9) levels. Reactive Oxygen Species 258-261 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 28534518-7 2017 Furthermore, we demonstrate that CDK20 competes with NRF2 for KEAP1 binding, enhances the transcriptional activity of NRF2 and lowers the cellular reactive oxygen species level. Reactive Oxygen Species 147-170 NFE2 like bZIP transcription factor 2 Homo sapiens 53-57 28829589-5 2017 GD ameliorated OGD/R-induced apoptosis by elevating the protein expression of nuclear peroxisome proliferator-activated receptor gamma (PPARgamma) and nuclear factor erythroid 2-related factor 2 (Nrf2), thereby attenuating reactive oxygen species (ROS) generation. Reactive Oxygen Species 223-246 NFE2 like bZIP transcription factor 2 Homo sapiens 196-200 28829589-5 2017 GD ameliorated OGD/R-induced apoptosis by elevating the protein expression of nuclear peroxisome proliferator-activated receptor gamma (PPARgamma) and nuclear factor erythroid 2-related factor 2 (Nrf2), thereby attenuating reactive oxygen species (ROS) generation. Reactive Oxygen Species 248-251 NFE2 like bZIP transcription factor 2 Homo sapiens 196-200 28874782-5 2017 DHC also activated nuclear-related factor-2 (Nrf2) which involves antioxidant enzymes like superoxide dismutase (SOD) and glutathione peroxidase (GPx), and significantly decreased oxidative stress and inflammation via down-regulated reactive oxygen species (ROS), NADPH oxidase (NOX2, NOX4), nuclear factor kappa-beta (NF-kB), and nitric oxide (NO), including matrix metalloproteinases-9 (MMP-9) levels. Reactive Oxygen Species 233-256 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 28864287-8 2017 The UPR also enhances the overproduction of reactive oxygen species (ROS), which damage lens constituents and induce failure of the Nrf2 dependent cytoprotection. Reactive Oxygen Species 44-67 NFE2 like bZIP transcription factor 2 Homo sapiens 132-136 28552716-4 2017 Nrf2 is a promising target to limit reactive oxygen species (ROS)-mediated damage in PD. Reactive Oxygen Species 36-59 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 28552716-4 2017 Nrf2 is a promising target to limit reactive oxygen species (ROS)-mediated damage in PD. Reactive Oxygen Species 61-64 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 28552716-9 2017 Altogether, our results suggest that TUDCA is a promising agent to limit ROS-mediated damage, in different models of PD acting, at least in part, through modulation of the Nrf2 signaling pathway. Reactive Oxygen Species 73-76 NFE2 like bZIP transcription factor 2 Homo sapiens 172-176 28864287-8 2017 The UPR also enhances the overproduction of reactive oxygen species (ROS), which damage lens constituents and induce failure of the Nrf2 dependent cytoprotection. Reactive Oxygen Species 69-72 NFE2 like bZIP transcription factor 2 Homo sapiens 132-136 28718813-3 2017 Since anticancer agents usually utilize ROS as an arsenal for killing cancer cells, we hypothesized that inhibition of Nrf2 activity could increase the sensitivity of CSCs to anticancer drugs, and thus enhancing their therapeutic efficacy. Reactive Oxygen Species 40-43 NFE2 like bZIP transcription factor 2 Homo sapiens 119-123 28627706-1 2017 Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a master regulator of antioxidant and detoxification activities that can eliminate reactive oxygen species (ROS) produced via irradiation. Reactive Oxygen Species 137-160 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 28627706-1 2017 Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a master regulator of antioxidant and detoxification activities that can eliminate reactive oxygen species (ROS) produced via irradiation. Reactive Oxygen Species 137-160 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 28627706-1 2017 Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a master regulator of antioxidant and detoxification activities that can eliminate reactive oxygen species (ROS) produced via irradiation. Reactive Oxygen Species 162-165 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 28627706-1 2017 Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a master regulator of antioxidant and detoxification activities that can eliminate reactive oxygen species (ROS) produced via irradiation. Reactive Oxygen Species 162-165 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 28724916-7 2017 In conclusion, we reveal that erythrophagocytosis relies on an interplay between p62 and NRF2, potentially acting as protective mechanism to maintain reactive oxygen species at basal levels and preserve macrophage homeostasis. Reactive Oxygen Species 150-173 NFE2 like bZIP transcription factor 2 Homo sapiens 89-93 28411557-5 2017 The upregulation of Nrf2 leads to activation of cytoprotective genes thus helping malignant cells to withstand high levels of ROS and to avoid apoptosis, eventually becoming resistant to conventional anticancer therapy. Reactive Oxygen Species 126-129 NFE2 like bZIP transcription factor 2 Homo sapiens 20-24 28525375-0 2017 ROS enhance angiogenic properties via regulation of NRF2 in tumor endothelial cells. Reactive Oxygen Species 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 52-56 28525375-9 2017 These results indicated that ROS-induced BGN caused the pro-angiogenic phenotype in TECs via NRF2 dysregulation. Reactive Oxygen Species 29-32 NFE2 like bZIP transcription factor 2 Homo sapiens 93-97 28525375-8 2017 ROS inhibited NRF2 expression in TECs but not in NECs, and NRF2 inhibited phosphorylation of SMAD2/3, which activates transcription of BGN. Reactive Oxygen Species 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 28453992-11 2017 Importantly, we confirmed that combination treatment of Nrf2-deficient CNE2 cells with SAL and IR markedly increased the level of reactive oxygen species (ROS) and DNA damage. Reactive Oxygen Species 130-153 NFE2 like bZIP transcription factor 2 Homo sapiens 56-60 28453992-11 2017 Importantly, we confirmed that combination treatment of Nrf2-deficient CNE2 cells with SAL and IR markedly increased the level of reactive oxygen species (ROS) and DNA damage. Reactive Oxygen Species 155-158 NFE2 like bZIP transcription factor 2 Homo sapiens 56-60 28283194-6 2017 Thus, activation of Nrf2 through resin monomer-induced oxidative stress due to the increased formation of reactive oxygen species (ROS) could be a molecular mechanism underlying the inhibition of LPS-stimulated responses such as the release of pro- or anti-inflammatory cytokines. Reactive Oxygen Species 106-129 NFE2 like bZIP transcription factor 2 Homo sapiens 20-24 28523248-5 2017 Unregulated NRF2 confers on cancer cells high-level resistance to anticancer drugs and reactive oxygen species (ROS) and directs cancer cells toward metabolic reprogramming. Reactive Oxygen Species 87-110 NFE2 like bZIP transcription factor 2 Homo sapiens 12-16 28523248-5 2017 Unregulated NRF2 confers on cancer cells high-level resistance to anticancer drugs and reactive oxygen species (ROS) and directs cancer cells toward metabolic reprogramming. Reactive Oxygen Species 112-115 NFE2 like bZIP transcription factor 2 Homo sapiens 12-16 28560379-7 2017 The Nrf2 inhibitors VPA and MEL successfully reduced Nrf2 expression and survival in U251-TMZ cells treated with TMZ, accompanied by increased reactive oxygen species levels and apoptosis. Reactive Oxygen Species 143-166 NFE2 like bZIP transcription factor 2 Homo sapiens 4-8 28283194-6 2017 Thus, activation of Nrf2 through resin monomer-induced oxidative stress due to the increased formation of reactive oxygen species (ROS) could be a molecular mechanism underlying the inhibition of LPS-stimulated responses such as the release of pro- or anti-inflammatory cytokines. Reactive Oxygen Species 131-134 NFE2 like bZIP transcription factor 2 Homo sapiens 20-24 28280124-9 2017 Furthermore, susceptibility to reactive oxygen species was significantly enhanced in the Nrf2-null clones as determined by decreased mitochondrial membrane potential and cell viability. Reactive Oxygen Species 31-54 NFE2 like bZIP transcription factor 2 Homo sapiens 89-93 28260004-5 2017 We discovered that Nrf2 deficiency led to a decrease in U251 cell proliferation and caused intracellular redox imbalance [diminished glutathione (GSH) levels and increased reactive oxygen species (ROS) levels]. Reactive Oxygen Species 172-195 NFE2 like bZIP transcription factor 2 Homo sapiens 19-23 28383481-7 2017 Nrf2 is a transcription factor that controls the expression of antioxidant-response genes, allowing the cell to regulate reactive oxygen species. Reactive Oxygen Species 121-144 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 28281193-12 2017 Experimentally, ROS enhanced Nrf2 expression, 8-OHdG formation and tumor progression in HCC cells. Reactive Oxygen Species 16-19 NFE2 like bZIP transcription factor 2 Homo sapiens 29-33 28260004-5 2017 We discovered that Nrf2 deficiency led to a decrease in U251 cell proliferation and caused intracellular redox imbalance [diminished glutathione (GSH) levels and increased reactive oxygen species (ROS) levels]. Reactive Oxygen Species 197-200 NFE2 like bZIP transcription factor 2 Homo sapiens 19-23 28148777-7 2017 A major transcriptional regulator of the cellular antioxidant response, nuclear factor (erythroid-derived 2)-like 2 (NRF2), shuttled to the nucleus, as expected, in response to ACA11-driven increases in ROS; however, transcriptional up-regulation of some of NRF2"s antioxidant target genes was abrogated in the presence of ACA11 overexpression. Reactive Oxygen Species 203-206 NFE2 like bZIP transcription factor 2 Homo sapiens 72-115 28182008-7 2017 Furthermore, carboplatin plus thioridazine induced upregulation of the expression of proteasome subunit alpha 5 (PSMA5) through mitochondrial reactive oxygen species (ROS)-dependent nuclear factor E2-related factor 2 (Nrf2) activation. Reactive Oxygen Species 142-165 NFE2 like bZIP transcription factor 2 Homo sapiens 218-222 28182008-7 2017 Furthermore, carboplatin plus thioridazine induced upregulation of the expression of proteasome subunit alpha 5 (PSMA5) through mitochondrial reactive oxygen species (ROS)-dependent nuclear factor E2-related factor 2 (Nrf2) activation. Reactive Oxygen Species 167-170 NFE2 like bZIP transcription factor 2 Homo sapiens 218-222 28510041-0 2017 The Keap1-Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases. Reactive Oxygen Species 67-70 NFE2 like bZIP transcription factor 2 Homo sapiens 10-14 28012783-3 2017 In addition to other cellular and enzymatic defense systems, the retina is also equipped with the nuclear erythroid-2-p45-related factor-2 (Nrf2) antioxidant response element signaling pathway, which controls the expression of genes important in detoxification and elimination of ROS. Reactive Oxygen Species 280-283 NFE2 like bZIP transcription factor 2 Homo sapiens 140-144 28148777-7 2017 A major transcriptional regulator of the cellular antioxidant response, nuclear factor (erythroid-derived 2)-like 2 (NRF2), shuttled to the nucleus, as expected, in response to ACA11-driven increases in ROS; however, transcriptional up-regulation of some of NRF2"s antioxidant target genes was abrogated in the presence of ACA11 overexpression. Reactive Oxygen Species 203-206 NFE2 like bZIP transcription factor 2 Homo sapiens 117-121 28148777-7 2017 A major transcriptional regulator of the cellular antioxidant response, nuclear factor (erythroid-derived 2)-like 2 (NRF2), shuttled to the nucleus, as expected, in response to ACA11-driven increases in ROS; however, transcriptional up-regulation of some of NRF2"s antioxidant target genes was abrogated in the presence of ACA11 overexpression. Reactive Oxygen Species 203-206 NFE2 like bZIP transcription factor 2 Homo sapiens 258-262 28585211-12 2017 Accumulation of toxic levels of reactive oxygen species (ROS) is caused by the ineffectual cycling of the endoplasmic reticulum (ER) oxidoreductin (Ero1)-protein disulfide isomerase oxidation cycle through the downstream of the inner membrane mitochondrial oxidative metabolism and Kelch like-ECH-associated protein 1 (Keap1)- Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway. Reactive Oxygen Species 32-55 NFE2 like bZIP transcription factor 2 Homo sapiens 327-370 27702566-5 2017 Microarray and qRT-PCR analysis of human hair follicles after Nrf2 activation using sulforaphane identified the modulation of phase II metabolism, reactive oxygen species clearance, the pentose phosphate pathway, and glutathione homeostasis. Reactive Oxygen Species 147-170 NFE2 like bZIP transcription factor 2 Homo sapiens 62-66 27702566-7 2017 Importantly, Nrf2 activation significantly reduced reactive oxygen species levels and associated lipid peroxidation. Reactive Oxygen Species 51-74 NFE2 like bZIP transcription factor 2 Homo sapiens 13-17 27702566-8 2017 Nrf2 preactivation reduced premature catagen and hair growth inhibition induced by oxidative stress (H2O2 or menadione), significantly ameliorated the H2O2-dependent increase in matrix keratinocyte apoptosis and reversed the reactive oxygen species-induced reduction in hair matrix proliferation. Reactive Oxygen Species 225-248 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 27789056-9 2017 These findings demonstrate that tubular hyperactivation of Nrf2 in the initial phase of injury prevents the progression of reactive oxygen species-mediated tubular damage by inducing antioxidant enzymes and NADPH synthesis. Reactive Oxygen Species 123-146 NFE2 like bZIP transcription factor 2 Homo sapiens 59-63 28585211-12 2017 Accumulation of toxic levels of reactive oxygen species (ROS) is caused by the ineffectual cycling of the endoplasmic reticulum (ER) oxidoreductin (Ero1)-protein disulfide isomerase oxidation cycle through the downstream of the inner membrane mitochondrial oxidative metabolism and Kelch like-ECH-associated protein 1 (Keap1)- Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway. Reactive Oxygen Species 32-55 NFE2 like bZIP transcription factor 2 Homo sapiens 372-376 28585211-12 2017 Accumulation of toxic levels of reactive oxygen species (ROS) is caused by the ineffectual cycling of the endoplasmic reticulum (ER) oxidoreductin (Ero1)-protein disulfide isomerase oxidation cycle through the downstream of the inner membrane mitochondrial oxidative metabolism and Kelch like-ECH-associated protein 1 (Keap1)- Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway. Reactive Oxygen Species 57-60 NFE2 like bZIP transcription factor 2 Homo sapiens 327-370 28585211-12 2017 Accumulation of toxic levels of reactive oxygen species (ROS) is caused by the ineffectual cycling of the endoplasmic reticulum (ER) oxidoreductin (Ero1)-protein disulfide isomerase oxidation cycle through the downstream of the inner membrane mitochondrial oxidative metabolism and Kelch like-ECH-associated protein 1 (Keap1)- Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway. Reactive Oxygen Species 57-60 NFE2 like bZIP transcription factor 2 Homo sapiens 372-376 28356018-0 2017 Enhancement of the Effect of Methyl Pyropheophorbide-a-Mediated Photodynamic Therapy was Achieved by Increasing ROS through Inhibition of Nrf2-HO-1 or Nrf2-ABCG2 Signaling. Reactive Oxygen Species 112-115 NFE2 like bZIP transcription factor 2 Homo sapiens 138-142 28502971-4 2017 SUMMARY: Oxidative-stress molecules, such as reactive oxygen species, accumulate in the kidneys of animal models for acute kidney injury (AKI), in which NRF2 is transiently and slightly activated. Reactive Oxygen Species 45-68 NFE2 like bZIP transcription factor 2 Homo sapiens 153-157 28356018-7 2017 Nrf2 down -regulation increased reactive oxygen species (ROS) levels by attenuating antioxidants or pumping Mppa out of cells,which resulted from the inhibition of Nrf2-HO-1 or Nrf2- ABCG2 signaling. Reactive Oxygen Species 32-55 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 28356018-7 2017 Nrf2 down -regulation increased reactive oxygen species (ROS) levels by attenuating antioxidants or pumping Mppa out of cells,which resulted from the inhibition of Nrf2-HO-1 or Nrf2- ABCG2 signaling. Reactive Oxygen Species 32-55 NFE2 like bZIP transcription factor 2 Homo sapiens 164-168 28356018-0 2017 Enhancement of the Effect of Methyl Pyropheophorbide-a-Mediated Photodynamic Therapy was Achieved by Increasing ROS through Inhibition of Nrf2-HO-1 or Nrf2-ABCG2 Signaling. Reactive Oxygen Species 112-115 NFE2 like bZIP transcription factor 2 Homo sapiens 151-155 28356018-7 2017 Nrf2 down -regulation increased reactive oxygen species (ROS) levels by attenuating antioxidants or pumping Mppa out of cells,which resulted from the inhibition of Nrf2-HO-1 or Nrf2- ABCG2 signaling. Reactive Oxygen Species 32-55 NFE2 like bZIP transcription factor 2 Homo sapiens 164-168 28356018-7 2017 Nrf2 down -regulation increased reactive oxygen species (ROS) levels by attenuating antioxidants or pumping Mppa out of cells,which resulted from the inhibition of Nrf2-HO-1 or Nrf2- ABCG2 signaling. Reactive Oxygen Species 57-60 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 27976481-5 2017 Accumulation of ROS and subsequent activation of NRF2, p53, AP-1 and NF-kappaB-dependent pathways, with downstream activation of antioxidant mechanisms (e.g., SOD2 and HMOX1 expression), is observed in the UV-treated cells. Reactive Oxygen Species 16-19 NFE2 like bZIP transcription factor 2 Homo sapiens 49-53 28356018-7 2017 Nrf2 down -regulation increased reactive oxygen species (ROS) levels by attenuating antioxidants or pumping Mppa out of cells,which resulted from the inhibition of Nrf2-HO-1 or Nrf2- ABCG2 signaling. Reactive Oxygen Species 57-60 NFE2 like bZIP transcription factor 2 Homo sapiens 164-168 28356018-7 2017 Nrf2 down -regulation increased reactive oxygen species (ROS) levels by attenuating antioxidants or pumping Mppa out of cells,which resulted from the inhibition of Nrf2-HO-1 or Nrf2- ABCG2 signaling. Reactive Oxygen Species 57-60 NFE2 like bZIP transcription factor 2 Homo sapiens 164-168 27887985-7 2017 Together, our findings suggest that IGF-1 protects SH-SY5Y cells against Abeta25-35-induced cell injury by scavenging ROS via the PI3K/Akt-Nrf2 signaling pathway. Reactive Oxygen Species 118-121 NFE2 like bZIP transcription factor 2 Homo sapiens 139-143 27780373-4 2016 The nuclear factor erythroid 2-related factor 2 (Nrf2)-Kelch-like ECH-associated protein 1 (Keap1) pathway plays a crucial role in the protection of cells against ROS-mediated oxidative damage. Reactive Oxygen Species 163-166 NFE2 like bZIP transcription factor 2 Homo sapiens 4-47 29431065-7 2017 In the early stage, inducible Nrf2 fights against elevated ROS to decrease cell transformation by its antioxidant protection property. Reactive Oxygen Species 59-62 NFE2 like bZIP transcription factor 2 Homo sapiens 30-34 29431065-8 2017 In the late stage, constitutively activated Nrf2 manipulates reduced ROS to perform a comfortable environment for apoptosis resistance through an oncogenic role. Reactive Oxygen Species 69-72 NFE2 like bZIP transcription factor 2 Homo sapiens 44-48 29431065-9 2017 Interestingly, a cunning carcinogenic mechanism takes advantage of the dual role of Nrf2 to implement the dual role of ROS through a series of redox adaption mechanisms. Reactive Oxygen Species 119-122 NFE2 like bZIP transcription factor 2 Homo sapiens 84-88 29181121-0 2017 Ginger Oleoresin Alleviated gamma-Ray Irradiation-Induced Reactive Oxygen Species via the Nrf2 Protective Response in Human Mesenchymal Stem Cells. Reactive Oxygen Species 58-81 NFE2 like bZIP transcription factor 2 Homo sapiens 90-94 28203648-2 2016 The actions of ROS are mitigated by the transcription factor NRF2, which regulates expression of antioxidant genes via its interaction with cis-regulatory antioxidant response elements (AREs). Reactive Oxygen Species 15-18 NFE2 like bZIP transcription factor 2 Homo sapiens 61-65 28203648-3 2016 However, despite the seemingly straightforward relationship between the opposing forces of ROS and NRF2, regulatory precision in the NRF2 network is essential. Reactive Oxygen Species 91-94 NFE2 like bZIP transcription factor 2 Homo sapiens 133-137 28607561-3 2017 The transcription factor Nrf2 regulates the expression of antioxidant enzymes in response to ROS. Reactive Oxygen Species 93-96 NFE2 like bZIP transcription factor 2 Homo sapiens 25-29 28607561-6 2017 Nrf2 knockdown led to a reduction of antioxidant gene expression and increased ROS. Reactive Oxygen Species 79-82 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 28607561-10 2017 RESULTS: Nrf2 knockdown led to a reduction of antioxidant gene expression and increased ROS. Reactive Oxygen Species 88-91 NFE2 like bZIP transcription factor 2 Homo sapiens 9-13 27982079-11 2016 Nrf2 knockdown partially abolished the Rg1-induced decrease of ROS production and increase of HDAC2. Reactive Oxygen Species 63-66 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 27780373-4 2016 The nuclear factor erythroid 2-related factor 2 (Nrf2)-Kelch-like ECH-associated protein 1 (Keap1) pathway plays a crucial role in the protection of cells against ROS-mediated oxidative damage. Reactive Oxygen Species 163-166 NFE2 like bZIP transcription factor 2 Homo sapiens 49-53 27821769-5 2016 This action is part of a response driven by the transcription factor NRF2 to the excessive generation of reactive oxygen species induced by heme that results in the expression of genes involved in antioxidant responses, including p62/SQTM1. Reactive Oxygen Species 105-128 NFE2 like bZIP transcription factor 2 Homo sapiens 69-73 28078853-6 2016 Allergen-induced reactive oxygen species (ROS) is involved in p38 MAPK, phosphoinositide-3-kinase (PI3K)/Akt and nuclear factor erythroid 2-related factor (Nrf2) kinase pathway signaling. Reactive Oxygen Species 17-40 NFE2 like bZIP transcription factor 2 Homo sapiens 113-154 27713148-4 2016 Here we report novel actions of anti-HER2 drugs, Trastuzumab and Pertuzumab, involving NRF2.HER2 targeting by antibodies inhibited growth in association with persistent generation of reactive oxygen species (ROS), glutathione (GSH) depletion, reduction in NRF2 levels and inhibition of NRF2 function in ovarian cancer cell lines. Reactive Oxygen Species 183-206 NFE2 like bZIP transcription factor 2 Homo sapiens 87-91 27713148-4 2016 Here we report novel actions of anti-HER2 drugs, Trastuzumab and Pertuzumab, involving NRF2.HER2 targeting by antibodies inhibited growth in association with persistent generation of reactive oxygen species (ROS), glutathione (GSH) depletion, reduction in NRF2 levels and inhibition of NRF2 function in ovarian cancer cell lines. Reactive Oxygen Species 208-211 NFE2 like bZIP transcription factor 2 Homo sapiens 87-91 27671111-6 2016 Chromatin immunoprecipitation identified the antioxidant NRF2 as being directly responsible for inducing Marco Concordantly, Hif-2alpha-/- MPhis exhibited reduced antioxidant gene expression, and inhibition of mitochondrial reactive oxygen species suppressed Marco expression and phagocytic uptake. Reactive Oxygen Species 224-247 NFE2 like bZIP transcription factor 2 Homo sapiens 57-61 27498709-5 2016 Herein, we examined the EGCG-mediated antioxidant mechanism in hMSCs exposed to ROS which involves Nrf2 activation. Reactive Oxygen Species 80-83 NFE2 like bZIP transcription factor 2 Homo sapiens 99-103 27693327-4 2016 In this study, the interactions between the Nrf2-ARE signalling pathway and SVCV replication were investigated, which demonstrated that SVCV infection induced accumulation of ROS as well as protein carbonyl groups and 8-OHdG, accompanied by the up-regulation of Nrf2 and its downstream genes. Reactive Oxygen Species 175-178 NFE2 like bZIP transcription factor 2 Homo sapiens 44-48 27708248-6 2016 Activation of ATM/AKT/GSK-3beta signaling also increased nuclear accumulation of nuclear factor erythroid 2-related factor 2, leading to increased expression of antioxidants, which mitigated cellular damage from excessive reactive oxygen species production induced by high-dose radiation. Reactive Oxygen Species 222-245 NFE2 like bZIP transcription factor 2 Homo sapiens 81-124 28078853-6 2016 Allergen-induced reactive oxygen species (ROS) is involved in p38 MAPK, phosphoinositide-3-kinase (PI3K)/Akt and nuclear factor erythroid 2-related factor (Nrf2) kinase pathway signaling. Reactive Oxygen Species 17-40 NFE2 like bZIP transcription factor 2 Homo sapiens 156-160 28078853-6 2016 Allergen-induced reactive oxygen species (ROS) is involved in p38 MAPK, phosphoinositide-3-kinase (PI3K)/Akt and nuclear factor erythroid 2-related factor (Nrf2) kinase pathway signaling. Reactive Oxygen Species 42-45 NFE2 like bZIP transcription factor 2 Homo sapiens 113-154 28078853-6 2016 Allergen-induced reactive oxygen species (ROS) is involved in p38 MAPK, phosphoinositide-3-kinase (PI3K)/Akt and nuclear factor erythroid 2-related factor (Nrf2) kinase pathway signaling. Reactive Oxygen Species 42-45 NFE2 like bZIP transcription factor 2 Homo sapiens 156-160 27555347-1 2016 Cancer requires mechanisms to mitigate reactive oxygen species (ROS) generated during rapid growth, such as induction of the antioxidant transcription factor, Nrf2. Reactive Oxygen Species 39-62 NFE2 like bZIP transcription factor 2 Homo sapiens 159-163 27555347-1 2016 Cancer requires mechanisms to mitigate reactive oxygen species (ROS) generated during rapid growth, such as induction of the antioxidant transcription factor, Nrf2. Reactive Oxygen Species 64-67 NFE2 like bZIP transcription factor 2 Homo sapiens 159-163 27643930-3 2016 In this regulation levels of reactive oxygen species (ROS) play an important role in cellular signaling, where Nrf2 is the key regulator of redox homeostasis. Reactive Oxygen Species 29-52 NFE2 like bZIP transcription factor 2 Homo sapiens 111-115 27542238-5 2016 In addition, treatment with ANM eliminated HG-induced reactive oxygen species (ROS) through the induction of anti-oxidant genes, HO-1 and NQO-1 via transcriptional activation of Nrf2. Reactive Oxygen Species 79-82 NFE2 like bZIP transcription factor 2 Homo sapiens 178-182 27643930-3 2016 In this regulation levels of reactive oxygen species (ROS) play an important role in cellular signaling, where Nrf2 is the key regulator of redox homeostasis. Reactive Oxygen Species 54-57 NFE2 like bZIP transcription factor 2 Homo sapiens 111-115 27643930-4 2016 Keap1-Nrf2-ARE system regulates a great set of detoxificant and antioxidant enzymes in cells after ROS and electrophiles exposure. Reactive Oxygen Species 99-102 NFE2 like bZIP transcription factor 2 Homo sapiens 6-10 27470422-10 2016 These results indicate that before transformation, ROS plays a critical role while Nrf2 not in Cr(VI)-induced inflammation, whereas after transformation (CrT cells), Nrf2 is constitutively activated and this protein maintains inflammation while ROS not. Reactive Oxygen Species 245-248 NFE2 like bZIP transcription factor 2 Homo sapiens 166-170 27094017-12 2016 In C2C12 myoblasts, acute treatment with exogenous H2 O2 (ROS)- and diethylenetriamine/NO adduct (NO donor) induced increases in mtTFA, which was prevented by small interfering RNA and short hairpin RNA knockdown of either NFE2L2 or NRF-1. Reactive Oxygen Species 58-61 NFE2 like bZIP transcription factor 2 Homo sapiens 223-229 27552253-8 2016 Interestingly, rutin prevented hyperglycemia-induced hyperpermeability, and dysfunction of the tight junction, a high level of reactive oxygen species, and activation of RhoA/ROCK were significantly abolished with the knockdown of Nrf2. Reactive Oxygen Species 127-150 NFE2 like bZIP transcription factor 2 Homo sapiens 231-235 27378427-8 2016 Furthermore, SIN prevented HG-increased reactive oxygen species (ROS) by activating nuclear factor-E2-related factor 2 (Nrf2). Reactive Oxygen Species 65-68 NFE2 like bZIP transcription factor 2 Homo sapiens 84-118 27378427-8 2016 Furthermore, SIN prevented HG-increased reactive oxygen species (ROS) by activating nuclear factor-E2-related factor 2 (Nrf2). Reactive Oxygen Species 65-68 NFE2 like bZIP transcription factor 2 Homo sapiens 120-124 27378427-11 2016 High ROS level, tight junction dysfunction and RhoA/ROCK activation were significantly attenuated with knockdown of Nrf2. Reactive Oxygen Species 5-8 NFE2 like bZIP transcription factor 2 Homo sapiens 116-120 27378427-12 2016 Mediated by activation of Nrf2, SIN managed to significantly prevent HG-disrupted renal endothelial barrier function by suppressing the RhoA/ROCK signaling pathway through reducing ROS. Reactive Oxygen Species 181-184 NFE2 like bZIP transcription factor 2 Homo sapiens 26-30 27196781-6 2016 Small molecule PIM kinase inhibitors prevent Nrf2 from accumulating in the nucleus, reducing the transcription of cytoprotective genes and leading to the build-up of intracellular reactive oxygen species (ROS) to toxic levels in hypoxic tumor cells. Reactive Oxygen Species 180-203 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 27540852-2 2016 (2016) show that sulfenylation of IRE1 by reactive oxygen species inhibits the role of IRE1 in the Unfolded Protein Response and activates a SKN-1/Nrf2-dependent response to oxidative stress. Reactive Oxygen Species 42-65 NFE2 like bZIP transcription factor 2 Homo sapiens 147-151 27539524-15 2016 Protein levels of Nrf2 and NQO1 were enhanced at high concentrations of PM2.5, and this mechanism may be related to increases in cellular ROS induced by PM2.5. Reactive Oxygen Species 138-141 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22 27237737-6 2016 Changes in mitochondrial dynamics regulate stem cell fate decisions by driving a physiological reactive oxygen species (ROS)-mediated process, which triggers a dual program to suppress self-renewal and promote differentiation via NRF2-mediated retrograde signaling. Reactive Oxygen Species 95-118 NFE2 like bZIP transcription factor 2 Homo sapiens 230-234 27237737-6 2016 Changes in mitochondrial dynamics regulate stem cell fate decisions by driving a physiological reactive oxygen species (ROS)-mediated process, which triggers a dual program to suppress self-renewal and promote differentiation via NRF2-mediated retrograde signaling. Reactive Oxygen Species 120-123 NFE2 like bZIP transcription factor 2 Homo sapiens 230-234 26991755-10 2016 In conclusion, ROS induction is important for antileukaemic activities of APR-246 and inhibiting the protective response of the Nrf-2/HMOX1 axis using PI3K inhibitors, enhances the antileukaemic effects. Reactive Oxygen Species 15-18 NFE2 like bZIP transcription factor 2 Homo sapiens 128-133 27196781-6 2016 Small molecule PIM kinase inhibitors prevent Nrf2 from accumulating in the nucleus, reducing the transcription of cytoprotective genes and leading to the build-up of intracellular reactive oxygen species (ROS) to toxic levels in hypoxic tumor cells. Reactive Oxygen Species 205-208 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 27450006-1 2016 During infection and host defense, nuclear factor, erythroid 2-like 2 (Nrf2) dependent signaling is an efficient antioxidant defensive mechanism used by host cells to control the destructive effects of reactive oxygen species. Reactive Oxygen Species 202-225 NFE2 like bZIP transcription factor 2 Homo sapiens 35-69 27450006-1 2016 During infection and host defense, nuclear factor, erythroid 2-like 2 (Nrf2) dependent signaling is an efficient antioxidant defensive mechanism used by host cells to control the destructive effects of reactive oxygen species. Reactive Oxygen Species 202-225 NFE2 like bZIP transcription factor 2 Homo sapiens 71-75 27348013-8 2016 An increase in ROS activates nuclear factor erythroid-2-related factor-2 (Nrf2) and hypoxia inducible factor (HIF) to provide protection to hepatocytes from ethanol toxicity. Reactive Oxygen Species 15-18 NFE2 like bZIP transcription factor 2 Homo sapiens 29-72 27348013-8 2016 An increase in ROS activates nuclear factor erythroid-2-related factor-2 (Nrf2) and hypoxia inducible factor (HIF) to provide protection to hepatocytes from ethanol toxicity. Reactive Oxygen Species 15-18 NFE2 like bZIP transcription factor 2 Homo sapiens 74-78 26857210-7 2016 Unlike previous findings, FoxO3 silencing led to decreased reactive oxygen species production, therefore protecting cells from oxidative stress-induced killing in an Nrf2-dependent manner. Reactive Oxygen Species 59-82 NFE2 like bZIP transcription factor 2 Homo sapiens 166-170 27304493-2 2016 A recent publication shows that one diabetes treatment approach, namely incretin-related DPP4 inhibitors, increases metastatic capacity by activating the antioxidant transcription factor NRF2 to decrease reactive oxygen species (ROS) levels. Reactive Oxygen Species 204-227 NFE2 like bZIP transcription factor 2 Homo sapiens 187-191 27304493-2 2016 A recent publication shows that one diabetes treatment approach, namely incretin-related DPP4 inhibitors, increases metastatic capacity by activating the antioxidant transcription factor NRF2 to decrease reactive oxygen species (ROS) levels. Reactive Oxygen Species 229-232 NFE2 like bZIP transcription factor 2 Homo sapiens 187-191 27091842-8 2016 The positive feedback regulation involving gankyrin and Nrf2 modulates a series of antioxidant enzymes, thereby lowering intracellular ROS and conferring a steadier intracellular environment, which prevents mitochondrial damage and cell death induced by excessive oxidative stress. Reactive Oxygen Species 135-138 NFE2 like bZIP transcription factor 2 Homo sapiens 56-60 26988975-5 2016 ROS lead to Nrf2 activation, which is known to activate antioxidant response gene transcription. Reactive Oxygen Species 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 12-16 27148686-4 2016 Costunolide decreased Nrf2 level; and ectopic Nrf2 expression decreased Costunolide-induced ROS generation. Reactive Oxygen Species 92-95 NFE2 like bZIP transcription factor 2 Homo sapiens 46-50 27183581-1 2016 The Nrf2 transcription factor is well known for its cytoprotective functions through regulation of genes involved in the detoxification of reactive oxygen species or toxic compounds. Reactive Oxygen Species 139-162 NFE2 like bZIP transcription factor 2 Homo sapiens 4-8 27006338-3 2016 We observe that persistent accumulation of ROS, due to a deficient JunD-/Nrf2-antioxidant response, reduces H2AX protein levels. Reactive Oxygen Species 43-46 NFE2 like bZIP transcription factor 2 Homo sapiens 73-77 26968795-12 2016 Thus, induction of HO-1 via the ROS-Nrf2 pathway in human ECs counteracts the anti-proliferative and inflammatory actions of PIs by generating bilirubin. Reactive Oxygen Species 32-35 NFE2 like bZIP transcription factor 2 Homo sapiens 36-40 26795536-0 2016 Tryptophan protects hepatocytes against reactive oxygen species-dependent cell death via multiple pathways including Nrf2-dependent gene induction. Reactive Oxygen Species 40-63 NFE2 like bZIP transcription factor 2 Homo sapiens 117-121 26878775-4 2016 ECG attenuated lipopolysaccharide (LPS)-induced inflammatory mediator expression and intracellular reactive oxygen species (ROS) generation through the induction of Nrf2/antioxidant response element (ARE)-driven glutathione (GSH) and hemeoxygenase-1 (HO-1) levels, interference with NF-kappaB and Nfr2/ARE transcriptional activities, and suppression of the MAPKs (JNK1/2 and p38) and PI3K/Akt signaling pathways. Reactive Oxygen Species 99-122 NFE2 like bZIP transcription factor 2 Homo sapiens 165-169 27569089-12 2016 Furthermore, in the presence of ROS inhibitor NAC (10mM) for 24 hrs, the JNK pathway was markedly activated, together with inhibition of NF-kappaB activity and a reduced level of Nrf2 expression. Reactive Oxygen Species 32-35 NFE2 like bZIP transcription factor 2 Homo sapiens 179-183 26151600-9 2016 The levels of antioxidant chemicals can be increased by supplementation, but increasing the levels of antioxidant enzymes requires activation of Nrf2 by reactive oxygen species (ROS)-dependent and-independent mechanisms. Reactive Oxygen Species 153-176 NFE2 like bZIP transcription factor 2 Homo sapiens 145-149 27197253-5 2016 Furthermore, B7-H3 promoted reactive oxygen species-dependent stabilization of HIF1alpha by suppressing the activity of the stress-activated transcription factor Nrf2 and its target genes, including the antioxidants SOD1, SOD2, and PRX3. Reactive Oxygen Species 28-51 NFE2 like bZIP transcription factor 2 Homo sapiens 162-166 26894974-9 2016 Together, these results showed that Nrf2 serves as a key regulator in chemotherapeutic resistance under hypoxia through ROS-Nrf2-GCLC-GSH pathway. Reactive Oxygen Species 120-123 NFE2 like bZIP transcription factor 2 Homo sapiens 36-40 26894974-9 2016 Together, these results showed that Nrf2 serves as a key regulator in chemotherapeutic resistance under hypoxia through ROS-Nrf2-GCLC-GSH pathway. Reactive Oxygen Species 120-123 NFE2 like bZIP transcription factor 2 Homo sapiens 124-128 25263748-10 2016 Collectively, the results indicate that p,p"-DDE treatment downregulates gamma-GCS activity in HepG2 cells by inducing ROS-mediated Nrf2 loss. Reactive Oxygen Species 119-122 NFE2 like bZIP transcription factor 2 Homo sapiens 132-136 26781848-6 2016 With regards to the underlying mechanism, allicin was able to markedly modulate the expression levels of ROS-associated enzymes, including superoxide dismutase, NADPH oxidase 4 and NAD(P)H dehydrogenase quinone 1, and elevate the activity of nuclear factor erythroid 2-related factor 2 in the H2O2-stimulated ARPE-19 cells. Reactive Oxygen Species 105-108 NFE2 like bZIP transcription factor 2 Homo sapiens 242-285 27109152-5 2016 We found that the 4[Formula: see text]-hydroxywithanolide E-induced ROS accumulation was correlated with the upregulation of Nrf2 and Nrf2-downstream genes, such as antioxidative defense enzymes. Reactive Oxygen Species 68-71 NFE2 like bZIP transcription factor 2 Homo sapiens 125-129 27109152-5 2016 We found that the 4[Formula: see text]-hydroxywithanolide E-induced ROS accumulation was correlated with the upregulation of Nrf2 and Nrf2-downstream genes, such as antioxidative defense enzymes. Reactive Oxygen Species 68-71 NFE2 like bZIP transcription factor 2 Homo sapiens 134-138 26601664-8 2016 Normal mechanisms of activation of Nrf2 requiring reactive oxygen species (ROS) may be impaired in HD, but certain antioxidant compounds can activate Nrf2 without ROS. Reactive Oxygen Species 50-73 NFE2 like bZIP transcription factor 2 Homo sapiens 35-39 26601664-8 2016 Normal mechanisms of activation of Nrf2 requiring reactive oxygen species (ROS) may be impaired in HD, but certain antioxidant compounds can activate Nrf2 without ROS. Reactive Oxygen Species 75-78 NFE2 like bZIP transcription factor 2 Homo sapiens 35-39 27045471-6 2016 Because either CDDP or DTIC produces reactive oxygen species that activate NRF2, we determined whether these agents would sensitize NQO1-low melanoma cells to 17-AAG. Reactive Oxygen Species 37-60 NFE2 like bZIP transcription factor 2 Homo sapiens 75-79 26904936-5 2016 Mechanistically, we show that an early burst in oxidative phosphorylation and elevated reactive oxygen species generation mediates increased NRF2 activity, which in turn initiates the HIFalpha-mediated glycolytic shift and may modulate glucose redistribution to the pentose phosphate pathway. Reactive Oxygen Species 87-110 NFE2 like bZIP transcription factor 2 Homo sapiens 141-145 26647385-7 2016 Western blotting demonstrated that chronic hyperglycemia-associated oxidative stress inhibits nuclear translocation of Nrf2 and impairs activation of antioxidant genes, thus contributing to ROS accumulation. Reactive Oxygen Species 190-193 NFE2 like bZIP transcription factor 2 Homo sapiens 119-123 26624249-10 2016 The increase in ROS formation correlated with an increase in expression of Nrf2-mediated antioxidant genes as well as the expression and production of proinflammatory cytokine TNF-alpha, and interleukin 1 beta (IL-1beta) (p < 0.05). Reactive Oxygen Species 16-19 NFE2 like bZIP transcription factor 2 Homo sapiens 75-79 26152902-4 2016 In response to the ROS production, the metabolism of glutathione (GSH) and its depletion were modeled by the action of an NFE2L2 gene-dependent pathway. Reactive Oxygen Species 19-22 NFE2 like bZIP transcription factor 2 Homo sapiens 122-128 27150150-11 2016 In conclusion, this is the first study demonstrating that compound C alters mitochondrial function and induces ROS production, which ultimately leads to phosphorylation of Nrf2 and induction of SESN2. Reactive Oxygen Species 111-114 NFE2 like bZIP transcription factor 2 Homo sapiens 172-176 26151600-9 2016 The levels of antioxidant chemicals can be increased by supplementation, but increasing the levels of antioxidant enzymes requires activation of Nrf2 by reactive oxygen species (ROS)-dependent and-independent mechanisms. Reactive Oxygen Species 178-181 NFE2 like bZIP transcription factor 2 Homo sapiens 145-149 26998193-3 2016 In this review paper, we particularly focus on the pattern of the generation and homeostasis of intracellular ROS, the mechanisms and targets of ROS impacting on cell-signaling proteins (NF-kappaB, MAPKs, Keap1-Nrf2-ARE, and PI3K-Akt), ion channels and transporters (Ca(2+) and mPTP), and modifying protein kinase and Ubiquitination/Proteasome System. Reactive Oxygen Species 145-148 NFE2 like bZIP transcription factor 2 Homo sapiens 211-215 26682001-8 2016 Here, we review the recent findings on the roles of NRF2 in maintenance of the redox state and multidrug resistance in CSCs, focusing on how NRF2-mediated ROS modulation influences the growth and resistance of CSCs. Reactive Oxygen Species 155-158 NFE2 like bZIP transcription factor 2 Homo sapiens 141-145 26682003-0 2016 The Relevance of Nrf2 Pathway and Autophagy in Pancreatic Cancer Cells upon Stimulation of Reactive Oxygen Species. Reactive Oxygen Species 91-114 NFE2 like bZIP transcription factor 2 Homo sapiens 17-21 26682003-2 2016 We, therefore, explored the relevance between Nrf2 pathway and autophagy in pancreatic cancer cells upon stimulation of reactive oxygen species (ROS). Reactive Oxygen Species 120-143 NFE2 like bZIP transcription factor 2 Homo sapiens 46-50 26682003-2 2016 We, therefore, explored the relevance between Nrf2 pathway and autophagy in pancreatic cancer cells upon stimulation of reactive oxygen species (ROS). Reactive Oxygen Species 145-148 NFE2 like bZIP transcription factor 2 Homo sapiens 46-50 26682003-8 2016 Moreover, our findings indicate that ROS promotes the activation of both Nrf2 pathway and autophagy in pancreatic cancer cells. Reactive Oxygen Species 37-40 NFE2 like bZIP transcription factor 2 Homo sapiens 73-77 26682003-9 2016 Moreover, our data demonstrate that suppression of autophagic activity at particular stages results in an increased promotion of Nrf2 pathway activation upon ROS stimulation. Reactive Oxygen Species 158-161 NFE2 like bZIP transcription factor 2 Homo sapiens 129-133 26682003-10 2016 Furthermore, we found that silencing of Nrf2 promotes autophagy upon ROS stimulation. Reactive Oxygen Species 69-72 NFE2 like bZIP transcription factor 2 Homo sapiens 40-44 26682003-11 2016 In addition, Nrf2 interference effectively promotes autophagic flux upon ROS stimulation. Reactive Oxygen Species 73-76 NFE2 like bZIP transcription factor 2 Homo sapiens 13-17 26682003-12 2016 In summary, our findings suggest that Nrf2 pathway and autophagy have a negative interaction with each other upon ROS stimulation. Reactive Oxygen Species 114-117 NFE2 like bZIP transcription factor 2 Homo sapiens 38-42 26904167-9 2016 Thus, taken together, our findings suggested that TGF-beta and hypoxia/reoxygenation promoted tumor progression and radioresistance of A549 cells through ROS-mediated activation of Nrf2 and EGFR. Reactive Oxygen Species 154-157 NFE2 like bZIP transcription factor 2 Homo sapiens 181-185 26087413-9 2015 HO-1 inhibitor and Nrf2 siRNA blocked the milk-induced inflammatory response such as production of ROS, expression of cytokines, chemokines, and MMPs. Reactive Oxygen Species 99-102 NFE2 like bZIP transcription factor 2 Homo sapiens 19-23 27340506-2 2016 In order to deal with an excessive amount of ROS, organisms are equipped with a sufficient amount of antioxidants together with NF-E2-related factor-2 (NRF2), a transcription factor that plays a key role in the protection of organisms against environmental or intracellular stresses. Reactive Oxygen Species 45-48 NFE2 like bZIP transcription factor 2 Homo sapiens 128-150 27340506-2 2016 In order to deal with an excessive amount of ROS, organisms are equipped with a sufficient amount of antioxidants together with NF-E2-related factor-2 (NRF2), a transcription factor that plays a key role in the protection of organisms against environmental or intracellular stresses. Reactive Oxygen Species 45-48 NFE2 like bZIP transcription factor 2 Homo sapiens 152-156 26566628-5 2016 On the other hand, estrogen simultaneously performs the antioxidative beneficial functions, which protects cancer cells from the potential cytotoxic effects of estrogen-mediated ROS through activation of nuclear factor-erythroid-2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) antioxidant response. Reactive Oxygen Species 178-181 NFE2 like bZIP transcription factor 2 Homo sapiens 204-247 26566628-5 2016 On the other hand, estrogen simultaneously performs the antioxidative beneficial functions, which protects cancer cells from the potential cytotoxic effects of estrogen-mediated ROS through activation of nuclear factor-erythroid-2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) antioxidant response. Reactive Oxygen Species 178-181 NFE2 like bZIP transcription factor 2 Homo sapiens 249-253 26453926-1 2015 Nuclear factor E2-related factor 2 (Nrf2) is a key transcription factor that regulates the expression of a number of antioxidant and detoxifying genes that provide cellular protection against various stressors including reactive oxygen species (ROS). Reactive Oxygen Species 220-243 NFE2 like bZIP transcription factor 2 Homo sapiens 0-34 26453926-1 2015 Nuclear factor E2-related factor 2 (Nrf2) is a key transcription factor that regulates the expression of a number of antioxidant and detoxifying genes that provide cellular protection against various stressors including reactive oxygen species (ROS). Reactive Oxygen Species 220-243 NFE2 like bZIP transcription factor 2 Homo sapiens 36-40 26453926-1 2015 Nuclear factor E2-related factor 2 (Nrf2) is a key transcription factor that regulates the expression of a number of antioxidant and detoxifying genes that provide cellular protection against various stressors including reactive oxygen species (ROS). Reactive Oxygen Species 245-248 NFE2 like bZIP transcription factor 2 Homo sapiens 0-34 26453926-1 2015 Nuclear factor E2-related factor 2 (Nrf2) is a key transcription factor that regulates the expression of a number of antioxidant and detoxifying genes that provide cellular protection against various stressors including reactive oxygen species (ROS). Reactive Oxygen Species 245-248 NFE2 like bZIP transcription factor 2 Homo sapiens 36-40 25358602-0 2015 Low fucose containing bacterial polysaccharide facilitate mitochondria-dependent ROS-induced apoptosis of human lung epithelial carcinoma via controlled regulation of MAPKs-mediated Nrf2/Keap1 homeostasis signaling. Reactive Oxygen Species 81-84 NFE2 like bZIP transcription factor 2 Homo sapiens 182-186 25358602-9 2015 Simultaneously, during apoptosis, the ROS-mediated stress as well as activated MAPKs triggered nuclear translocation of transcription factors like nuclear factor (erythroid-derived)-like 2 (Nrf2) and promoted further transcription of downstream cytoprotective genes, which somehow perturbed the chemotherapeutic efficacy of the polysaccharide, although using CuPP, a chemical inhibitor of HO-1, apoptosis increased significantly (P < 0.05). Reactive Oxygen Species 38-41 NFE2 like bZIP transcription factor 2 Homo sapiens 190-194 26555609-5 2015 Damaged mitochondria arising from stress conditions induced NRF2-dependent transcription of the PINK1 gene through production of reactive oxygen species (ROS). Reactive Oxygen Species 129-152 NFE2 like bZIP transcription factor 2 Homo sapiens 60-64 26870816-4 2016 ROS induces conformational changes in KEAP1 and releases NRF2, which activates AREs. Reactive Oxygen Species 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 57-61 26410779-2 2015 The involvement of Reactive Oxygen Species (ROS) in this inflammatory cascade is evident from the up-regulation of nuclear factor erythroid 2 related factor 2 (Nrf-2), a transcription factor involved in anti-oxidant response signaling in CSE exposed endothelial cells. Reactive Oxygen Species 19-42 NFE2 like bZIP transcription factor 2 Homo sapiens 115-158 26410779-2 2015 The involvement of Reactive Oxygen Species (ROS) in this inflammatory cascade is evident from the up-regulation of nuclear factor erythroid 2 related factor 2 (Nrf-2), a transcription factor involved in anti-oxidant response signaling in CSE exposed endothelial cells. Reactive Oxygen Species 19-42 NFE2 like bZIP transcription factor 2 Homo sapiens 160-165 26410779-2 2015 The involvement of Reactive Oxygen Species (ROS) in this inflammatory cascade is evident from the up-regulation of nuclear factor erythroid 2 related factor 2 (Nrf-2), a transcription factor involved in anti-oxidant response signaling in CSE exposed endothelial cells. Reactive Oxygen Species 44-47 NFE2 like bZIP transcription factor 2 Homo sapiens 115-158 26410779-2 2015 The involvement of Reactive Oxygen Species (ROS) in this inflammatory cascade is evident from the up-regulation of nuclear factor erythroid 2 related factor 2 (Nrf-2), a transcription factor involved in anti-oxidant response signaling in CSE exposed endothelial cells. Reactive Oxygen Species 44-47 NFE2 like bZIP transcription factor 2 Homo sapiens 160-165 26555609-5 2015 Damaged mitochondria arising from stress conditions induced NRF2-dependent transcription of the PINK1 gene through production of reactive oxygen species (ROS). Reactive Oxygen Species 154-157 NFE2 like bZIP transcription factor 2 Homo sapiens 60-64 25912479-4 2015 Since the Nrf2 transcription factor regulates a battery of genes involved in the defense against reactive oxygen species and in compound metabolism, it plays a key role in skin homeostasis, repair, and disease. Reactive Oxygen Species 97-120 NFE2 like bZIP transcription factor 2 Homo sapiens 10-14 26385919-6 2015 The knockdown of Nrf2 or p62 by small interfering RNA (siRNA) enhanced both ROS levels and As(3+)-induced apoptosis in transformed cells. Reactive Oxygen Species 76-79 NFE2 like bZIP transcription factor 2 Homo sapiens 17-21 25975984-2 2015 Nrf2 has a crucial role in the maintenance of cellular redox homeostasis by regulating the biosynthesis, utilization, and regeneration of glutathione, thioredoxin, and NADPH and by controlling the production of reactive oxygen species by mitochondria and NADPH oxidase. Reactive Oxygen Species 211-234 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 25975984-4 2015 Under conditions of stress or growth factor stimulation, activation of Nrf2 counteracts the increased reactive oxygen species production in mitochondria via transcriptional upregulation of uncoupling protein 3 and influences mitochondrial biogenesis by maintaining the levels of nuclear respiratory factor 1 and peroxisome proliferator-activated receptor gamma coactivator 1alpha, as well as by promoting purine nucleotide biosynthesis. Reactive Oxygen Species 102-125 NFE2 like bZIP transcription factor 2 Homo sapiens 71-75 26416516-9 2015 Terrein also alleviated reactive oxygen species formation through the Nrf2/HO-1/p-ERK1/2 pathway in aged cells. Reactive Oxygen Species 24-47 NFE2 like bZIP transcription factor 2 Homo sapiens 70-74 26595608-3 2015 Finally, we use this in vitro model to identify a partial agonist of NRF2 that is protective against reactive oxygen species (ROS)-induced cytotoxicity. Reactive Oxygen Species 101-124 NFE2 like bZIP transcription factor 2 Homo sapiens 69-73 26595608-3 2015 Finally, we use this in vitro model to identify a partial agonist of NRF2 that is protective against reactive oxygen species (ROS)-induced cytotoxicity. Reactive Oxygen Species 126-129 NFE2 like bZIP transcription factor 2 Homo sapiens 69-73 26595608-10 2015 We find that hsa-miR144 modulates NRF2 activity during ROS stress. Reactive Oxygen Species 55-58 NFE2 like bZIP transcription factor 2 Homo sapiens 34-38 26435321-0 2015 Lysine Methyltransferase SETD7 (SET7/9) Regulates ROS Signaling through mitochondria and NFE2L2/ARE pathway. Reactive Oxygen Species 50-53 NFE2 like bZIP transcription factor 2 Homo sapiens 89-95 26435321-8 2015 These results indicate that lysine methylation by SETD7 is important for the fine-tuning of ROS signaling through its regulation on pro-inflammatory responses, mitochondrial function and the NFE2L2/ARE pathway. Reactive Oxygen Species 92-95 NFE2 like bZIP transcription factor 2 Homo sapiens 191-197 26133229-8 2015 These results suggested that in response to increased intracellular levels of ROS, above a critical threshold, Nrf2 stimulates the expression of Klf9, resulting in a further increase in Klf9-mediated ROS production and subsequent cell death. Reactive Oxygen Species 78-81 NFE2 like bZIP transcription factor 2 Homo sapiens 111-115 26133229-8 2015 These results suggested that in response to increased intracellular levels of ROS, above a critical threshold, Nrf2 stimulates the expression of Klf9, resulting in a further increase in Klf9-mediated ROS production and subsequent cell death. Reactive Oxygen Species 200-203 NFE2 like bZIP transcription factor 2 Homo sapiens 111-115 26124081-0 2015 MicroRNA-153/Nrf-2/GPx1 pathway regulates radiosensitivity and stemness of glioma stem cells via reactive oxygen species. Reactive Oxygen Species 97-120 NFE2 like bZIP transcription factor 2 Homo sapiens 13-18 26124081-4 2015 The enhanced Nrf-2 expression increased glutathione peroxidase 1 (GPx1) transcription and decreased ROS level leading to radioresistance of GSCs. Reactive Oxygen Species 100-103 NFE2 like bZIP transcription factor 2 Homo sapiens 13-18 26124081-9 2015 These findings demonstrated that miR-153 overexpression decreased radioresistance and stemness of GSCs through targeting Nrf-2/GPx1/ROS pathway. Reactive Oxygen Species 132-135 NFE2 like bZIP transcription factor 2 Homo sapiens 121-126 25977183-8 2015 Taken together, these findings suggest that Z-lig can suppress UVB-induced ROS generation through Nrf2/HO-1 upregulation and inflammation by suppressing the NF-kappaB pathway, suggesting that Z-lig may be beneficial in protecting skin from UVB exposure. Reactive Oxygen Species 75-78 NFE2 like bZIP transcription factor 2 Homo sapiens 98-102 26208452-2 2015 The Nrf2-Keap1 pathway is crucial for the elimination of ROS in stressed cells. Reactive Oxygen Species 57-60 NFE2 like bZIP transcription factor 2 Homo sapiens 4-8 25546122-3 2015 The purpose of this review is to highlight and evaluate novel mechanisms by which dietary pro-oxidants, including bioactive phytochemicals and fatty acids, increase reactive oxygen species (ROS) concentrations just enough to activate transcription factor activation of nuclear factor erythroid 2 related factor 2 (Nrf-2) and heat shock factor (HSF), leading to an increase in levels of antioxidant enzymes and heat shock proteins that protect against the damaging effects of ROS. Reactive Oxygen Species 165-188 NFE2 like bZIP transcription factor 2 Homo sapiens 314-319 26051282-1 2015 BACKGROUND: We examined (a) the expression of the antioxidative factor glutathione peroxidase (GPx) and the transcription factor nuclear factor E2-related factor 2 (Nrf2) following low-dose X-irradiation in endothelial cells (ECs) and (b) the impact of reactive oxygen species (ROS) and Nrf2 on functional properties of ECs to gain further knowledge about the anti-inflammatory mode of action of low doses of ionizing radiation. Reactive Oxygen Species 253-276 NFE2 like bZIP transcription factor 2 Homo sapiens 165-169 26051282-1 2015 BACKGROUND: We examined (a) the expression of the antioxidative factor glutathione peroxidase (GPx) and the transcription factor nuclear factor E2-related factor 2 (Nrf2) following low-dose X-irradiation in endothelial cells (ECs) and (b) the impact of reactive oxygen species (ROS) and Nrf2 on functional properties of ECs to gain further knowledge about the anti-inflammatory mode of action of low doses of ionizing radiation. Reactive Oxygen Species 278-281 NFE2 like bZIP transcription factor 2 Homo sapiens 165-169 25649257-12 2015 It is concluded from the above mentioned results that JNK/Nrf2 signal pathway is involved in the regulation of UBE1L via intracellular ROS status when cells came in contact with polyphenols. Reactive Oxygen Species 135-138 NFE2 like bZIP transcription factor 2 Homo sapiens 58-62 25722131-8 2015 The internal regulatory mechanisms of autophagy by ROS can be summarized as transcriptional and post-transcriptional regulation, which includes various molecular signal pathways such as ROS-FOXO3-LC3/BNIP3-autophagy, ROS-NRF2-P62-autophagy, ROS-HIF1-BNIP3/NIX-autophagy, and ROS-TIGAR-autophagy. Reactive Oxygen Species 51-54 NFE2 like bZIP transcription factor 2 Homo sapiens 221-225 26222138-8 2015 As an underlying mechanism, we showed that NRF2-knockdown U937 retained high levels of cellular ROS and endoplasmic reticulum (ER) stress markers expression; and subsequently, PMA-stimulated levels of Ca2+ and PKCalpha were greater in NRF2-knockdown U937 cells, which caused enhanced nuclear accumulation of nuclear factor-kB (NFkB) p50 and extracellular signal-regulated kinase (ERK)-1/2 phosphorylation. Reactive Oxygen Species 96-99 NFE2 like bZIP transcription factor 2 Homo sapiens 43-47 26222138-10 2015 Taken together, our results suggest that the NRF2 system functions to suppress PMA-stimulated U937 cell differentiation into pro-inflammatory macrophages and provide evidence that the ROS-PKCalpha-ERK-NFkB axis is involved in PMA-facilitated differentiation of NRF2-silenced U937 cells. Reactive Oxygen Species 184-187 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 26222138-10 2015 Taken together, our results suggest that the NRF2 system functions to suppress PMA-stimulated U937 cell differentiation into pro-inflammatory macrophages and provide evidence that the ROS-PKCalpha-ERK-NFkB axis is involved in PMA-facilitated differentiation of NRF2-silenced U937 cells. Reactive Oxygen Species 184-187 NFE2 like bZIP transcription factor 2 Homo sapiens 261-265 25546122-3 2015 The purpose of this review is to highlight and evaluate novel mechanisms by which dietary pro-oxidants, including bioactive phytochemicals and fatty acids, increase reactive oxygen species (ROS) concentrations just enough to activate transcription factor activation of nuclear factor erythroid 2 related factor 2 (Nrf-2) and heat shock factor (HSF), leading to an increase in levels of antioxidant enzymes and heat shock proteins that protect against the damaging effects of ROS. Reactive Oxygen Species 190-193 NFE2 like bZIP transcription factor 2 Homo sapiens 314-319 26009175-4 2015 This vitamin D signalling stability hypothesis proposes that vitamin D, working in conjunction with klotho and Nrf2 (nuclear factor-erythroid-2-related factor 2), acts as a custodian to maintain the normal function of the ROS and Ca2+ signalling pathways. Reactive Oxygen Species 222-225 NFE2 like bZIP transcription factor 2 Homo sapiens 117-160 26056141-6 2015 This is achieved by accumulation of Erbin to block Ras activation of Raf and Nrf2 to scavenge ROS and can be rescued by knockdown of Nrf2 or Erbin. Reactive Oxygen Species 94-97 NFE2 like bZIP transcription factor 2 Homo sapiens 77-81 26056141-6 2015 This is achieved by accumulation of Erbin to block Ras activation of Raf and Nrf2 to scavenge ROS and can be rescued by knockdown of Nrf2 or Erbin. Reactive Oxygen Species 94-97 NFE2 like bZIP transcription factor 2 Homo sapiens 133-137 26056141-9 2015 By degrading Erbin and Nrf2, Sag activates the Ras-Raf pathway and causes ROS accumulation to trigger autophagy and senescence, eventually delaying Kras(G12D)-induced papillomagenesis and thus acting as a skin-specific tumor suppressor. Reactive Oxygen Species 74-77 NFE2 like bZIP transcription factor 2 Homo sapiens 23-27 25449014-6 2015 The basal levels of NRF2 and KEAP1 were cell line specific and maintained in tight correlation with their growth rates and ROS. Reactive Oxygen Species 123-126 NFE2 like bZIP transcription factor 2 Homo sapiens 20-24 25687825-1 2015 NF-E2-related factor 2 (Nrf2), known to protect against reactive oxygen species, has recently been reported to resolve acute inflammatory responses in activated macrophages. Reactive Oxygen Species 56-79 NFE2 like bZIP transcription factor 2 Homo sapiens 0-22 25687825-1 2015 NF-E2-related factor 2 (Nrf2), known to protect against reactive oxygen species, has recently been reported to resolve acute inflammatory responses in activated macrophages. Reactive Oxygen Species 56-79 NFE2 like bZIP transcription factor 2 Homo sapiens 24-28 25541259-14 2015 CONCLUSIONS: ALDH-positive CSCs might have increased Nrf2-induced antioxidant scavengers, which lower ROS level relevant to chemoresistance in ovarian clear cell carcinoma. Reactive Oxygen Species 102-105 NFE2 like bZIP transcription factor 2 Homo sapiens 53-57 26213634-6 2015 Nrf2 stimulates an array of antioxidant enzymes that convert excessive ROS to less reactive or less damaging forms. Reactive Oxygen Species 71-74 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 25897966-4 2015 By increasing Nrf2 activity, AIMs reduce reactive oxygen species and inflammation in the tumor microenvironment, which reverses tumor-mediated immune evasion and inhibits tumor growth and metastasis. Reactive Oxygen Species 41-64 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 25439010-2 2015 The transcription factor, nuclear factor (erythroid-derived 2)-like 2, (Nrf2), ia potent activator of genes with an antioxidant responsive element and Nrf2 can counteract oxidative injury by increasing expression of several antioxidative genes in response to ROS stress. Reactive Oxygen Species 259-262 NFE2 like bZIP transcription factor 2 Homo sapiens 72-76 25680693-6 2015 In accordance with these findings, Cyn actively inhibited generation of reactive oxygen species from keratinocytes irradiated with ultraviolet B (UVB) in a Nrf2-dependent manner. Reactive Oxygen Species 72-95 NFE2 like bZIP transcription factor 2 Homo sapiens 156-160 25716320-3 2015 Inactivation of Sesn2 or Nrf2 induced reactive oxygen species-mediated proteasomal inhibition and Pdgfrbeta accumulation. Reactive Oxygen Species 38-61 NFE2 like bZIP transcription factor 2 Homo sapiens 25-29 25582950-2 2015 It functions as a repressor of Nrf2, a key transcription factor that initiates the expression of cytoprotective enzymes during oxidative stress to protect cells from damage caused by reactive oxygen species. Reactive Oxygen Species 183-206 NFE2 like bZIP transcription factor 2 Homo sapiens 31-35 25439010-2 2015 The transcription factor, nuclear factor (erythroid-derived 2)-like 2, (Nrf2), ia potent activator of genes with an antioxidant responsive element and Nrf2 can counteract oxidative injury by increasing expression of several antioxidative genes in response to ROS stress. Reactive Oxygen Species 259-262 NFE2 like bZIP transcription factor 2 Homo sapiens 151-155 25527634-6 2015 As a feedback mechanism, nuclear translocation of Nrf2 stimulated the transcription of cytoprotective antioxidant genes, especially genes encoding enzymes that catalyze glutathione (GSH) production to reduce elevated ROS as an intrinsic resistance countermeasure. Reactive Oxygen Species 217-220 NFE2 like bZIP transcription factor 2 Homo sapiens 50-54 25691623-10 2015 Thus, Nrf2 transcribes HO-1 and other genes to reduce reactive oxygen species, and DDAH-1 and DDAH-2 to reduce asymmetric dimethylarginine and PPAR-gamma to increase eNOS and its phosphorylation and activity thereby coordinating 3 pathways that enhance endothelial NO generation. Reactive Oxygen Species 54-77 NFE2 like bZIP transcription factor 2 Homo sapiens 6-10 25759513-5 2015 Furthermore, SKN-1, a functional homolog of Nrf2 in C. elegans, is activated by mitochondrial reactive oxygen species and extends life span by promoting mitochondrial homeostasis (i.e., mitohormesis). Reactive Oxygen Species 94-117 NFE2 like bZIP transcription factor 2 Homo sapiens 44-48 25891728-8 2015 CONCLUSIONS: These results suggest that FK506 induces Nrf 2-driven transcriptional activation of the antioxidant response element by activating HO-1 and free radicals such as reactive oxygen species and nitric oxide. Reactive Oxygen Species 175-198 NFE2 like bZIP transcription factor 2 Homo sapiens 54-59 25527634-7 2015 RNAi-mediated depletion of Nrf2 or addition of beta-phenylethyl isothiocyanate inhibited the ROS detoxification process by reducing GSH levels, which, in turn, increased the efficacy of gemcitabine in vitro and in vivo. Reactive Oxygen Species 93-96 NFE2 like bZIP transcription factor 2 Homo sapiens 27-31 25733817-9 2015 CDDO-Me also scavenged reactive oxygen species through activation of the nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2) pathway in Ec109 and KYSE70 cells. Reactive Oxygen Species 23-46 NFE2 like bZIP transcription factor 2 Homo sapiens 128-132 25918581-10 2015 This review highlights the mechanisms by which leukaemic cells exploit the NRF2/ROS response to promote their growth and survival. Reactive Oxygen Species 80-83 NFE2 like bZIP transcription factor 2 Homo sapiens 75-79 25541286-7 2015 Taken together, these results suggest that shikonin protects against oxLDL-induced endothelial damage by suppressing ROS/NFkappaB-mediated ICAM-1 and E-selectin expression via up-regulation of PI3K/Akt/Nrf2-dependent antioxidant enzyme expression. Reactive Oxygen Species 117-120 NFE2 like bZIP transcription factor 2 Homo sapiens 202-206 25342287-5 2015 Notably, Nrf2 siRNA and the inhibitors of COX-2 and NOX attenuated the inhibition of propofol on ROS production. Reactive Oxygen Species 97-100 NFE2 like bZIP transcription factor 2 Homo sapiens 9-13 26237736-8 2015 In human retinal pigment epithelial cells we find that physiologically relevant doses of the n-3 PUFA docosahexaenoic acid (DHA) induce a transient increase in cellular reactive oxygen species (ROS) levels that activates the oxidative stress response regulator NFE2L2/NRF2 (nuclear factor, erythroid derived 2, like 2). Reactive Oxygen Species 169-192 NFE2 like bZIP transcription factor 2 Homo sapiens 261-267 26237736-8 2015 In human retinal pigment epithelial cells we find that physiologically relevant doses of the n-3 PUFA docosahexaenoic acid (DHA) induce a transient increase in cellular reactive oxygen species (ROS) levels that activates the oxidative stress response regulator NFE2L2/NRF2 (nuclear factor, erythroid derived 2, like 2). Reactive Oxygen Species 194-197 NFE2 like bZIP transcription factor 2 Homo sapiens 261-267 25505069-2 2015 Early during de novo infection of endothelial cells, KSHV induces Nrf2 through an intricate mechanism involving reactive oxygen species (ROS) and prostaglandin E2 (PGE2). Reactive Oxygen Species 112-135 NFE2 like bZIP transcription factor 2 Homo sapiens 66-70 25505069-2 2015 Early during de novo infection of endothelial cells, KSHV induces Nrf2 through an intricate mechanism involving reactive oxygen species (ROS) and prostaglandin E2 (PGE2). Reactive Oxygen Species 137-140 NFE2 like bZIP transcription factor 2 Homo sapiens 66-70 25505069-12 2015 Recently, Nrf2 has been implicated in oncogenesis and was shown to be activated during de novo KSHV infection of endothelial cells through ROS-dependent pathways. Reactive Oxygen Species 139-142 NFE2 like bZIP transcription factor 2 Homo sapiens 10-14 25358785-6 2014 Increased generation of reactive oxygen species and p21 led to activation of the NRF-2 signaling pathway. Reactive Oxygen Species 24-47 NFE2 like bZIP transcription factor 2 Homo sapiens 81-86 25173814-2 2014 The majority of cancer cells develop a ROS-scavenging anti-oxidant system regulated by Nrf2, which confers resistance to ROS-mediated cancer cell death. Reactive Oxygen Species 39-42 NFE2 like bZIP transcription factor 2 Homo sapiens 87-91 25173814-2 2014 The majority of cancer cells develop a ROS-scavenging anti-oxidant system regulated by Nrf2, which confers resistance to ROS-mediated cancer cell death. Reactive Oxygen Species 121-124 NFE2 like bZIP transcription factor 2 Homo sapiens 87-91 25173814-9 2014 Silencing of both Nrf2 and Srx sensitized HT29 cells, leads to ROS overproduction and decreased cell viability. Reactive Oxygen Species 63-66 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22 25340789-3 2014 One of the downstream targets of ROS is nuclear factor E2-related factor 2 (Nrf2), a transcription factor with important anti-oxidative functions. Reactive Oxygen Species 33-36 NFE2 like bZIP transcription factor 2 Homo sapiens 76-80 25340789-5 2014 Within 30 minutes of de novo KSHV infection of HMVEC-d cells, we observed Nrf2 activation through ROS-mediated dissociation from its inhibitor Keap1, Ser-40 phosphorylation, and subsequent nuclear translocation. Reactive Oxygen Species 98-101 NFE2 like bZIP transcription factor 2 Homo sapiens 74-78 25412177-0 2014 Bacterial fucose-rich polysaccharide stabilizes MAPK-mediated Nrf2/Keap1 signaling by directly scavenging reactive oxygen species during hydrogen peroxide-induced apoptosis of human lung fibroblast cells. Reactive Oxygen Species 106-129 NFE2 like bZIP transcription factor 2 Homo sapiens 62-66 25164826-5 2014 Although evidence is accumulating that activation of the Nrf2 pathway represents a promising therapeutic approach to restore the CNS redox balance by reducing ROS-mediated neuronal damage in experimental models of neurodegenerative disorders, only a few Nrf2-activating compounds have been tested in a clinical setting. Reactive Oxygen Species 159-162 NFE2 like bZIP transcription factor 2 Homo sapiens 57-61 25037998-2 2014 We previously reported that nuclear factor erythroid 2-related factor 2 (Nrf2) plays a crucial role in protecting cells against reactive oxygen species, and it facilitates the prevention of ketoprofen-induced GI mucosal ulcers. Reactive Oxygen Species 128-151 NFE2 like bZIP transcription factor 2 Homo sapiens 28-71 25111660-0 2014 The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: involvement of the Nrf2-ARE signaling pathway. Reactive Oxygen Species 90-113 NFE2 like bZIP transcription factor 2 Homo sapiens 134-138 25037998-2 2014 We previously reported that nuclear factor erythroid 2-related factor 2 (Nrf2) plays a crucial role in protecting cells against reactive oxygen species, and it facilitates the prevention of ketoprofen-induced GI mucosal ulcers. Reactive Oxygen Species 128-151 NFE2 like bZIP transcription factor 2 Homo sapiens 73-77 25226504-4 2014 Cells with stable NRF2 knockdown showed enhanced cytotoxicity and apoptotic/necrotic cell death following PDT along with increased levels of singlet oxygen and reactive oxygen species (ROS). Reactive Oxygen Species 160-183 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22 25226504-4 2014 Cells with stable NRF2 knockdown showed enhanced cytotoxicity and apoptotic/necrotic cell death following PDT along with increased levels of singlet oxygen and reactive oxygen species (ROS). Reactive Oxygen Species 185-188 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22 25226504-9 2014 In addition, NRF2-knockdown cells express low level of peroxiredoxin 3 compared to the control, which implies that diminished mitochondrial ROS defense system can be contributing to PDT sensitization. Reactive Oxygen Species 140-143 NFE2 like bZIP transcription factor 2 Homo sapiens 13-17 25226504-11 2014 Specifically, NRF2 knockdown resulted in enhanced cell death and increased singlet oxygen and ROS levels following PDT through the diminished expression of BCRP. Reactive Oxygen Species 94-97 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 25226504-12 2014 Similarly, PDT-induced ROS generation was substantially increased by treatment with NRF2 shRNA in breast carcinoma MCF-7 cells, colon carcinoma HCT116 cells, renal carcinoma A498 cells, and glioblastoma A172 cells. Reactive Oxygen Species 23-26 NFE2 like bZIP transcription factor 2 Homo sapiens 84-88 24599821-2 2014 Nrf2 is a transcription factor that mainly regulates the expression of a wide array of genes that produce the antioxidants and other proteins responsible for the detoxification of xenobiotics and reactive oxygen species. Reactive Oxygen Species 196-219 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 25203443-7 2014 Constitutive PERK-Nrf2 signaling protects de-differentiated cells from chemotherapy by reducing ROS levels and increasing drug efflux. Reactive Oxygen Species 96-99 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22 24953182-0 2014 Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent Notch signaling. Reactive Oxygen Species 33-36 NFE2 like bZIP transcription factor 2 Homo sapiens 96-100 24953182-4 2014 Changing ROS levels activate Nrf2, which activates the Notch pathway to stimulate ABSC self-renewal and an antioxidant program that scavenges intracellular ROS, returning overall ROS levels to a low state to maintain homeostatic balance. Reactive Oxygen Species 9-12 NFE2 like bZIP transcription factor 2 Homo sapiens 29-33 24953182-4 2014 Changing ROS levels activate Nrf2, which activates the Notch pathway to stimulate ABSC self-renewal and an antioxidant program that scavenges intracellular ROS, returning overall ROS levels to a low state to maintain homeostatic balance. Reactive Oxygen Species 156-159 NFE2 like bZIP transcription factor 2 Homo sapiens 29-33 24953182-4 2014 Changing ROS levels activate Nrf2, which activates the Notch pathway to stimulate ABSC self-renewal and an antioxidant program that scavenges intracellular ROS, returning overall ROS levels to a low state to maintain homeostatic balance. Reactive Oxygen Species 156-159 NFE2 like bZIP transcription factor 2 Homo sapiens 29-33 24526395-11 2014 In conclusion, the present work suggests that improving Nrf2 signaling by NGN supplementation would be a rational approach to facilitate ROS detoxification by augmenting both expression and activity of phase II detoxification enzymes for the alleviation of cardiac complications. Reactive Oxygen Species 137-140 NFE2 like bZIP transcription factor 2 Homo sapiens 56-60 25019514-3 2014 Cellular response to excess ROS involves the induction of antioxidant response element (ARE) genes under control of the transcriptional activator Nrf2 and the transcriptional repressor Bach1. Reactive Oxygen Species 28-31 NFE2 like bZIP transcription factor 2 Homo sapiens 146-150 24509533-8 2014 UVA induced ATF3 expression through reactive oxygen species-mediated nuclear factor erythroid 2-related factor 2 (NRF2) activation independently of calcineurin/NFAT inhibition. Reactive Oxygen Species 36-59 NFE2 like bZIP transcription factor 2 Homo sapiens 69-112 24509533-8 2014 UVA induced ATF3 expression through reactive oxygen species-mediated nuclear factor erythroid 2-related factor 2 (NRF2) activation independently of calcineurin/NFAT inhibition. Reactive Oxygen Species 36-59 NFE2 like bZIP transcription factor 2 Homo sapiens 114-118 25337579-2 2014 Modification of Kelch-like ECH-associated protein 1 (Keap1) by reactive oxygen species stabilizes Nrf2 by escaping from degradation. Reactive Oxygen Species 63-86 NFE2 like bZIP transcription factor 2 Homo sapiens 98-102 24500083-5 2014 Nuclear translocation of the transcription factor NF-E2-related factor-2 (Nrf2), which is a master regulator of the inducible antioxidant cell response, and intracellular levels of reactive oxygen species (ROS) were increased in PECAM-1-deficient HUVECs, respectively. Reactive Oxygen Species 181-204 NFE2 like bZIP transcription factor 2 Homo sapiens 74-78 24666416-2 2014 When exposed to environmental stresses such as ROS, NFE-related factor 2 (Nrf2) is the key to antioxidant response by transcriptionally activating various detoxification and antioxidant enzymes. Reactive Oxygen Species 47-50 NFE2 like bZIP transcription factor 2 Homo sapiens 52-72 24666416-2 2014 When exposed to environmental stresses such as ROS, NFE-related factor 2 (Nrf2) is the key to antioxidant response by transcriptionally activating various detoxification and antioxidant enzymes. Reactive Oxygen Species 47-50 NFE2 like bZIP transcription factor 2 Homo sapiens 74-78 24530478-2 2014 alphaTocopheryl succinate inhibits oxidative phosphorylation at the level of mitochondrial complexes I and II, thus enhancing reactive oxygen species generation which, in turn, induces the expression of Nrf2-driven antioxidant/detoxifying genes. Reactive Oxygen Species 126-149 NFE2 like bZIP transcription factor 2 Homo sapiens 203-207 24588654-8 2014 Taken together, these findings suggest that Z-Ligustilide can suppress BaP-induced CYP1A1 upregulation through ROS-dependent Nrf2 pathway activation and may be beneficial in preventing or treating BaP-induced skin damage. Reactive Oxygen Species 111-114 NFE2 like bZIP transcription factor 2 Homo sapiens 125-129 24714453-8 2014 ROS production by shikonin resulted in the inhibition of nuclear translocation of Nrf2. Reactive Oxygen Species 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 82-86 24714453-9 2014 Stable overexpression of Nrf2 in glioma cells inhibited ROS generation by shikonin. Reactive Oxygen Species 56-59 NFE2 like bZIP transcription factor 2 Homo sapiens 25-29 24588654-0 2014 Z-Ligustilide inhibits benzo(a)pyrene-induced CYP1A1 upregulation in cultured human keratinocytes via ROS-dependent Nrf2 activation. Reactive Oxygen Species 102-105 NFE2 like bZIP transcription factor 2 Homo sapiens 116-120 24361488-0 2014 Nrf2/ARE pathway activation, HO-1 and NQO1 induction by polychlorinated biphenyl quinone is associated with reactive oxygen species and PI3K/AKT signaling. Reactive Oxygen Species 108-131 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 24636985-4 2014 Down-regulation of Nrf2 was a surprising result, since the high levels of ROS should have inactivated Keap1, the primary ubiquitin ligase regulating Nrf2 levels. Reactive Oxygen Species 74-77 NFE2 like bZIP transcription factor 2 Homo sapiens 19-23 24636985-4 2014 Down-regulation of Nrf2 was a surprising result, since the high levels of ROS should have inactivated Keap1, the primary ubiquitin ligase regulating Nrf2 levels. Reactive Oxygen Species 74-77 NFE2 like bZIP transcription factor 2 Homo sapiens 149-153 24355171-10 2014 Taken together, TQ induces HO-1 expression in HaCaT cells by activating Nrf2 through ROS-mediated phosphorylation of Akt and AMPKalpha. Reactive Oxygen Species 85-88 NFE2 like bZIP transcription factor 2 Homo sapiens 72-76 24361488-12 2014 At last, reactive oxygen species (ROS) scavengers inhibited PCB29-pQ induced Nrf2 activation partly. Reactive Oxygen Species 9-32 NFE2 like bZIP transcription factor 2 Homo sapiens 77-81 24361488-12 2014 At last, reactive oxygen species (ROS) scavengers inhibited PCB29-pQ induced Nrf2 activation partly. Reactive Oxygen Species 34-37 NFE2 like bZIP transcription factor 2 Homo sapiens 77-81 24491031-9 2014 RESULTS: We found an accumulation of reactive oxygen species during MSC transformation that correlated with the transcriptional down-regulation of antioxidants and Nrf2-downstream genes. Reactive Oxygen Species 37-60 NFE2 like bZIP transcription factor 2 Homo sapiens 164-168 24361488-13 2014 These results suggested that Nrf2 activation by PCB29-pQ in HepG2 cells is associated with ROS and AKT pathway but not MAPK signaling, the activation of Nrf2/ARE may be an adaptive response to oxidative stress. Reactive Oxygen Species 91-94 NFE2 like bZIP transcription factor 2 Homo sapiens 29-33 24591852-3 2014 This review will focus on reactive oxygen species (ROS)-related inflammation in MS. Special emphasis will be placed on the nuclear factor erythroid-2-related factor 2 (Nrf2) as it regulates the transcription of ROS-protective genes. Reactive Oxygen Species 26-49 NFE2 like bZIP transcription factor 2 Homo sapiens 123-166 24591852-3 2014 This review will focus on reactive oxygen species (ROS)-related inflammation in MS. Special emphasis will be placed on the nuclear factor erythroid-2-related factor 2 (Nrf2) as it regulates the transcription of ROS-protective genes. Reactive Oxygen Species 26-49 NFE2 like bZIP transcription factor 2 Homo sapiens 168-172 24591852-3 2014 This review will focus on reactive oxygen species (ROS)-related inflammation in MS. Special emphasis will be placed on the nuclear factor erythroid-2-related factor 2 (Nrf2) as it regulates the transcription of ROS-protective genes. Reactive Oxygen Species 51-54 NFE2 like bZIP transcription factor 2 Homo sapiens 123-166 24591852-3 2014 This review will focus on reactive oxygen species (ROS)-related inflammation in MS. Special emphasis will be placed on the nuclear factor erythroid-2-related factor 2 (Nrf2) as it regulates the transcription of ROS-protective genes. Reactive Oxygen Species 51-54 NFE2 like bZIP transcription factor 2 Homo sapiens 168-172 24591852-3 2014 This review will focus on reactive oxygen species (ROS)-related inflammation in MS. Special emphasis will be placed on the nuclear factor erythroid-2-related factor 2 (Nrf2) as it regulates the transcription of ROS-protective genes. Reactive Oxygen Species 211-214 NFE2 like bZIP transcription factor 2 Homo sapiens 123-166 24591852-3 2014 This review will focus on reactive oxygen species (ROS)-related inflammation in MS. Special emphasis will be placed on the nuclear factor erythroid-2-related factor 2 (Nrf2) as it regulates the transcription of ROS-protective genes. Reactive Oxygen Species 211-214 NFE2 like bZIP transcription factor 2 Homo sapiens 168-172 24591852-5 2014 If challenged by ROS Nrf2, binding to Keap1 is abrogated, and it translocates into the nucleus. Reactive Oxygen Species 17-20 NFE2 like bZIP transcription factor 2 Homo sapiens 21-25 24491031-11 2014 Furthermore, restoration of Nrf2 function in transformed cells decreased reactive oxygen species and impaired in vivo tumor growth (P = 0.001) by mechanisms that included sensitization to apoptosis, and a decreased hypoxic/angiogenic response through HIF-1alpha destabilization and VEGFA repression. Reactive Oxygen Species 73-96 NFE2 like bZIP transcription factor 2 Homo sapiens 28-32 23820265-4 2013 In addition to protecting cells from reactive oxygen species, Nrf2 seems to play a direct role in cell growth control and is related to apoptosis-regulating pathways. Reactive Oxygen Species 37-60 NFE2 like bZIP transcription factor 2 Homo sapiens 62-66 25227109-5 2014 Using biochemical assays and free radical medical experiments in vitro, it was identified that the RNAi-mediated reduction of Nrf2 expression in lung cancer cells induces the generation of reactive oxygen species, decreases the level of reduced glutathione and results in an increase in the A549 cell proliferation inhibition rate. Reactive Oxygen Species 189-212 NFE2 like bZIP transcription factor 2 Homo sapiens 126-130 24239896-9 2014 Thus, induction of HO-1 via the ROS-Nrf2 pathway counteracts the anti-proliferative and inflammatory actions of CM. Reactive Oxygen Species 32-35 NFE2 like bZIP transcription factor 2 Homo sapiens 36-40 24969860-5 2014 This review focuses on the molecular mechanisms through which ROS directly interact with critical signaling molecules to initiate signaling in a broad variety of cellular processes, such as proliferation and survival (MAP kinases and PI3 kinase), ROS homeostasis, and antioxidant gene regulation (Ref-1 and Nrf-2). Reactive Oxygen Species 62-65 NFE2 like bZIP transcription factor 2 Homo sapiens 307-312 24323934-8 2013 In addition to the allosteric regulation of the PPP, which is associated with the activation of glycolysis, the PPP in astroglia can also be activated by ROS through the Kelch-like enoyl-CoA hydratase-associated protein 1 (Keap1)/nuclear factor-erythroid 2 p45 subunit-related factor 2 (Nrf2) system. Reactive Oxygen Species 154-157 NFE2 like bZIP transcription factor 2 Homo sapiens 287-291 24323934-10 2013 ROS is thought to modify the thiol residue of Keap1 and to facilitate Nrf2 dissociation from Keap1. Reactive Oxygen Species 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 70-74 23954465-12 2013 Results indicated Nrf2 siRNA abolished BBR-induced HO-1, NGF, neurite outgrowth and ROS decrease. Reactive Oxygen Species 84-87 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22 23836589-8 2013 Both heme oxygenase 1 (HO-1) and nuclear factor erythroid 2-related factor 2 (Nrf2) knockdown attenuated the isothiocyanate inhibition of oxLDL-induced ROS production, kappaB-reporter activity, and adhesion molecule expression. Reactive Oxygen Species 152-155 NFE2 like bZIP transcription factor 2 Homo sapiens 33-76 23836589-8 2013 Both heme oxygenase 1 (HO-1) and nuclear factor erythroid 2-related factor 2 (Nrf2) knockdown attenuated the isothiocyanate inhibition of oxLDL-induced ROS production, kappaB-reporter activity, and adhesion molecule expression. Reactive Oxygen Species 152-155 NFE2 like bZIP transcription factor 2 Homo sapiens 78-82 23722164-3 2013 We hypothesized that prophylactic activation of the antioxidant genome with Nrf2 activators would attenuate high-altitude-induced ROS formation and cerebral vascular leak and that some drugs currently used to treat AMS symptoms have an additional trait of Nrf2 activation. Reactive Oxygen Species 130-133 NFE2 like bZIP transcription factor 2 Homo sapiens 76-80 24007566-8 2013 The only pathways significant after multiple comparison corrections (FDR <0.05) were the Nrf2-mediated reactive oxygen species (ROS) oxidative response (superoxide dismutase 2, catalase, peroxiredoxin 1, PIK3C3, DNAJC17, microsomal glutathione S-transferase 3) and superoxide radical degradation (SOD2, CAT). Reactive Oxygen Species 106-129 NFE2 like bZIP transcription factor 2 Homo sapiens 92-96 24046186-8 2013 This inhibition of Nrf2 signaling results in the accelerated generation of reactive oxygen species and exacerbation of cytotoxicity in cisplatin-treated A549 cells. Reactive Oxygen Species 75-98 NFE2 like bZIP transcription factor 2 Homo sapiens 19-23 24007566-8 2013 The only pathways significant after multiple comparison corrections (FDR <0.05) were the Nrf2-mediated reactive oxygen species (ROS) oxidative response (superoxide dismutase 2, catalase, peroxiredoxin 1, PIK3C3, DNAJC17, microsomal glutathione S-transferase 3) and superoxide radical degradation (SOD2, CAT). Reactive Oxygen Species 131-134 NFE2 like bZIP transcription factor 2 Homo sapiens 92-96 23922950-1 2013 The Nrf2 (NF-E2 related factor 2)-ARE (antioxidant response element) pathway controls a powerful array of endogenous cellular antioxidant systems and is an important pathway in the detoxification of reactive oxygen species (ROS) in the brain. Reactive Oxygen Species 199-222 NFE2 like bZIP transcription factor 2 Homo sapiens 4-8 23880293-3 2013 MicroRNAs are able to "fine-tune" the regulation of processes including those directly interacting with the Nrf2 pathway and the generation of reactive oxygen species (ROS). Reactive Oxygen Species 143-166 NFE2 like bZIP transcription factor 2 Homo sapiens 108-112 23880293-3 2013 MicroRNAs are able to "fine-tune" the regulation of processes including those directly interacting with the Nrf2 pathway and the generation of reactive oxygen species (ROS). Reactive Oxygen Species 168-171 NFE2 like bZIP transcription factor 2 Homo sapiens 108-112 24029073-1 2013 Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a key transcription factor that regulates the expression of over a hundred cytoprotective and antioxidant genes that provide cellular protection from reactive oxygen species. Reactive Oxygen Species 204-227 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 24029073-1 2013 Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a key transcription factor that regulates the expression of over a hundred cytoprotective and antioxidant genes that provide cellular protection from reactive oxygen species. Reactive Oxygen Species 204-227 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 23729024-9 2013 The effectiveness of miltefosine for positive induction of ROS via NADPH correlated with a decrease in HO-1/ERK/Nrf-2-dependent parasite load. Reactive Oxygen Species 59-62 NFE2 like bZIP transcription factor 2 Homo sapiens 112-117 24015256-0 2013 Pseudomonas aeruginosa pyocyanin activates NRF2-ARE-mediated transcriptional response via the ROS-EGFR-PI3K-AKT/MEK-ERK MAP kinase signaling in pulmonary epithelial cells. Reactive Oxygen Species 94-97 NFE2 like bZIP transcription factor 2 Homo sapiens 43-47 24015256-2 2013 Nuclear factor (erythroid-derived 2)-like 2 (NRF2) confers protection against ROS-mediated cell death by inducing the expression of detoxifying enzymes and proteins via its binding to the cis-acting antioxidant response element (ARE). Reactive Oxygen Species 78-81 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 23311665-5 2013 We review the identity, source, and biological activities of ROS produced during macrophage activation, and discuss how they shape the key transcriptional responses evoked by hypoxia-inducible transcription factors, nuclear-erythroid 2-p45-related factor 2 (Nrf2), and peroxisome proliferator-activated receptor-gamma. Reactive Oxygen Species 61-64 NFE2 like bZIP transcription factor 2 Homo sapiens 216-256 23311665-5 2013 We review the identity, source, and biological activities of ROS produced during macrophage activation, and discuss how they shape the key transcriptional responses evoked by hypoxia-inducible transcription factors, nuclear-erythroid 2-p45-related factor 2 (Nrf2), and peroxisome proliferator-activated receptor-gamma. Reactive Oxygen Species 61-64 NFE2 like bZIP transcription factor 2 Homo sapiens 258-262 23186333-6 2013 INNOVATION: Taken together, these results suggest that Prx I functions as an Nrf2-dependently inducible tumor suppressant in K-ras-driven lung adenocarcinogenesis by opposing ROS/ERK/cyclin D1 pathway activation. Reactive Oxygen Species 175-178 NFE2 like bZIP transcription factor 2 Homo sapiens 77-81 23922950-1 2013 The Nrf2 (NF-E2 related factor 2)-ARE (antioxidant response element) pathway controls a powerful array of endogenous cellular antioxidant systems and is an important pathway in the detoxification of reactive oxygen species (ROS) in the brain. Reactive Oxygen Species 199-222 NFE2 like bZIP transcription factor 2 Homo sapiens 10-32 23922950-1 2013 The Nrf2 (NF-E2 related factor 2)-ARE (antioxidant response element) pathway controls a powerful array of endogenous cellular antioxidant systems and is an important pathway in the detoxification of reactive oxygen species (ROS) in the brain. Reactive Oxygen Species 224-227 NFE2 like bZIP transcription factor 2 Homo sapiens 4-8 23922950-1 2013 The Nrf2 (NF-E2 related factor 2)-ARE (antioxidant response element) pathway controls a powerful array of endogenous cellular antioxidant systems and is an important pathway in the detoxification of reactive oxygen species (ROS) in the brain. Reactive Oxygen Species 224-227 NFE2 like bZIP transcription factor 2 Homo sapiens 10-32 23922950-5 2013 In this study, we show that induction of Nrf2 reduces levels of reactive oxygen species (ROS) produced by various oxidative stressors and results in robust cytoprotection. Reactive Oxygen Species 64-87 NFE2 like bZIP transcription factor 2 Homo sapiens 41-45 23922950-5 2013 In this study, we show that induction of Nrf2 reduces levels of reactive oxygen species (ROS) produced by various oxidative stressors and results in robust cytoprotection. Reactive Oxygen Species 89-92 NFE2 like bZIP transcription factor 2 Homo sapiens 41-45 23583297-1 2013 Nuclear factor erythroid-2-related factor 2 (NRF2; NFE2L2) plays an important role in mediating cellular protection against reactive oxygen species. Reactive Oxygen Species 124-147 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 23583297-1 2013 Nuclear factor erythroid-2-related factor 2 (NRF2; NFE2L2) plays an important role in mediating cellular protection against reactive oxygen species. Reactive Oxygen Species 124-147 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 23583297-1 2013 Nuclear factor erythroid-2-related factor 2 (NRF2; NFE2L2) plays an important role in mediating cellular protection against reactive oxygen species. Reactive Oxygen Species 124-147 NFE2 like bZIP transcription factor 2 Homo sapiens 51-57 23432033-2 2013 An important stress response is the Nrf-2 mediated oxidative stress response pathway where electrophilic chemicals or chemicals that cause the formation of reactive oxygen species initiate the production of antioxidants and metabolic detoxification enzymes. Reactive Oxygen Species 156-179 NFE2 like bZIP transcription factor 2 Homo sapiens 36-41 23633659-2 2013 NF-E2-related factor 2 (Nrf2), a redox sensitive factor, provides cellular defenses against the cytotoxic ROS. Reactive Oxygen Species 106-109 NFE2 like bZIP transcription factor 2 Homo sapiens 0-22 21809430-5 2013 Our results showed that intracellular ROS were both dose- and time-dependent induced by inorganic arsenic; Cellular Nrf2 protein levels increased rapidly after 2 h of exposure, elevated significantly at 6 h, and reached the maximum at 12 h. The endogenous Nrf2-regulated downstream HO-1 mRNA and protein were also induced dramatically and lasted for as long as 24 h. In addition, intracellular GSH levels elevated in consistent with Nrf2 activation. Reactive Oxygen Species 38-41 NFE2 like bZIP transcription factor 2 Homo sapiens 116-120 21809430-5 2013 Our results showed that intracellular ROS were both dose- and time-dependent induced by inorganic arsenic; Cellular Nrf2 protein levels increased rapidly after 2 h of exposure, elevated significantly at 6 h, and reached the maximum at 12 h. The endogenous Nrf2-regulated downstream HO-1 mRNA and protein were also induced dramatically and lasted for as long as 24 h. In addition, intracellular GSH levels elevated in consistent with Nrf2 activation. Reactive Oxygen Species 38-41 NFE2 like bZIP transcription factor 2 Homo sapiens 256-260 21809430-5 2013 Our results showed that intracellular ROS were both dose- and time-dependent induced by inorganic arsenic; Cellular Nrf2 protein levels increased rapidly after 2 h of exposure, elevated significantly at 6 h, and reached the maximum at 12 h. The endogenous Nrf2-regulated downstream HO-1 mRNA and protein were also induced dramatically and lasted for as long as 24 h. In addition, intracellular GSH levels elevated in consistent with Nrf2 activation. Reactive Oxygen Species 38-41 NFE2 like bZIP transcription factor 2 Homo sapiens 256-260 24024172-5 2013 Interference with the supply of glucose or the pentose phosphate pathway and NADPH generation not only hampers Nrf2-mediated detoxification of reactive oxygen species on the enzyme level but also Nrf2-initiated expression of antioxidant defense proteins, such as glutathione reductase and heme-oxygenase1. Reactive Oxygen Species 143-166 NFE2 like bZIP transcription factor 2 Homo sapiens 111-115 24024172-5 2013 Interference with the supply of glucose or the pentose phosphate pathway and NADPH generation not only hampers Nrf2-mediated detoxification of reactive oxygen species on the enzyme level but also Nrf2-initiated expression of antioxidant defense proteins, such as glutathione reductase and heme-oxygenase1. Reactive Oxygen Species 143-166 NFE2 like bZIP transcription factor 2 Homo sapiens 196-200 23604711-10 2013 In conclusion, the present study demonstrates that a hemodynamically relevant level of cyclic strain stimulates HO-1 gene expression in ECs via the ROS-Nrf2 signaling pathway to inhibit EC death. Reactive Oxygen Species 148-151 NFE2 like bZIP transcription factor 2 Homo sapiens 152-156 23633659-2 2013 NF-E2-related factor 2 (Nrf2), a redox sensitive factor, provides cellular defenses against the cytotoxic ROS. Reactive Oxygen Species 106-109 NFE2 like bZIP transcription factor 2 Homo sapiens 24-28 23404377-0 2013 Reactive oxygen species regulate FSH-induced expression of vascular endothelial growth factor via Nrf2 and HIF1alpha signaling in human epithelial ovarian cancer. Reactive Oxygen Species 0-23 NFE2 like bZIP transcription factor 2 Homo sapiens 110-114 23543485-9 2013 This observation suggests that mitochondrial hyperfilamentation acts upstream of a reactive oxygen species-dependent NRF2 transcriptional activity, possibly impacting neuronal maturation, such a process being impaired by insufficient amount of OPA1. Reactive Oxygen Species 83-106 NFE2 like bZIP transcription factor 2 Homo sapiens 117-121 23525690-6 2013 We also found that Nrf2 overexpression suppressed and Nrf2 knockdown increased PM(2.5)-induced ROS generation. Reactive Oxygen Species 95-98 NFE2 like bZIP transcription factor 2 Homo sapiens 54-58 23525690-9 2013 Taken together, our results suggest that PM(2.5)-induced ROS may function as signaling molecules to activate Nrf2-mediated defenses, such as HO-1 expression, against oxidative stress induced by PM(2.5) through the PI3K/AKT signaling pathway. Reactive Oxygen Species 57-60 NFE2 like bZIP transcription factor 2 Homo sapiens 109-113 23404377-4 2013 This study was performed to investigate whether FSH induces VEGF expression via a ROS-mediated Nrf2 signaling pathway. Reactive Oxygen Species 94-97 NFE2 like bZIP transcription factor 2 Homo sapiens 107-111 23404377-10 2013 Blockage of the FSH-ROS-Nrf2-HIF1alpha signaling pathway attenuated FSH-induced binding of HIF1alpha to the VEGF promoter. Reactive Oxygen Species 20-23 NFE2 like bZIP transcription factor 2 Homo sapiens 24-28 23281030-4 2013 Adenoviral overexpression of Nrf2 counteracted OTA-mediated reduction in HO-1 and erythropoietin expression and cell proliferation as well as increase in reactive oxygen species (ROS) generation and TGFbeta expression. Reactive Oxygen Species 154-177 NFE2 like bZIP transcription factor 2 Homo sapiens 29-33 23281030-10 2013 CONCLUSION: We showed that attenuation of Nrf2 and HO-1 expression through induction of miR-132 and miR-200c by OTA elevates ROS levels and profibrotic TGFbeta expression. Reactive Oxygen Species 125-128 NFE2 like bZIP transcription factor 2 Homo sapiens 42-46 23281030-4 2013 Adenoviral overexpression of Nrf2 counteracted OTA-mediated reduction in HO-1 and erythropoietin expression and cell proliferation as well as increase in reactive oxygen species (ROS) generation and TGFbeta expression. Reactive Oxygen Species 179-182 NFE2 like bZIP transcription factor 2 Homo sapiens 29-33 23046979-11 2013 CONCLUSIONS: DATTS activates the ROS-eIF2alpha/Nrf2 HO-1 signaling cascades leading to the up-regulation of HO-1. Reactive Oxygen Species 33-36 NFE2 like bZIP transcription factor 2 Homo sapiens 47-51 24381719-6 2013 We also discuss the neuroprotective role of the nuclear factor erythroid 2-related factor (Nrf2) in the aged brain in response to oxidative stressors and nanoparticle-mediated delivery of ROS-scavenging drugs. Reactive Oxygen Species 188-191 NFE2 like bZIP transcription factor 2 Homo sapiens 48-89 23533696-6 2013 An exposure to oxidized ecDNA stimulates a synthesis of reactive oxygen species (ROS) that evokes an adaptive response that includes transposition of the homologous loci within the nucleus, polymerization and the formation of the stress fibers of the actin, as well as activation of the ribosomal gene expression, and nuclear translocation of NF-E2 related factor-2 (NRF2) that, in turn, mediates induction of phase II detoxifying and antioxidant enzymes. Reactive Oxygen Species 56-79 NFE2 like bZIP transcription factor 2 Homo sapiens 343-365 23533696-6 2013 An exposure to oxidized ecDNA stimulates a synthesis of reactive oxygen species (ROS) that evokes an adaptive response that includes transposition of the homologous loci within the nucleus, polymerization and the formation of the stress fibers of the actin, as well as activation of the ribosomal gene expression, and nuclear translocation of NF-E2 related factor-2 (NRF2) that, in turn, mediates induction of phase II detoxifying and antioxidant enzymes. Reactive Oxygen Species 56-79 NFE2 like bZIP transcription factor 2 Homo sapiens 367-371 23533696-6 2013 An exposure to oxidized ecDNA stimulates a synthesis of reactive oxygen species (ROS) that evokes an adaptive response that includes transposition of the homologous loci within the nucleus, polymerization and the formation of the stress fibers of the actin, as well as activation of the ribosomal gene expression, and nuclear translocation of NF-E2 related factor-2 (NRF2) that, in turn, mediates induction of phase II detoxifying and antioxidant enzymes. Reactive Oxygen Species 81-84 NFE2 like bZIP transcription factor 2 Homo sapiens 343-365 23533696-6 2013 An exposure to oxidized ecDNA stimulates a synthesis of reactive oxygen species (ROS) that evokes an adaptive response that includes transposition of the homologous loci within the nucleus, polymerization and the formation of the stress fibers of the actin, as well as activation of the ribosomal gene expression, and nuclear translocation of NF-E2 related factor-2 (NRF2) that, in turn, mediates induction of phase II detoxifying and antioxidant enzymes. Reactive Oxygen Species 81-84 NFE2 like bZIP transcription factor 2 Homo sapiens 367-371 23538677-0 2013 Fisetin inhibits osteoclastogenesis through prevention of RANKL-induced ROS production by Nrf2-mediated up-regulation of phase II antioxidant enzymes. Reactive Oxygen Species 72-75 NFE2 like bZIP transcription factor 2 Homo sapiens 90-94 23781297-3 2013 Natural ITCs are key chemopreventive ingredients of cruciferous vegetables, and one of the prime chemopreventive mechanisms of natural isothiocyanates is the induction of Nrf2/ARE-dependent gene expression that plays a critical role in cellular defense against electrophiles and reactive oxygen species. Reactive Oxygen Species 279-302 NFE2 like bZIP transcription factor 2 Homo sapiens 171-175 24381719-6 2013 We also discuss the neuroprotective role of the nuclear factor erythroid 2-related factor (Nrf2) in the aged brain in response to oxidative stressors and nanoparticle-mediated delivery of ROS-scavenging drugs. Reactive Oxygen Species 188-191 NFE2 like bZIP transcription factor 2 Homo sapiens 91-95 23036869-6 2012 Nrf2 activation was associated with increased reactive oxygen species production. Reactive Oxygen Species 46-69 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 23400918-13 2013 Blocking Nrf2 by siRNA-Nrf2 decreases GSH and increases ROS and lipid peroxidation, resulting in decreased mitochondrial membrane potential and loss of cell viability of E47 cells but not C34 cells. Reactive Oxygen Species 56-59 NFE2 like bZIP transcription factor 2 Homo sapiens 9-13 23400918-13 2013 Blocking Nrf2 by siRNA-Nrf2 decreases GSH and increases ROS and lipid peroxidation, resulting in decreased mitochondrial membrane potential and loss of cell viability of E47 cells but not C34 cells. Reactive Oxygen Species 56-59 NFE2 like bZIP transcription factor 2 Homo sapiens 23-27 23272301-4 2012 Following exposure to electrophiles or reactive oxygen species, Nrf2 becomes stabilized, translocates into the nucleus, and activates the transcription of various cytoprotective genes. Reactive Oxygen Species 39-62 NFE2 like bZIP transcription factor 2 Homo sapiens 64-68 22964583-12 2012 NRF2 and SRXN1 genetic polymorphisms are associated with breast cancer risk and survival, implicating that mechanisms associated with reactive oxygen species and NRF2 pathway are involved in breast cancer initiation and progression. Reactive Oxygen Species 134-157 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 22983983-6 2012 The protective effect is lost under conditions of Nrf2 deficiency, implying that it is due to induction of Nrf2-dependent cytoprotective proteins, and that this strategy could provide protection against any potentially photosensitizing drugs that generate electrophilic or reactive oxygen species. Reactive Oxygen Species 273-296 NFE2 like bZIP transcription factor 2 Homo sapiens 50-54 22940790-1 2012 In response to reactive oxygen species (ROS) or electrophiles, the transcription factor nuclear factor-erythroid 2 (NF-E2)-related factor 2 (Nrf2) rapidly translocates into the nucleus and induces the expression of various antioxidant genes, such as heme oxygenase-1 (HO-1). Reactive Oxygen Species 15-38 NFE2 like bZIP transcription factor 2 Homo sapiens 141-145 22648520-2 2012 Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates transcription of genes encoding enzymes important for protection against ROS. Reactive Oxygen Species 134-137 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 22648520-2 2012 Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates transcription of genes encoding enzymes important for protection against ROS. Reactive Oxygen Species 134-137 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 22940790-1 2012 In response to reactive oxygen species (ROS) or electrophiles, the transcription factor nuclear factor-erythroid 2 (NF-E2)-related factor 2 (Nrf2) rapidly translocates into the nucleus and induces the expression of various antioxidant genes, such as heme oxygenase-1 (HO-1). Reactive Oxygen Species 40-43 NFE2 like bZIP transcription factor 2 Homo sapiens 141-145 22964297-9 2012 Thus, the upregulation of ROS might exceed the Nrf2 dependent antioxidant defense protection in the LECs and result in the highly oxidized lenses and resulted in ARCs. Reactive Oxygen Species 26-29 NFE2 like bZIP transcription factor 2 Homo sapiens 47-51 22951256-8 2012 Additionally, TGFbeta1 rapidly increased cellular ROS levels, which in turn activated the Nrf2-ARE pathway. Reactive Oxygen Species 50-53 NFE2 like bZIP transcription factor 2 Homo sapiens 90-94 22951256-12 2012 These data show the regulation of AR by TGFbeta1 is induced by TGFbeta1 stimulation of ROS, which activates the Nrf2-ARE pathway allowing Nrf2 to directly increase AR expression in HRMCs. Reactive Oxygen Species 87-90 NFE2 like bZIP transcription factor 2 Homo sapiens 112-116 22864061-8 2012 In conclusion, these studies demonstrate that sildenafil stimulates the expression of HO-1 and iNOS via the ROS-Nrf2 and sGC-cGMP pathway, respectively. Reactive Oxygen Species 108-111 NFE2 like bZIP transcription factor 2 Homo sapiens 112-116 22351438-5 2012 This raised basal expression of NRF2 appeared to be a response to on-going production of ROS, since treatment with the antioxidant and GSH precursor N-acetylcysteine (NAC) reduced NRF2 expression. Reactive Oxygen Species 89-92 NFE2 like bZIP transcription factor 2 Homo sapiens 32-36 22951256-12 2012 These data show the regulation of AR by TGFbeta1 is induced by TGFbeta1 stimulation of ROS, which activates the Nrf2-ARE pathway allowing Nrf2 to directly increase AR expression in HRMCs. Reactive Oxygen Species 87-90 NFE2 like bZIP transcription factor 2 Homo sapiens 138-142 22351438-5 2012 This raised basal expression of NRF2 appeared to be a response to on-going production of ROS, since treatment with the antioxidant and GSH precursor N-acetylcysteine (NAC) reduced NRF2 expression. Reactive Oxygen Species 89-92 NFE2 like bZIP transcription factor 2 Homo sapiens 180-184 21878367-6 2012 This review focuses on the antioxidative effect of insulin and highlights insulin-induced regulation of various antioxidant enzymes via insulin signaling pathways and the cross talk between key transcription factors, including nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor kappaB (NF-kappaB) which are responsible for the transcription of antioxidant enzymes, leading to reduced generation of reactive oxygen species (ROS) and the enhancement of the elimination of ROS. Reactive Oxygen Species 417-440 NFE2 like bZIP transcription factor 2 Homo sapiens 227-270 22721804-9 2012 Phospho-nuclear factor erythroid 2-related factor 2 (p-Nrf2) showed a ROS-dependent translocation to the nucleus, which suggested that Nrf2 might increase cell survival by suppressing ROS accumulation and apoptosis mediated by oxidative stress. Reactive Oxygen Species 70-73 NFE2 like bZIP transcription factor 2 Homo sapiens 55-59 22721804-9 2012 Phospho-nuclear factor erythroid 2-related factor 2 (p-Nrf2) showed a ROS-dependent translocation to the nucleus, which suggested that Nrf2 might increase cell survival by suppressing ROS accumulation and apoptosis mediated by oxidative stress. Reactive Oxygen Species 70-73 NFE2 like bZIP transcription factor 2 Homo sapiens 135-139 22721804-9 2012 Phospho-nuclear factor erythroid 2-related factor 2 (p-Nrf2) showed a ROS-dependent translocation to the nucleus, which suggested that Nrf2 might increase cell survival by suppressing ROS accumulation and apoptosis mediated by oxidative stress. Reactive Oxygen Species 184-187 NFE2 like bZIP transcription factor 2 Homo sapiens 55-59 22721804-9 2012 Phospho-nuclear factor erythroid 2-related factor 2 (p-Nrf2) showed a ROS-dependent translocation to the nucleus, which suggested that Nrf2 might increase cell survival by suppressing ROS accumulation and apoptosis mediated by oxidative stress. Reactive Oxygen Species 184-187 NFE2 like bZIP transcription factor 2 Homo sapiens 135-139 22546375-6 2012 Target gene analysis revealed that nAg-mediated increase in gamma-glutamate cysteine ligase expression is NRF2-dependent: nAg-treated NRF2i showed a reduction in glutathione (GSH) content and elevation in ROS level in comparison with the control cells. Reactive Oxygen Species 205-208 NFE2 like bZIP transcription factor 2 Homo sapiens 106-110 22213475-7 2012 AIB1 suppressed ROS by up-regulating antioxidants such as glutathione synthetase and glutathione peroxidase, which are targets of the NF-E2-related factor 2 (Nrf2), a critical transcription factor that regulates antioxidants, detoxification enzymes, and drug efflux proteins. Reactive Oxygen Species 16-19 NFE2 like bZIP transcription factor 2 Homo sapiens 134-156 22213475-7 2012 AIB1 suppressed ROS by up-regulating antioxidants such as glutathione synthetase and glutathione peroxidase, which are targets of the NF-E2-related factor 2 (Nrf2), a critical transcription factor that regulates antioxidants, detoxification enzymes, and drug efflux proteins. Reactive Oxygen Species 16-19 NFE2 like bZIP transcription factor 2 Homo sapiens 158-162 22480519-9 2012 KEY FINDINGS: Tat caused a significant decrease in the intracellular glutathione (GSH) levels, a mild increase in the expression of nuclear levels of NF-E2-related factor-2 (Nrf2), a significant increase in the levels of NF-kappaB (phosphorylation of p65 and IKK) and a significant increase in ROS production. Reactive Oxygen Species 294-297 NFE2 like bZIP transcription factor 2 Homo sapiens 174-178 22192953-6 2012 Overexpression of Nrf2 in BRCA1 deficient cells reduced elevated ROS to the control levels. Reactive Oxygen Species 65-68 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22 22192953-10 2012 In conclusion, we demonstrated that the lack of BRCA1 renders cells more susceptible to ROS-induced DNA damage, which may eventually result in tumorigenesis, and that administration of Nrf2-activating bioactive food components can reduce those risks. Reactive Oxygen Species 88-91 NFE2 like bZIP transcription factor 2 Homo sapiens 185-189 22314914-1 2012 The Nrf2/ARE pathway is a major cellular defense mechanism that prevents damage by reactive oxygen species through induction of antioxidative phase II enzymes. Reactive Oxygen Species 83-106 NFE2 like bZIP transcription factor 2 Homo sapiens 4-8 21878367-6 2012 This review focuses on the antioxidative effect of insulin and highlights insulin-induced regulation of various antioxidant enzymes via insulin signaling pathways and the cross talk between key transcription factors, including nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor kappaB (NF-kappaB) which are responsible for the transcription of antioxidant enzymes, leading to reduced generation of reactive oxygen species (ROS) and the enhancement of the elimination of ROS. Reactive Oxygen Species 417-440 NFE2 like bZIP transcription factor 2 Homo sapiens 272-276 21878367-6 2012 This review focuses on the antioxidative effect of insulin and highlights insulin-induced regulation of various antioxidant enzymes via insulin signaling pathways and the cross talk between key transcription factors, including nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor kappaB (NF-kappaB) which are responsible for the transcription of antioxidant enzymes, leading to reduced generation of reactive oxygen species (ROS) and the enhancement of the elimination of ROS. Reactive Oxygen Species 442-445 NFE2 like bZIP transcription factor 2 Homo sapiens 227-270 21878367-6 2012 This review focuses on the antioxidative effect of insulin and highlights insulin-induced regulation of various antioxidant enzymes via insulin signaling pathways and the cross talk between key transcription factors, including nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor kappaB (NF-kappaB) which are responsible for the transcription of antioxidant enzymes, leading to reduced generation of reactive oxygen species (ROS) and the enhancement of the elimination of ROS. Reactive Oxygen Species 442-445 NFE2 like bZIP transcription factor 2 Homo sapiens 272-276 21878367-6 2012 This review focuses on the antioxidative effect of insulin and highlights insulin-induced regulation of various antioxidant enzymes via insulin signaling pathways and the cross talk between key transcription factors, including nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor kappaB (NF-kappaB) which are responsible for the transcription of antioxidant enzymes, leading to reduced generation of reactive oxygen species (ROS) and the enhancement of the elimination of ROS. Reactive Oxygen Species 489-492 NFE2 like bZIP transcription factor 2 Homo sapiens 227-270 21878367-6 2012 This review focuses on the antioxidative effect of insulin and highlights insulin-induced regulation of various antioxidant enzymes via insulin signaling pathways and the cross talk between key transcription factors, including nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor kappaB (NF-kappaB) which are responsible for the transcription of antioxidant enzymes, leading to reduced generation of reactive oxygen species (ROS) and the enhancement of the elimination of ROS. Reactive Oxygen Species 489-492 NFE2 like bZIP transcription factor 2 Homo sapiens 272-276 22253942-3 2012 Thus, the capacity of endogenous free radical clearance can be of patho-physiological importance; in this regard, the major reactive oxygen species defense machinery, the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) system needs to be precisely modulated in response to pathological alterations. Reactive Oxygen Species 124-147 NFE2 like bZIP transcription factor 2 Homo sapiens 171-214 22019695-0 2012 Reactive oxygen species and PI3K/Akt signaling play key roles in the induction of Nrf2-driven heme oxygenase-1 expression in sulforaphane-treated human mesothelioma MSTO-211H cells. Reactive Oxygen Species 0-23 NFE2 like bZIP transcription factor 2 Homo sapiens 82-86 22019695-9 2012 Overall, our results indicate that ROS generation and/or activation of PI3K/Akt signaling regulate cell survival and Nrf2-driven HO-1 expression in sulforaphane-treated MSTO-211H cells. Reactive Oxygen Species 35-38 NFE2 like bZIP transcription factor 2 Homo sapiens 117-121 22253942-3 2012 Thus, the capacity of endogenous free radical clearance can be of patho-physiological importance; in this regard, the major reactive oxygen species defense machinery, the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) system needs to be precisely modulated in response to pathological alterations. Reactive Oxygen Species 124-147 NFE2 like bZIP transcription factor 2 Homo sapiens 216-220 22346778-3 2011 NAD(P)H:quinone oxidoreductase (NQO1) is a highly inducible enzyme that is regulated by the Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway, which is central to efficient detoxification of reactive metabolites and reactive oxygen species (ROS). Reactive Oxygen Species 304-327 NFE2 like bZIP transcription factor 2 Homo sapiens 181-185 22246987-12 2012 CONCLUSIONS: ALA-hx PDT more potently produced intracellular ROS in MCF-7/ADR cells, which might be due to down-regulation of Nrf2-mediated anti-oxidant gene transcription and up-regulation of PpIX synthesis via the induction of CPO and PPO. Reactive Oxygen Species 61-64 NFE2 like bZIP transcription factor 2 Homo sapiens 126-130 22346778-3 2011 NAD(P)H:quinone oxidoreductase (NQO1) is a highly inducible enzyme that is regulated by the Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway, which is central to efficient detoxification of reactive metabolites and reactive oxygen species (ROS). Reactive Oxygen Species 304-327 NFE2 like bZIP transcription factor 2 Homo sapiens 136-179 22346778-3 2011 NAD(P)H:quinone oxidoreductase (NQO1) is a highly inducible enzyme that is regulated by the Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway, which is central to efficient detoxification of reactive metabolites and reactive oxygen species (ROS). Reactive Oxygen Species 329-332 NFE2 like bZIP transcription factor 2 Homo sapiens 136-179 22346778-3 2011 NAD(P)H:quinone oxidoreductase (NQO1) is a highly inducible enzyme that is regulated by the Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway, which is central to efficient detoxification of reactive metabolites and reactive oxygen species (ROS). Reactive Oxygen Species 329-332 NFE2 like bZIP transcription factor 2 Homo sapiens 181-185 22346778-9 2011 CONCLUSION: Our results suggest that CO-induced Nrf2 increases the expression of NQO1 which is well known to detoxify reactive metabolites and ROS. Reactive Oxygen Species 143-146 NFE2 like bZIP transcription factor 2 Homo sapiens 48-52 22024084-3 2011 This study was designed to investigate whether curcumin-induced Nrf2 nuclear translocation could reduce ROS-mediated insulin resistance in cultured LO2 hepatocytes. Reactive Oxygen Species 104-107 NFE2 like bZIP transcription factor 2 Homo sapiens 64-68 22065904-8 2011 Nrf2 protein levels in both nuclear and whole cell lysates were increased by SFN treatment, which was dependent on ROS production. Reactive Oxygen Species 115-118 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 22024084-10 2011 CONCLUSIONS: These findings suggest that curcumin could reduce ROS-mediated insulin resistance in hepatocytes, at least in part through nuclear translocation of Nrf2. Reactive Oxygen Species 63-66 NFE2 like bZIP transcription factor 2 Homo sapiens 161-165 21635873-4 2011 Compound C also stimulated Nrf2 expression this was associated with an increase in the production of reactive oxygen species and with a decline in intracellular glutathione levels. Reactive Oxygen Species 101-124 NFE2 like bZIP transcription factor 2 Homo sapiens 27-31 21878644-11 2011 Further studies provided evidence for the stabilization of Nrf2 due to reduced 26 S proteasome activity and increased p21 association as the driving signaling event that contributes to the transition from a high ROS quiescent state to a low ROS proliferating stage in drug-induced tumor stem cell enrichment. Reactive Oxygen Species 212-215 NFE2 like bZIP transcription factor 2 Homo sapiens 59-63 21878644-11 2011 Further studies provided evidence for the stabilization of Nrf2 due to reduced 26 S proteasome activity and increased p21 association as the driving signaling event that contributes to the transition from a high ROS quiescent state to a low ROS proliferating stage in drug-induced tumor stem cell enrichment. Reactive Oxygen Species 241-244 NFE2 like bZIP transcription factor 2 Homo sapiens 59-63 21861804-0 2011 ROS acts as a double-edged sword in the pathogenesis of type 2 diabetes mellitus: is Nrf2 a potential target for the treatment? Reactive Oxygen Species 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 85-89 21620964-0 2011 An IkappaBalpha phosphorylation inhibitor induces heme oxygenase-1(HO-1) expression through the activation of reactive oxygen species (ROS)-Nrf2-ARE signaling and ROS-PI3K/Akt signaling in an NF-kappaB-independent mechanism. Reactive Oxygen Species 110-133 NFE2 like bZIP transcription factor 2 Homo sapiens 140-144 21620964-0 2011 An IkappaBalpha phosphorylation inhibitor induces heme oxygenase-1(HO-1) expression through the activation of reactive oxygen species (ROS)-Nrf2-ARE signaling and ROS-PI3K/Akt signaling in an NF-kappaB-independent mechanism. Reactive Oxygen Species 135-138 NFE2 like bZIP transcription factor 2 Homo sapiens 140-144 21620964-11 2011 Taken together, our results suggest that in human colon cancer HT29 cells, Bay induces HO-1 expression by increasing ROS production in an Nrf2-ARE and PI3K dependent manner, but Bay acts independently of NF-kappaB. Reactive Oxygen Species 117-120 NFE2 like bZIP transcription factor 2 Homo sapiens 138-142 21728338-9 2011 These findings, taken all together, suggest that intracellular accumulation of ROS formed as a consequence of initial depletion of GSH can activate Akt, which in turn induces Nrf2 activation and subsequently the expression of GCLC, leading to the restoration of GSH. Reactive Oxygen Species 79-82 NFE2 like bZIP transcription factor 2 Homo sapiens 175-179 21728338-6 2011 The reactive oxygen species (ROS) scavenger N-acetylcysteine (NAC) abolished the 15d-PGJ2-induced Nrf2 activation and GCLC expression. Reactive Oxygen Species 4-27 NFE2 like bZIP transcription factor 2 Homo sapiens 98-102 21728338-6 2011 The reactive oxygen species (ROS) scavenger N-acetylcysteine (NAC) abolished the 15d-PGJ2-induced Nrf2 activation and GCLC expression. Reactive Oxygen Species 29-32 NFE2 like bZIP transcription factor 2 Homo sapiens 98-102 21443946-7 2011 Knockdown of Nrf2 expression using an siRNA approach attenuated basal Nox4 expression; however, it enhanced superoxide/ROS generation under both normoxia and hyperoxia. Reactive Oxygen Species 119-122 NFE2 like bZIP transcription factor 2 Homo sapiens 13-17 21670314-8 2011 We also showed that autocrine TNF secretion was responsible for this sustained Nrf2 response and that Nrf2 activation by TNF was mediated by the generation of reactive oxygen species. Reactive Oxygen Species 159-182 NFE2 like bZIP transcription factor 2 Homo sapiens 102-106 21333731-8 2011 On the other hand, RSG notably increased the expression of key antioxidant transcription factor Nrf2 and antioxidant enzyme HO-1 in a PPARgamma-dependent manner, leading to the elimination of excessive ROS. Reactive Oxygen Species 202-205 NFE2 like bZIP transcription factor 2 Homo sapiens 96-100 21787718-9 2011 Overall, our data suggest that cadmium-induced ROS cause up-regulation of AKR1C3 expression, at least partially via the activation of PI3K-related intracellular signaling pathways, and Nrf2 activation, thereby contributing to an adaptive intracellular response to cadmium toxicity. Reactive Oxygen Species 47-50 NFE2 like bZIP transcription factor 2 Homo sapiens 185-189 21391649-1 2011 Activation of the transcription factor NF-E2-related factor-2 (Nrf2) through modification of Kelch-like ECH-associated protein 1 (Keap1) cysteines, leading to up-regulation of the antioxidant response element (ARE), is an important mechanism of cellular defense against reactive oxygen species and xenobiotic electrophiles. Reactive Oxygen Species 270-293 NFE2 like bZIP transcription factor 2 Homo sapiens 39-61 21391649-1 2011 Activation of the transcription factor NF-E2-related factor-2 (Nrf2) through modification of Kelch-like ECH-associated protein 1 (Keap1) cysteines, leading to up-regulation of the antioxidant response element (ARE), is an important mechanism of cellular defense against reactive oxygen species and xenobiotic electrophiles. Reactive Oxygen Species 270-293 NFE2 like bZIP transcription factor 2 Homo sapiens 63-67 21212410-5 2011 Bortezomib stimulates cytotoxicity through accumulation of reactive oxygen species (ROS) but elevated basal levels of nuclear Nrf2 present in AML cells reduced ROS levels, permitting AML cells to survive drug treatment. Reactive Oxygen Species 160-163 NFE2 like bZIP transcription factor 2 Homo sapiens 126-130 21396911-5 2011 This study proposes that in response to arsenic exposure, the NRF2-mediated adaptive induction of endogenous antioxidant enzymes blunts insulin-stimulated ROS signaling and thus impairs ISGU. Reactive Oxygen Species 155-158 NFE2 like bZIP transcription factor 2 Homo sapiens 62-66 20446774-9 2010 In conclusion, the Nrf2-mediated HO-1 upregulation upon glucose deprivation is mediated by ROS in HepG2 cells, and responsible for the adaptive survival response. Reactive Oxygen Species 91-94 NFE2 like bZIP transcription factor 2 Homo sapiens 19-23 21195017-1 2011 Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that regulates Antioxidant Response Element (ARE)-mediated transcription of a plethora of antioxidant and protective genes to counteract the harmful effects of reactive oxygen species or environmental carcinogens. Reactive Oxygen Species 228-251 NFE2 like bZIP transcription factor 2 Homo sapiens 0-34 21195017-1 2011 Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that regulates Antioxidant Response Element (ARE)-mediated transcription of a plethora of antioxidant and protective genes to counteract the harmful effects of reactive oxygen species or environmental carcinogens. Reactive Oxygen Species 228-251 NFE2 like bZIP transcription factor 2 Homo sapiens 36-40 21931870-0 2011 Hepatitis C virus proteins activate NRF2/ARE pathway by distinct ROS-dependent and independent mechanisms in HUH7 cells. Reactive Oxygen Species 65-68 NFE2 like bZIP transcription factor 2 Homo sapiens 36-40 21931870-6 2011 All five proteins induced Nrf2 activation by protein kinase C in response to accumulation of reactive oxygen species (ROS). Reactive Oxygen Species 93-116 NFE2 like bZIP transcription factor 2 Homo sapiens 26-30 21931870-6 2011 All five proteins induced Nrf2 activation by protein kinase C in response to accumulation of reactive oxygen species (ROS). Reactive Oxygen Species 118-121 NFE2 like bZIP transcription factor 2 Homo sapiens 26-30 21931870-7 2011 In addition, expression of core, E1, E2, NS4B, and NS5A proteins resulted in the activation of Nrf2 in a ROS-independent manner. Reactive Oxygen Species 105-108 NFE2 like bZIP transcription factor 2 Homo sapiens 95-99 20804866-6 2010 Exposure to chronic intermittent hypoxia (CIH) activates antioxidant responses via the regulator Nrf-2, in association with an increase in ROS and the induction of HIF-1alpha. Reactive Oxygen Species 139-142 NFE2 like bZIP transcription factor 2 Homo sapiens 97-102 19901266-0 2010 NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation. Reactive Oxygen Species 36-39 NFE2 like bZIP transcription factor 2 Homo sapiens 22-26 20708680-5 2010 Conversely, a sedentary lifestyle is negatively associated with these adaptations mainly because of dysregulation of Nrf2-Keap1 redox signaling that renders the intracellular environment prone to reactive oxygen species-mediated toxicity. Reactive Oxygen Species 196-219 NFE2 like bZIP transcription factor 2 Homo sapiens 117-121 20446765-0 2010 Copper and myeloperoxidase-modified LDLs activate Nrf2 through different pathways of ROS production in macrophages. Reactive Oxygen Species 85-88 NFE2 like bZIP transcription factor 2 Homo sapiens 50-54 20446765-8 2010 This study highlights that OxLDLs and MoxLDLs induce an oxidative stress, through distinct ROS-producing mechanisms, which is responsible for the differential activation of the Nrf2 pathway. Reactive Oxygen Species 91-94 NFE2 like bZIP transcription factor 2 Homo sapiens 177-181 20940400-6 2010 Compared with wild-type fibroblasts, Nrf2-deficient fibroblasts had relatively high basal levels of reactive oxygen species that increased greatly five days after radiation exposure. Reactive Oxygen Species 100-123 NFE2 like bZIP transcription factor 2 Homo sapiens 37-41 20673799-3 2010 To counteract the damaging effects of ROS the CNS is endowed with a repertoire of endogenous antioxidant enzymes, which are regulated by the transcription factor NF-E2-related factor 2 (Nrf2). Reactive Oxygen Species 38-41 NFE2 like bZIP transcription factor 2 Homo sapiens 162-184 20673799-3 2010 To counteract the damaging effects of ROS the CNS is endowed with a repertoire of endogenous antioxidant enzymes, which are regulated by the transcription factor NF-E2-related factor 2 (Nrf2). Reactive Oxygen Species 38-41 NFE2 like bZIP transcription factor 2 Homo sapiens 186-190 20673799-4 2010 Upon exposure to ROS, Nrf2 translocates to the nucleus allowing transcriptional activation of various antioxidant enzymes. Reactive Oxygen Species 17-20 NFE2 like bZIP transcription factor 2 Homo sapiens 22-26 20484052-1 2010 The transcription factor nuclear factor E2-related factor 2 (Nrf2) induces the expression of antioxidant gene products that neutralize reactive oxygen species and restore redox homeostasis. Reactive Oxygen Species 135-158 NFE2 like bZIP transcription factor 2 Homo sapiens 25-59 20484052-1 2010 The transcription factor nuclear factor E2-related factor 2 (Nrf2) induces the expression of antioxidant gene products that neutralize reactive oxygen species and restore redox homeostasis. Reactive Oxygen Species 135-158 NFE2 like bZIP transcription factor 2 Homo sapiens 61-65 20100676-5 2010 OBJECTIVES: We tested the hypothesis that activation of Nrf2 and induction of antioxidant enzymes in response to arsenic exposure impedes glucose-triggered ROS signaling and thus GSIS. Reactive Oxygen Species 156-159 NFE2 like bZIP transcription factor 2 Homo sapiens 56-60 20216230-3 2010 Nuclear factor erythroid-2 related factor 2 (Nrf2), a basic-region leucine-zipper transcription factor, is believed to protect against ROS damage by activating a series of antioxidant enzymes; Nrf2 is also reported to reduce NE activity. Reactive Oxygen Species 135-138 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 20216230-3 2010 Nuclear factor erythroid-2 related factor 2 (Nrf2), a basic-region leucine-zipper transcription factor, is believed to protect against ROS damage by activating a series of antioxidant enzymes; Nrf2 is also reported to reduce NE activity. Reactive Oxygen Species 135-138 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 20216230-3 2010 Nuclear factor erythroid-2 related factor 2 (Nrf2), a basic-region leucine-zipper transcription factor, is believed to protect against ROS damage by activating a series of antioxidant enzymes; Nrf2 is also reported to reduce NE activity. Reactive Oxygen Species 135-138 NFE2 like bZIP transcription factor 2 Homo sapiens 193-197 20216230-9 2010 The results showed that NCI-H292 epithelial cells, in which the Nrf2 gene expression repressed, were highly predisposed to NE stimulation, with marked exacerbation of ROS generation and reduced secretory leukocyte protease inhibitor production, resulting in high MUC5AC expression. Reactive Oxygen Species 167-170 NFE2 like bZIP transcription factor 2 Homo sapiens 64-68 20216230-11 2010 These results demonstrate that Nrf2 is a novel nuclear factor involved in down-regulating MUC5AC synthesis by inhibiting ROS generation and augmenting proteinase inhibitor production. Reactive Oxygen Species 121-124 NFE2 like bZIP transcription factor 2 Homo sapiens 31-35 20516531-9 2010 ROS may also influence nuclear factor-kappaB (NF-kappaB) intracellular signaling repressing the Nrf2-ARE pathway at transcriptional level. Reactive Oxygen Species 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 96-100 19501608-5 2010 On the other hand, the induction of antioxidant enzymes by Nrf2 activation blunts glucose-triggered ROS signaling, thus resulting in reduced GSIS. Reactive Oxygen Species 100-103 NFE2 like bZIP transcription factor 2 Homo sapiens 59-63 19732782-4 2010 The transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of the expression of a subset of genes, which produce proteins responsible for the detoxication of electrophiles and reactive oxygen species as well as the removal or repair of some of their damage products. Reactive Oxygen Species 194-217 NFE2 like bZIP transcription factor 2 Homo sapiens 25-29 19732782-4 2010 The transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of the expression of a subset of genes, which produce proteins responsible for the detoxication of electrophiles and reactive oxygen species as well as the removal or repair of some of their damage products. Reactive Oxygen Species 194-217 NFE2 like bZIP transcription factor 2 Homo sapiens 31-53 20530669-3 2010 Activation of the Nrf2-mediated cellular defense response protects cells against the toxic and carcinogenic effects of environmental insults by upregulating an array of genes that detoxify reactive oxygen species and restore cellular redox homeostasis. Reactive Oxygen Species 189-212 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22 20440267-3 2010 Nrf2 suppression by Keap1-directed ubiquitylation or the expression of independent short hairpin RNA (shRNA)/siRNA sequences enhanced cellular levels of reactive oxygen species, Smad-dependent tumor cell motility and growth in soft agar. Reactive Oxygen Species 153-176 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 24281119-2 2010 This review covers the possible roles of two ROS-induced transcription factors, Nrf1 and Nrf2, and the antioxidant proteins peroxiredoxin-1 (Prx-1) and Thioredoxin-1 (Txn-1) in modulating AR expression and signaling in aggressive prostate cancer (PCa) cells. Reactive Oxygen Species 45-48 NFE2 like bZIP transcription factor 2 Homo sapiens 89-93 20307651-13 2010 In conclusion, Pin1 induction during neointimal formation may be associated with ROS-mediated VSMC proliferation via down-regulation of Nrf2/ARE-dependent HO-1 expression. Reactive Oxygen Species 81-84 NFE2 like bZIP transcription factor 2 Homo sapiens 136-140 20516531-8 2010 However, after direct attack by ROS, Nrf2 is released from Keap1 repression and translocated into nucleus where it binds with ARE sequence to initiate gene expression. Reactive Oxygen Species 32-35 NFE2 like bZIP transcription factor 2 Homo sapiens 37-41 19889935-6 2010 The HCV-mediated activation of Nrf2 was abrogated in the presence of an antioxidant, PDTC (pyrrolidine dithiocarbamate), and a Ca(2+) chelator, BAPTA-AM [1,2-bis(aminophenoxy)ethane N,N,N,N-tetraacetic acid tetra(acetoxymethyl) ester], which suggests a role for both reactive oxygen species and Ca(2+) signalling in the Nrf2-activation process. Reactive Oxygen Species 267-290 NFE2 like bZIP transcription factor 2 Homo sapiens 31-35 20124447-7 2010 DU-145 cells constitutively expressing Nrf2 short hairpin RNA had lower levels of total glutathione and higher levels of intracellular reactive oxygen species. Reactive Oxygen Species 135-158 NFE2 like bZIP transcription factor 2 Homo sapiens 39-43 19901266-10 2010 These results suggest that p45 dominates over Nrf2 to enhance megakaryocytic maturation by promoting ROS accumulation. Reactive Oxygen Species 101-104 NFE2 like bZIP transcription factor 2 Homo sapiens 46-50 19901266-4 2010 Because p45 and Nrf2 have similar DNA-binding specificities, we hypothesized that p45 competes with Nrf2 to repress stress-responsive genes and achieves favorable intracellular conditions to allow ROS to be efficiently used as signaling molecules. Reactive Oxygen Species 197-200 NFE2 like bZIP transcription factor 2 Homo sapiens 16-20 19901266-4 2010 Because p45 and Nrf2 have similar DNA-binding specificities, we hypothesized that p45 competes with Nrf2 to repress stress-responsive genes and achieves favorable intracellular conditions to allow ROS to be efficiently used as signaling molecules. Reactive Oxygen Species 197-200 NFE2 like bZIP transcription factor 2 Homo sapiens 100-104 19797052-0 2009 Active NF-E2-related factor (Nrf2) contributes to keep endothelial NO synthase (eNOS) in the coupled state: role of reactive oxygen species (ROS), eNOS, and heme oxygenase (HO-1) levels. Reactive Oxygen Species 116-139 NFE2 like bZIP transcription factor 2 Homo sapiens 29-33 20030899-5 2010 Additionally, epicatechin-induced NF-kappaB and Nrf2 were connected to reactive oxygen species intracellular levels and to the activation of cell survival and proliferation pathways, being phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) associated to Nrf2 modulation and ERK to NF-kappaB induction. Reactive Oxygen Species 71-94 NFE2 like bZIP transcription factor 2 Homo sapiens 48-52 19797052-0 2009 Active NF-E2-related factor (Nrf2) contributes to keep endothelial NO synthase (eNOS) in the coupled state: role of reactive oxygen species (ROS), eNOS, and heme oxygenase (HO-1) levels. Reactive Oxygen Species 141-144 NFE2 like bZIP transcription factor 2 Homo sapiens 29-33 20528745-0 2010 Tungsten carbide-cobalt particles activate Nrf2 and its downstream target genes in JB6 cells possibly by ROS generation. Reactive Oxygen Species 105-108 NFE2 like bZIP transcription factor 2 Homo sapiens 43-47 20528745-8 2010 These findings suggest that activation of Nrf2 and its downstream genes may be initiated by ROS generation, and ROS may act as a major contributor in nano-WC-Co particle-induced adverse health effects. Reactive Oxygen Species 92-95 NFE2 like bZIP transcription factor 2 Homo sapiens 42-46 20873109-3 2010 Situation is changed under stressful conditions,when electrophiles and/or reactiveoxygen species (ROS) cause dissociation of Nrf2 from Keap1. Reactive Oxygen Species 74-96 NFE2 like bZIP transcription factor 2 Homo sapiens 125-129 20873109-3 2010 Situation is changed under stressful conditions,when electrophiles and/or reactiveoxygen species (ROS) cause dissociation of Nrf2 from Keap1. Reactive Oxygen Species 98-101 NFE2 like bZIP transcription factor 2 Homo sapiens 125-129 20873109-4 2010 As a consequence, Nrf2 is translocated to the nucleus, that leads to activation of cytoprotective genes involved in electrophile conjugation, excretion of xenobiotics, ROS scavenging and stabilization of cellular redox potential. Reactive Oxygen Species 168-171 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22 19286452-0 2009 Ebselen attenuates cisplatin-induced ROS generation through Nrf2 activation in auditory cells. Reactive Oxygen Species 37-40 NFE2 like bZIP transcription factor 2 Homo sapiens 60-64 19179352-5 2009 Thus, NAD(P)H oxidase may serve as a double-edged sword, with transient activation providing a feedback defense against excessive ROS generation through the activation of receptor tyrosine kinases and the redox-sensitive Nrf2-Keap1 signalling pathway. Reactive Oxygen Species 130-133 NFE2 like bZIP transcription factor 2 Homo sapiens 221-225 18981988-9 2009 This study provides insights into the mechanism by which the NRP/B modulates Nrf2-dependent NQO1 induction in cellular protection against ROS in brain tumors. Reactive Oxygen Species 138-141 NFE2 like bZIP transcription factor 2 Homo sapiens 77-81 18824091-0 2008 Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease? Reactive Oxygen Species 70-73 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 19272177-8 2009 Therefore, PI3K, PKC, and ROS are involved in the signaling pathway that leads to the shear-induced nuclear translocation of Nrf2. Reactive Oxygen Species 26-29 NFE2 like bZIP transcription factor 2 Homo sapiens 125-129 18824091-7 2008 Here we provide an overview of the involvement of ROS-induced oxidative damage in Alzheimer"s disease, Parkinson"s disease, and Huntington"s disease and we discuss the potential therapeutic effects of antioxidant enzymes and compounds that activate the Nrf2-ARE pathway. Reactive Oxygen Species 50-53 NFE2 like bZIP transcription factor 2 Homo sapiens 253-257 18633117-8 2008 ROS formation was increased further by knockdown of nrf2 and transketolase expression. Reactive Oxygen Species 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 52-56 18587629-5 2008 While nrf2-deficient MEFs lost the inducibility of antioxidant genes, which resulted in higher levels of reactive oxygen species accumulation, caspase-3 activation, and cell death than wild-type cells. Reactive Oxygen Species 105-128 NFE2 like bZIP transcription factor 2 Homo sapiens 6-10 18829555-4 2008 RNAi-mediated reduction of Nrf2 expression in lung cancer cells induces generation of reactive oxygen species, suppresses tumor growth, and results in increased sensitivity to chemotherapeutic drug-induced cell death in vitro and in vivo. Reactive Oxygen Species 86-109 NFE2 like bZIP transcription factor 2 Homo sapiens 27-31 18554677-7 2008 Taken together, these results suggest that the PI3K and ERK/Nrf2 signaling pathway controls the intracellular levels of ROS by regulating the expression of the antioxidant enzyme HO-1. Reactive Oxygen Species 120-123 NFE2 like bZIP transcription factor 2 Homo sapiens 60-64 18802114-7 2008 These results demonstrated that LTA-induced ROS generation was mediated through the TLR2/MyD88/TRAF6/c-Src/NADPH oxidase pathway, in turn initiates the activation of Nrf2, and ultimately induces HO-1 expression in HTSMCs. Reactive Oxygen Species 44-47 NFE2 like bZIP transcription factor 2 Homo sapiens 166-170 17822364-0 2007 Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils. Reactive Oxygen Species 150-173 NFE2 like bZIP transcription factor 2 Homo sapiens 40-44 18372916-0 2008 The role of Nrf2 in increased reactive oxygen species and DNA damage in prostate tumorigenesis. Reactive Oxygen Species 30-53 NFE2 like bZIP transcription factor 2 Homo sapiens 12-16 18414027-1 2008 The Nrf2 transcription factor is a crucial regulator of the cellular redox homeostasis through its capacity to induce the expression of enzymes, which detoxify reactive oxygen species, and of other antioxidant proteins. Reactive Oxygen Species 160-183 NFE2 like bZIP transcription factor 2 Homo sapiens 4-8 18458092-2 2008 It has also been determined that excess ROS induce electrophile-response element (EpRE)-driven gene expression via activation of nuclear factor erythroid 2-related factor 2 (Nrf2). Reactive Oxygen Species 40-43 NFE2 like bZIP transcription factor 2 Homo sapiens 129-172 18458092-2 2008 It has also been determined that excess ROS induce electrophile-response element (EpRE)-driven gene expression via activation of nuclear factor erythroid 2-related factor 2 (Nrf2). Reactive Oxygen Species 40-43 NFE2 like bZIP transcription factor 2 Homo sapiens 174-178 18458092-3 2008 Nonetheless, the relationship between the metabolism of ROS (eg, H(2)O(2)) through glutathione (GSH) up-regulation, GSH-dependent reduction of H(2)O(2), and Nrf2-dependent gene regulation is not well established. Reactive Oxygen Species 56-59 NFE2 like bZIP transcription factor 2 Homo sapiens 157-161 17077087-8 2006 Considering that p53-induced apoptosis requires an accumulation of reactive oxygen species, this negative control on the Nrf2 transactivation appears to be aimed to prevent the generation of a strong anti-oxidant intracellular environment that could hinder the induction of apoptosis. Reactive Oxygen Species 67-90 NFE2 like bZIP transcription factor 2 Homo sapiens 121-125 17266942-8 2007 Linkage between AhR and Nrf2 batteries is probably achieved by multiple mechanisms, including Nrf2 as a target gene of the AhR, indirect activation of Nrf2 via CYP1A1-generated reactive oxygen species, and direct cross-interaction of AhR/XRE and Nrf2/ARE signaling. Reactive Oxygen Species 177-200 NFE2 like bZIP transcription factor 2 Homo sapiens 24-28 17266942-11 2007 Tightened coupling between Phases I and II by AhR- and Nrf2-induced XMEs may greatly attenuate health risks posed by CYP1A1-generated toxic intermediates and reactive oxygen species. Reactive Oxygen Species 158-181 NFE2 like bZIP transcription factor 2 Homo sapiens 55-59 17143561-8 2007 Nrf2 was induced by curcumin treatment, which was also partly ROS dependent. Reactive Oxygen Species 62-65 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 17127771-2 2007 Nrf2-regulated gene expression regulates detoxification of reactive oxygen species. Reactive Oxygen Species 59-82 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 17266519-5 2007 It has been proposed that tBHQ enhances Nrf2-mediated transcription by promoting reactive oxygen species-mediated dissociation of Nrf2-Keap1, Nrf2 stabilization, phosphatidylinositol 3-kinase (PI3K)/Akt activity, and MAPK pathway activation. Reactive Oxygen Species 81-104 NFE2 like bZIP transcription factor 2 Homo sapiens 40-44 17266519-5 2007 It has been proposed that tBHQ enhances Nrf2-mediated transcription by promoting reactive oxygen species-mediated dissociation of Nrf2-Keap1, Nrf2 stabilization, phosphatidylinositol 3-kinase (PI3K)/Akt activity, and MAPK pathway activation. Reactive Oxygen Species 81-104 NFE2 like bZIP transcription factor 2 Homo sapiens 130-134 17266519-5 2007 It has been proposed that tBHQ enhances Nrf2-mediated transcription by promoting reactive oxygen species-mediated dissociation of Nrf2-Keap1, Nrf2 stabilization, phosphatidylinositol 3-kinase (PI3K)/Akt activity, and MAPK pathway activation. Reactive Oxygen Species 81-104 NFE2 like bZIP transcription factor 2 Homo sapiens 130-134 17142801-9 2006 These results indicate that reoxygenation-dependent Nrf-2 activity facilitates ischemic preconditioning through the induction of antioxidant gene expression and that ROS may be critical in signaling this event. Reactive Oxygen Species 166-169 NFE2 like bZIP transcription factor 2 Homo sapiens 52-57 12730081-6 2003 Because NQO-1 gene induction is reduced by antioxidants, it could be related to the ROS generated by DEP, most likely through the activation of the stress-sensitive Nrf2 transcription factor. Reactive Oxygen Species 84-87 NFE2 like bZIP transcription factor 2 Homo sapiens 165-169 17142801-7 2006 Attenuating reactive oxygen species (ROS) in reoxygenation using the antioxidant N-acetyl cysteine results in inhibition of Nrf-2 activation. Reactive Oxygen Species 12-35 NFE2 like bZIP transcription factor 2 Homo sapiens 124-129 17142801-7 2006 Attenuating reactive oxygen species (ROS) in reoxygenation using the antioxidant N-acetyl cysteine results in inhibition of Nrf-2 activation. Reactive Oxygen Species 37-40 NFE2 like bZIP transcription factor 2 Homo sapiens 124-129 16887173-0 2006 Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Reactive Oxygen Species 79-102 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 16374848-7 2006 Increases in Nrf2 protein and mRNA are blocked by inhibitors of CYP2E1 activity and a reactive oxygen species (ROS) scavenger, N-acetylcysteine, which decrease ROS levels as well as Nrf2 mRNA induction. Reactive Oxygen Species 86-109 NFE2 like bZIP transcription factor 2 Homo sapiens 13-17 16374848-7 2006 Increases in Nrf2 protein and mRNA are blocked by inhibitors of CYP2E1 activity and a reactive oxygen species (ROS) scavenger, N-acetylcysteine, which decrease ROS levels as well as Nrf2 mRNA induction. Reactive Oxygen Species 86-109 NFE2 like bZIP transcription factor 2 Homo sapiens 182-186 16374848-7 2006 Increases in Nrf2 protein and mRNA are blocked by inhibitors of CYP2E1 activity and a reactive oxygen species (ROS) scavenger, N-acetylcysteine, which decrease ROS levels as well as Nrf2 mRNA induction. Reactive Oxygen Species 111-114 NFE2 like bZIP transcription factor 2 Homo sapiens 13-17 16374848-7 2006 Increases in Nrf2 protein and mRNA are blocked by inhibitors of CYP2E1 activity and a reactive oxygen species (ROS) scavenger, N-acetylcysteine, which decrease ROS levels as well as Nrf2 mRNA induction. Reactive Oxygen Species 111-114 NFE2 like bZIP transcription factor 2 Homo sapiens 182-186 16374848-7 2006 Increases in Nrf2 protein and mRNA are blocked by inhibitors of CYP2E1 activity and a reactive oxygen species (ROS) scavenger, N-acetylcysteine, which decrease ROS levels as well as Nrf2 mRNA induction. Reactive Oxygen Species 160-163 NFE2 like bZIP transcription factor 2 Homo sapiens 13-17 16374848-9 2006 Blocking Nrf2 by siRNA-Nrf2 decreases glutathione and increases ROS and lipid peroxidation, resulting in decreased mitochondrial membrane potential and loss of cell viability of E47 cells but not C34 cells. Reactive Oxygen Species 64-67 NFE2 like bZIP transcription factor 2 Homo sapiens 9-13 16374848-9 2006 Blocking Nrf2 by siRNA-Nrf2 decreases glutathione and increases ROS and lipid peroxidation, resulting in decreased mitochondrial membrane potential and loss of cell viability of E47 cells but not C34 cells. Reactive Oxygen Species 64-67 NFE2 like bZIP transcription factor 2 Homo sapiens 23-27 14978030-3 2004 We now demonstrate that Nrf2 activation contributes to the maintenance of glutathione levels, which in turn functions as a buffer for the accumulation of reactive oxygen species during the unfolded protein response. Reactive Oxygen Species 154-177 NFE2 like bZIP transcription factor 2 Homo sapiens 24-28 33771976-7 2021 Increased reactive oxygen species (ROS) levels and the expression of HIF-1alpha and Nrf2 decreased under the hypoxic condition following incubation with N-acetylcysteine, a ROS scavenger, which was associated with a decrease in CXCR4 expression. Reactive Oxygen Species 173-176 NFE2 like bZIP transcription factor 2 Homo sapiens 84-88 11429414-3 2001 Once bound to its recognition DNA sequence termed antioxidant-responsive element or Maf-recognition element, Nrf2/small Maf induces a set of antioxidative stress genes, including heme oxygenase-1 and gamma-glutamylcysteine synthetase, whose products have been demonstrated to contribute to the scavenging of reactive oxygen species and to exhibit anti-inflammatory effects. Reactive Oxygen Species 308-331 NFE2 like bZIP transcription factor 2 Homo sapiens 109-113 33761438-8 2021 Hypoxia- or CoCl2-induced ROS increased HIF-1alpha and Nrf2 levels, which were attenuated by treatment with N-acetyl-L-cysteine (NAC), a ROS scavenger. Reactive Oxygen Species 26-29 NFE2 like bZIP transcription factor 2 Homo sapiens 55-59 33761438-14 2021 The results indicate that B cells could be regulated by crosstalk of HIF-1alpha and Nrf2 through ROS-mediated Syk activation. Reactive Oxygen Species 97-100 NFE2 like bZIP transcription factor 2 Homo sapiens 84-88 33771701-2 2021 Increased levels of Reactive Oxygen Species (ROS) stimulate Nrf2 signaling, enhancing the activity of antioxidant enzymes such as catalase, superoxide dismutase and glutathione peroxidase. Reactive Oxygen Species 20-43 NFE2 like bZIP transcription factor 2 Homo sapiens 60-64 33771701-2 2021 Increased levels of Reactive Oxygen Species (ROS) stimulate Nrf2 signaling, enhancing the activity of antioxidant enzymes such as catalase, superoxide dismutase and glutathione peroxidase. Reactive Oxygen Species 45-48 NFE2 like bZIP transcription factor 2 Homo sapiens 60-64 33771701-4 2021 On the other hand, Nrf2 activation in cancer cells is responsible for the development of chemoresistance due to disrupting oxidative mediated-cell death by reducing ROS levels. Reactive Oxygen Species 165-168 NFE2 like bZIP transcription factor 2 Homo sapiens 19-23 33771701-11 2021 Reducing ROS levels and preventing cell death are the most important factors involved in alleviating CP toxicity upon Nrf2 activation. Reactive Oxygen Species 9-12 NFE2 like bZIP transcription factor 2 Homo sapiens 118-122 33819919-8 2021 What"s more, in Fru-stimulated cells, CA-alleviated inflammatory response and reactive oxygen species (ROS) production were evidently abolished by Nrf-2 knockdown. Reactive Oxygen Species 78-101 NFE2 like bZIP transcription factor 2 Homo sapiens 147-152 33819919-8 2021 What"s more, in Fru-stimulated cells, CA-alleviated inflammatory response and reactive oxygen species (ROS) production were evidently abolished by Nrf-2 knockdown. Reactive Oxygen Species 103-106 NFE2 like bZIP transcription factor 2 Homo sapiens 147-152 14500406-11 2003 In summary, the use of the indole analogues identified NADPH oxidase activity as a novel upstream activity regulating Nrf2/Keap1 signaling of GCLC, provided data supporting the hypothesis that Keap1 is a downstream effector for oxidase activity, and afforded in vivo data to support the hypothesis that Keap1 thiols can act as molecular sensors of reactive oxygen species. Reactive Oxygen Species 348-371 NFE2 like bZIP transcription factor 2 Homo sapiens 118-122 33770188-21 2021 Furthermore, PSF enhances Nrf2 activation and HO-1 expression through ERK and AKT signaling in HRMECs, resulting in intracellular ROS scavenging. Reactive Oxygen Species 130-133 NFE2 like bZIP transcription factor 2 Homo sapiens 26-30 33807689-8 2021 The results indicated that the extracts of digested pastes prevented the macrophages from experiencing lipopolysaccharide (LPS)-stimulated intracellular reactive oxygen species accumulation, mainly by the Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2) signalling pathway. Reactive Oxygen Species 153-176 NFE2 like bZIP transcription factor 2 Homo sapiens 249-292 33807689-8 2021 The results indicated that the extracts of digested pastes prevented the macrophages from experiencing lipopolysaccharide (LPS)-stimulated intracellular reactive oxygen species accumulation, mainly by the Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2) signalling pathway. Reactive Oxygen Species 153-176 NFE2 like bZIP transcription factor 2 Homo sapiens 294-298 26640566-17 2015 Either 0 or 20% of atmospheric O2 activated the UPR and the Nrf2/Keap1-mediated antioxidant system in LECs and chronic exposure to O2 fluctuation led to ROS production and cell death. Reactive Oxygen Species 153-156 NFE2 like bZIP transcription factor 2 Homo sapiens 60-64 33426091-10 2020 TNF-alpha promoted expression and nuclear translocation of nrf2 in RA-FLS and increased the intracellular reactive oxygen species (ROS) level. Reactive Oxygen Species 106-129 NFE2 like bZIP transcription factor 2 Homo sapiens 59-63 33426091-10 2020 TNF-alpha promoted expression and nuclear translocation of nrf2 in RA-FLS and increased the intracellular reactive oxygen species (ROS) level. Reactive Oxygen Species 131-134 NFE2 like bZIP transcription factor 2 Homo sapiens 59-63 33426091-11 2020 Nrf2 nuclear translocation was blocked by ROS inhibitor N-acetylcysteine. Reactive Oxygen Species 42-45 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 33426091-16 2020 In conclusion, nrf2 is overexpressed in synovial tissues of RA patients, which may be promoted by TNF-alpha and ROS levels. Reactive Oxygen Species 112-115 NFE2 like bZIP transcription factor 2 Homo sapiens 15-19 34686779-0 2022 Valproic acid disables the Nrf2 anti-oxidant response in acute myeloid leukaemia cells enhancing reactive oxygen species-mediated killing. Reactive Oxygen Species 97-120 NFE2 like bZIP transcription factor 2 Homo sapiens 27-31 26119783-5 2015 Because the proliferation and differentiation of diverse cell types are often influenced and modulated by the cellular redox balance, Nrf2 has been considered to control these cellular processes by regulating the cellular levels of reactive oxygen species (ROS). Reactive Oxygen Species 232-255 NFE2 like bZIP transcription factor 2 Homo sapiens 134-138 26119783-5 2015 Because the proliferation and differentiation of diverse cell types are often influenced and modulated by the cellular redox balance, Nrf2 has been considered to control these cellular processes by regulating the cellular levels of reactive oxygen species (ROS). Reactive Oxygen Species 257-260 NFE2 like bZIP transcription factor 2 Homo sapiens 134-138 26122708-15 2015 Specifically, too little Nrf2 activity will lead to loss of cytoprotection, diminished antioxidant capacity, and lowered beta-oxidation of fatty acids, while conversely also exhibiting heightened sensitivity to ROS-based signaling that involves receptor tyrosine kinases and apoptosis signal-regulating kinase-1. Reactive Oxygen Species 211-214 NFE2 like bZIP transcription factor 2 Homo sapiens 25-29 25157103-4 2014 The knockdown of Nrf2 or p62 by siRNA enhances ROS levels and cadmium-induced apoptosis. Reactive Oxygen Species 47-50 NFE2 like bZIP transcription factor 2 Homo sapiens 17-21 23645672-2 2013 Provided that Nrf2 is sensitive to hypoxia during ischemia, Nrf2 may affect reactive oxygen species metabolism during reoxygenation. Reactive Oxygen Species 76-99 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 23645672-2 2013 Provided that Nrf2 is sensitive to hypoxia during ischemia, Nrf2 may affect reactive oxygen species metabolism during reoxygenation. Reactive Oxygen Species 76-99 NFE2 like bZIP transcription factor 2 Homo sapiens 60-64 20019356-5 2010 In addition, ROS can stimulate signal transduction pathways and lead to activation of key transcription factors such as Nrf2 and NF-kappaB. Reactive Oxygen Species 13-16 NFE2 like bZIP transcription factor 2 Homo sapiens 120-124 34718002-7 2022 To further decipher the mechanisms of Nrf2 upregulation at early stage of Cr(VI) exposure, we demonstrated that miR-27a and miR-27b were redox sensitive miRNAs, since reactive oxygen species (ROS) scavengers induced miR-27a/b expression. Reactive Oxygen Species 167-190 NFE2 like bZIP transcription factor 2 Homo sapiens 38-42 34718002-7 2022 To further decipher the mechanisms of Nrf2 upregulation at early stage of Cr(VI) exposure, we demonstrated that miR-27a and miR-27b were redox sensitive miRNAs, since reactive oxygen species (ROS) scavengers induced miR-27a/b expression. Reactive Oxygen Species 192-195 NFE2 like bZIP transcription factor 2 Homo sapiens 38-42 26122708-16 2015 By contrast, too much Nrf2 activity disturbs the homeostatic balance in favor of reduction, and so may have deleterious consequences including overproduction of reduced glutathione and NADPH, the blunting of ROS-based signal transduction, epithelial cell hyperplasia, and failure of certain cell types to differentiate correctly. Reactive Oxygen Species 208-211 NFE2 like bZIP transcription factor 2 Homo sapiens 22-26 34686779-7 2022 Overexpression of Nrf2 in K562 and KG1a completely inhibited ROS production and rescued cells from VAL/BaP 0.1 mM/VBaP killing. Reactive Oxygen Species 61-64 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22 34838592-4 2022 In this study, we found that the ubiquitin-specific protease 10 (USP10) protein reduces dopamine-induced ROS production of neuronal cells and ROS-dependent apoptosis by stimulating the antioxidant activity of Nrf2. Reactive Oxygen Species 105-108 NFE2 like bZIP transcription factor 2 Homo sapiens 209-213 34954022-5 2022 As Nrf2 is a master regulator of the oxidative stress response inducing antioxidant-encoding gene expression, we hypothesized that AntiOxCIN4 could increase the resistance of human hepatoma-derived HepG2 to oxidative stress by Nrf2-dependent mechanisms, in a process mediated by mitochondrial ROS (mtROS). Reactive Oxygen Species 293-296 NFE2 like bZIP transcription factor 2 Homo sapiens 3-7 34954022-5 2022 As Nrf2 is a master regulator of the oxidative stress response inducing antioxidant-encoding gene expression, we hypothesized that AntiOxCIN4 could increase the resistance of human hepatoma-derived HepG2 to oxidative stress by Nrf2-dependent mechanisms, in a process mediated by mitochondrial ROS (mtROS). Reactive Oxygen Species 293-296 NFE2 like bZIP transcription factor 2 Homo sapiens 227-231 34785107-15 2022 Agrimoniin increased the ROS level in pancreatic cancer cells by suppressing Nrf2-dependent ROS scavenging system and disrupting normal mitochondrial membrane potential. Reactive Oxygen Species 25-28 NFE2 like bZIP transcription factor 2 Homo sapiens 77-81 34785107-15 2022 Agrimoniin increased the ROS level in pancreatic cancer cells by suppressing Nrf2-dependent ROS scavenging system and disrupting normal mitochondrial membrane potential. Reactive Oxygen Species 92-95 NFE2 like bZIP transcription factor 2 Homo sapiens 77-81 34875217-9 2022 Additionally, the results identified that Nrf2 silence induced ROS accumulation enhances HIF-1alpha protein expression, while miR-125b could offset this effect via promoting HIF-1alpha protein degradation. Reactive Oxygen Species 63-66 NFE2 like bZIP transcription factor 2 Homo sapiens 42-46 34838592-4 2022 In this study, we found that the ubiquitin-specific protease 10 (USP10) protein reduces dopamine-induced ROS production of neuronal cells and ROS-dependent apoptosis by stimulating the antioxidant activity of Nrf2. Reactive Oxygen Species 142-145 NFE2 like bZIP transcription factor 2 Homo sapiens 209-213 34951143-4 2022 Our results showed that inhibition of NRF2 leads to a loss of reactive oxygen species protection, but at the same time to an induction of an epithelial mesenchymal transition (EMT) phenotype and an up-regulation of the stem cell marker CD44. Reactive Oxygen Species 62-85 NFE2 like bZIP transcription factor 2 Homo sapiens 38-42 34757179-9 2022 Inhibition of Nrf2 or Sirt3 could decrease the protective effects of vitamin D3 and enhance mitochondrial ROS production via modulating mitochondrial redox balance. Reactive Oxygen Species 106-109 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 34975454-4 2021 Nuclear factor erythroid 2-like 2 (NRF2), a redox-regulated transcription factor, is the master regulator of the cellular response to excess reactive oxygen species. Reactive Oxygen Species 141-164 NFE2 like bZIP transcription factor 2 Homo sapiens 0-33 34943127-9 2021 This was associated with a reduction in intracellular ROS levels, probably through the measured increased activity of ARE/Nrf2. Reactive Oxygen Species 54-57 NFE2 like bZIP transcription factor 2 Homo sapiens 122-126 34975454-4 2021 Nuclear factor erythroid 2-like 2 (NRF2), a redox-regulated transcription factor, is the master regulator of the cellular response to excess reactive oxygen species. Reactive Oxygen Species 141-164 NFE2 like bZIP transcription factor 2 Homo sapiens 35-39 34912465-8 2021 Compound C, si-Nrf2, and si-HO-1 administration inhibits the AMPK/Nrf2/HO-1 signaling pathway, increases ROS generation, and inhibits the antagonistic effect of SKN on ox-LDL-induced HUVECs damage. Reactive Oxygen Species 105-108 NFE2 like bZIP transcription factor 2 Homo sapiens 15-19 34553295-7 2021 TXNRD1 mRNA and protein levels were induced by MR via a ROS-dependent mechanism mediated by the transcriptional regulators NRF2 and ATF4. Reactive Oxygen Species 56-59 NFE2 like bZIP transcription factor 2 Homo sapiens 123-127 34940692-7 2021 EEB decreased UVB-induced reactive oxygen species (ROS) generation by upregulating glutathione peroxidase 1 (GPx1) and heme oxygenase-1 (HO-1) expression via nuclear factor erythroid-2-related factor 2 (Nrf2) activation in Hs68 cells. Reactive Oxygen Species 26-49 NFE2 like bZIP transcription factor 2 Homo sapiens 158-201 34940692-7 2021 EEB decreased UVB-induced reactive oxygen species (ROS) generation by upregulating glutathione peroxidase 1 (GPx1) and heme oxygenase-1 (HO-1) expression via nuclear factor erythroid-2-related factor 2 (Nrf2) activation in Hs68 cells. Reactive Oxygen Species 26-49 NFE2 like bZIP transcription factor 2 Homo sapiens 203-207 34940692-7 2021 EEB decreased UVB-induced reactive oxygen species (ROS) generation by upregulating glutathione peroxidase 1 (GPx1) and heme oxygenase-1 (HO-1) expression via nuclear factor erythroid-2-related factor 2 (Nrf2) activation in Hs68 cells. Reactive Oxygen Species 51-54 NFE2 like bZIP transcription factor 2 Homo sapiens 158-201 34940692-7 2021 EEB decreased UVB-induced reactive oxygen species (ROS) generation by upregulating glutathione peroxidase 1 (GPx1) and heme oxygenase-1 (HO-1) expression via nuclear factor erythroid-2-related factor 2 (Nrf2) activation in Hs68 cells. Reactive Oxygen Species 51-54 NFE2 like bZIP transcription factor 2 Homo sapiens 203-207 34530259-0 2021 Curcumin hinders PBDE-47-induced neutrophil extracellular traps release via Nrf2-associated ROS inhibition. Reactive Oxygen Species 92-95 NFE2 like bZIP transcription factor 2 Homo sapiens 76-80 34238028-11 2021 By contrast, suppression of ROS signaling mitigated shockwave-induced MAPK phosphorylation, Nrf2 nuclear translocation, and ECM synthesis. Reactive Oxygen Species 28-31 NFE2 like bZIP transcription factor 2 Homo sapiens 92-96 34238028-14 2021 CONCLUSIONS: Shockwaves activated Nrf2 activity through the induction of transient ROS signaling and subsequently enhanced ECM synthesis in chondrocytes. Reactive Oxygen Species 83-86 NFE2 like bZIP transcription factor 2 Homo sapiens 34-38 34530259-9 2021 In conclusion, this study revealed that Cur hindered PBDE-47-induced NETs via Nrf2-associated ROS inhibition, which enriched the cytotoxicity mechanism of PBDE-47, and provided a new clue for the development of Cur as an antagonist of PBDE-47-related immune injury. Reactive Oxygen Species 94-97 NFE2 like bZIP transcription factor 2 Homo sapiens 78-82 34944445-9 2021 Further, ANDRO blocked hypoxia-triggered ROS generation by suppressing NADPH oxidase (NOX) activation and augmenting nuclear factor erythroid 2-related factor 2 (Nrf2) expression both in vitro and in vivo. Reactive Oxygen Species 41-44 NFE2 like bZIP transcription factor 2 Homo sapiens 117-160 34944445-9 2021 Further, ANDRO blocked hypoxia-triggered ROS generation by suppressing NADPH oxidase (NOX) activation and augmenting nuclear factor erythroid 2-related factor 2 (Nrf2) expression both in vitro and in vivo. Reactive Oxygen Species 41-44 NFE2 like bZIP transcription factor 2 Homo sapiens 162-166 34857985-9 2021 Resveratrol suppressed 5-FU-induced overproduction of ROS by upregulating anti-oxidant defense genes through Nrf2 activation and SIRT-1 expression. Reactive Oxygen Species 54-57 NFE2 like bZIP transcription factor 2 Homo sapiens 109-113 34939763-12 2021 Conclusion: Our study demonstrated that SFN protects human GCs against H2O2 induced-OS by reducing the intracellular ROS production and the following apoptosis through a mechanism by which NRF2 increases the antioxidant enzymes such as SOD and CAT. Reactive Oxygen Species 117-120 NFE2 like bZIP transcription factor 2 Homo sapiens 189-193 34543701-4 2021 Elevated ROS generation was concomitant with decreased expression of NF-E2- related factor 2 (NRF2), superoxide dismutases (SOD-1,2) and thioredoxins (TrX-1,2). Reactive Oxygen Species 9-12 NFE2 like bZIP transcription factor 2 Homo sapiens 94-98 34525490-9 2021 Moreover, Nrf2 overexpression in hypoxia-induced HTR-8/SVneo cells exerted inhibitory effects on levels of GSH, MDA, ROS, and Fe2+ , and promotive effects on Nrf2/HO-1 signaling activation and expression of SCL7A11, GPX4, and FPN1, indicating that Nrf2 overexpression decreased oxidative stress and ferroptosis in hypoxia-induced HTR-8/SVneo cells. Reactive Oxygen Species 117-120 NFE2 like bZIP transcription factor 2 Homo sapiens 10-14 34525490-9 2021 Moreover, Nrf2 overexpression in hypoxia-induced HTR-8/SVneo cells exerted inhibitory effects on levels of GSH, MDA, ROS, and Fe2+ , and promotive effects on Nrf2/HO-1 signaling activation and expression of SCL7A11, GPX4, and FPN1, indicating that Nrf2 overexpression decreased oxidative stress and ferroptosis in hypoxia-induced HTR-8/SVneo cells. Reactive Oxygen Species 117-120 NFE2 like bZIP transcription factor 2 Homo sapiens 248-252 34829520-6 2021 In this review, we highlight recent advances regarding the regulation of NRF2, including the effect of Angiotensin II as an endogenous signalling molecule able to regulate ROS production and oxidative stress in dopaminergic neurons. Reactive Oxygen Species 172-175 NFE2 like bZIP transcription factor 2 Homo sapiens 73-77 34638586-13 2021 The upregulation of NEDD4-1 attenuated PTEN expression and promoted the AKT/NRF2/HO-1 oxidative stress signaling axis, which in turn conferred amplified defense against reactive oxygen species (ROS) and eventually higher resistance against TMZ treatment. Reactive Oxygen Species 169-192 NFE2 like bZIP transcription factor 2 Homo sapiens 76-80 34385063-7 2021 At the same time, Met can reduce the intracellular reactive oxygen species (ROS) level by activating the AMPK/nuclear factor erythroid-2 related factor 2 (Nrf2) signaling pathway, thus alleviating Cr(VI)-induced neutrophils apoptosis. Reactive Oxygen Species 76-79 NFE2 like bZIP transcription factor 2 Homo sapiens 105-153 34385063-7 2021 At the same time, Met can reduce the intracellular reactive oxygen species (ROS) level by activating the AMPK/nuclear factor erythroid-2 related factor 2 (Nrf2) signaling pathway, thus alleviating Cr(VI)-induced neutrophils apoptosis. Reactive Oxygen Species 76-79 NFE2 like bZIP transcription factor 2 Homo sapiens 155-159 34624146-1 2022 Nrf2 is a master regulator of reactive oxygen species (ROS) and inflammation and has been implicated in both human and murine inflammatory disease models. Reactive Oxygen Species 30-53 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 34624146-1 2022 Nrf2 is a master regulator of reactive oxygen species (ROS) and inflammation and has been implicated in both human and murine inflammatory disease models. Reactive Oxygen Species 55-58 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 34446347-10 2021 A recent study shows that Neoaves have constitutively active nuclear factor erythroid 2-related factor 2 (NRF2) due to deletion of the C-terminal part of the KEAP1 protein, thus allowing Neoaves to express antioxidant enzymes to overcome ROS leakage. Reactive Oxygen Species 238-241 NFE2 like bZIP transcription factor 2 Homo sapiens 61-104 34638586-13 2021 The upregulation of NEDD4-1 attenuated PTEN expression and promoted the AKT/NRF2/HO-1 oxidative stress signaling axis, which in turn conferred amplified defense against reactive oxygen species (ROS) and eventually higher resistance against TMZ treatment. Reactive Oxygen Species 194-197 NFE2 like bZIP transcription factor 2 Homo sapiens 76-80 34531248-0 2021 Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes. Reactive Oxygen Species 14-37 NFE2 like bZIP transcription factor 2 Homo sapiens 103-107 34763128-9 2021 In conclusion, our study indicates the ROS-Nrf2 pathway mediates the development of TGF-beta1-induced EMT through the activation of Notch signaling. Reactive Oxygen Species 39-42 NFE2 like bZIP transcription factor 2 Homo sapiens 43-47 34214916-6 2021 Nrf2 levels increased after ROS scavenging by N-acetyl-L-cysteine (NAC), which indicated that the Nrf2 pathway may be affected by oxidative stress. Reactive Oxygen Species 28-31 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 34214916-6 2021 Nrf2 levels increased after ROS scavenging by N-acetyl-L-cysteine (NAC), which indicated that the Nrf2 pathway may be affected by oxidative stress. Reactive Oxygen Species 28-31 NFE2 like bZIP transcription factor 2 Homo sapiens 98-102 34763128-0 2021 ROS-Nrf2 pathway mediates the development of TGF-beta1-induced epithelial-mesenchymal transition through the activation of Notch signaling. Reactive Oxygen Species 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 4-8 34763128-5 2021 In this study, we show a pivotal role for reactive oxygen species (ROS)-Nrf2 pathway in TGF-beta1-induced Notch signaling activation and EMT development. Reactive Oxygen Species 42-65 NFE2 like bZIP transcription factor 2 Homo sapiens 72-76 34763128-5 2021 In this study, we show a pivotal role for reactive oxygen species (ROS)-Nrf2 pathway in TGF-beta1-induced Notch signaling activation and EMT development. Reactive Oxygen Species 67-70 NFE2 like bZIP transcription factor 2 Homo sapiens 72-76 34763128-6 2021 TGF-beta1 induces Nrf2 activation through ROS production. Reactive Oxygen Species 42-45 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22 34763128-7 2021 Inhibiting Nrf2 activation either by reducing ROS levels by N-acetylcysteine or by knocking down of Nrf2 by small interfering RNA attenuated both Notch signaling activation and EMT development. Reactive Oxygen Species 46-49 NFE2 like bZIP transcription factor 2 Homo sapiens 11-15 34147842-4 2021 Characterization of the transcriptional signature of breast cancer cells treated with Kv11.1 potassium channel activators strikingly revealed an adaptive response to the potentially lethal augmentation of ROS by increasing Nrf2-dependent transcription of antioxidant genes. Reactive Oxygen Species 205-208 NFE2 like bZIP transcription factor 2 Homo sapiens 223-227 34296312-9 2021 In addition, DI effectively reduced reactive oxygen species production through the Nrf-2/HO-1 pathway. Reactive Oxygen Species 36-59 NFE2 like bZIP transcription factor 2 Homo sapiens 83-88 34360702-5 2021 Overexpression of Nrf2 or its target gene heme oxygenase 1 (HO1) significantly blocked the ROS accumulation in MCF-7 cells under T-2 toxin treatment. Reactive Oxygen Species 91-94 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22 34174470-4 2021 Nrf-2, a molecule that regulates oxidative stress, can inhibit endothelial stimulation by reactive oxygen species (ROS). Reactive Oxygen Species 90-113 NFE2 like bZIP transcription factor 2 Homo sapiens 0-5 34174470-4 2021 Nrf-2, a molecule that regulates oxidative stress, can inhibit endothelial stimulation by reactive oxygen species (ROS). Reactive Oxygen Species 115-118 NFE2 like bZIP transcription factor 2 Homo sapiens 0-5 34575034-0 2021 Dexamethasone Sensitizes Cancer Stem Cells to Gemcitabine and 5-Fluorouracil by Increasing Reactive Oxygen Species Production through NRF2 Reduction. Reactive Oxygen Species 91-114 NFE2 like bZIP transcription factor 2 Homo sapiens 134-138 34575034-9 2021 Our study suggests that dexamethasone can sensitize CSCs to chemotherapeutic agents by promoting chemotherapy-induced ROS production through suppressing NRF2 expression. Reactive Oxygen Species 118-121 NFE2 like bZIP transcription factor 2 Homo sapiens 153-157 34820581-5 2022 The underlying molecular mechanism lies in the upregulation of phosphorylated nuclear factor erythroid 2-related factor 2 (Nrf2) to scavenge ROS and subsequently inhibit the nuclear factor kappa-B (NF-kappaB) signal pathway. Reactive Oxygen Species 141-144 NFE2 like bZIP transcription factor 2 Homo sapiens 78-121 34820581-5 2022 The underlying molecular mechanism lies in the upregulation of phosphorylated nuclear factor erythroid 2-related factor 2 (Nrf2) to scavenge ROS and subsequently inhibit the nuclear factor kappa-B (NF-kappaB) signal pathway. Reactive Oxygen Species 141-144 NFE2 like bZIP transcription factor 2 Homo sapiens 123-127 34440653-2 2021 When reactive oxygen species (ROS) or reactive nitrogen species (RNS) are detected, Nrf2 translocates from the cytoplasm into the nucleus and binds to the antioxidant response element (ARE), which regulates the expression of antioxidant and anti-inflammatory genes. Reactive Oxygen Species 5-28 NFE2 like bZIP transcription factor 2 Homo sapiens 84-88 34174470-15 2021 Finally, we up-regulated Nrf-2 in HUVECs by rescue experiments, and we found that activation of Nrf-2 attenuated endothelial cell apoptosis, ROS production and reduced C3 and C5b-9 levels. Reactive Oxygen Species 141-144 NFE2 like bZIP transcription factor 2 Homo sapiens 25-30 34174470-15 2021 Finally, we up-regulated Nrf-2 in HUVECs by rescue experiments, and we found that activation of Nrf-2 attenuated endothelial cell apoptosis, ROS production and reduced C3 and C5b-9 levels. Reactive Oxygen Species 141-144 NFE2 like bZIP transcription factor 2 Homo sapiens 96-101 34332753-2 2021 ROS can be removed by eight endogenous antioxidant and redox systems, many components of which are expressed under the influence of the activated Nrf2 transcription factor. Reactive Oxygen Species 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 146-150 34440653-2 2021 When reactive oxygen species (ROS) or reactive nitrogen species (RNS) are detected, Nrf2 translocates from the cytoplasm into the nucleus and binds to the antioxidant response element (ARE), which regulates the expression of antioxidant and anti-inflammatory genes. Reactive Oxygen Species 30-33 NFE2 like bZIP transcription factor 2 Homo sapiens 84-88 34360702-8 2021 Altogether, our results demonstrated that T-2 toxin-induced ROS accumulation via ATF3DeltaZip2a/2b mediated ubiquitination and degradation of Nrf2, which provided a new insight into the mechanism of T-2 toxin-induced oxidative stress. Reactive Oxygen Species 60-63 NFE2 like bZIP transcription factor 2 Homo sapiens 142-146 34277453-4 2021 Here we reviewed references showing that ROS and ROS-associated signaling pathways, specifically via NRF2, HIF-1, and Nf-kappaB pathways, may bridge mutual impact between COVID-19 and lung cancer. Reactive Oxygen Species 41-44 NFE2 like bZIP transcription factor 2 Homo sapiens 101-105 34439417-7 2021 The cellular components mediating the downregulation of ROS included extracellular signal-regulated kinase 1/2 (ERK1/2), nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and uncoupling protein 2 (UCP2). Reactive Oxygen Species 56-59 NFE2 like bZIP transcription factor 2 Homo sapiens 121-164 34439417-7 2021 The cellular components mediating the downregulation of ROS included extracellular signal-regulated kinase 1/2 (ERK1/2), nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and uncoupling protein 2 (UCP2). Reactive Oxygen Species 56-59 NFE2 like bZIP transcription factor 2 Homo sapiens 166-170 34277453-4 2021 Here we reviewed references showing that ROS and ROS-associated signaling pathways, specifically via NRF2, HIF-1, and Nf-kappaB pathways, may bridge mutual impact between COVID-19 and lung cancer. Reactive Oxygen Species 49-52 NFE2 like bZIP transcription factor 2 Homo sapiens 101-105 34198827-8 2021 Taken together, these results indicate that carnosic acid could down-regulate ROS level in an early stage of MPI-induced adipocyte differentiation by attenuating ROS generation through suppression of NF-kappaB-mediated translation of Nox4 enzyme and increasing ROS neutralization through induction of Nrf2-mediated translation of phase II antioxidant enzymes such as HO-1, gamma-GCS, and GST, leading to its anti-adipogenetic effect. Reactive Oxygen Species 78-81 NFE2 like bZIP transcription factor 2 Homo sapiens 301-305 34077701-0 2021 Formononetin attenuates H2O2-induced cell death through decreasing ROS level by PI3K/Akt-Nrf2-activated antioxidant gene expression and suppressing MAPK-regulated apoptosis in neuronal SH-SY5Y cells. Reactive Oxygen Species 67-70 NFE2 like bZIP transcription factor 2 Homo sapiens 89-93 34077701-8 2021 Nuclear factor erythroid 2-related factor 2 (Nrf2) siRNA decreased antioxidant gene expression and elevated the H2O2-induced ROS level in the formononetin-treated cells. Reactive Oxygen Species 125-128 NFE2 like bZIP transcription factor 2 Homo sapiens 0-43 34077701-8 2021 Nuclear factor erythroid 2-related factor 2 (Nrf2) siRNA decreased antioxidant gene expression and elevated the H2O2-induced ROS level in the formononetin-treated cells. Reactive Oxygen Species 125-128 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 34200377-8 2021 At short times, Aldo-induced ROS generation was linked to increased Nrf2 activation. Reactive Oxygen Species 29-32 NFE2 like bZIP transcription factor 2 Homo sapiens 68-72 34198827-8 2021 Taken together, these results indicate that carnosic acid could down-regulate ROS level in an early stage of MPI-induced adipocyte differentiation by attenuating ROS generation through suppression of NF-kappaB-mediated translation of Nox4 enzyme and increasing ROS neutralization through induction of Nrf2-mediated translation of phase II antioxidant enzymes such as HO-1, gamma-GCS, and GST, leading to its anti-adipogenetic effect. Reactive Oxygen Species 261-264 NFE2 like bZIP transcription factor 2 Homo sapiens 301-305 34079797-3 2021 NFE2-related factor 2 (NRF2) is a molecule that plays a significant role in regulating cellular ROS homeostasis, but whether there is a correlation between hTERT and NRF2 remains unclear. Reactive Oxygen Species 96-99 NFE2 like bZIP transcription factor 2 Homo sapiens 0-21 34103686-8 2021 Interestingly, we found that CDCA2 triggers the BRCA1-NRF2 cascade, which elevates antioxidant response and attenuates ROS levels. Reactive Oxygen Species 119-122 NFE2 like bZIP transcription factor 2 Homo sapiens 54-58 34069743-5 2021 We also noticed a rapid increase in reactive oxygen species (ROS) with subsequent activation of the antioxidant Nrf2 pathway. Reactive Oxygen Species 36-59 NFE2 like bZIP transcription factor 2 Homo sapiens 112-116 34069743-5 2021 We also noticed a rapid increase in reactive oxygen species (ROS) with subsequent activation of the antioxidant Nrf2 pathway. Reactive Oxygen Species 61-64 NFE2 like bZIP transcription factor 2 Homo sapiens 112-116 34079797-3 2021 NFE2-related factor 2 (NRF2) is a molecule that plays a significant role in regulating cellular ROS homeostasis, but whether there is a correlation between hTERT and NRF2 remains unclear. Reactive Oxygen Species 96-99 NFE2 like bZIP transcription factor 2 Homo sapiens 23-27 35636015-10 2022 Mechanistically, TRIM22 inhibited OS progression through NRF2-mediated intracellular reactive oxygen species (ROS) imbalance. Reactive Oxygen Species 85-108 NFE2 like bZIP transcription factor 2 Homo sapiens 57-61 35588955-4 2022 Although metformin"s effect against T2DM, cancers, and ageing, are believed mostly attributed to the activation of AMP-activated protein kinase (AMPK), the cellular responses involving metformin-ROS-Nrf2 axis might be another natural asset to improve healthspan and lifespan. Reactive Oxygen Species 195-198 NFE2 like bZIP transcription factor 2 Homo sapiens 199-203 35567884-3 2022 Furthermore, UroA lessened the accumulation of intracellular reactive oxygen species, which promoted the phosphorylation and afterwards nuclear translocation of NRF2, subsequently driving the activation of downstream antioxidative enzymes. Reactive Oxygen Species 61-84 NFE2 like bZIP transcription factor 2 Homo sapiens 161-165 35588955-0 2022 Metformin-ROS-Nrf2 connection in the host defense mechanism against oxidative stress, apoptosis, cancers, and ageing. Reactive Oxygen Species 10-13 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 35588955-3 2022 The ROS seems to induce anti-oxidative stress response via activation of nuclear factor erythroid 2- related factor 2 (Nrf2) and glutathione peroxidase (GPx), which results in not only elimination of ROS but also activation of cellular responses including resistance to apoptosis, metabolic changes, cell proliferation, senescence prevention, lifespan extension, and immune T cell activation against cancers, regardless of its effect controlling blood glucose level and T2DM. Reactive Oxygen Species 4-7 NFE2 like bZIP transcription factor 2 Homo sapiens 73-117 35588955-3 2022 The ROS seems to induce anti-oxidative stress response via activation of nuclear factor erythroid 2- related factor 2 (Nrf2) and glutathione peroxidase (GPx), which results in not only elimination of ROS but also activation of cellular responses including resistance to apoptosis, metabolic changes, cell proliferation, senescence prevention, lifespan extension, and immune T cell activation against cancers, regardless of its effect controlling blood glucose level and T2DM. Reactive Oxygen Species 4-7 NFE2 like bZIP transcription factor 2 Homo sapiens 119-123 35588955-3 2022 The ROS seems to induce anti-oxidative stress response via activation of nuclear factor erythroid 2- related factor 2 (Nrf2) and glutathione peroxidase (GPx), which results in not only elimination of ROS but also activation of cellular responses including resistance to apoptosis, metabolic changes, cell proliferation, senescence prevention, lifespan extension, and immune T cell activation against cancers, regardless of its effect controlling blood glucose level and T2DM. Reactive Oxygen Species 200-203 NFE2 like bZIP transcription factor 2 Homo sapiens 73-117 35588955-3 2022 The ROS seems to induce anti-oxidative stress response via activation of nuclear factor erythroid 2- related factor 2 (Nrf2) and glutathione peroxidase (GPx), which results in not only elimination of ROS but also activation of cellular responses including resistance to apoptosis, metabolic changes, cell proliferation, senescence prevention, lifespan extension, and immune T cell activation against cancers, regardless of its effect controlling blood glucose level and T2DM. Reactive Oxygen Species 200-203 NFE2 like bZIP transcription factor 2 Homo sapiens 119-123 35636015-10 2022 Mechanistically, TRIM22 inhibited OS progression through NRF2-mediated intracellular reactive oxygen species (ROS) imbalance. Reactive Oxygen Species 110-113 NFE2 like bZIP transcription factor 2 Homo sapiens 57-61 35636015-15 2022 In conclusion, our study indicated that TRIM22 inhibits OS progression by promoting proteasomal degradation of NRF2 independent of KEAP1, thereby activating ROS/AMPK/mTOR/Autophagy signaling that leads to autophagic cell death in OS. Reactive Oxygen Species 157-160 NFE2 like bZIP transcription factor 2 Homo sapiens 111-115 35605918-10 2022 Moreover, DPH5 could enhance antioxidant capacity by activating Nrf2/HO-1 elements, including increasing Nrf2, HO-1, SOD, NQO1, and GSH-Px expression and reducing MDA, ROS, and JNK levels, thereby improving oxidative stress and ultimately alleviating IR. Reactive Oxygen Species 168-171 NFE2 like bZIP transcription factor 2 Homo sapiens 64-68 35464301-13 2022 Furthermore, following ATRA treatment, an increase in cellular ROS content was associated with suppressing nuclear factor erythroid 2-related factor 2 (NFE2L2 or NRF2) and NRF2-downstream active genes. Reactive Oxygen Species 63-66 NFE2 like bZIP transcription factor 2 Homo sapiens 107-150 35464301-13 2022 Furthermore, following ATRA treatment, an increase in cellular ROS content was associated with suppressing nuclear factor erythroid 2-related factor 2 (NFE2L2 or NRF2) and NRF2-downstream active genes. Reactive Oxygen Species 63-66 NFE2 like bZIP transcription factor 2 Homo sapiens 152-158 35464301-13 2022 Furthermore, following ATRA treatment, an increase in cellular ROS content was associated with suppressing nuclear factor erythroid 2-related factor 2 (NFE2L2 or NRF2) and NRF2-downstream active genes. Reactive Oxygen Species 63-66 NFE2 like bZIP transcription factor 2 Homo sapiens 162-166 35464301-13 2022 Furthermore, following ATRA treatment, an increase in cellular ROS content was associated with suppressing nuclear factor erythroid 2-related factor 2 (NFE2L2 or NRF2) and NRF2-downstream active genes. Reactive Oxygen Species 63-66 NFE2 like bZIP transcription factor 2 Homo sapiens 172-176 35537139-11 2022 Meanwhile, the increased expression of SIRT1/PPAR-alpha and Nrf2/HO-1 pathways under the pretreatment of CPs in LO2 cells indicated that CPs could markedly relieve high fat-induced fatty liver injury, regulate insulin sensitivity, and reduce production of ROS. Reactive Oxygen Species 256-259 NFE2 like bZIP transcription factor 2 Homo sapiens 60-64 35606794-8 2022 Our rescue experiment revealed that nuclear factor-erythroid 2-related factor 2 (Nrf2) silencing reversed the effects of NOX4 blockade on ROS production and osteoclast differentiation. Reactive Oxygen Species 138-141 NFE2 like bZIP transcription factor 2 Homo sapiens 36-79 35606794-8 2022 Our rescue experiment revealed that nuclear factor-erythroid 2-related factor 2 (Nrf2) silencing reversed the effects of NOX4 blockade on ROS production and osteoclast differentiation. Reactive Oxygen Species 138-141 NFE2 like bZIP transcription factor 2 Homo sapiens 81-85 35624854-11 2022 These data suggest that tomentosin-induced Nrf2 signaling is mediated both by tomentosin-induced ROS production and the activation of p38 MAPK and JNK. Reactive Oxygen Species 97-100 NFE2 like bZIP transcription factor 2 Homo sapiens 43-47 35258778-3 2022 Its pro-survival effect was accompanied by the inhibition of ROS and subsequent inhibition of NF-kappaB which is mediated through nuclear factor erythroid 2-related factor 2 (Nrf2), in that activation of Nrf2 by CO inhibited ROS via up-regulation of NQO-1 while down-regulation of Nrf2 reversed the pro-survival effect of CO both in vitro and in vivo. Reactive Oxygen Species 61-64 NFE2 like bZIP transcription factor 2 Homo sapiens 130-173 35624854-6 2022 These data indicate that tomentosin induces ROS production at an early stage which activates the Nrf2 pathway by disrupting the Nrf2-Keap1 complex. Reactive Oxygen Species 44-47 NFE2 like bZIP transcription factor 2 Homo sapiens 97-101 35624854-6 2022 These data indicate that tomentosin induces ROS production at an early stage which activates the Nrf2 pathway by disrupting the Nrf2-Keap1 complex. Reactive Oxygen Species 44-47 NFE2 like bZIP transcription factor 2 Homo sapiens 128-132 35305818-8 2022 As a potential mechanism, the expression of intracellular reactive oxygen species (ROS) and its related proteins, including p-ERK, NRF2, p-p38, HO-1, and gammaH2AX, was affected in EOC cells. Reactive Oxygen Species 58-81 NFE2 like bZIP transcription factor 2 Homo sapiens 131-135 35305818-8 2022 As a potential mechanism, the expression of intracellular reactive oxygen species (ROS) and its related proteins, including p-ERK, NRF2, p-p38, HO-1, and gammaH2AX, was affected in EOC cells. Reactive Oxygen Species 83-86 NFE2 like bZIP transcription factor 2 Homo sapiens 131-135 35258778-3 2022 Its pro-survival effect was accompanied by the inhibition of ROS and subsequent inhibition of NF-kappaB which is mediated through nuclear factor erythroid 2-related factor 2 (Nrf2), in that activation of Nrf2 by CO inhibited ROS via up-regulation of NQO-1 while down-regulation of Nrf2 reversed the pro-survival effect of CO both in vitro and in vivo. Reactive Oxygen Species 61-64 NFE2 like bZIP transcription factor 2 Homo sapiens 175-179 35258778-3 2022 Its pro-survival effect was accompanied by the inhibition of ROS and subsequent inhibition of NF-kappaB which is mediated through nuclear factor erythroid 2-related factor 2 (Nrf2), in that activation of Nrf2 by CO inhibited ROS via up-regulation of NQO-1 while down-regulation of Nrf2 reversed the pro-survival effect of CO both in vitro and in vivo. Reactive Oxygen Species 61-64 NFE2 like bZIP transcription factor 2 Homo sapiens 204-208 35258778-3 2022 Its pro-survival effect was accompanied by the inhibition of ROS and subsequent inhibition of NF-kappaB which is mediated through nuclear factor erythroid 2-related factor 2 (Nrf2), in that activation of Nrf2 by CO inhibited ROS via up-regulation of NQO-1 while down-regulation of Nrf2 reversed the pro-survival effect of CO both in vitro and in vivo. Reactive Oxygen Species 225-228 NFE2 like bZIP transcription factor 2 Homo sapiens 130-173 35258778-3 2022 Its pro-survival effect was accompanied by the inhibition of ROS and subsequent inhibition of NF-kappaB which is mediated through nuclear factor erythroid 2-related factor 2 (Nrf2), in that activation of Nrf2 by CO inhibited ROS via up-regulation of NQO-1 while down-regulation of Nrf2 reversed the pro-survival effect of CO both in vitro and in vivo. Reactive Oxygen Species 225-228 NFE2 like bZIP transcription factor 2 Homo sapiens 175-179 35258778-3 2022 Its pro-survival effect was accompanied by the inhibition of ROS and subsequent inhibition of NF-kappaB which is mediated through nuclear factor erythroid 2-related factor 2 (Nrf2), in that activation of Nrf2 by CO inhibited ROS via up-regulation of NQO-1 while down-regulation of Nrf2 reversed the pro-survival effect of CO both in vitro and in vivo. Reactive Oxygen Species 225-228 NFE2 like bZIP transcription factor 2 Homo sapiens 204-208 35467062-3 2022 Besides being one of the main cellular defense mechanisms that regulates antioxidant pathways for detoxifying reactive oxygen species (ROS), the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) promotes tumor proliferation by increasing metabolic activity. Reactive Oxygen Species 110-133 NFE2 like bZIP transcription factor 2 Homo sapiens 166-209 35467062-3 2022 Besides being one of the main cellular defense mechanisms that regulates antioxidant pathways for detoxifying reactive oxygen species (ROS), the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) promotes tumor proliferation by increasing metabolic activity. Reactive Oxygen Species 110-133 NFE2 like bZIP transcription factor 2 Homo sapiens 211-215 35466502-10 2022 Nrf2-silenced HCC cells displayed sensitivity to lenvatinib and high lipid ROS levels. Reactive Oxygen Species 75-78 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 35467062-3 2022 Besides being one of the main cellular defense mechanisms that regulates antioxidant pathways for detoxifying reactive oxygen species (ROS), the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) promotes tumor proliferation by increasing metabolic activity. Reactive Oxygen Species 135-138 NFE2 like bZIP transcription factor 2 Homo sapiens 166-209 35467062-3 2022 Besides being one of the main cellular defense mechanisms that regulates antioxidant pathways for detoxifying reactive oxygen species (ROS), the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) promotes tumor proliferation by increasing metabolic activity. Reactive Oxygen Species 135-138 NFE2 like bZIP transcription factor 2 Homo sapiens 211-215 35044251-6 2022 In this context, accumulating evidence suggests a central role for Nrf2-mediated antioxidant response, one of the most studied cellular defensive mechanisms against ROS accumulation. Reactive Oxygen Species 165-168 NFE2 like bZIP transcription factor 2 Homo sapiens 67-71 35496911-8 2022 In summary, these findings indicated that HO-1 protects HCs from gentamicin by up-regulating its expression in HCs and interacting with Nrf2 to inhibit reactive oxygen species (ROS). Reactive Oxygen Species 152-175 NFE2 like bZIP transcription factor 2 Homo sapiens 136-140 35496911-8 2022 In summary, these findings indicated that HO-1 protects HCs from gentamicin by up-regulating its expression in HCs and interacting with Nrf2 to inhibit reactive oxygen species (ROS). Reactive Oxygen Species 177-180 NFE2 like bZIP transcription factor 2 Homo sapiens 136-140 35455944-2 2022 Peroxiredoxin 6 (Prdx6), an antioxidant gene downstream target for the Nrf2 pathway, plays a role in regulating ROS homeostasis. Reactive Oxygen Species 112-115 NFE2 like bZIP transcription factor 2 Homo sapiens 71-75 35408731-6 2022 It could reduce UV-induced intracellular ROS generation and initiate the antioxidant defense system by activating the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway in human skin fibroblasts. Reactive Oxygen Species 41-44 NFE2 like bZIP transcription factor 2 Homo sapiens 118-161 35408731-6 2022 It could reduce UV-induced intracellular ROS generation and initiate the antioxidant defense system by activating the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway in human skin fibroblasts. Reactive Oxygen Species 41-44 NFE2 like bZIP transcription factor 2 Homo sapiens 163-167 35453467-0 2022 HO-1 Upregulation by Kaempferol via ROS-Dependent Nrf2-ARE Cascade Attenuates Lipopolysaccharide-Mediated Intercellular Cell Adhesion Molecule-1 Expression in Human Pulmonary Alveolar Epithelial Cells. Reactive Oxygen Species 36-39 NFE2 like bZIP transcription factor 2 Homo sapiens 50-54 35266255-0 2022 Decabromodiphenyl ether induces ROS-mediated intestinal toxicity through the Keap1-Nrf2 pathway. Reactive Oxygen Species 32-35 NFE2 like bZIP transcription factor 2 Homo sapiens 83-87 35350102-10 2022 Furthermore, spermine enhanced Nrf2 nuclear translocation, thereby increasing heme oxygenase-1 and NADPH quinone oxidoreductase-1 expression, which subsequently reduced ROS production. Reactive Oxygen Species 169-172 NFE2 like bZIP transcription factor 2 Homo sapiens 31-35 35453348-4 2022 Increased levels of Reactive Oxygen Species (ROS) activate NRF2 signalling, inducing the expression of antioxidant enzymes, such as haem oxygenase (HO-1), catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD), that protect cells against oxidative stress. Reactive Oxygen Species 20-43 NFE2 like bZIP transcription factor 2 Homo sapiens 59-63 35091323-4 2022 The Kelch like ECH-associated protein 1 (KEAP1)-nuclear factor, erythroid 2 like 2 (Nrf2) pathway provides antioxidant defense against lipotoxic stress by eliminating ROS and can be activated by the p62-Unc-51 like autophagy activating kinase 1 (ULK1) axis. Reactive Oxygen Species 167-170 NFE2 like bZIP transcription factor 2 Homo sapiens 48-82 35091323-4 2022 The Kelch like ECH-associated protein 1 (KEAP1)-nuclear factor, erythroid 2 like 2 (Nrf2) pathway provides antioxidant defense against lipotoxic stress by eliminating ROS and can be activated by the p62-Unc-51 like autophagy activating kinase 1 (ULK1) axis. Reactive Oxygen Species 167-170 NFE2 like bZIP transcription factor 2 Homo sapiens 84-88 35560290-4 2022 Four reactivity assays were used for concentration dependent detection of reactive oxygen species (ROS) generated by NFs: abiotic assays FRAS, EPR and DCFH2-DA, as well as the in vitro assay of NRF2/ARE responsive luciferase reporter activation in the HEK293 cell line. Reactive Oxygen Species 74-97 NFE2 like bZIP transcription factor 2 Homo sapiens 194-198 35560290-4 2022 Four reactivity assays were used for concentration dependent detection of reactive oxygen species (ROS) generated by NFs: abiotic assays FRAS, EPR and DCFH2-DA, as well as the in vitro assay of NRF2/ARE responsive luciferase reporter activation in the HEK293 cell line. Reactive Oxygen Species 99-102 NFE2 like bZIP transcription factor 2 Homo sapiens 194-198 35453348-4 2022 Increased levels of Reactive Oxygen Species (ROS) activate NRF2 signalling, inducing the expression of antioxidant enzymes, such as haem oxygenase (HO-1), catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD), that protect cells against oxidative stress. Reactive Oxygen Species 45-48 NFE2 like bZIP transcription factor 2 Homo sapiens 59-63 35368867-4 2022 Activation of Nrf2 signaling pathway could upregulate multifarious antioxidant and detoxifying enzymes, further scavenging excessive reactive oxygen species (ROS). Reactive Oxygen Species 133-156 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 35505966-8 2022 Collectively, TAZ might ameliorate the microglia-mediated inflammatory response through the Nrf2-reactive oxygen species (ROS)-nuclear factor kappaB (NF-kappaB) pathway. Reactive Oxygen Species 97-120 NFE2 like bZIP transcription factor 2 Homo sapiens 92-96 35332611-4 2022 The expression level of nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 markedly increased after BE treatment will intimidate A549 cells proliferation by the ROS-independent pathway via the antioxidant pathway. Reactive Oxygen Species 175-178 NFE2 like bZIP transcription factor 2 Homo sapiens 24-67 35368867-4 2022 Activation of Nrf2 signaling pathway could upregulate multifarious antioxidant and detoxifying enzymes, further scavenging excessive reactive oxygen species (ROS). Reactive Oxygen Species 158-161 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 35288099-2 2022 Melanocytes are protected from damage by reactive oxygen species by means of certain pathways, one of which involves the nuclear factor erythroid 2-related factor 2 (Nrf2) transcription factor. Reactive Oxygen Species 41-64 NFE2 like bZIP transcription factor 2 Homo sapiens 121-164 35288099-2 2022 Melanocytes are protected from damage by reactive oxygen species by means of certain pathways, one of which involves the nuclear factor erythroid 2-related factor 2 (Nrf2) transcription factor. Reactive Oxygen Species 41-64 NFE2 like bZIP transcription factor 2 Homo sapiens 166-170 35101864-1 2022 The Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2-related factor 2 (NRF2) pathway plays a physiologic protective role against xenobiotics and reactive oxygen species. Reactive Oxygen Species 167-190 NFE2 like bZIP transcription factor 2 Homo sapiens 48-91 35434015-9 2022 These results suggest that Nrf2 regulates NQO1 to attenuate ROS, which negatively regulates NLRP3 inflammasome. Reactive Oxygen Species 60-63 NFE2 like bZIP transcription factor 2 Homo sapiens 27-31 35434015-10 2022 Conclusions: Nrf2/NQO1 was an inhibitor of ROS-induced NLRP3 inflammasome activation in Q-VD-OPH-induced necroptosis following cerebral I/R injury. Reactive Oxygen Species 43-46 NFE2 like bZIP transcription factor 2 Homo sapiens 13-17 35308171-0 2022 Four-Octyl Itaconate Attenuates UVB-Induced Melanocytes and Keratinocytes Apoptosis by Nrf2 Activation-Dependent ROS Inhibition. Reactive Oxygen Species 113-116 NFE2 like bZIP transcription factor 2 Homo sapiens 87-91 35308171-9 2022 Moreover, 4-OI induced nuclear translocation and activation of nuclear factor erythroid 2-related factor 2 (Nrf2), and Nrf2 silencing reversed the inhibitory effect of 4-OI on the UVB-induced increase in ROS production and apoptosis in HaCaT and PIG1 cells. Reactive Oxygen Species 204-207 NFE2 like bZIP transcription factor 2 Homo sapiens 108-112 35308171-9 2022 Moreover, 4-OI induced nuclear translocation and activation of nuclear factor erythroid 2-related factor 2 (Nrf2), and Nrf2 silencing reversed the inhibitory effect of 4-OI on the UVB-induced increase in ROS production and apoptosis in HaCaT and PIG1 cells. Reactive Oxygen Species 204-207 NFE2 like bZIP transcription factor 2 Homo sapiens 119-123 35019712-9 2022 Further analysis of NRF2-mediated oxidative stress response signaling indicated IAV inhibits accumulation of reactive oxygen species (ROS), but ROS levels significantly increased during IAV infection in PSMA2 KD cells. Reactive Oxygen Species 109-132 NFE2 like bZIP transcription factor 2 Homo sapiens 20-24 35019712-9 2022 Further analysis of NRF2-mediated oxidative stress response signaling indicated IAV inhibits accumulation of reactive oxygen species (ROS), but ROS levels significantly increased during IAV infection in PSMA2 KD cells. Reactive Oxygen Species 134-137 NFE2 like bZIP transcription factor 2 Homo sapiens 20-24 35019712-9 2022 Further analysis of NRF2-mediated oxidative stress response signaling indicated IAV inhibits accumulation of reactive oxygen species (ROS), but ROS levels significantly increased during IAV infection in PSMA2 KD cells. Reactive Oxygen Species 144-147 NFE2 like bZIP transcription factor 2 Homo sapiens 20-24 35019712-11 2022 This indicates that PSMA2 is required for NRF2-mediated ROS neutralization and that IAV uses PSMA2 to escape viral clearance via NRF2-mediated cellular oxidative response. Reactive Oxygen Species 56-59 NFE2 like bZIP transcription factor 2 Homo sapiens 42-46 35101864-1 2022 The Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2-related factor 2 (NRF2) pathway plays a physiologic protective role against xenobiotics and reactive oxygen species. Reactive Oxygen Species 167-190 NFE2 like bZIP transcription factor 2 Homo sapiens 93-97 35222799-5 2022 Mechanistically, 4-OI significantly suppressed the overproduction of reactive oxygen species (ROS) through activation of Nrf2; the downregulation of ROS level induced a downregulation of AMP-dependent protein kinase (AMPK) phosphorylation level which finally ameliorated excessive lipid accumulation in FFA-stimulated hepatocytes. Reactive Oxygen Species 69-92 NFE2 like bZIP transcription factor 2 Homo sapiens 121-125 35122929-8 2022 Taken together, these findings suggested quercetin could alleviate o,p"-DDT-induced toxicity in HL-7702 cells via inhibiting ROS production, which is modulated by down-regulating nuclear Nrf2 levels and NADPH oxidase expression. Reactive Oxygen Species 125-128 NFE2 like bZIP transcription factor 2 Homo sapiens 187-191 35111249-13 2022 Concurrent inhibition of CD44v9 and Nrf2 may trigger apoptosis induction, potentiate chemosensitivity and enhance antitumor activities through the ROS-activated p38/p21 pathway. Reactive Oxygen Species 147-150 NFE2 like bZIP transcription factor 2 Homo sapiens 36-40 35268019-2 2022 ROS and inflammatory responses are regulated by the activation of nuclear factor erythroid-2-related factor 2 (Nrf2) and the expression of Nrf2 target genes, superoxide dismutase (SOD) and heme oxygenase-1 (HO-1). Reactive Oxygen Species 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 66-109 35268019-2 2022 ROS and inflammatory responses are regulated by the activation of nuclear factor erythroid-2-related factor 2 (Nrf2) and the expression of Nrf2 target genes, superoxide dismutase (SOD) and heme oxygenase-1 (HO-1). Reactive Oxygen Species 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 111-115 35268019-2 2022 ROS and inflammatory responses are regulated by the activation of nuclear factor erythroid-2-related factor 2 (Nrf2) and the expression of Nrf2 target genes, superoxide dismutase (SOD) and heme oxygenase-1 (HO-1). Reactive Oxygen Species 0-3 NFE2 like bZIP transcription factor 2 Homo sapiens 139-143 35222799-5 2022 Mechanistically, 4-OI significantly suppressed the overproduction of reactive oxygen species (ROS) through activation of Nrf2; the downregulation of ROS level induced a downregulation of AMP-dependent protein kinase (AMPK) phosphorylation level which finally ameliorated excessive lipid accumulation in FFA-stimulated hepatocytes. Reactive Oxygen Species 94-97 NFE2 like bZIP transcription factor 2 Homo sapiens 121-125 35115586-2 2022 On molecular level the NRF2 pathway, a cellular defense mechanism against reactive oxygen species, is induced. Reactive Oxygen Species 74-97 NFE2 like bZIP transcription factor 2 Homo sapiens 23-27 35242279-2 2022 The activated Nrf2 signaling pathway that responds to the excessive ROS regulated the expressions of antiapoptotic proteins, antioxidative enzymes, drug transporters, and detoxifying factors. Reactive Oxygen Species 68-71 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 35077153-0 2022 Enhanced ROS-Boosted Phototherapy against Pancreatic Cancer via Nrf2-Mediated Stress-Defense Pathway Suppression and Ferroptosis Induction. Reactive Oxygen Species 9-12 NFE2 like bZIP transcription factor 2 Homo sapiens 64-68 35181114-5 2022 Both peptides were able to reduce the H2O2-induced reactive oxygen species (ROS), lipid peroxidation, and nitric oxide (NO) production levels in HepG2 cells, via the modulation of Nrf-2 and iNOS pathways, respectively. Reactive Oxygen Species 51-74 NFE2 like bZIP transcription factor 2 Homo sapiens 180-185 35181114-5 2022 Both peptides were able to reduce the H2O2-induced reactive oxygen species (ROS), lipid peroxidation, and nitric oxide (NO) production levels in HepG2 cells, via the modulation of Nrf-2 and iNOS pathways, respectively. Reactive Oxygen Species 76-79 NFE2 like bZIP transcription factor 2 Homo sapiens 180-185 35136484-5 2022 Increased expression of PPARgamma also decreased sepsis-induced reactive oxygen species (ROS) by promoting the expression of Nrf2. Reactive Oxygen Species 64-87 NFE2 like bZIP transcription factor 2 Homo sapiens 125-129 35136484-5 2022 Increased expression of PPARgamma also decreased sepsis-induced reactive oxygen species (ROS) by promoting the expression of Nrf2. Reactive Oxygen Species 89-92 NFE2 like bZIP transcription factor 2 Homo sapiens 125-129 35103096-6 2022 Under oxidative stress, ROS could induce autophagy by activating the Nrf2 antioxidant pathway of melanocytes. Reactive Oxygen Species 24-27 NFE2 like bZIP transcription factor 2 Homo sapiens 69-73 35101046-1 2022 BACKGROUND: Nuclear factor E2-related factor 2 (Nrf2) is an important transcription factor which plays a pivotal role in detoxifying reactive oxygen species (ROS) and has been more recently shown to regulate inflammatory and antiviral responses. Reactive Oxygen Species 133-156 NFE2 like bZIP transcription factor 2 Homo sapiens 48-52 35101046-1 2022 BACKGROUND: Nuclear factor E2-related factor 2 (Nrf2) is an important transcription factor which plays a pivotal role in detoxifying reactive oxygen species (ROS) and has been more recently shown to regulate inflammatory and antiviral responses. Reactive Oxygen Species 158-161 NFE2 like bZIP transcription factor 2 Homo sapiens 48-52 35141161-4 2022 DMF/Vem treatment induced cell death through inhibiting the expression and transcriptional activity of NRF2 thereby resulting in more reactive oxygen species (ROS) and via inhibiting the expression of YAP, a key downstream effector of Hippo pathway. Reactive Oxygen Species 134-157 NFE2 like bZIP transcription factor 2 Homo sapiens 103-107 35141161-4 2022 DMF/Vem treatment induced cell death through inhibiting the expression and transcriptional activity of NRF2 thereby resulting in more reactive oxygen species (ROS) and via inhibiting the expression of YAP, a key downstream effector of Hippo pathway. Reactive Oxygen Species 159-162 NFE2 like bZIP transcription factor 2 Homo sapiens 103-107 35103096-7 2022 However, persistent stimulation of ROS might eventually lead to excessive activation of Nrf2 antioxidant pathway, which in turn will inactivate autophagy. Reactive Oxygen Species 35-38 NFE2 like bZIP transcription factor 2 Homo sapiens 88-92 35087488-5 2021 Further, Dengue replication suppresses the accumulation of ROS in differentiating cells, probably by only augmenting the activity of the transcription factor NFE2L2 without influencing the expression of the coding gene. Reactive Oxygen Species 59-62 NFE2 like bZIP transcription factor 2 Homo sapiens 158-164 35087488-6 2021 Interestingly pharmacological modulation of NFE2L2 activity showed a simultaneous but opposite effect on intracellular ROS and virus replication suggesting the former to have an inhibitory effect on the later. Reactive Oxygen Species 119-122 NFE2 like bZIP transcription factor 2 Homo sapiens 44-50 35013107-9 2022 MET pretreatment also significantly suppressed MGO-stimulated ROS production, increased signaling through the ROS-mediated PI3K/Akt and Nrf2/HO-1 pathways, and markedly elevated the levels of its downstream antioxidants. Reactive Oxygen Species 110-113 NFE2 like bZIP transcription factor 2 Homo sapiens 136-140 35092379-7 2022 Increased formation of ROS was causally related with suppression of Nrf2 and its down-stream antioxidant and cytoprotective enzymes. Reactive Oxygen Species 23-26 NFE2 like bZIP transcription factor 2 Homo sapiens 68-72 35126144-7 2021 Additionally, CAG also promoted the nuclear factor-erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1)/anti-oxidative response element (ARE) pathway that scavenges reactive oxygen species (ROS). Reactive Oxygen Species 192-215 NFE2 like bZIP transcription factor 2 Homo sapiens 36-79 35126144-7 2021 Additionally, CAG also promoted the nuclear factor-erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1)/anti-oxidative response element (ARE) pathway that scavenges reactive oxygen species (ROS). Reactive Oxygen Species 192-215 NFE2 like bZIP transcription factor 2 Homo sapiens 81-85 35126144-7 2021 Additionally, CAG also promoted the nuclear factor-erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1)/anti-oxidative response element (ARE) pathway that scavenges reactive oxygen species (ROS). Reactive Oxygen Species 217-220 NFE2 like bZIP transcription factor 2 Homo sapiens 36-79 35126144-7 2021 Additionally, CAG also promoted the nuclear factor-erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1)/anti-oxidative response element (ARE) pathway that scavenges reactive oxygen species (ROS). Reactive Oxygen Species 217-220 NFE2 like bZIP transcription factor 2 Homo sapiens 81-85