PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31391454-0 2019 Avenanthramide A triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3. Reactive Oxygen Species 33-36 DEAD-box helicase 3 X-linked Homo sapiens 108-112 31391454-7 2019 DDX3 overexpression reversed the ROS-mediated CRC apoptosis induced by AVNs. Reactive Oxygen Species 33-36 DEAD-box helicase 3 X-linked Homo sapiens 0-4 28869602-9 2018 Overall, we conclude that DDX3 inhibition with RK-33 causes radiosensitization in breast cancer through inhibition of mitochondrial translation, which results in reduced oxidative phosphorylation capacity and increased ROS levels, culminating in a bioenergetic catastrophe. Reactive Oxygen Species 219-222 DEAD-box helicase 3 X-linked Homo sapiens 26-30 27735940-3 2016 We show that genetic inactivation of DDX3 leads to the accumulation of mitochondrial reactive oxygen species (ROS) associated with a defect in hydrogen peroxide detoxification. Reactive Oxygen Species 85-108 DEAD-box helicase 3 X-linked Homo sapiens 37-41 27735940-3 2016 We show that genetic inactivation of DDX3 leads to the accumulation of mitochondrial reactive oxygen species (ROS) associated with a defect in hydrogen peroxide detoxification. Reactive Oxygen Species 110-113 DEAD-box helicase 3 X-linked Homo sapiens 37-41 27735940-9 2016 As a result of the inability of DDX3-depleted Leishmania to recover from ROS damage and to survive various stresses in the host macrophage, parasite intracellular development was impaired. Reactive Oxygen Species 73-76 DEAD-box helicase 3 X-linked Homo sapiens 32-36 27735940-10 2016 Collectively, these observations support a central role for the Leishmania DDX3 homolog in preventing ROS-mediated damage and in maintaining mitochondrial protein quality control. Reactive Oxygen Species 102-105 DEAD-box helicase 3 X-linked Homo sapiens 75-79