PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11952335-4 2002 We have shown that PCB metabolism generates ROS in vitro and in cells in culture and this leads to oxidative DNA damage, like DNA strand breaks and 8-oxo-dG formation. Reactive Oxygen Species 44-47 pyruvate carboxylase Homo sapiens 19-22 16291560-8 2006 Recently it was also reported that PCB and some BFRs induce formation of reactive oxygen species (ROS) in neurons. Reactive Oxygen Species 73-96 pyruvate carboxylase Homo sapiens 35-38 16291560-8 2006 Recently it was also reported that PCB and some BFRs induce formation of reactive oxygen species (ROS) in neurons. Reactive Oxygen Species 98-101 pyruvate carboxylase Homo sapiens 35-38 16291560-10 2006 In the case of PCB exposure, a correlation between ROS formation and death of neurons was found. Reactive Oxygen Species 51-54 pyruvate carboxylase Homo sapiens 15-18 28592194-6 2017 In addition, scavenging of reactive oxygen species (ROS) by 10 muM N-acetyl-l-cysteine (NAC) partly rescued impaired insulin-induced eNOS activities and NO productions induced by PCB-118 in HUVECs. Reactive Oxygen Species 27-50 pyruvate carboxylase Homo sapiens 179-182 10943438-0 2000 Mechanisms of toxicity of PCB metabolites: generation of reactive oxygen species and glutathione depletion. Reactive Oxygen Species 57-80 pyruvate carboxylase Homo sapiens 26-29 11222876-0 2001 Production of DNA strand breaks in vitro and reactive oxygen species in vitro and in HL-60 cells by PCB metabolites. Reactive Oxygen Species 45-68 pyruvate carboxylase Homo sapiens 100-103 11222876-6 2001 We hypothesized that reactive oxygen species (ROS) are produced by redox reactions of PCB metabolites. Reactive Oxygen Species 21-44 pyruvate carboxylase Homo sapiens 86-89 11222876-6 2001 We hypothesized that reactive oxygen species (ROS) are produced by redox reactions of PCB metabolites. Reactive Oxygen Species 46-49 pyruvate carboxylase Homo sapiens 86-89 11222876-14 2001 We conclude that dihydroxylated PCBs, and PCB quinones after reaction with GSH, produce superoxide and other ROS both in vitro and in HL-60 cells, and oxidative DNA damage in the form of DNA strand breaks in vitro. Reactive Oxygen Species 109-112 pyruvate carboxylase Homo sapiens 32-35 28592194-6 2017 In addition, scavenging of reactive oxygen species (ROS) by 10 muM N-acetyl-l-cysteine (NAC) partly rescued impaired insulin-induced eNOS activities and NO productions induced by PCB-118 in HUVECs. Reactive Oxygen Species 52-55 pyruvate carboxylase Homo sapiens 179-182 28592194-7 2017 Taken together, these results indicate that PCB-118 mediates lower eNOS activity and impairs insulin-induced NO production partly through excessive ROS production in endothelial cells. Reactive Oxygen Species 148-151 pyruvate carboxylase Homo sapiens 44-47 28399781-7 2017 Taken together, PCB 118-induced endothelial cell apoptosis was partially initiated by excessive ROS production. Reactive Oxygen Species 96-99 pyruvate carboxylase Homo sapiens 16-19 27194217-8 2016 At high concentrations (10-20 muM), PCB 52 induced more ROS than PCB 153 and PCB 180. Reactive Oxygen Species 56-59 pyruvate carboxylase Homo sapiens 36-39 28399781-0 2017 PCB 118-induced endothelial cell apoptosis is partially mediated by excessive ROS production. Reactive Oxygen Species 78-81 pyruvate carboxylase Homo sapiens 0-3 28399781-4 2017 As expected, exposure to PCB 118 increased the intracellular reactive oxygen species (ROS) levels in HUVECs. Reactive Oxygen Species 61-84 pyruvate carboxylase Homo sapiens 25-28 28399781-4 2017 As expected, exposure to PCB 118 increased the intracellular reactive oxygen species (ROS) levels in HUVECs. Reactive Oxygen Species 86-89 pyruvate carboxylase Homo sapiens 25-28 28288918-3 2017 Enhanced MPs production requires mitochondrial reactive oxygen species production, which is mediated by activities of pyruvate carboxylase and phosphoenolpyruvate carboxykinase. Reactive Oxygen Species 47-70 pyruvate carboxylase Homo sapiens 118-138 27194217-9 2016 The role of extracellular signal-regulated kinase (ERK) 1/2 and/or ERK 5 signalling in PCB-induced ROS production was implicated through the reduction in ROS in the presence of the specific inhibitor U0126, whereas reduced ROS production after the use of SB203580 and SP600125 indicated the involvement of the p38 mitogen-activated protein kinase (MAPK) and c-Jun amino-terminal kinase (JNK) pathways, respectively. Reactive Oxygen Species 99-102 pyruvate carboxylase Homo sapiens 87-90 19233261-10 2009 Intervention studies with known reactive oxygen species (ROS) modifiers suggested that H(2)O(2), singlet oxygen, hydroxyl radical, and superoxide may also be involved in this PCB-mediated oxidative DNA damage. Reactive Oxygen Species 32-55 pyruvate carboxylase Homo sapiens 175-178 27194217-9 2016 The role of extracellular signal-regulated kinase (ERK) 1/2 and/or ERK 5 signalling in PCB-induced ROS production was implicated through the reduction in ROS in the presence of the specific inhibitor U0126, whereas reduced ROS production after the use of SB203580 and SP600125 indicated the involvement of the p38 mitogen-activated protein kinase (MAPK) and c-Jun amino-terminal kinase (JNK) pathways, respectively. Reactive Oxygen Species 154-157 pyruvate carboxylase Homo sapiens 87-90 27194217-9 2016 The role of extracellular signal-regulated kinase (ERK) 1/2 and/or ERK 5 signalling in PCB-induced ROS production was implicated through the reduction in ROS in the presence of the specific inhibitor U0126, whereas reduced ROS production after the use of SB203580 and SP600125 indicated the involvement of the p38 mitogen-activated protein kinase (MAPK) and c-Jun amino-terminal kinase (JNK) pathways, respectively. Reactive Oxygen Species 154-157 pyruvate carboxylase Homo sapiens 87-90 27194217-11 2016 The intracellular signalling mechanisms involved in ROS production in human neutrophil granulocytes appeared to be similar for PCB 52, PCB 153 and PCB 180. Reactive Oxygen Species 52-55 pyruvate carboxylase Homo sapiens 127-130 27194217-11 2016 The intracellular signalling mechanisms involved in ROS production in human neutrophil granulocytes appeared to be similar for PCB 52, PCB 153 and PCB 180. Reactive Oxygen Species 52-55 pyruvate carboxylase Homo sapiens 135-138 27194217-11 2016 The intracellular signalling mechanisms involved in ROS production in human neutrophil granulocytes appeared to be similar for PCB 52, PCB 153 and PCB 180. Reactive Oxygen Species 52-55 pyruvate carboxylase Homo sapiens 135-138 24942145-4 2015 Reactive oxygen species (ROS), malondialdehyde (MDA) and superoxide dismutase (SOD) (except 48 h) showed a significant increase at higher concentrations of PCB 101 than those at the lower concentrations with the passage of time. Reactive Oxygen Species 0-23 pyruvate carboxylase Homo sapiens 156-159 24942145-4 2015 Reactive oxygen species (ROS), malondialdehyde (MDA) and superoxide dismutase (SOD) (except 48 h) showed a significant increase at higher concentrations of PCB 101 than those at the lower concentrations with the passage of time. Reactive Oxygen Species 25-28 pyruvate carboxylase Homo sapiens 156-159 22580158-8 2012 We have found that exposure to PCB quinones leads to: (1) a decrease in cell viability; (2) an increase in both the total ROS production and superoxide production; (3) only 3Cl-PCBQ caused significant increase in the thiobarbituric acid reactive substances (TBARS) level; (4) an increase in SOD activity and a decrease in catalase activity; and (5) a decrease in GST activity and GSH level. Reactive Oxygen Species 122-125 pyruvate carboxylase Homo sapiens 31-34 20307652-2 2010 We investigate the hypothesis that PCB induced perturbations in ROS signaling regulate the entry of quiescent cells into the proliferative cycle. Reactive Oxygen Species 64-67 pyruvate carboxylase Homo sapiens 35-38 20394812-2 2010 We have shown previously that PCB-153 increased reactive oxygen species levels in non-tumorigenic MCF-10A human mammary epithelial cells, which were associated with DNA damage, growth inhibition, and cytotoxicity. Reactive Oxygen Species 48-71 pyruvate carboxylase Homo sapiens 30-33 26757638-5 2016 Further examination revealed that PC(O-16:0/2:0) similarly promotes a global increase in ceramide accumulation in human neurons which was associated with mitochondrial-derived reactive oxygen species (ROS) and toxicity. Reactive Oxygen Species 176-199 pyruvate carboxylase Homo sapiens 34-36 26757638-5 2016 Further examination revealed that PC(O-16:0/2:0) similarly promotes a global increase in ceramide accumulation in human neurons which was associated with mitochondrial-derived reactive oxygen species (ROS) and toxicity. Reactive Oxygen Species 201-204 pyruvate carboxylase Homo sapiens 34-36 26757638-6 2016 These findings suggest that PC(O-16:0/2:0)-dependent mitochondrial dysfunction may be an underlying contributing factor to the ROS production associated with AD. Reactive Oxygen Species 127-130 pyruvate carboxylase Homo sapiens 28-30 24059442-3 2013 Quinones derived from the oxidative metabolism of PCBs (PCB-quinones) react with nucleophilic sites in proteins and also undergo redox cycling to generate reactive oxygen species. Reactive Oxygen Species 155-178 pyruvate carboxylase Homo sapiens 50-53 19233261-10 2009 Intervention studies with known reactive oxygen species (ROS) modifiers suggested that H(2)O(2), singlet oxygen, hydroxyl radical, and superoxide may also be involved in this PCB-mediated oxidative DNA damage. Reactive Oxygen Species 57-60 pyruvate carboxylase Homo sapiens 175-178 19233261-11 2009 These data indicate a mechanistic role for several ROS, in addition to copper, in PCB-induced DNA damage and provide further support for oxidative DNA damage in PCB-mediated carcinogenesis. Reactive Oxygen Species 51-54 pyruvate carboxylase Homo sapiens 82-85 18691649-2 2008 We investigated the hypothesis that PCB-induced changes in the levels of cellular reactive oxygen species (ROS) induce DNA damage resulting in cytotoxicity. Reactive Oxygen Species 82-105 pyruvate carboxylase Homo sapiens 36-39 18691649-2 2008 We investigated the hypothesis that PCB-induced changes in the levels of cellular reactive oxygen species (ROS) induce DNA damage resulting in cytotoxicity. Reactive Oxygen Species 107-110 pyruvate carboxylase Homo sapiens 36-39 18691649-9 2008 Our results demonstrate a PCB-induced increase in cellular levels of ROS causing DNA damage, resulting in cell killing. Reactive Oxygen Species 69-72 pyruvate carboxylase Homo sapiens 26-29