PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14730207-12 2004 In summary, our results suggest that E(2) inhibits Ang-II-induced cell proliferation and ET-1 gene expression, partially by interfering with the ERK pathway via attenuation of ROS generation. Reactive Oxygen Species 176-179 angiogenin Rattus norvegicus 51-54 15691621-8 2005 The Ang II-stimulated ROS increase was greater in 9- and 16-week-old SHR versus 4-week SHR (P < .05). Reactive Oxygen Species 22-25 angiogenin Rattus norvegicus 4-7 28076452-10 2017 Ang(1-7) treatment also suppressed the production of reactive oxygen species, reduced renal tissue inflammation, ameliorated mesangial expansion, and decreased renal fibrosis. Reactive Oxygen Species 53-76 angiogenin Rattus norvegicus 0-7 12710530-1 2003 We investigated the role of receptor tyrosine kinases in Ang II-stimulated generation of reactive oxygen species (ROS) and assessed whether MAP kinase signaling by Ang II is mediated via redox-sensitive pathways. Reactive Oxygen Species 89-112 angiogenin Rattus norvegicus 57-60 12710530-6 2003 Ang II stimulated NADPH oxidase activity and dose-dependently increased ROS production (p < 0.05). Reactive Oxygen Species 72-75 angiogenin Rattus norvegicus 0-3 12710530-12 2003 Thus Ang II stimulates production of NADPH-inducible ROS partially through transactivation of IGF-1R and EGFR. Reactive Oxygen Species 53-56 angiogenin Rattus norvegicus 5-8 12710530-13 2003 Inhibition of receptor tyrosine kinases and reduced ROS bioavaliability attenuated Ang II-induced phosphorylation of p38 MAP kinase and ERK5, but not of ERK1/2. Reactive Oxygen Species 52-55 angiogenin Rattus norvegicus 83-86 11567882-4 2002 Both ionizing radiation and Ang II signal via generation of reactive oxygen species (ROS). Reactive Oxygen Species 60-83 angiogenin Rattus norvegicus 28-31 11567882-4 2002 Both ionizing radiation and Ang II signal via generation of reactive oxygen species (ROS). Reactive Oxygen Species 85-88 angiogenin Rattus norvegicus 28-31 26550173-10 2015 CONCLUSIONS: CTS could inhibit the inflammatory factors such as TNF-alpha and IL-6 in myocardial cells induced by Ang II with dose dependent, its mechanism may be related with that CTS could decrease the levels of ROS in myocardial cells and inhibit NF-kappaB translocation into the nucleus. Reactive Oxygen Species 214-217 angiogenin Rattus norvegicus 114-117 26741265-8 2016 In addition, RSG increased superoxide dismutase activity in the liver of Ang II-infused rats in vivo, and decreased Ang II-stimulated reactive oxygen species (ROS) production in hepatocytes in vitro. Reactive Oxygen Species 134-157 angiogenin Rattus norvegicus 116-119 27064837-5 2016 In addition, we observed the elevated reactive oxygen species (ROS) generation and NADPH oxidase activity and reduced superoxide dismutase activity in Ang II-treated VSMCs, which were dose-dependently reversed by TQ. Reactive Oxygen Species 38-61 angiogenin Rattus norvegicus 151-154 26701640-5 2015 Effects of Ang II on reactive oxygen species (ROS) generation were detected by dihydroethidium (DHE) staining. Reactive Oxygen Species 21-44 angiogenin Rattus norvegicus 11-14 26701640-5 2015 Effects of Ang II on reactive oxygen species (ROS) generation were detected by dihydroethidium (DHE) staining. Reactive Oxygen Species 46-49 angiogenin Rattus norvegicus 11-14 25488910-5 2015 Further investigation demonstrated that polydatin attenuated the Ang II-induced increase in the reactive oxygen species levels and NADPH oxidase activity in vivo and in vitro. Reactive Oxygen Species 96-119 angiogenin Rattus norvegicus 65-68 18094033-2 2008 We have demonstrated that rats infused with ANG II manifest increased cortical cyclooxygenase (COX)-2 expression and activity via NADPH oxidase-derived reactive oxygen species (ROS). Reactive Oxygen Species 152-175 angiogenin Rattus norvegicus 44-47 21476213-8 2011 Tanshinone IIA also inhibited Ang II-increased ROS formation, and ERK phosphorylation. Reactive Oxygen Species 47-50 angiogenin Rattus norvegicus 30-33 21346392-8 2011 Nicorandil also inhibited Ang-II-increased ROS and ERK phosphorylation. Reactive Oxygen Species 43-46 angiogenin Rattus norvegicus 26-29 19246278-3 2009 RESULTS: Compared with the normal control cells, Ang II treatment of the cardiac fibroblasts resulted in significantly increased ROS production, the effect of which was inhibited by the application of APO. Reactive Oxygen Species 129-132 angiogenin Rattus norvegicus 49-52 25801006-6 2015 Ang-(1-9) treatment suppressed cardiac NADPH oxidase activity and reduced formation of reactive oxygen species. Reactive Oxygen Species 87-110 angiogenin Rattus norvegicus 0-8 24193198-5 2014 Additionally, Ang-(1-7) significantly suppressed the reactive oxygen species production in I/R, especially during the ischemic phase. Reactive Oxygen Species 53-76 angiogenin Rattus norvegicus 14-22 24108391-8 2014 Therefore, in the states of metabolic syndrome, ROS overproduction in mitochondrial complex I enhances Ang II-mediated vascular contraction via an AT1-dependent pathway. Reactive Oxygen Species 48-51 angiogenin Rattus norvegicus 103-106 23657856-2 2013 After binding to its receptor(s), ANG II generates reactive oxygen species (ROS) and produces Ca2+ influx into cells, leading to activation of a plethora of signaling cascades, including, e.g., calcineurin and small GTPases, such as Rac-1 and RhoA. Reactive Oxygen Species 51-74 angiogenin Rattus norvegicus 34-37 23657856-2 2013 After binding to its receptor(s), ANG II generates reactive oxygen species (ROS) and produces Ca2+ influx into cells, leading to activation of a plethora of signaling cascades, including, e.g., calcineurin and small GTPases, such as Rac-1 and RhoA. Reactive Oxygen Species 76-79 angiogenin Rattus norvegicus 34-37 23657856-10 2013 Our data suggest that cellular ROS generation and active Ca2+ signaling are involved in ANG II-induced increases in glomerular permeability. Reactive Oxygen Species 31-34 angiogenin Rattus norvegicus 88-91 18094033-2 2008 We have demonstrated that rats infused with ANG II manifest increased cortical cyclooxygenase (COX)-2 expression and activity via NADPH oxidase-derived reactive oxygen species (ROS). Reactive Oxygen Species 177-180 angiogenin Rattus norvegicus 44-47 17463319-11 2007 In summary, Ang II induced LCC alpha1C subunit expression via a protein kinase C-, reactive oxygen species-, and CREB-dependent pathway and was blocked by losartan and simvastatin. Reactive Oxygen Species 83-106 angiogenin Rattus norvegicus 12-15