PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18774957-9	2009	Knockdown of NPC1 mRNA both in normal fibroblasts and in human SH-SY5Y neuroblastoma cells caused increased ROS concentrations.	Reactive Oxygen Species	108-111	NPC intracellular cholesterol transporter 1	Homo sapiens	13-17	
18774957-10	2009	ALLO treatment of fibroblasts from NPC patients or NPC1 knockdown cells reduced the levels of ROS and lipid peroxidation and prevented peroxide-induced apoptosis and NF-kB activation.	Reactive Oxygen Species	94-97	NPC intracellular cholesterol transporter 1	Homo sapiens	51-55	
33924575-13	2021	As a site note, comparable NPC1-deficient cells suffer from a lack of catalase and display an increased level of ROS.	Reactive Oxygen Species	113-116	NPC intracellular cholesterol transporter 1	Homo sapiens	27-31	
33081384-10	2020	Higher ROS levels, as determined by DCF (dichlorodihydrofluorescein) fluorescence, indicated oxidative stress in all NPC1-deficient cell lines.	Reactive Oxygen Species	7-10	NPC intracellular cholesterol transporter 1	Homo sapiens	117-121	
33081384-14	2020	As catalase is a key enzyme of the cellular antioxidative defense system, we concluded that the lack of catalase contributes to the elevated ROS levels observed in NPC1-deficient cells.	Reactive Oxygen Species	141-144	NPC intracellular cholesterol transporter 1	Homo sapiens	164-168