PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29216908-10 2017 Detailed evaluation of the pyramidal motor system found a similar degree of neurodegeneration and TDP-43 pathology as in sALS and C9orf72+ cases; however, cases with TIA1 mutations had increased numbers of lower motor neurons containing round eosinophilic and Lewy body-like inclusions on HE stain and round compact cytoplasmic inclusions with TDP-43 immunohistochemistry. Helium 289-291 TIA1 cytotoxic granule associated RNA binding protein Homo sapiens 166-170