PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18544536-6	2008	Interestingly, two rexinoids, bexarotene (LGD1069/Targretin) and LG100268, caused a rapid and sustained decrease in the protein levels of both SXR and RXR.	rexinoids	19-28	nuclear receptor subfamily 1 group I member 2	Homo sapiens	143-146	
18544536-8	2008	Thus, we have demonstrated a novel, rexinoid-modulated mechanism regulating SXR protein stability, which may explain why rexinoids are only weak activators of SXR/RXR-mediated transcription, despite reports that they bind to SXR with high affinity.	rexinoids	121-130	nuclear receptor subfamily 1 group I member 2	Homo sapiens	76-79	
18544536-9	2008	We suggest that the ability of rexinoids to induce degradation of both SXR and RXR, in combination with competition for binding to SXR, can also explain why rexinoids antagonize the activation of SXR by drugs like rifampicin.	rexinoids	31-40	nuclear receptor subfamily 1 group I member 2	Homo sapiens	71-74	
18544536-9	2008	We suggest that the ability of rexinoids to induce degradation of both SXR and RXR, in combination with competition for binding to SXR, can also explain why rexinoids antagonize the activation of SXR by drugs like rifampicin.	rexinoids	157-166	nuclear receptor subfamily 1 group I member 2	Homo sapiens	71-74	
18544536-9	2008	We suggest that the ability of rexinoids to induce degradation of both SXR and RXR, in combination with competition for binding to SXR, can also explain why rexinoids antagonize the activation of SXR by drugs like rifampicin.	rexinoids	157-166	nuclear receptor subfamily 1 group I member 2	Homo sapiens	131-134	
18544536-9	2008	We suggest that the ability of rexinoids to induce degradation of both SXR and RXR, in combination with competition for binding to SXR, can also explain why rexinoids antagonize the activation of SXR by drugs like rifampicin.	rexinoids	157-166	nuclear receptor subfamily 1 group I member 2	Homo sapiens	131-134	
18544536-3	2008	We investigated the effect of RXR-selective ligands, rexinoids, on SXR/RXR activity.	rexinoids	53-62	nuclear receptor subfamily 1 group I member 2	Homo sapiens	67-70	
18544536-4	2008	In agreement with previous reports, we found that rexinoids are weak activators of SXR, but we also found that they can antagonize SXR activation by the potent SXR agonist rifampicin.	rexinoids	50-59	nuclear receptor subfamily 1 group I member 2	Homo sapiens	83-86	
18544536-4	2008	In agreement with previous reports, we found that rexinoids are weak activators of SXR, but we also found that they can antagonize SXR activation by the potent SXR agonist rifampicin.	rexinoids	50-59	nuclear receptor subfamily 1 group I member 2	Homo sapiens	131-134	
18544536-4	2008	In agreement with previous reports, we found that rexinoids are weak activators of SXR, but we also found that they can antagonize SXR activation by the potent SXR agonist rifampicin.	rexinoids	50-59	nuclear receptor subfamily 1 group I member 2	Homo sapiens	131-134