PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29695672-1 2018 The objective of this study was to evaluate the efficacy of a non-selective COX inhibitor (tolfenamic acid) and a selective COX-2 inhibitor (robenacoxib) for post-operative pain control in cats. robenacoxib 141-152 cytochrome c oxidase subunit II Felis catus 124-129 19161452-1 2009 This study investigated the analgesic, anti-inflammatory and antipyretic efficacy of the new COX-2 selective inhibitor robenacoxib in the cat and established pharmacodynamic (PD) parameters for these effects. robenacoxib 119-130 cytochrome c oxidase subunit II Felis catus 93-98 19161452-0 2009 Use of a pharmacokinetic/pharmacodynamic approach in the cat to determine a dosage regimen for the COX-2 selective drug robenacoxib. robenacoxib 120-131 cytochrome c oxidase subunit II Felis catus 99-104 35460083-4 2022 At registered dosages (2 mg/kg subcutaneously in dogs and cats, 1-4 mg/kg orally in dogs and 1-2.4 mg/kg orally in cats), robenacoxib produces significant inhibition of COX-2 whilst sparing COX-1. robenacoxib 122-133 cytochrome c oxidase subunit II Felis catus 169-174 21736587-1 2012 The safety of robenacoxib, a nonsteroidal anti-inflammatory drug with high selectivity for inhibition of the cyclooxygenase (COX)-2 isoform of COX, was investigated in the cat in two randomized, blinded, placebo-controlled, parallel-group studies. robenacoxib 14-25 cytochrome c oxidase subunit II Felis catus 109-131 24628410-13 2014 In vivo IC50 COX-1/IC50 COX-2 ratios were 66.9:1 for robenacoxib and 1:107 for S(+) ketoprofen. robenacoxib 53-64 cytochrome c oxidase subunit II Felis catus 24-29 21736587-5 2012 Pharmacokinetic-pharmacodynamic simulations indicated that all dosages of robenacoxib were associated with marked inhibition of COX-2 at peak effect (median I(max) 97.8-99.4% inhibition) with lesser inhibition of COX-1 (median I(max) 26.8-58.3% inhibition). robenacoxib 74-85 cytochrome c oxidase subunit II Felis catus 128-133 21767277-4 2012 A tissue cage model of acute inflammation was used to determine robenacoxib"s pharmacokinetics and its ex vivo and in vivo selectivity for COX-1 and COX-2 using serum TxB(2) and exudate PGE(2) as surrogate markers for enzyme activity, respectively. robenacoxib 64-75 cytochrome c oxidase subunit II Felis catus 149-154