PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35460083-4	2022	At registered dosages (2 mg/kg subcutaneously in dogs and cats, 1-4 mg/kg orally in dogs and 1-2.4 mg/kg orally in cats), robenacoxib produces significant inhibition of COX-2 whilst sparing COX-1.	robenacoxib	122-133	cytochrome c oxidase subunit I	Felis catus	190-195	
24628410-13	2014	In vivo IC50 COX-1/IC50 COX-2 ratios were 66.9:1 for robenacoxib and 1:107 for S(+) ketoprofen.	robenacoxib	53-64	cytochrome c oxidase subunit I	Felis catus	13-18	
21736587-5	2012	Pharmacokinetic-pharmacodynamic simulations indicated that all dosages of robenacoxib were associated with marked inhibition of COX-2 at peak effect (median I(max) 97.8-99.4% inhibition) with lesser inhibition of COX-1 (median I(max) 26.8-58.3% inhibition).	robenacoxib	74-85	cytochrome c oxidase subunit I	Felis catus	213-218	
21767277-4	2012	A tissue cage model of acute inflammation was used to determine robenacoxib"s pharmacokinetics and its ex vivo and in vivo selectivity for COX-1 and COX-2 using serum TxB(2) and exudate PGE(2) as surrogate markers for enzyme activity, respectively.	robenacoxib	64-75	cytochrome c oxidase subunit I	Felis catus	139-144	
21767277-7	2012	Robenacoxib inhibition of COX-1 in blood was transient, occurring only at high concentrations, but inhibition of COX-2 in exudate persisted to 24 h. The potency ratio (IC(50) COX-1: IC(50) COX-2) was 171:1, and slopes of the concentration-effect relationship were 1.36 and 1.12 for COX-1 and COX-2, respectively.	robenacoxib	0-11	cytochrome c oxidase subunit I	Felis catus	26-31	
21767277-7	2012	Robenacoxib inhibition of COX-1 in blood was transient, occurring only at high concentrations, but inhibition of COX-2 in exudate persisted to 24 h. The potency ratio (IC(50) COX-1: IC(50) COX-2) was 171:1, and slopes of the concentration-effect relationship were 1.36 and 1.12 for COX-1 and COX-2, respectively.	robenacoxib	0-11	cytochrome c oxidase subunit I	Felis catus	175-180	
21767277-7	2012	Robenacoxib inhibition of COX-1 in blood was transient, occurring only at high concentrations, but inhibition of COX-2 in exudate persisted to 24 h. The potency ratio (IC(50) COX-1: IC(50) COX-2) was 171:1, and slopes of the concentration-effect relationship were 1.36 and 1.12 for COX-1 and COX-2, respectively.	robenacoxib	0-11	cytochrome c oxidase subunit I	Felis catus	175-180