PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16340664-4	2006	Endothelin-1 in vitro can inhibit sodium or water transport in the collecting duct and thick ascending limb through autocrine pathways.	Sodium	34-40	endothelin 1	Mus musculus	0-12	
18391099-13	2008	These data demonstrate that collecting duct-derived endothelin-1 is important in the following: (1) chronic N(G)-nitro-l-arginine methyl ester-induced hypertension; (2) full expression of pressure-dependent changes in sodium excretion; and (3) control of inner medullary NOS1 and NOS3 activity.	Sodium	218-224	endothelin 1	Mus musculus	52-64	
16340664-7	2006	Mice with collecting duct-specific knockout of the endothelin-1 gene have impaired sodium excretion in response to sodium loading and have hypertension which worsens with high salt intake.	Sodium	83-89	endothelin 1	Mus musculus	51-63	
16340664-7	2006	Mice with collecting duct-specific knockout of the endothelin-1 gene have impaired sodium excretion in response to sodium loading and have hypertension which worsens with high salt intake.	Sodium	115-121	endothelin 1	Mus musculus	51-63	
16340664-11	2006	SUMMARY: Medullary endothelin-1 regulates renal sodium and water transport and medullary blood flow.	Sodium	48-54	endothelin 1	Mus musculus	19-31	
16340664-13	2006	Medullary endothelin-1 is fundamentally important in physiologic regulation of renal sodium and water excretion and maintenance of normal systemic blood pressure.	Sodium	85-91	endothelin 1	Mus musculus	10-22	
15314687-0	2004	Collecting duct-specific knockout of endothelin-1 causes hypertension and sodium retention.	Sodium	74-80	endothelin 1	Mus musculus	37-49	
28120456-7	2017	Because vitamin D-induced hypercalcaemia increases the renal expression of endothelin (ET)-1, we hypothesized that ET-1 mediates the effects of hypercalcaemia on renal sodium and water handling.	Sodium	168-174	endothelin 1	Mus musculus	75-92	
8770164-2	1996	It has been suggested that medullary ET-1 may affect water and sodium absorption along the collecting ducts in an autocrine fashion.	Sodium	63-69	endothelin 1	Mus musculus	37-41	
35129370-6	2022	The increased sodium retention is associated with altered expression of glucocorticoid and mineralocorticoid receptors, increased serum aldosterone, and increased medullary endothelin-1 compared to control (CNTL) mice.	Sodium	14-20	endothelin 1	Mus musculus	173-185	
26775567-2	2016	Paradoxically, aldosterone also induces transcription of the endothelin-1 (Edn1) gene to increase protein (ET-1) levels, which inhibits sodium reabsorption.	Sodium	136-142	endothelin 1	Mus musculus	61-73	
26775567-2	2016	Paradoxically, aldosterone also induces transcription of the endothelin-1 (Edn1) gene to increase protein (ET-1) levels, which inhibits sodium reabsorption.	Sodium	136-142	endothelin 1	Mus musculus	75-79	
26775567-2	2016	Paradoxically, aldosterone also induces transcription of the endothelin-1 (Edn1) gene to increase protein (ET-1) levels, which inhibits sodium reabsorption.	Sodium	136-142	endothelin 1	Mus musculus	107-111	
23160444-8	2013	SUMMARY: In the collecting duct, the ET1/nitric oxide pathways are intimately linked, and deletion of collecting duct ET1, ETB receptor or NOS1beta results in a salt-sensitive phenotype, which is at least partially dependent on dysregulation of sodium and water reabsorption.	Sodium	245-251	endothelin 1	Mus musculus	118-121	
23698114-0	2013	Endothelin-1 inhibits sodium reabsorption by ET(A) and ET(B) receptors in the mouse cortical collecting duct.	Sodium	22-28	endothelin 1	Mus musculus	0-12	
21918182-2	2012	Compromise of ET-1 signaling or ETB receptors in the CD cause sodium retention and increase blood pressure.	Sodium	62-68	endothelin 1	Mus musculus	14-18	
21893992-3	2011	A large number of in vitro studies have supported this notion of an autocrine function for ET-1, demonstrating that the peptide, largely through activation of the ET(B) receptor, inhibits both sodium (Na) and water reabsorption in the CD.	Sodium	193-199	endothelin 1	Mus musculus	91-95