PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2832471-0 1988 Haemodynamic, hormonal and renal effects of adrenocorticotrophic hormone in sodium-restricted man. Sodium 76-82 proopiomelanocortin Homo sapiens 44-72 9251765-2 1997 Intraperitoneal (ip) injection of alpha-MSH (3 and 9.6 nmol) induced a significant increase in urinary sodium, potassium and water excretion. Sodium 103-109 proopiomelanocortin Homo sapiens 34-43 8137388-2 1994 The fact that one of the breakdown products of the common precursor (proopiomelanocortin, POMC) ACTH and opioid peptides, i.e. ACTH 1-24 has a saluretic effect (balancing perhaps sodium retention after activation of the adrenal cortex) was not generally accepted yet although MSH as well as some fragments of the ACTH molecule have a natriuretic effect. Sodium 179-185 proopiomelanocortin Homo sapiens 90-94 8137388-2 1994 The fact that one of the breakdown products of the common precursor (proopiomelanocortin, POMC) ACTH and opioid peptides, i.e. ACTH 1-24 has a saluretic effect (balancing perhaps sodium retention after activation of the adrenal cortex) was not generally accepted yet although MSH as well as some fragments of the ACTH molecule have a natriuretic effect. Sodium 179-185 proopiomelanocortin Homo sapiens 96-100 8137388-2 1994 The fact that one of the breakdown products of the common precursor (proopiomelanocortin, POMC) ACTH and opioid peptides, i.e. ACTH 1-24 has a saluretic effect (balancing perhaps sodium retention after activation of the adrenal cortex) was not generally accepted yet although MSH as well as some fragments of the ACTH molecule have a natriuretic effect. Sodium 179-185 proopiomelanocortin Homo sapiens 127-131 8137388-2 1994 The fact that one of the breakdown products of the common precursor (proopiomelanocortin, POMC) ACTH and opioid peptides, i.e. ACTH 1-24 has a saluretic effect (balancing perhaps sodium retention after activation of the adrenal cortex) was not generally accepted yet although MSH as well as some fragments of the ACTH molecule have a natriuretic effect. Sodium 179-185 proopiomelanocortin Homo sapiens 276-279 8137388-2 1994 The fact that one of the breakdown products of the common precursor (proopiomelanocortin, POMC) ACTH and opioid peptides, i.e. ACTH 1-24 has a saluretic effect (balancing perhaps sodium retention after activation of the adrenal cortex) was not generally accepted yet although MSH as well as some fragments of the ACTH molecule have a natriuretic effect. Sodium 179-185 proopiomelanocortin Homo sapiens 127-131 1322161-0 1992 Low sodium intake enhances sensitivity of 11-deoxycortisol and deoxycorticosterone to ACTH in ACTH-suppressed normal subjects. Sodium 4-10 proopiomelanocortin Homo sapiens 86-90 1322161-0 1992 Low sodium intake enhances sensitivity of 11-deoxycortisol and deoxycorticosterone to ACTH in ACTH-suppressed normal subjects. Sodium 4-10 proopiomelanocortin Homo sapiens 94-98 1330385-1 1992 19-hydroxy-androstenedione (19-OH-A), a C19 steroid, is an amplifier of the sodium retaining action of aldosterone under the control of ACTH and renin-angiotensin system. Sodium 76-82 proopiomelanocortin Homo sapiens 136-140 7508015-7 1993 In rats, gamma-MSH-related peptides are involved in the reflex control of sodium excretion in situations such as the natriuresis that occurs (a) from the remaining kidney after acute unilateral nephrectomy, (b) from the contralateral kidney shortly after unilateral ureteral pressure elevation, and (c) after unilateral carotid artery traction. Sodium 74-80 proopiomelanocortin Homo sapiens 9-18 1321309-2 1992 Our experimental studies in normal subjects show that ACTH reproducibly increases blood pressure in association with a rise in cardiac output, plasma and extracellular fluid volumes and exchangeable sodium. Sodium 199-205 proopiomelanocortin Homo sapiens 54-58 2832471-1 1988 The effect of a dietary sodium restriction (15 mmol/day) on the development of adrenocorticotrophic hormone (ACTH) hypertension was examined in six normal male subjects. Sodium 24-30 proopiomelanocortin Homo sapiens 79-107 2832471-1 1988 The effect of a dietary sodium restriction (15 mmol/day) on the development of adrenocorticotrophic hormone (ACTH) hypertension was examined in six normal male subjects. Sodium 24-30 proopiomelanocortin Homo sapiens 109-113 2832471-2 1988 When ACTH (1 mg/day) was given for 5 days to subjects on a sodium-restricted diet, systolic blood pressure rose (116 +/- 4 to 125 +/- 4 mmHg, P less than 0.001), while diastolic blood pressure was unchanged. Sodium 59-65 proopiomelanocortin Homo sapiens 5-9 2822310-0 1987 Effect of sodium depletion on pressor responsiveness in ACTH-induced hypertension in man. Sodium 10-16 proopiomelanocortin Homo sapiens 56-60 6303639-2 1983 ACTH administration was associated with urinary sodium retention, hypokalaemia, elevation of fasting blood glucose, lymphopaenia and eosinopaenia. Sodium 48-54 proopiomelanocortin Homo sapiens 0-4 2992854-1 1985 ACTH 1 mg/day for 5 days raises systolic blood pressure (SBP) in normotensive and hypertensive subjects on a fixed electrolyte intake of 100 mmol/day sodium (Na) and potassium (K) (Whitworth et al. Sodium 150-156 proopiomelanocortin Homo sapiens 0-4 6323866-6 1984 In supine, sodium repleted states, ACTH is a potent stimulus of aldosterone at 000-0600 h and 1700-1900 h clocktime, whereas during daytime renin-angiotensin is an additional regulator. Sodium 11-17 proopiomelanocortin Homo sapiens 35-39 2982239-9 1985 However, the marked suppression of aldosterone secretion observed in sodium-replete individuals during prolonged ACTH treatment was not seen in this study. Sodium 69-75 proopiomelanocortin Homo sapiens 113-117 2982239-10 1985 Angiotensin II or a different factor associated with sodium depletion may, therefore, partly protect the zona glomerulosa from adverse effects of ACTH observed in the sodium-replete state. Sodium 53-59 proopiomelanocortin Homo sapiens 146-150 2982239-10 1985 Angiotensin II or a different factor associated with sodium depletion may, therefore, partly protect the zona glomerulosa from adverse effects of ACTH observed in the sodium-replete state. Sodium 167-173 proopiomelanocortin Homo sapiens 146-150 3001754-7 1985 The regulated release of gamma MSH peptides may contribute to CNS regulation of renal sodium excretion. Sodium 86-92 proopiomelanocortin Homo sapiens 25-34 6291809-1 1982 It is well established that the response of plasma aldosterone to ACTH is enhanced in the sodium depleted state. Sodium 90-96 proopiomelanocortin Homo sapiens 66-70 6321067-3 1984 In this context, it is potentially important that stress causing ACTH release, as well as other neurohumoral effects, causes increased salt appetite and can impair renal sodium excretion. Sodium 170-176 proopiomelanocortin Homo sapiens 65-69 6325055-2 1984 ACTH administration produced hypokalaemia, initial urinary sodium retention, a fall in active plasma renin concentration, a transient rise in plasma aldosterone concentration and sustained rises in plasma deoxycorticosterone concentration and urinary kallikrein activity. Sodium 59-65 proopiomelanocortin Homo sapiens 0-4 6285371-0 1982 Beta-endorphin: opiate receptor binding activities of six naturally occurring beta-endorphin homologs studied by using tritiated human hormone and naloxone as primary ligands--effects of sodium ion. Sodium 187-193 proopiomelanocortin Homo sapiens 0-14 6291809-11 1982 Thus, endogenous prostaglandins appear to be of far greater importance than the renin-angiotensin system in mediating the increased aldosterone response to ACTH administration during the sodium depleted state in man. Sodium 187-193 proopiomelanocortin Homo sapiens 156-160 6252230-1 1980 The role of the renin-angiotensin system in enhancing aldosterone responsiveness to ACTH during acute sodium depletion was studied in 14 healthy medical students. Sodium 102-108 proopiomelanocortin Homo sapiens 84-88 6266960-7 1981 Although the adrenal glomerulosa cells were markedly sensitive to ACTH during sodium deficiency, they remained almost totally refractory to AII since aldosterone secretion failed to increase significantly in response to continuous infusion of a pressor dose of AII for 1 hour. Sodium 78-84 proopiomelanocortin Homo sapiens 66-70 6266960-9 1981 These data demonstrate that some non-ACTH pituitary factor(s) is essential for a normal aldosterone response to ACTH, AII, and sodium deficiency. Sodium 127-133 proopiomelanocortin Homo sapiens 37-41 6254355-5 1980 Plasma ACTH concentrations were significantly higher in patients with sodium-losing CAH than in patients with non-sodium-losing CAH. Sodium 70-76 proopiomelanocortin Homo sapiens 7-11 6254355-5 1980 Plasma ACTH concentrations were significantly higher in patients with sodium-losing CAH than in patients with non-sodium-losing CAH. Sodium 114-120 proopiomelanocortin Homo sapiens 7-11 6254355-6 1980 These findings support the concepts that patients with the sodium-losing condition have a more severe enzyme deficiency and that ACTH stimulation may be affected by sodium balance. Sodium 165-171 proopiomelanocortin Homo sapiens 129-133 6252230-5 1980 The administration of ACTH, but not of vehicle, produced significant increases in plasma aldosterone in both control and acute sodium-depleted subjects. Sodium 127-133 proopiomelanocortin Homo sapiens 22-26 6252230-6 1980 However, the ACTH-induced increases in plasma aldosterone and their maximal net and percent increments during acute sodium depletion were significantly greater than control values. Sodium 116-122 proopiomelanocortin Homo sapiens 13-17 6252231-8 1980 The results demonstrate that in normal males on a sodium-restricted diet, baseline aldosterone levels are controlled in part by ACTH. Sodium 50-56 proopiomelanocortin Homo sapiens 128-132 6255463-3 1980 Scatchard analysis of the binding data shows heterogeneity of the binding sites that can be resolved into two populations with apparent dissociation constants of 3.0 (+/-2.0) X 10(-10) and 3.3 (+/- 0.5) X 10(-9) M. Sodium ions decrease the binding of human beta-endorphin to spinal cord to the same extent as found in rat brain. Sodium 215-221 proopiomelanocortin Homo sapiens 257-271 226768-8 1979 The effect of ACTH alone as compared to the effect of ACTH and indomethacin showed: plasma sodium concentration, 139 +/- 1 vs. 131 +/ 3 mEg/liter (P less than 0.01, mean +/- SEM); plasma osmolality, 287 +/- 3 vs. 270 +/- 3 mOsm/liter (P less than 0.01); free water clearance, 97 +/- 66 vs. -1100 +/- 380 ml/24hr (P less than 0.01); urine volume, 2,000 +/- 60 vs. 950 +/- 200 ml/day (P less than 0.01); and urine osmolality 282 +/- 12 vs. 720 +/- 144 mOsm/liter (P less than 0.01). Sodium 91-97 proopiomelanocortin Homo sapiens 14-18 218456-4 1979 Administration of adrenocorticotropic hormone (ACTH) to women during the third trimester of pregnancy was noted previously to result in marked sodium retention, while aldosterone excretion declined. Sodium 143-149 proopiomelanocortin Homo sapiens 18-45 218456-4 1979 Administration of adrenocorticotropic hormone (ACTH) to women during the third trimester of pregnancy was noted previously to result in marked sodium retention, while aldosterone excretion declined. Sodium 143-149 proopiomelanocortin Homo sapiens 47-51 218456-5 1979 Since urinary tetrahydrodesoxycorticosterone increased substantially, sodium retention resulting from ACTH was ascribed to enhanced DOC secretion. Sodium 70-76 proopiomelanocortin Homo sapiens 102-106 6249864-0 1980 Reduced aldosterone secretory response to acute ACTH stimulation in sodium-restricted elderly subjects. Sodium 68-74 proopiomelanocortin Homo sapiens 48-52 6243671-4 1980 ACTH infusion produced natriuresis, suggesting the need for additional sodium supplementation during the stress of illness, with a resultant increase in ACTH secretion. Sodium 71-77 proopiomelanocortin Homo sapiens 0-4 6243671-4 1980 ACTH infusion produced natriuresis, suggesting the need for additional sodium supplementation during the stress of illness, with a resultant increase in ACTH secretion. Sodium 71-77 proopiomelanocortin Homo sapiens 153-157 315865-7 1979 Changes in urinary excretion of sodium and potassium are considered to be consequence of direct renal action of MSH. Sodium 32-38 proopiomelanocortin Homo sapiens 112-115 226768-8 1979 The effect of ACTH alone as compared to the effect of ACTH and indomethacin showed: plasma sodium concentration, 139 +/- 1 vs. 131 +/ 3 mEg/liter (P less than 0.01, mean +/- SEM); plasma osmolality, 287 +/- 3 vs. 270 +/- 3 mOsm/liter (P less than 0.01); free water clearance, 97 +/- 66 vs. -1100 +/- 380 ml/24hr (P less than 0.01); urine volume, 2,000 +/- 60 vs. 950 +/- 200 ml/day (P less than 0.01); and urine osmolality 282 +/- 12 vs. 720 +/- 144 mOsm/liter (P less than 0.01). Sodium 91-97 proopiomelanocortin Homo sapiens 54-58 233670-1 1978 A study was performed to determine the possible role of angiotensin II (AII) in mediating the increased adrenal aldosterone response to infused alpha 1-24-ACTH, induced by sodium deprivation. Sodium 172-178 proopiomelanocortin Homo sapiens 155-159 221530-5 1979 ACTH induced sodium retention and weight gain. Sodium 13-19 proopiomelanocortin Homo sapiens 0-4 215819-12 1978 Although aldo and DOC and sodium retention may contribute to the ACTH induced blood pressure elevation, other factors must play a role. Sodium 26-32 proopiomelanocortin Homo sapiens 65-69 168714-9 1975 Our results indicate that in normal supine man the influence of ACTH and renin on PA may vary with different sodium intakes. Sodium 109-115 proopiomelanocortin Homo sapiens 64-68 168714-11 1975 When the secretion of ACTH is suppressed by dexamethasone, renin controls PA both under normal and low sodium intake. Sodium 103-109 proopiomelanocortin Homo sapiens 22-26 168229-1 1975 The brief (60-min) infusion of a small amount (1.25 mug) of ACTH into 7 normal subjects on an unrestricted sodium intake resulted in a vigorous plasma aldosterone response in each case. Sodium 107-113 proopiomelanocortin Homo sapiens 60-64 172003-3 1975 The sodium depletion induced by furosemide during continuous ACTH infusion increases plasma renin activity but does not change PA. Sodium 4-10 proopiomelanocortin Homo sapiens 61-65 4362400-0 1974 ACTH-induced sodium retention in pregnancy. Sodium 13-19 proopiomelanocortin Homo sapiens 0-4 233670-5 1978 ACTH infusion produced an increase in the plasma aldosterone concentration which was significantly greater during sodium restriction than when sodium intake was unlimited. Sodium 114-120 proopiomelanocortin Homo sapiens 0-4 233670-5 1978 ACTH infusion produced an increase in the plasma aldosterone concentration which was significantly greater during sodium restriction than when sodium intake was unlimited. Sodium 143-149 proopiomelanocortin Homo sapiens 0-4 4344726-6 1972 It therefore appears that ACTH and potassium stimulate steroidogenesis at an early step in the biosynthetic pathway through the activation of cyclic AMP, whereas the effect of angiotensins I and II involve another mechanism and decreased sodium concentration affects a later step in steroidogenesis. Sodium 238-244 proopiomelanocortin Homo sapiens 26-30 4336938-7 1972 Administration of mineralocorticoid or ACTH consistently caused sodium retention. Sodium 64-70 proopiomelanocortin Homo sapiens 39-43 14480554-0 1962 The effects of sodium, chloride, and calcium concentration on the response of melanophores to melanocyte-stimulating hormone (MSH). Sodium 15-21 proopiomelanocortin Homo sapiens 94-124 4299011-8 1968 This observation suggests that the hyper-aldosteronism is secondary to a tendency to sodium loss in the patient whose ACTH production is not suppressed. Sodium 85-91 proopiomelanocortin Homo sapiens 118-122 4288511-0 1966 [Sodium-potassium quotient during ACTH administration--a simple function test of the adrenal cortex]. Sodium 1-7 proopiomelanocortin Homo sapiens 34-38 14480554-0 1962 The effects of sodium, chloride, and calcium concentration on the response of melanophores to melanocyte-stimulating hormone (MSH). Sodium 15-21 proopiomelanocortin Homo sapiens 126-129 13448105-0 1957 [Study of clinical aspects and water, sodium and potassium excretion during treatment with ACTH, cortisone and related compounds]. Sodium 38-44 proopiomelanocortin Homo sapiens 91-95 13797479-0 1960 Urinary sodium retention after ACTH stimulation: a rapid, simple screening test for adrenal cortical insufficiency. Sodium 8-14 proopiomelanocortin Homo sapiens 31-35 13181026-0 1954 [Clinical study of renal tubular resorption of potassium and sodium under the action of ACTH and cortisone. Sodium 61-67 proopiomelanocortin Homo sapiens 88-92 13983844-0 1962 [Comparisons between sodium excretion in the ACTH-electrolyte test and eosinopenia after ACTH administration in rheumatics]. Sodium 21-27 proopiomelanocortin Homo sapiens 45-49 13016143-0 1952 The influence of ACTH on the sodium and potassium concentrations of human saliva. Sodium 29-35 proopiomelanocortin Homo sapiens 17-21 13035064-26 1953 In interpreting the experimental results on theoretical grounds, it is suggested (a) that in normal skin, it is the variation in the electric conductance in skin of chloride ions which essentially, although not exclusively, determines the rate of net uptake of sodium chloride, (b) that a factor in the ACTH preparation used, possibly ACTH itself, may have lowered the electric conductance in skin of sodium ions either truly or apparently, (c) that potassium ions are treated by the skin primarily as passive ions. Sodium 261-267 proopiomelanocortin Homo sapiens 303-307 13035064-26 1953 In interpreting the experimental results on theoretical grounds, it is suggested (a) that in normal skin, it is the variation in the electric conductance in skin of chloride ions which essentially, although not exclusively, determines the rate of net uptake of sodium chloride, (b) that a factor in the ACTH preparation used, possibly ACTH itself, may have lowered the electric conductance in skin of sodium ions either truly or apparently, (c) that potassium ions are treated by the skin primarily as passive ions. Sodium 261-267 proopiomelanocortin Homo sapiens 335-339 14917842-0 1952 The effect of ACTH and cortisone on the sodium and potassium levels of human saliva. Sodium 40-46 proopiomelanocortin Homo sapiens 14-18 14927720-0 1952 The influence of ACTH on the sodium and potassium concentration of human mixed saliva. Sodium 29-35 proopiomelanocortin Homo sapiens 17-21 15436808-0 1950 The effect of sodium intake on the action of ACTH in uncomplicated essential hypertension. Sodium 14-20 proopiomelanocortin Homo sapiens 45-49 30740300-7 2019 The present case of isolated ACTH deficiency was characterized by a slowly progressive decline in the serum sodium level, which became manifest well before appearance of any clinical symptoms, suggesting that the serum sodium level may be used to predict progression to isolated ACTH deficiency.Thus, not only serum sodium levels need to be monitored in patients suspected of having isolated ACTH deficiency, but ACTH and cortisol levels need to be monitored in those exhibiting a decline in serum sodium levels. Sodium 108-114 proopiomelanocortin Homo sapiens 29-33 14795066-0 1950 The effects of sodium and potassium on the metabolic and physiologic responses to ACTH. Sodium 15-21 proopiomelanocortin Homo sapiens 82-86 14795090-0 1950 The effect of ACTH on tubular reabsorption of sodium and potassium. Sodium 46-52 proopiomelanocortin Homo sapiens 14-18 13108985-0 1953 The prevention of ACTH-induced sodium retention by the use of potassium salts: a quantitative study. Sodium 31-37 proopiomelanocortin Homo sapiens 18-22 30740300-7 2019 The present case of isolated ACTH deficiency was characterized by a slowly progressive decline in the serum sodium level, which became manifest well before appearance of any clinical symptoms, suggesting that the serum sodium level may be used to predict progression to isolated ACTH deficiency.Thus, not only serum sodium levels need to be monitored in patients suspected of having isolated ACTH deficiency, but ACTH and cortisol levels need to be monitored in those exhibiting a decline in serum sodium levels. Sodium 219-225 proopiomelanocortin Homo sapiens 29-33 30740300-7 2019 The present case of isolated ACTH deficiency was characterized by a slowly progressive decline in the serum sodium level, which became manifest well before appearance of any clinical symptoms, suggesting that the serum sodium level may be used to predict progression to isolated ACTH deficiency.Thus, not only serum sodium levels need to be monitored in patients suspected of having isolated ACTH deficiency, but ACTH and cortisol levels need to be monitored in those exhibiting a decline in serum sodium levels. Sodium 219-225 proopiomelanocortin Homo sapiens 279-283 30740300-7 2019 The present case of isolated ACTH deficiency was characterized by a slowly progressive decline in the serum sodium level, which became manifest well before appearance of any clinical symptoms, suggesting that the serum sodium level may be used to predict progression to isolated ACTH deficiency.Thus, not only serum sodium levels need to be monitored in patients suspected of having isolated ACTH deficiency, but ACTH and cortisol levels need to be monitored in those exhibiting a decline in serum sodium levels. Sodium 219-225 proopiomelanocortin Homo sapiens 279-283 30740300-7 2019 The present case of isolated ACTH deficiency was characterized by a slowly progressive decline in the serum sodium level, which became manifest well before appearance of any clinical symptoms, suggesting that the serum sodium level may be used to predict progression to isolated ACTH deficiency.Thus, not only serum sodium levels need to be monitored in patients suspected of having isolated ACTH deficiency, but ACTH and cortisol levels need to be monitored in those exhibiting a decline in serum sodium levels. Sodium 219-225 proopiomelanocortin Homo sapiens 279-283 30740300-7 2019 The present case of isolated ACTH deficiency was characterized by a slowly progressive decline in the serum sodium level, which became manifest well before appearance of any clinical symptoms, suggesting that the serum sodium level may be used to predict progression to isolated ACTH deficiency.Thus, not only serum sodium levels need to be monitored in patients suspected of having isolated ACTH deficiency, but ACTH and cortisol levels need to be monitored in those exhibiting a decline in serum sodium levels. Sodium 219-225 proopiomelanocortin Homo sapiens 29-33 30740300-7 2019 The present case of isolated ACTH deficiency was characterized by a slowly progressive decline in the serum sodium level, which became manifest well before appearance of any clinical symptoms, suggesting that the serum sodium level may be used to predict progression to isolated ACTH deficiency.Thus, not only serum sodium levels need to be monitored in patients suspected of having isolated ACTH deficiency, but ACTH and cortisol levels need to be monitored in those exhibiting a decline in serum sodium levels. Sodium 219-225 proopiomelanocortin Homo sapiens 279-283 30740300-7 2019 The present case of isolated ACTH deficiency was characterized by a slowly progressive decline in the serum sodium level, which became manifest well before appearance of any clinical symptoms, suggesting that the serum sodium level may be used to predict progression to isolated ACTH deficiency.Thus, not only serum sodium levels need to be monitored in patients suspected of having isolated ACTH deficiency, but ACTH and cortisol levels need to be monitored in those exhibiting a decline in serum sodium levels. Sodium 219-225 proopiomelanocortin Homo sapiens 279-283 30740300-7 2019 The present case of isolated ACTH deficiency was characterized by a slowly progressive decline in the serum sodium level, which became manifest well before appearance of any clinical symptoms, suggesting that the serum sodium level may be used to predict progression to isolated ACTH deficiency.Thus, not only serum sodium levels need to be monitored in patients suspected of having isolated ACTH deficiency, but ACTH and cortisol levels need to be monitored in those exhibiting a decline in serum sodium levels. Sodium 219-225 proopiomelanocortin Homo sapiens 279-283 30740300-7 2019 The present case of isolated ACTH deficiency was characterized by a slowly progressive decline in the serum sodium level, which became manifest well before appearance of any clinical symptoms, suggesting that the serum sodium level may be used to predict progression to isolated ACTH deficiency.Thus, not only serum sodium levels need to be monitored in patients suspected of having isolated ACTH deficiency, but ACTH and cortisol levels need to be monitored in those exhibiting a decline in serum sodium levels. Sodium 219-225 proopiomelanocortin Homo sapiens 29-33 30740300-7 2019 The present case of isolated ACTH deficiency was characterized by a slowly progressive decline in the serum sodium level, which became manifest well before appearance of any clinical symptoms, suggesting that the serum sodium level may be used to predict progression to isolated ACTH deficiency.Thus, not only serum sodium levels need to be monitored in patients suspected of having isolated ACTH deficiency, but ACTH and cortisol levels need to be monitored in those exhibiting a decline in serum sodium levels. Sodium 219-225 proopiomelanocortin Homo sapiens 279-283 30740300-7 2019 The present case of isolated ACTH deficiency was characterized by a slowly progressive decline in the serum sodium level, which became manifest well before appearance of any clinical symptoms, suggesting that the serum sodium level may be used to predict progression to isolated ACTH deficiency.Thus, not only serum sodium levels need to be monitored in patients suspected of having isolated ACTH deficiency, but ACTH and cortisol levels need to be monitored in those exhibiting a decline in serum sodium levels. Sodium 219-225 proopiomelanocortin Homo sapiens 279-283 30740300-7 2019 The present case of isolated ACTH deficiency was characterized by a slowly progressive decline in the serum sodium level, which became manifest well before appearance of any clinical symptoms, suggesting that the serum sodium level may be used to predict progression to isolated ACTH deficiency.Thus, not only serum sodium levels need to be monitored in patients suspected of having isolated ACTH deficiency, but ACTH and cortisol levels need to be monitored in those exhibiting a decline in serum sodium levels. Sodium 219-225 proopiomelanocortin Homo sapiens 279-283 30498610-1 2018 We present a case of small-cell lung cancer (SCLC) with syndrome of inappropriate antidiuretic hormone secretion (SIADH) in which serum sodium gradually normalized with the onset of hypertension, refractory hypokalemia, and chloride-resistant metabolic alkalosis due to ectopic adrenocorticotrophic hormone (ACTH) secretion (EAS). Sodium 136-142 proopiomelanocortin Homo sapiens 308-312 29143051-0 2018 An open holey structure enhanced rate capability in a NaTi2(PO4)3/C nanocomposite and provided ultralong-life sodium-ion storage. Sodium 110-116 proopiomelanocortin Homo sapiens 54-67 29395172-1 2018 OBJECTIVES: To define the incidence and risk factors of postoperative sodium alterations in pediatric patients undergoing transsphenoidal surgery (TSS) for adrenocorticotropic hormone and growth hormone secreting pituitary adenomas. Sodium 70-76 proopiomelanocortin Homo sapiens 156-183 19635986-1 2009 Experiments in Cushing patients and healthy control subjects receiving adrenocorticotropic hormone (ACTH) indicate that transient renal sodium retention may contribute to the generation of hypertension. Sodium 136-142 proopiomelanocortin Homo sapiens 71-98 19635986-1 2009 Experiments in Cushing patients and healthy control subjects receiving adrenocorticotropic hormone (ACTH) indicate that transient renal sodium retention may contribute to the generation of hypertension. Sodium 136-142 proopiomelanocortin Homo sapiens 100-104 17418447-6 2007 SIADH in patients with ectopic ACTH syndrome may be underdiagnosed due to the antagonistic hormone actions of cortisol and ADH on renal sodium excretion. Sodium 136-142 proopiomelanocortin Homo sapiens 31-35 14761863-6 2004 In rodents, a high-sodium diet (HSD) increases the pituitary abundance of POMC mRNA and of gamma-MSH content and results in a doubling of plasma gamma-MSH concentration. Sodium 19-25 proopiomelanocortin Homo sapiens 74-78 14761863-6 2004 In rodents, a high-sodium diet (HSD) increases the pituitary abundance of POMC mRNA and of gamma-MSH content and results in a doubling of plasma gamma-MSH concentration. Sodium 19-25 proopiomelanocortin Homo sapiens 91-100 14761863-6 2004 In rodents, a high-sodium diet (HSD) increases the pituitary abundance of POMC mRNA and of gamma-MSH content and results in a doubling of plasma gamma-MSH concentration. Sodium 19-25 proopiomelanocortin Homo sapiens 145-154