PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28760780-7 2017 In contrast, NS309 sits more "forward" and directly hydrogen bonds with R362 in KCa3.1. 6,7-dichloro-1H-indole-2,3-dione 3-oxime 13-18 potassium calcium-activated channel subfamily N member 4 Homo sapiens 80-86 27470924-3 2016 The channel expression was demonstrated as a significant increase in the voltage-independent current by NS309, a KCa 3.1/KCa 2 activator, followed by full inhibition upon co-application with NS6180, a highly selective KCa 3.1 inhibitor. 6,7-dichloro-1H-indole-2,3-dione 3-oxime 104-109 potassium calcium-activated channel subfamily N member 4 Homo sapiens 113-120 27470924-3 2016 The channel expression was demonstrated as a significant increase in the voltage-independent current by NS309, a KCa 3.1/KCa 2 activator, followed by full inhibition upon co-application with NS6180, a highly selective KCa 3.1 inhibitor. 6,7-dichloro-1H-indole-2,3-dione 3-oxime 104-109 potassium calcium-activated channel subfamily N member 4 Homo sapiens 218-225 34468723-7 2021 With the compound NS309, we mimic a gain-of-function mutation of KCa3.1. 6,7-dichloro-1H-indole-2,3-dione 3-oxime 18-23 potassium calcium-activated channel subfamily N member 4 Homo sapiens 65-71 31415760-5 2019 KCa2.3-mediated vasodilatation responses to acetylcholine and NS309 (agonist of KCa2.3 and KCa3.1) were impaired by incubation of normal mesenteric arteries with 100 muM PA for 24 h. In cultured human umbilical vein endothelial cells (HUVECs), PA decreased KCa2.3 current and expression at mRNA and protein levels. 6,7-dichloro-1H-indole-2,3-dione 3-oxime 62-67 potassium calcium-activated channel subfamily N member 4 Homo sapiens 91-97