PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7592579-1 1995 We demonstrate here that RNA levels of 25-hydroxy-vitamin D3-24-hydroxylase (24-(OH)ase), a key catabolic enzyme for 1,25-dihydroxyvitamin D3, are increased by a highly selective retinoid X receptor (RXR) ligand, LG100268, in mice within hours. LG 100268 213-221 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 50-75 7592579-1 1995 We demonstrate here that RNA levels of 25-hydroxy-vitamin D3-24-hydroxylase (24-(OH)ase), a key catabolic enzyme for 1,25-dihydroxyvitamin D3, are increased by a highly selective retinoid X receptor (RXR) ligand, LG100268, in mice within hours. LG 100268 213-221 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 77-87 7592579-4 1995 Additionally, we show that LG100268 stimulates transcription of a luciferase reporter plasmid driven by 24-(OH)ase promoter sequences in the presence of RXR in CV-1 cell cotransactivation assays. LG 100268 27-35 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 104-114