PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15021987-9 2005 There was also a positive correlation between the level of iNOS expression and the extent of 3-NT formation. 3-nitrotyrosine 93-97 nitric oxide synthase 2 Homo sapiens 59-63 15331549-6 2004 As compared with nondiabetic specimens, diabetic specimens showed higher levels of both iNOS mRNA and protein levels (P < 0.001) associated with the highest tissue levels of nitrotyrosine and O(2)(-) (P < 0.001). 3-nitrotyrosine 177-190 nitric oxide synthase 2 Homo sapiens 88-92 12849870-7 2003 Inducible nitric oxide synthase (iNOS) protein expression was assessed using Western blot and 3 nitrotyrosine (3NTYR) by reversed phase high performance liquid chromatography (RP HPLC). 3-nitrotyrosine 94-109 nitric oxide synthase 2 Homo sapiens 33-37 15366433-6 2004 RESULTS: iNOS immunostaining correlated significantly with nitrotyrosine formation (r = 0.86, p < 0.001). 3-nitrotyrosine 59-72 nitric oxide synthase 2 Homo sapiens 9-13 15366433-11 2004 CONCLUSIONS: In heart failure, iNOS protein expression is associated with nitrotyrosine formation. 3-nitrotyrosine 74-87 nitric oxide synthase 2 Homo sapiens 31-35 15145615-7 2004 The markers for myelin damage, nitrotyrosine (an index of iNOS mediated damage via peroxynitrite formation), along with MBP fragments, were also observed associated with iNOS in MS plaques. 3-nitrotyrosine 31-44 nitric oxide synthase 2 Homo sapiens 58-62 15145615-7 2004 The markers for myelin damage, nitrotyrosine (an index of iNOS mediated damage via peroxynitrite formation), along with MBP fragments, were also observed associated with iNOS in MS plaques. 3-nitrotyrosine 31-44 nitric oxide synthase 2 Homo sapiens 170-174 12200641-11 2002 CONCLUSION: Cox-2 and iNOS are co-expressed in hibernating myocardium with nitrotyrosine suggesting nitric oxide production and peroxynitrite formation. 3-nitrotyrosine 75-88 nitric oxide synthase 2 Homo sapiens 22-26 12384247-8 2002 In addition, double immunolabeling studies revealed that in these glial cells iNOS and eNOS are co-localized with nitrotyrosine. 3-nitrotyrosine 114-127 nitric oxide synthase 2 Homo sapiens 78-82 12200641-0 2002 Immunocytochemical evidence for inducible nitric oxide synthase and cyclooxygenase-2 expression with nitrotyrosine formation in human hibernating myocardium. 3-nitrotyrosine 101-114 nitric oxide synthase 2 Homo sapiens 32-63 12134039-7 2002 In a murine (Mus musculus) model of HCPS (infection of NZB/BLNJ mice with lymphocytic choriomeningitis virus clone 13), HCPS-like disease was associated with elevated expression of iNOS in the lungs and NT formation in plasma, cardiac tissue, and the lungs. 3-nitrotyrosine 203-205 nitric oxide synthase 2 Homo sapiens 181-185 12235514-12 2002 Further, a higher iNOS score correlated with a higher 3-NT accumulation. 3-nitrotyrosine 54-58 nitric oxide synthase 2 Homo sapiens 18-22 11948371-4 2002 Evidence suggests that sustained upregulation of the inducible isoform of nitric oxide synthase (NOS-2) co-localizes with enterocyte apoptosis and immunoreactivity to 3-nitrotyrosine, the footprint of peroxynitrite (ONOO-), a potent oxidant formed by the reaction of nitric oxide (NO) with superoxide. 3-nitrotyrosine 167-182 nitric oxide synthase 2 Homo sapiens 97-102 10690346-2 1999 The aim of the present study was to examine the topographical and cellular distribution of inducible nitric oxide synthase (iNOS or NOS II) within different stages of atherosclerosis and its colocalization with ceroid deposits and nitrotyrosine. 3-nitrotyrosine 231-244 nitric oxide synthase 2 Homo sapiens 124-128 11500085-7 2001 In addition, CD23 antigen was co-localized with iNOS and nitrotyrosine on brain tissue from patients with HIV1-related encephalitis, suggesting that CD23 participates in iNOS activation of astrocytes in vivo. 3-nitrotyrosine 57-70 nitric oxide synthase 2 Homo sapiens 170-174 10767722-12 2000 The intensity of immunoreactivity for nitrotyrosine corresponded to that of iNOS. 3-nitrotyrosine 38-51 nitric oxide synthase 2 Homo sapiens 76-80 12123211-12 2002 In summary, we found a marked interstitial increase in iNOS protein expression together with a decrease in glomerular eNOS expression in CRTF patients, associated with a significant increment in ROS and nitrotyrosine-positive cells in the interstitium. 3-nitrotyrosine 203-216 nitric oxide synthase 2 Homo sapiens 55-59 11112156-9 2000 (3) NOS2 expression in skeletal myocytes was strongly co-localized with nitrotyrosine, revealing muscular peroxynitrite generation during the septic process, before the muscle was biopsied. 3-nitrotyrosine 72-85 nitric oxide synthase 2 Homo sapiens 4-8 10791101-7 1999 Further, the immunohistochemical study indicates that iNOS, located mainly in vascular cells, is predominantly responsible for nitrotyrosine production. 3-nitrotyrosine 127-140 nitric oxide synthase 2 Homo sapiens 54-58 10547586-8 1999 By contrast, iNOS staining increased with the grade of skin lesion, a pattern paralleled by endothelial nitrotyrosine expression. 3-nitrotyrosine 104-117 nitric oxide synthase 2 Homo sapiens 13-17 9916929-6 1999 Use of an anti-nitrotyrosine antibody, recognizing nitrosilated amino acid residues derived from nitric oxide production, revealed a consistent positivity within the cells expressing iNOS, thus suggesting that iNOS is functionally active. 3-nitrotyrosine 15-28 nitric oxide synthase 2 Homo sapiens 183-187 10389926-11 1999 The expression of iNOS and nitrotyrosine in the gastric mucosa was significantly higher in H. pylori-positive groups A and B than in H. pylori-negative group C. Among the H. pylori-positive patients, the expression of iNOS and nitrotyrosine was significantly higher in group A than in group B. 3-nitrotyrosine 227-240 nitric oxide synthase 2 Homo sapiens 18-22 10389926-11 1999 The expression of iNOS and nitrotyrosine in the gastric mucosa was significantly higher in H. pylori-positive groups A and B than in H. pylori-negative group C. Among the H. pylori-positive patients, the expression of iNOS and nitrotyrosine was significantly higher in group A than in group B. 3-nitrotyrosine 227-240 nitric oxide synthase 2 Homo sapiens 218-222 10090667-7 1999 iNOS-positive cells also were immunoreactive for nitrotyrosine, reflecting protein nitration by NO-derived peroxynitrite and nitrites. 3-nitrotyrosine 49-62 nitric oxide synthase 2 Homo sapiens 0-4 10341846-10 1999 The expression of iNOS was associated with the presence of nitrotyrosine residues, a marker of peroxynitrite formation. 3-nitrotyrosine 59-72 nitric oxide synthase 2 Homo sapiens 18-22 9916929-6 1999 Use of an anti-nitrotyrosine antibody, recognizing nitrosilated amino acid residues derived from nitric oxide production, revealed a consistent positivity within the cells expressing iNOS, thus suggesting that iNOS is functionally active. 3-nitrotyrosine 15-28 nitric oxide synthase 2 Homo sapiens 210-214 8831582-6 1996 Nitrotyrosine labeling was also observed in the inflamed colonic epithelium and was associated with nearby iNOS staining; nitrotyrosine was undetectable in normal mucosal epithelium. 3-nitrotyrosine 0-13 nitric oxide synthase 2 Homo sapiens 107-111 9251676-7 1997 In addition, nitrotyrosine staining was detected in the enterocytes of celiac disease patients and was associated with iNOS staining. 3-nitrotyrosine 13-26 nitric oxide synthase 2 Homo sapiens 119-123 9665945-7 1998 Immunohistochemical staining of acute-MS lesions with an antibody to nitrotyrosine revealed codistribution of iNOS- and nitrotyrosine-positive cells, although nitrotyrosine staining was more widespread in cells of the monocyte/macrophage lineage. 3-nitrotyrosine 69-82 nitric oxide synthase 2 Homo sapiens 110-114 9639378-11 1998 Nitrotyrosine immunoreactivity colocalized with iNOS expression in arteries with TCAD, distributed in macrophages and smooth muscle cells. 3-nitrotyrosine 0-13 nitric oxide synthase 2 Homo sapiens 48-52 9539092-9 1998 iNOS immunoreactivity was strongest in macrophages and adjacent myocytes, which also showed high levels of nitrotyrosine, representing damage by peroxynitrite. 3-nitrotyrosine 107-120 nitric oxide synthase 2 Homo sapiens 0-4 9443414-13 1998 However, only a subset of the NOS2-expressing TMCs stained positively for 3-nitrotyrosine, which is a marker for peroxynitrite formation. 3-nitrotyrosine 74-89 nitric oxide synthase 2 Homo sapiens 30-34 25989960-6 1998 Degenerating myocytes in that area in all of that group showing positive staining for iNOS were also stained positive for anti-nitrotyrosine antibody selfsame. 3-nitrotyrosine 127-140 nitric oxide synthase 2 Homo sapiens 86-90 25564962-10 2015 Moreover, the activity of nitrotyrosine was significantly correlated with iNOS immunoreactivity (R-Spearman of 0.5, p=0.0001). 3-nitrotyrosine 26-39 nitric oxide synthase 2 Homo sapiens 74-78 30233382-17 2018 Nitrotyrosine, a marker recognized as a hallmark of inflammation, especially when seen in association with an upregulation of iNOS, was detected in the epithelial and stromal cells in addition to VECs in MD. 3-nitrotyrosine 0-13 nitric oxide synthase 2 Homo sapiens 126-130 27495376-8 2016 In addition, clear upregulated expression of the inducible NO synthase (iNOS) with high nitrite levels were observed in RTT fibroblasts, justifying the increased nitrotyrosine protein modifications. 3-nitrotyrosine 162-175 nitric oxide synthase 2 Homo sapiens 49-70 27495376-8 2016 In addition, clear upregulated expression of the inducible NO synthase (iNOS) with high nitrite levels were observed in RTT fibroblasts, justifying the increased nitrotyrosine protein modifications. 3-nitrotyrosine 162-175 nitric oxide synthase 2 Homo sapiens 72-76 19628975-6 2009 Although nitric oxide (NO) hyperproduction due to inducible NO synthase (iNOS) is observed in asthma and COPD, nitrotyrosine formation via the reaction between NO and O(2)- in addition to the myeloperoxidase-mediated pathway. 3-nitrotyrosine 111-124 nitric oxide synthase 2 Homo sapiens 73-77 22417974-6 2012 Analysis of human biopsies of colitis and colon cancer using immunohistochemistry revealed elevated iNOS protein expression levels, which were strongly paralleled by increased expression of nitrotyrosine suggesting that iNOS has been highly activated in these tissues. 3-nitrotyrosine 190-203 nitric oxide synthase 2 Homo sapiens 220-224 22092728-10 2012 Only iNOS protein predicted NT levels (r = 0.48, P = 0.003) with the strongest relationship in severe asthma (r = 0.61, P = 0.009). 3-nitrotyrosine 28-30 nitric oxide synthase 2 Homo sapiens 5-9 19443526-6 2009 3-Nitrotyrosine significantly inhibited gel contraction (p<0.01) compared with control and this inhibition was abolished by nitric oxide synthase (NOS) inhibitor. 3-nitrotyrosine 0-15 nitric oxide synthase 2 Homo sapiens 127-148 16718354-3 2006 To address this issue, we examined skeletal muscles of DMD and BMD patients for co-expression of NO synthase (NOS) with nitrotyrosine and transcription factor CREB, as well as with enzymes engaged in NO signaling. 3-nitrotyrosine 120-133 nitric oxide synthase 2 Homo sapiens 97-108 18472017-3 2008 The expression of iNOS in patient tumors was found to associate with nitrotyrosine, COX2, pSTAT3, and arginase. 3-nitrotyrosine 69-82 nitric oxide synthase 2 Homo sapiens 18-22 18296660-12 2008 CONCLUSIONS: The increased expression and activity of iNOS in the TM of patients with POAG are proportional to the visual field defect and could lead to the increased of nitrotyrosine levels which may serve as marker of oxidative stress in the progression of cell death of the TM in POAG. 3-nitrotyrosine 170-183 nitric oxide synthase 2 Homo sapiens 54-58 16983333-4 2007 Analysing prostate cancer biopsies by immunohistochemistry we found iNOS protein expression in tumor cells strongly paralleled by nitrotyrosine suggesting that iNOS is fully active. 3-nitrotyrosine 130-143 nitric oxide synthase 2 Homo sapiens 68-72 16983333-4 2007 Analysing prostate cancer biopsies by immunohistochemistry we found iNOS protein expression in tumor cells strongly paralleled by nitrotyrosine suggesting that iNOS is fully active. 3-nitrotyrosine 130-143 nitric oxide synthase 2 Homo sapiens 160-164