PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2795009-3 1989 This enzymatic increase was (a) transient (occurring between 24 and 60 h) and accompanied by declines in all other identifiable AChE isoforms; (b) observed after concurrent denervation and inactivation of the enzyme with diisopropylfluorophosphate, but not following treatment with cycloheximide; and (c) more prominent in the extracellular compartment of muscle endplate regions. Isoflurophate 221-247 acetylcholinesterase Rattus norvegicus 128-132 3603567-0 1987 Differences in central and peripheral neural actions between soman and diisopropyl fluorophosphate, organophosphorus inhibitors of acetylcholinesterase. Isoflurophate 71-98 acetylcholinesterase Rattus norvegicus 131-151 2587621-0 1989 In vitro and in vivo action of diisopropylfluorophosphate, of atropine and their synergism on acetylcholinesterase activity. Isoflurophate 31-57 acetylcholinesterase Rattus norvegicus 94-114 2587621-1 1989 Modifications of acetylcholinesterase (AChE) activity, caused by diisopropylfluorophosphate (DFP) and atropine and their synergism, were determined in vitro and in vivo in the rat. Isoflurophate 65-91 acetylcholinesterase Rattus norvegicus 17-37 2587621-1 1989 Modifications of acetylcholinesterase (AChE) activity, caused by diisopropylfluorophosphate (DFP) and atropine and their synergism, were determined in vitro and in vivo in the rat. Isoflurophate 65-91 acetylcholinesterase Rattus norvegicus 39-43 2587621-1 1989 Modifications of acetylcholinesterase (AChE) activity, caused by diisopropylfluorophosphate (DFP) and atropine and their synergism, were determined in vitro and in vivo in the rat. Isoflurophate 93-96 acetylcholinesterase Rattus norvegicus 17-37 2587621-1 1989 Modifications of acetylcholinesterase (AChE) activity, caused by diisopropylfluorophosphate (DFP) and atropine and their synergism, were determined in vitro and in vivo in the rat. Isoflurophate 93-96 acetylcholinesterase Rattus norvegicus 39-43 2726774-0 1989 Effect of glycyl-L-glutamine on the rate of regeneration of acetylcholinesterase in the rat gastrocnemius muscle after diisopropyl phosphorofluoridate administration. Isoflurophate 119-150 acetylcholinesterase Rattus norvegicus 60-80 2726774-2 1989 The infusion of 1.2 mumol of Gly-Gln per 24 hr resulted in a significant increase in the acetylcholinesterase (AcChoEase; acetylcholine acetylhydrolase, EC 3.1.1.7) activity of the gastrocnemius muscles over that of rats that received DFP only. Isoflurophate 235-238 acetylcholinesterase Rattus norvegicus 89-109 2726774-2 1989 The infusion of 1.2 mumol of Gly-Gln per 24 hr resulted in a significant increase in the acetylcholinesterase (AcChoEase; acetylcholine acetylhydrolase, EC 3.1.1.7) activity of the gastrocnemius muscles over that of rats that received DFP only. Isoflurophate 235-238 acetylcholinesterase Rattus norvegicus 111-120 2496574-0 1989 Differences in response of acetylcholinesterase to diisopropylfluorophosphate in the mesencephalic raphe region. Isoflurophate 51-77 acetylcholinesterase Rattus norvegicus 27-47 3746405-5 1986 Furthermore, in the same nuclei, they reduced the number of cell bodies positively stained for AChE after pretreatment with diisopropylfluorophosphate (a method known to result in reliable identification of cholinergic neurons in the septal area). Isoflurophate 124-150 acetylcholinesterase Rattus norvegicus 95-99 3584552-1 1987 To identify and describe neurons in neostriatal transplants that synthesize acetylcholinesterase (AChE), the present study has utilized the irreversible AChE inhibitor diisopropylfluorophosphate (DFP) combined with AChE histochemistry. Isoflurophate 168-194 acetylcholinesterase Rattus norvegicus 153-157 3584552-1 1987 To identify and describe neurons in neostriatal transplants that synthesize acetylcholinesterase (AChE), the present study has utilized the irreversible AChE inhibitor diisopropylfluorophosphate (DFP) combined with AChE histochemistry. Isoflurophate 168-194 acetylcholinesterase Rattus norvegicus 153-157 3584552-1 1987 To identify and describe neurons in neostriatal transplants that synthesize acetylcholinesterase (AChE), the present study has utilized the irreversible AChE inhibitor diisopropylfluorophosphate (DFP) combined with AChE histochemistry. Isoflurophate 196-199 acetylcholinesterase Rattus norvegicus 76-96 3574585-0 1987 Intracellular distribution of molecular forms of acetylcholinesterase in rat brain and changes after diisopropylfluorophosphate treatment. Isoflurophate 101-127 acetylcholinesterase Rattus norvegicus 49-69 3574585-6 1987 After diisopropylfluorophosphate administration the recovery of acetylcholinesterase molecular forms in various subcellular fractions differed at different recovery periods. Isoflurophate 6-32 acetylcholinesterase Rattus norvegicus 64-84 3441321-1 1987 DFP, an irreversible acetylcholinesterase inhibitor, markedly increases spontaneous unit activity and reduces light-evoked responses in the superficial layers of the rat superior colliculus (Cheney et al., 1987). Isoflurophate 0-3 acetylcholinesterase Rattus norvegicus 21-41 3561766-1 1987 The organophosphates, diisopropyl phosphorofluoridate and soman have a common mechanism of action (inhibition of acetylcholinesterase), but result in very different behavioral responses in the rat. Isoflurophate 22-53 acetylcholinesterase Rattus norvegicus 113-133 3726874-1 1986 Diisopropylphosphorofluoridate (DFP), an irreversible inhibitor of acetylcholinesterase (AChE) activity, when given as an acute dose (1.5 mg/kg, sc) caused fasciculations and induced necrosis in rat skeletal muscle fibers. Isoflurophate 0-30 acetylcholinesterase Rattus norvegicus 89-93 3726874-1 1986 Diisopropylphosphorofluoridate (DFP), an irreversible inhibitor of acetylcholinesterase (AChE) activity, when given as an acute dose (1.5 mg/kg, sc) caused fasciculations and induced necrosis in rat skeletal muscle fibers. Isoflurophate 32-35 acetylcholinesterase Rattus norvegicus 89-93 4010469-5 1985 injection of either soman (10-40 micrograms/kg), neostigmine (75 micrograms/kg) or DFP (350 micrograms/kg) caused marked suppression of behavior and AChE activity of the gut, without affecting brain AChE. Isoflurophate 83-86 acetylcholinesterase Rattus norvegicus 149-153 4092885-1 1985 Rats treated daily with diisopropylfluorophosphate (DFP) (0.5 mg/kg, sc), an inhibitor of acetylcholinesterase (AChE) activity, exhibited the symptoms of cholinergic hyperactivity between Days 3 and 5 similar to those observed 15 min after a single acute dosage (1.5 mg/kg, sc). Isoflurophate 24-50 acetylcholinesterase Rattus norvegicus 112-116 4092885-1 1985 Rats treated daily with diisopropylfluorophosphate (DFP) (0.5 mg/kg, sc), an inhibitor of acetylcholinesterase (AChE) activity, exhibited the symptoms of cholinergic hyperactivity between Days 3 and 5 similar to those observed 15 min after a single acute dosage (1.5 mg/kg, sc). Isoflurophate 52-55 acetylcholinesterase Rattus norvegicus 112-116 2419522-3 1985 Echothiophate (poorly lipid soluble) drastically reduced only extracellular AChE activity, whereas sequential treatment with BW284C51 (poorly lipid soluble) and diisopropylfluorophosphate (lipid soluble) primarily eliminated intracellular AChE. Isoflurophate 161-187 acetylcholinesterase Rattus norvegicus 239-243 4010469-5 1985 injection of either soman (10-40 micrograms/kg), neostigmine (75 micrograms/kg) or DFP (350 micrograms/kg) caused marked suppression of behavior and AChE activity of the gut, without affecting brain AChE. Isoflurophate 83-86 acetylcholinesterase Rattus norvegicus 199-203 4010469-7 1985 Injection of DFP, 500 micrograms/kg, s.c., inhibited AChE in both the brain and gut. Isoflurophate 13-16 acetylcholinesterase Rattus norvegicus 53-57 6152405-5 1984 Dose-dependent depression of synaptic transmission in soman also occurred after pretreatment with the irreversible AChE inhibitor diisopropylphosphofluoridate (DFP; 100 microM), which inhibited greater than 98% of the AChE activity in the ganglia. Isoflurophate 130-158 acetylcholinesterase Rattus norvegicus 115-119 6152405-5 1984 Dose-dependent depression of synaptic transmission in soman also occurred after pretreatment with the irreversible AChE inhibitor diisopropylphosphofluoridate (DFP; 100 microM), which inhibited greater than 98% of the AChE activity in the ganglia. Isoflurophate 130-158 acetylcholinesterase Rattus norvegicus 218-222 6152405-5 1984 Dose-dependent depression of synaptic transmission in soman also occurred after pretreatment with the irreversible AChE inhibitor diisopropylphosphofluoridate (DFP; 100 microM), which inhibited greater than 98% of the AChE activity in the ganglia. Isoflurophate 160-163 acetylcholinesterase Rattus norvegicus 115-119 6152405-5 1984 Dose-dependent depression of synaptic transmission in soman also occurred after pretreatment with the irreversible AChE inhibitor diisopropylphosphofluoridate (DFP; 100 microM), which inhibited greater than 98% of the AChE activity in the ganglia. Isoflurophate 160-163 acetylcholinesterase Rattus norvegicus 218-222 6521855-1 1984 The time course of the effects of the topical administration of 1 microgram of diisopropylfluorophosphate (DFP) onto the cornea of the rat on the function of the iris and the biochemistry of acetylcholine (ACh) was followed for 6 hr after the acute inhibition of acetylcholinesterase (AChE) in the iris. Isoflurophate 107-110 acetylcholinesterase Rattus norvegicus 263-283 6521855-1 1984 The time course of the effects of the topical administration of 1 microgram of diisopropylfluorophosphate (DFP) onto the cornea of the rat on the function of the iris and the biochemistry of acetylcholine (ACh) was followed for 6 hr after the acute inhibition of acetylcholinesterase (AChE) in the iris. Isoflurophate 107-110 acetylcholinesterase Rattus norvegicus 285-289 6177182-1 1981 The AChE activity was demonstrated in some brain regions of adult rats after intoxication with DFP ( (di-isopropyl-fluorophosphate). Isoflurophate 95-98 acetylcholinesterase Rattus norvegicus 4-8 6142926-1 1984 Chronic inhibition of acetylcholinesterase activity by treatment with diisopropylfluorophosphate (DFP) decreased the capacity of acetylcholine (ACh) acting at a muscarinic receptor to inhibit basal adenylate cyclase activity in homogenates from rat striatum. Isoflurophate 70-96 acetylcholinesterase Rattus norvegicus 22-42 6142926-1 1984 Chronic inhibition of acetylcholinesterase activity by treatment with diisopropylfluorophosphate (DFP) decreased the capacity of acetylcholine (ACh) acting at a muscarinic receptor to inhibit basal adenylate cyclase activity in homogenates from rat striatum. Isoflurophate 98-101 acetylcholinesterase Rattus norvegicus 22-42 7116156-1 1982 Systemic injection of the acetylcholinesterase inhibitor, di-isopropylfluorophosphate, in rats causes a marked increase in glucose use in the superficial layers of the superior colliculus. Isoflurophate 58-85 acetylcholinesterase Rattus norvegicus 26-46 7131594-3 1982 Intraocular injection of kainic acid prevented the increase in the stratum griseum superficialis activity typically produced by systemic injection of the acetylcholinesterase inhibitor diisopropylfluorophosphate (DFP). Isoflurophate 185-211 acetylcholinesterase Rattus norvegicus 154-174 7131594-3 1982 Intraocular injection of kainic acid prevented the increase in the stratum griseum superficialis activity typically produced by systemic injection of the acetylcholinesterase inhibitor diisopropylfluorophosphate (DFP). Isoflurophate 213-216 acetylcholinesterase Rattus norvegicus 154-174 6480897-2 1984 Neurons with overlapping distribution synthesize acetylcholinesterase (AChE) as shown histochemically after systemic administration of diisopropylfluorophosphate (DFP). Isoflurophate 135-161 acetylcholinesterase Rattus norvegicus 49-69 6480897-2 1984 Neurons with overlapping distribution synthesize acetylcholinesterase (AChE) as shown histochemically after systemic administration of diisopropylfluorophosphate (DFP). Isoflurophate 135-161 acetylcholinesterase Rattus norvegicus 71-75 6480897-2 1984 Neurons with overlapping distribution synthesize acetylcholinesterase (AChE) as shown histochemically after systemic administration of diisopropylfluorophosphate (DFP). Isoflurophate 163-166 acetylcholinesterase Rattus norvegicus 49-69 6480897-2 1984 Neurons with overlapping distribution synthesize acetylcholinesterase (AChE) as shown histochemically after systemic administration of diisopropylfluorophosphate (DFP). Isoflurophate 163-166 acetylcholinesterase Rattus norvegicus 71-75 6697180-3 1984 They are morphologically similar to the AChE-containing neurons disclosed in the striatum of rat, cat and monkey after AChE inhibitor (DFP) pretreatment. Isoflurophate 135-138 acetylcholinesterase Rattus norvegicus 40-44 6697180-3 1984 They are morphologically similar to the AChE-containing neurons disclosed in the striatum of rat, cat and monkey after AChE inhibitor (DFP) pretreatment. Isoflurophate 135-138 acetylcholinesterase Rattus norvegicus 119-123 6320044-8 1983 At all post-diisopropylphosphorofluoridate survival times, heavy deposits of acetylcholinesterase reaction product were found within the perikarya of this cell type, for the most part within the cisternae of the granular endoplasmic reticulum. Isoflurophate 12-42 acetylcholinesterase Rattus norvegicus 77-97 6320044-14 1983 These findings indicate that the large-sized neuron is the only striatal structure that shows rapid regeneration of acetylcholinesterase activity during the early recovery phase after diisopropylphosphorofluoridate administration. Isoflurophate 184-214 acetylcholinesterase Rattus norvegicus 116-136 24010172-1 1983 A combination of a retrograde fluorescent dye tracing technique and staining for acetylcholinesterase (AChE) after di-isopropyl-phosphorofluoridate (DFP) pretreatment was used to identify cells which project to the nodulus, flocculus or cerebellar hemisphere. Isoflurophate 115-147 acetylcholinesterase Rattus norvegicus 103-107 24010172-1 1983 A combination of a retrograde fluorescent dye tracing technique and staining for acetylcholinesterase (AChE) after di-isopropyl-phosphorofluoridate (DFP) pretreatment was used to identify cells which project to the nodulus, flocculus or cerebellar hemisphere. Isoflurophate 149-152 acetylcholinesterase Rattus norvegicus 103-107 7121056-1 1982 The retrograde fluorescent tracing technique was combined with the di-isopropylfluorophosphate (DFP) histochemical procedure for acetylcholinesterase (AChE). Isoflurophate 96-99 acetylcholinesterase Rattus norvegicus 151-155 6954889-0 1982 Mechanisms of recovery of brain acetylcholinesterase in rats during chronic intoxication by isoflurophate. Isoflurophate 92-105 acetylcholinesterase Rattus norvegicus 32-52 7290286-1 1981 The effects of acute administration of diisopropyl fluorophosphate, Isofluorophate (DFP) 1.1 mg/kg SC on soluble brain acetylcholinesterase were studied in male Sprague-Dawley rats sacrificed at time intervals ranging from 3 hr to 25 days. Isoflurophate 39-66 acetylcholinesterase Rattus norvegicus 119-139 7290286-1 1981 The effects of acute administration of diisopropyl fluorophosphate, Isofluorophate (DFP) 1.1 mg/kg SC on soluble brain acetylcholinesterase were studied in male Sprague-Dawley rats sacrificed at time intervals ranging from 3 hr to 25 days. Isoflurophate 84-87 acetylcholinesterase Rattus norvegicus 119-139 6177182-1 1981 The AChE activity was demonstrated in some brain regions of adult rats after intoxication with DFP ( (di-isopropyl-fluorophosphate). Isoflurophate 102-130 acetylcholinesterase Rattus norvegicus 4-8 7234437-6 1980 The AChE activity was also reduced in relation to the control group ranging in the liver homogenate from 49.7% (DFP) to 75.6% (IPO-63), in the microsomal fraction from 33.0% (DFP) to 63.8% (IPO-63), in the mitochondrial fraction from 45.5% (DFP) to 72.9% (IPO-63), and in the soluble fraction from 52.8% (DFP) to 80.5% (DDVP). Isoflurophate 112-115 acetylcholinesterase Rattus norvegicus 4-8 6161227-13 1980 Evidence for the participation of the transport process in the renewal of AChE in the distal portions of the axon was obtained in experiments using diisopropylphosphorofluoridate and cycloheximide. Isoflurophate 148-178 acetylcholinesterase Rattus norvegicus 74-78 311237-2 1979 Visualization of AChE-positive neurones in the ventral forebrain was facilitated by pretreatment of rats with 1.5 mg/kg di-isopropyl phosphofluoridate (DFP). Isoflurophate 120-150 acetylcholinesterase Rattus norvegicus 17-21 317106-8 1979 The depressant effect of H12-HTX on extrinsic responses persisted both when carbachol was used as the agonist and when acetylcholinesterase was inhibited with diisopropylfluorophosphate. Isoflurophate 159-185 acetylcholinesterase Rattus norvegicus 119-139 465887-2 1979 The rates of recovery from both these effects were recorded.3 In a series of experiments with dyflos (which inhibits acetylcholinesterase by forming a phosphorylated enzyme which does not undergo spontaneous reactivation) the relationship between functional acetylcholinesterase activity and neuromuscular blocking activity of exogenous acetylcholine was also determined.4 From the data obtained, the relationship between functional acetylcholinesterase activity and tetanic fade was calculated. Isoflurophate 94-100 acetylcholinesterase Rattus norvegicus 117-137 465887-2 1979 The rates of recovery from both these effects were recorded.3 In a series of experiments with dyflos (which inhibits acetylcholinesterase by forming a phosphorylated enzyme which does not undergo spontaneous reactivation) the relationship between functional acetylcholinesterase activity and neuromuscular blocking activity of exogenous acetylcholine was also determined.4 From the data obtained, the relationship between functional acetylcholinesterase activity and tetanic fade was calculated. Isoflurophate 94-100 acetylcholinesterase Rattus norvegicus 258-278 465887-2 1979 The rates of recovery from both these effects were recorded.3 In a series of experiments with dyflos (which inhibits acetylcholinesterase by forming a phosphorylated enzyme which does not undergo spontaneous reactivation) the relationship between functional acetylcholinesterase activity and neuromuscular blocking activity of exogenous acetylcholine was also determined.4 From the data obtained, the relationship between functional acetylcholinesterase activity and tetanic fade was calculated. Isoflurophate 94-100 acetylcholinesterase Rattus norvegicus 258-278 1004714-0 1976 The recovery of acetylcholinesterase activity in the superior cervical ganglion of the rat following its inhibition by diisopropylphosphorofluoridate: a biochemical and cytochemical study. Isoflurophate 119-149 acetylcholinesterase Rattus norvegicus 16-36 1276870-5 1976 During development AChE appeared in the caudate-putamen nucleus in a lateral to medial topographic order; analogously, enzyme staining in the neostriatum reappeared in the same lateral to medial topographic order in adult rats following irreversible AChE inhibition by intramuscularly injected bis-(1-methylethyl)phosphorofluoridate (di-isopropylfluorophosphate: DFP). Isoflurophate 294-332 acetylcholinesterase Rattus norvegicus 19-23 1276870-5 1976 During development AChE appeared in the caudate-putamen nucleus in a lateral to medial topographic order; analogously, enzyme staining in the neostriatum reappeared in the same lateral to medial topographic order in adult rats following irreversible AChE inhibition by intramuscularly injected bis-(1-methylethyl)phosphorofluoridate (di-isopropylfluorophosphate: DFP). Isoflurophate 334-361 acetylcholinesterase Rattus norvegicus 19-23 1276870-5 1976 During development AChE appeared in the caudate-putamen nucleus in a lateral to medial topographic order; analogously, enzyme staining in the neostriatum reappeared in the same lateral to medial topographic order in adult rats following irreversible AChE inhibition by intramuscularly injected bis-(1-methylethyl)phosphorofluoridate (di-isopropylfluorophosphate: DFP). Isoflurophate 363-366 acetylcholinesterase Rattus norvegicus 19-23 25461321-1 2015 Utilizing our previously reported in silico pharmacophore model for reactivation efficacy of oximes, we present here a discovery of twelve new non-oxime reactivators of diisopropylfluorophosphate (DFP)-inhibited acetylcholinesterase (AChE) obtained through virtual screening of an in-house compound database. Isoflurophate 169-195 acetylcholinesterase Rattus norvegicus 234-238 1234757-0 1975 Acetylcholinesterase-containing neurons in the neostriatum and substantia nigra revealed after punctate intracerebral injection of di-isopropylfluorophosphate. Isoflurophate 131-158 acetylcholinesterase Rattus norvegicus 0-20 1234757-1 1975 Infusion of 1 mul arachis oil containing 1.5 mug bis-(1 -methylethyl)phosphorofluoridate (di-isopropylfluorophosphate: DFP) into the caudate--putamen nucleus and substantia nigra of rats produced a considerable reduction of histochemical staining for acetylcholinesterase (AChE) in these two brain regions 30--120 min after injection. Isoflurophate 49-88 acetylcholinesterase Rattus norvegicus 251-271 1234757-1 1975 Infusion of 1 mul arachis oil containing 1.5 mug bis-(1 -methylethyl)phosphorofluoridate (di-isopropylfluorophosphate: DFP) into the caudate--putamen nucleus and substantia nigra of rats produced a considerable reduction of histochemical staining for acetylcholinesterase (AChE) in these two brain regions 30--120 min after injection. Isoflurophate 49-88 acetylcholinesterase Rattus norvegicus 273-277 4140010-0 1974 Analysis of acetylcholinesterase synthesis and transport in the rat hippocampus: recovery of acetylcholinesterase activity in the septum and hippocampus after administration of diisopropylfluorophosphate. Isoflurophate 177-203 acetylcholinesterase Rattus norvegicus 12-32 4140010-0 1974 Analysis of acetylcholinesterase synthesis and transport in the rat hippocampus: recovery of acetylcholinesterase activity in the septum and hippocampus after administration of diisopropylfluorophosphate. Isoflurophate 177-203 acetylcholinesterase Rattus norvegicus 93-113 30389396-1 2019 Diisopropyl fluorophosphate (DFP), a surrogate of nerve agent sarin, is an organophosphorus (OP) compound which inhibits neuronal enzyme acetylcholinesterase (AChE). Isoflurophate 0-27 acetylcholinesterase Rattus norvegicus 137-157 30389396-1 2019 Diisopropyl fluorophosphate (DFP), a surrogate of nerve agent sarin, is an organophosphorus (OP) compound which inhibits neuronal enzyme acetylcholinesterase (AChE). Isoflurophate 0-27 acetylcholinesterase Rattus norvegicus 159-163 30389396-1 2019 Diisopropyl fluorophosphate (DFP), a surrogate of nerve agent sarin, is an organophosphorus (OP) compound which inhibits neuronal enzyme acetylcholinesterase (AChE). Isoflurophate 29-32 acetylcholinesterase Rattus norvegicus 137-157 30389396-1 2019 Diisopropyl fluorophosphate (DFP), a surrogate of nerve agent sarin, is an organophosphorus (OP) compound which inhibits neuronal enzyme acetylcholinesterase (AChE). Isoflurophate 29-32 acetylcholinesterase Rattus norvegicus 159-163 28329845-1 2017 Similar to organophosphate (OP) nerve agents, diisopropylfluorophosphate (DFP) rapidly and irreversibly inhibits acetylcholinesterase, leading to convulsions that can progress to status epilepticus (SE). Isoflurophate 46-72 acetylcholinesterase Rattus norvegicus 113-133 28329845-1 2017 Similar to organophosphate (OP) nerve agents, diisopropylfluorophosphate (DFP) rapidly and irreversibly inhibits acetylcholinesterase, leading to convulsions that can progress to status epilepticus (SE). Isoflurophate 74-77 acetylcholinesterase Rattus norvegicus 113-133 25461321-1 2015 Utilizing our previously reported in silico pharmacophore model for reactivation efficacy of oximes, we present here a discovery of twelve new non-oxime reactivators of diisopropylfluorophosphate (DFP)-inhibited acetylcholinesterase (AChE) obtained through virtual screening of an in-house compound database. Isoflurophate 197-200 acetylcholinesterase Rattus norvegicus 234-238 20981864-0 2011 Pretreatment for acute exposure to diisopropylfluorophosphate: in vivo efficacy of various acetylcholinesterase inhibitors. Isoflurophate 35-61 acetylcholinesterase Rattus norvegicus 91-111 23537526-1 2013 Diisopropylfluorophosphate exerts its toxic effect by irreversibly inhibiting acetylcholinesterase. Isoflurophate 0-26 acetylcholinesterase Rattus norvegicus 78-98 23537526-3 2013 The aim of the present study was to evaluate the possible preventive effects of acute treatment with reversible acetylcholinesterase inhibitor galantamine against the signs of cholinergic toxic syndrome provoked by diisopropylfluorophosphate, such as hypothermia, muscular fasciculations, oral dyskinesia and decreased locomotor performance in a rat model of intoxication. Isoflurophate 215-241 acetylcholinesterase Rattus norvegicus 112-132 12576409-2 2003 To test this hypothesis in rats, small amounts of an acetylcholinesterase inhibitor [diisopropylfluorophosphate (DFP)] were injected into the proximal half of the gastrocnemius muscle, and the muscle nerve was electrically stimulated for 30-60 min for induction of muscle twitches. Isoflurophate 85-111 acetylcholinesterase Rattus norvegicus 53-73 18991751-7 2008 Correlations between the different in vitro and in vivo data available reveal that an oxime with a low in vitro AChE inhibitory activity (high IC(50)) is rather non-toxic and reduces DFP-induced mortality (low cumulative relative risk). Isoflurophate 183-186 acetylcholinesterase Rattus norvegicus 112-116 16289123-3 2005 In the brains of naive, un-stressed rats, the irreversible organophosphate antiChE, diisopropylfluorophosphonate (DFP) induced post-treatment accumulation of catalytically active G1 monomers of acetylcholinesterase (AChE). Isoflurophate 84-112 acetylcholinesterase Rattus norvegicus 194-214 16289123-3 2005 In the brains of naive, un-stressed rats, the irreversible organophosphate antiChE, diisopropylfluorophosphonate (DFP) induced post-treatment accumulation of catalytically active G1 monomers of acetylcholinesterase (AChE). Isoflurophate 84-112 acetylcholinesterase Rattus norvegicus 216-220 16289123-3 2005 In the brains of naive, un-stressed rats, the irreversible organophosphate antiChE, diisopropylfluorophosphonate (DFP) induced post-treatment accumulation of catalytically active G1 monomers of acetylcholinesterase (AChE). Isoflurophate 114-117 acetylcholinesterase Rattus norvegicus 194-214 16289123-3 2005 In the brains of naive, un-stressed rats, the irreversible organophosphate antiChE, diisopropylfluorophosphonate (DFP) induced post-treatment accumulation of catalytically active G1 monomers of acetylcholinesterase (AChE). Isoflurophate 114-117 acetylcholinesterase Rattus norvegicus 216-220 12893843-2 2003 Extensive in vitro tests of these oximes with acetylcholinesterase inhibited by two different organophosphate agents, echothiophate and diisopropylfluorophosphate, revealed one compound with particularly good reactivation kinetics and affinity for phosphorylated acetylcholinesterase (AChE). Isoflurophate 136-162 acetylcholinesterase Rattus norvegicus 46-66 12893843-2 2003 Extensive in vitro tests of these oximes with acetylcholinesterase inhibited by two different organophosphate agents, echothiophate and diisopropylfluorophosphate, revealed one compound with particularly good reactivation kinetics and affinity for phosphorylated acetylcholinesterase (AChE). Isoflurophate 136-162 acetylcholinesterase Rattus norvegicus 263-283 12893843-2 2003 Extensive in vitro tests of these oximes with acetylcholinesterase inhibited by two different organophosphate agents, echothiophate and diisopropylfluorophosphate, revealed one compound with particularly good reactivation kinetics and affinity for phosphorylated acetylcholinesterase (AChE). Isoflurophate 136-162 acetylcholinesterase Rattus norvegicus 285-289 12576409-2 2003 To test this hypothesis in rats, small amounts of an acetylcholinesterase inhibitor [diisopropylfluorophosphate (DFP)] were injected into the proximal half of the gastrocnemius muscle, and the muscle nerve was electrically stimulated for 30-60 min for induction of muscle twitches. Isoflurophate 113-116 acetylcholinesterase Rattus norvegicus 53-73 10661498-8 2000 In separate groups of rats, non-toxic doses (50 and 250 microg/kg) of the acetylcholinesterase (AChE) inhibitor, diisopropylflurophosphate (DFP) were administered as single daily injections concomitant with the morphine infusion. Isoflurophate 140-143 acetylcholinesterase Rattus norvegicus 74-94 12565696-3 2003 In all postnatal ages investigated (4, 7, 14, 20, 27, 40 days-old and adult rats), AChE effect on binding was concentration-dependent and blocked by propidium, BW 284c51, diisopropylfluorophosphonate and eserine, therefore requiring indemnity of both peripheral and active sites of the enzyme. Isoflurophate 171-199 acetylcholinesterase Rattus norvegicus 83-87 10661498-8 2000 In separate groups of rats, non-toxic doses (50 and 250 microg/kg) of the acetylcholinesterase (AChE) inhibitor, diisopropylflurophosphate (DFP) were administered as single daily injections concomitant with the morphine infusion. Isoflurophate 140-143 acetylcholinesterase Rattus norvegicus 96-100 10378121-2 1999 The procedure involved in vivo irreversible inhibition of AChE by administration of the inhibitor diisopropyl fluorophosphate (DFP; 1.2 mg/kg b.w., i.m.) Isoflurophate 98-125 acetylcholinesterase Rattus norvegicus 58-62 10378121-2 1999 The procedure involved in vivo irreversible inhibition of AChE by administration of the inhibitor diisopropyl fluorophosphate (DFP; 1.2 mg/kg b.w., i.m.) Isoflurophate 127-130 acetylcholinesterase Rattus norvegicus 58-62 10206338-3 1999 The animals were pretreated with an irreversible AChE inhibitor, diisopropyl fluorophosphate, for the measurement of AChE activities. Isoflurophate 65-92 acetylcholinesterase Rattus norvegicus 49-53 10206338-3 1999 The animals were pretreated with an irreversible AChE inhibitor, diisopropyl fluorophosphate, for the measurement of AChE activities. Isoflurophate 65-92 acetylcholinesterase Rattus norvegicus 117-121 8973828-3 1996 Injection of sublethal doses of the acetylcholinesterase blocker, diisopropylfluorophosphate produced dose-dependent increases in ACh release, reaching 79.9 fmol/h with a dose of 0.7-times the LD50. Isoflurophate 66-92 acetylcholinesterase Rattus norvegicus 36-56 9507142-4 1998 The irreversible AChE inhibitor diisopropyl fluorophosphate (DFP) usually caused a sustained increase, with an initial peak followed by a gradual change to a final level higher than before DFP. Isoflurophate 32-59 acetylcholinesterase Rattus norvegicus 17-21 9507142-4 1998 The irreversible AChE inhibitor diisopropyl fluorophosphate (DFP) usually caused a sustained increase, with an initial peak followed by a gradual change to a final level higher than before DFP. Isoflurophate 61-64 acetylcholinesterase Rattus norvegicus 17-21 8019748-19 1994 Physostigmine, neostigmine, tacrine and DFP (all at 30 microM) each produced near-total (> 96%) inhibition of AChE activity. Isoflurophate 40-43 acetylcholinesterase Rattus norvegicus 113-117 8658512-3 1996 To induce muscle necrosis, rats were treated with 1.0 or 2.0 mg/kg diisopropylphosphorofluoridate (DFP), an irreversible inhibitor of AChE that induced muscle fasciculations, and were euthanized 30-120 min after the DFP treatment. Isoflurophate 99-102 acetylcholinesterase Rattus norvegicus 134-138 8722500-3 1996 Both enantiomers premixed with AChE preparations, dose-dependently protected the enzyme from inactivation by diisopropylfluorophosphate (DFP). Isoflurophate 109-135 acetylcholinesterase Rattus norvegicus 31-35 8722500-3 1996 Both enantiomers premixed with AChE preparations, dose-dependently protected the enzyme from inactivation by diisopropylfluorophosphate (DFP). Isoflurophate 137-140 acetylcholinesterase Rattus norvegicus 31-35 8019748-20 1994 However, DFP at a concentration (60 microM) that produced a degree of AChE inhibition equal to that of physostigmine 30 microM, did not significantly reduce nicotine-induced dopamine release. Isoflurophate 9-12 acetylcholinesterase Rattus norvegicus 70-74 1322503-7 1992 Chronic diisopropylfluorophosphate (DFP) administration induced a marked decrease of AChE activity and down-regulation of muscarinic receptors whereas atropine administration resulted in receptor up-regulation in cerebral cortex, striatum and hippocampus of both control and MAM rats. Isoflurophate 8-34 acetylcholinesterase Rattus norvegicus 85-89 8010100-8 1994 They were different from isoflurophate to bond to AChE in a reversible manner. Isoflurophate 25-38 acetylcholinesterase Rattus norvegicus 50-54 1322503-7 1992 Chronic diisopropylfluorophosphate (DFP) administration induced a marked decrease of AChE activity and down-regulation of muscarinic receptors whereas atropine administration resulted in receptor up-regulation in cerebral cortex, striatum and hippocampus of both control and MAM rats. Isoflurophate 36-39 acetylcholinesterase Rattus norvegicus 85-89 1673267-2 1991 The present study was designed to determine the effect of a single injection of an organophosphate acetylcholinesterase inhibitor, diisopropylfluorophosphate (DFP), on anterior pituitary function in male rats. Isoflurophate 131-157 acetylcholinesterase Rattus norvegicus 99-119 1673267-2 1991 The present study was designed to determine the effect of a single injection of an organophosphate acetylcholinesterase inhibitor, diisopropylfluorophosphate (DFP), on anterior pituitary function in male rats. Isoflurophate 159-162 acetylcholinesterase Rattus norvegicus 99-119 1663554-2 1991 Adult male rats were treated either once or multiple times over a period of 10 days with the irreversible acetylcholinesterase inhibitor diisopropylfluorophosphate (DFP). Isoflurophate 137-163 acetylcholinesterase Rattus norvegicus 106-126 1663554-2 1991 Adult male rats were treated either once or multiple times over a period of 10 days with the irreversible acetylcholinesterase inhibitor diisopropylfluorophosphate (DFP). Isoflurophate 165-168 acetylcholinesterase Rattus norvegicus 106-126 2340076-2 1990 The sequence around the serine residue labeled by diisopropylfluorophosphate (DFP) was found to be TVTLFGESAGAASVGM which is similar to the active sites of AChE from other tissues. Isoflurophate 50-76 acetylcholinesterase Rattus norvegicus 156-160 2340076-2 1990 The sequence around the serine residue labeled by diisopropylfluorophosphate (DFP) was found to be TVTLFGESAGAASVGM which is similar to the active sites of AChE from other tissues. Isoflurophate 78-81 acetylcholinesterase Rattus norvegicus 156-160 2256118-0 1990 Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropylfluorophosphate. Isoflurophate 110-136 acetylcholinesterase Rattus norvegicus 86-106 2077431-0 1990 In vivo and in vitro effects of diisopropyl fluorophosphate and paraoxon on individual molecular forms of rat brain acetylcholinesterase. Isoflurophate 32-59 acetylcholinesterase Rattus norvegicus 116-136 2077431-1 1990 Previous study in this laboratory showed that following a sc injection of an organophosphorus compound, diisopropyl fluorophosphate (DFP), into rats the inhibition of 10S molecular forms was considerably more pronounced than that of 4S forms of brain acetylcholinesterase (AChE). Isoflurophate 104-131 acetylcholinesterase Rattus norvegicus 251-271 2077431-1 1990 Previous study in this laboratory showed that following a sc injection of an organophosphorus compound, diisopropyl fluorophosphate (DFP), into rats the inhibition of 10S molecular forms was considerably more pronounced than that of 4S forms of brain acetylcholinesterase (AChE). Isoflurophate 104-131 acetylcholinesterase Rattus norvegicus 273-277 2396896-1 1990 Diisopropyl fluorophosphate (DFP) given to rats in lethal concentration (100 mg/m3, by inhalation for 40 min) significantly inhibited acetylcholinesterase activity in the blood, lung, liver and brain, and induced hyperglycaemia and glycogen mobilization in the liver, diaphragm and brain. Isoflurophate 0-27 acetylcholinesterase Rattus norvegicus 134-154 2396896-1 1990 Diisopropyl fluorophosphate (DFP) given to rats in lethal concentration (100 mg/m3, by inhalation for 40 min) significantly inhibited acetylcholinesterase activity in the blood, lung, liver and brain, and induced hyperglycaemia and glycogen mobilization in the liver, diaphragm and brain. Isoflurophate 29-32 acetylcholinesterase Rattus norvegicus 134-154