PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10653476-3 1999 Concerning UCP1, its presence in brown-fat mitochondria is associated with innate uncoupling, high GDP-binding capacity, and GDP-inhibitable Cl- permeability and uncoupling--but the high fatty acid sensitivity found in these mitochondria is observed even in the absence of UCP1. Guanosine Diphosphate 99-102 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 11-15 12912909-6 2003 The GDP-sensitive proton conductance induced by hydroxynonenal correlated with tissue expression of UCPs, appeared in yeast mitochondria expressing UCP1 and was absent in skeletal muscle mitochondria from UCP3 knockout mice. Guanosine Diphosphate 4-7 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 148-152 11389685-1 2001 Uncoupling protein 1 (UCP1) from mouse was expressed in yeast and the specific (GDP-inhibitable) and artifactual (GDP-insensitive) effects on mitochondrial uncoupling were assessed. Guanosine Diphosphate 80-83 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 0-26 11389685-1 2001 Uncoupling protein 1 (UCP1) from mouse was expressed in yeast and the specific (GDP-inhibitable) and artifactual (GDP-insensitive) effects on mitochondrial uncoupling were assessed. Guanosine Diphosphate 114-117 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 0-26 10653476-3 1999 Concerning UCP1, its presence in brown-fat mitochondria is associated with innate uncoupling, high GDP-binding capacity, and GDP-inhibitable Cl- permeability and uncoupling--but the high fatty acid sensitivity found in these mitochondria is observed even in the absence of UCP1. Guanosine Diphosphate 125-128 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 11-15 24290753-4 2013 The UCP1 was thermogenically functional, in that these mitochondria exhibited UCP1-dependent thermogenesis with lipid or carbohydrate substrates with canonical guanosine diphosphate (GDP) sensitivity and loss of thermogenesis in UCP1 knockout (KO) mice. Guanosine Diphosphate 160-181 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 4-8 9530130-9 1998 Moreover, significant GDP binding was detected in the white fat and muscle of the CL-treated mice, at about one-fourth and one-thirteenth the activity of brown fat, respectively, suggesting that ectopically expressed UCP is functionally active. Guanosine Diphosphate 22-25 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 217-220 3925790-5 1985 However, the concentration of thermogenin in isolated mitochondria was unchanged by fasting or exposure of the mice to 33 degrees C for 48 h. By contrast, marked reduction in [3H]GDP binding to isolated mitochondria were observed after exposure of the mice to 33 degrees C. Mice acclimated at 4 but not those acclimated at 21 degrees C showed reduction in GDP binding to isolated mitochondria during fasting. Guanosine Diphosphate 179-182 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 30-41 27986537-8 2017 First, we employed the purine nucleotide guanosine diphosphate (GDP) to directly quantify the fraction of thermogenesis enabled by UCP1 activity. Guanosine Diphosphate 64-67 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 131-135 10050760-2 1999 Ectopic UCP1 (approximately 0.8 mol UCP1/mol respiratory chain) decreased the delta psi(m) and rendered the potential sensitive to GDP and fatty acids. Guanosine Diphosphate 131-134 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 8-12 10050760-2 1999 Ectopic UCP1 (approximately 0.8 mol UCP1/mol respiratory chain) decreased the delta psi(m) and rendered the potential sensitive to GDP and fatty acids. Guanosine Diphosphate 131-134 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 36-40 24290753-4 2013 The UCP1 was thermogenically functional, in that these mitochondria exhibited UCP1-dependent thermogenesis with lipid or carbohydrate substrates with canonical guanosine diphosphate (GDP) sensitivity and loss of thermogenesis in UCP1 knockout (KO) mice. Guanosine Diphosphate 183-186 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 4-8 24290753-4 2013 The UCP1 was thermogenically functional, in that these mitochondria exhibited UCP1-dependent thermogenesis with lipid or carbohydrate substrates with canonical guanosine diphosphate (GDP) sensitivity and loss of thermogenesis in UCP1 knockout (KO) mice. Guanosine Diphosphate 160-181 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 78-82 24290753-4 2013 The UCP1 was thermogenically functional, in that these mitochondria exhibited UCP1-dependent thermogenesis with lipid or carbohydrate substrates with canonical guanosine diphosphate (GDP) sensitivity and loss of thermogenesis in UCP1 knockout (KO) mice. Guanosine Diphosphate 160-181 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 78-82 24290753-4 2013 The UCP1 was thermogenically functional, in that these mitochondria exhibited UCP1-dependent thermogenesis with lipid or carbohydrate substrates with canonical guanosine diphosphate (GDP) sensitivity and loss of thermogenesis in UCP1 knockout (KO) mice. Guanosine Diphosphate 183-186 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 78-82 24290753-4 2013 The UCP1 was thermogenically functional, in that these mitochondria exhibited UCP1-dependent thermogenesis with lipid or carbohydrate substrates with canonical guanosine diphosphate (GDP) sensitivity and loss of thermogenesis in UCP1 knockout (KO) mice. Guanosine Diphosphate 183-186 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 78-82 23757405-4 2013 UCP1 expression in muscle mitochondria was ~13% of levels in brown adipose tissue (BAT) mitochondria and caused increased GDP-sensitive proton leak. Guanosine Diphosphate 122-125 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 0-4 23757405-9 2013 Inhibition of UCP1 with GDP in muscle mitochondria increased ROS emission ~2.8-fold relative to WT muscle mitochondria. Guanosine Diphosphate 24-27 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 14-18 22864539-4 2012 Livers of mice fed a diet supplemented with CLA showed high UCP2 mRNA levels and the isolated hepatic mitochondria showed indications of UCP activity: in the presence of guanosine diphosphate, the higher stimulation of respiration promoted by linoleic acid in mitochondria from the CLA mice was almost completely reduced to the level of the stimulation from the control mice. Guanosine Diphosphate 170-191 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 60-63 22311417-7 2012 Mitochondrial uncoupling was partly inhibited by the UCP inhibitor GDP (-1.1 +- 0.1 pmol O(2) s(-1) [mg protein](-1)). Guanosine Diphosphate 67-70 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 53-56 19958747-4 2010 We show that the skeletal muscle UCP1 can be fully inhibited by a purine nucleotide (GDP) and reactivated by fatty acids (palmitate). Guanosine Diphosphate 85-88 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 33-37 18237274-5 2008 Binding of the purine nucleotides GDP and GTP to UCP-1, detected in the near-UV CD region, supported the existence of the functional form of the protein in digitonin micelles. Guanosine Diphosphate 34-37 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 49-54 17761507-4 2007 Moreover, with HF feeding GDP-inhibitable proton conductance, specific for UCP1, equaled that seen in the 129 strain. Guanosine Diphosphate 26-29 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 75-79 15695816-4 2005 Evidence for functional UCP 1 in thymus mitochondria was obtained by a comparative analysis with the kinetics of GDP binding in mitochondria from brown adipose tissue. Guanosine Diphosphate 113-116 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 24-29 15208325-5 2004 By identifying the UCP1-mediated fraction of the response, we could conclude that the interaction between purine nucleotides (GDP) and fatty acids (oleate) unexpectedly displayed simple competitive kinetics. Guanosine Diphosphate 126-129 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 19-23