PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18076383-10	2008	In both the basal and the insulin state, 90% of the total Rab10 was in the inactive GDP state.	Guanosine Diphosphate	84-87	insulin	Homo sapiens	26-33	
21187662-7	2011	Since glucose converts Rab27a from the GTP- to GDP-bound form, we suggested that Rab27a plays a crucial role in stimulus-endocytosis coupling in pancreatic beta-cells, and that this is the key molecule for membrane recycling of insulin granules.	Guanosine Diphosphate	47-50	insulin	Homo sapiens	228-235	
21187662-8	2011	In this review, we provide an overview of the roles of Rab27a and its GTP- and GDP-dependent effectors in the insulin secretory pathway of pancreatic beta-cells.	Guanosine Diphosphate	79-82	insulin	Homo sapiens	110-117	
16306371-0	2005	Rho guanosine diphosphate-dissociation inhibitor plays a negative modulatory role in glucose-stimulated insulin secretion.	Guanosine Diphosphate	4-25	insulin	Homo sapiens	104-111	
16306371-2	2005	However, very little is known with regard to potential regulation by G-protein regulatory factors (e.g., the guanosine diphosphate-dissociation inhibitor [GDI]) of insulin secretion from the islet beta-cell.	Guanosine Diphosphate	109-130	insulin	Homo sapiens	164-171	
7918472-3	1994	Herein, we characterize nucleoside diphosphokinase (NDP kinase) activity, which catalyzes the transphosphorylation of nucleotide diphosphate (e.g., GDP) to nucleotide triphosphates (e.g., GTP) in insulin-secreting cells.	Guanosine Diphosphate	148-151	insulin	Homo sapiens	196-203	
7988425-5	1994	Insulin increased GEF activity in both fractions (48 +/- 12% [3H]GDP released vs. 24 +/- 6% in control plasma membranes, and 65 +/- 13% vs. 13 +/- 4% in control cytosolic fractions), whereas EGF enhanced only the plasma membrane-associated activity (43 +/- 12% of [3H]GDP release in the plasma membrane fraction and 10 +/- 2% in the cytosol).	Guanosine Diphosphate	65-68	insulin	Homo sapiens	0-7	
7988425-5	1994	Insulin increased GEF activity in both fractions (48 +/- 12% [3H]GDP released vs. 24 +/- 6% in control plasma membranes, and 65 +/- 13% vs. 13 +/- 4% in control cytosolic fractions), whereas EGF enhanced only the plasma membrane-associated activity (43 +/- 12% of [3H]GDP release in the plasma membrane fraction and 10 +/- 2% in the cytosol).	Guanosine Diphosphate	268-271	insulin	Homo sapiens	0-7	
9914469-9	1999	The monomeric GTPase Rab3A controls insulin secretion through cycling between a guanosine triphosphate liganded vesicle-bound form and a guanosine diphosphate liganded, cytosolic form.	Guanosine Diphosphate	137-158	insulin	Homo sapiens	36-43	
8663461-1	1996	Insulin and epidermal growth factor (EGF) stimulate a rapid but transient increase in the amount of GTP bound to Ras that returns to the basal GDP-bound state within 10-30 min.	Guanosine Diphosphate	143-146	insulin	Homo sapiens	0-7	
8139548-2	1994	Insulin-induced membrane ruffling was inhibited by microinjection of rho GDI, an inhibitory GDP/GTP exchange regulator for both rho p21 and rac p21 small GTP-binding proteins, but not inhibited by microinjection of botulinum exoenzyme C3, known to selectively ADP-ribosylate rho p21 and to impair its function.	Guanosine Diphosphate	92-95	insulin	Homo sapiens	0-7	
8263034-0	1993	Insulin stimulates GDP release from G proteins in the rat and human liver plasma membranes.	Guanosine Diphosphate	19-22	insulin	Homo sapiens	0-7	
8263034-7	1993	In the rat membranes, 1-100 nM glucagon (used as a positive control) stimulated [32P]GDP release by about 17% (P < .05); similarly, 0.1-100 nM insulin stimulated [32P]GDP release by 10-13% (P < .05).	Guanosine Diphosphate	170-173	insulin	Homo sapiens	146-153	
8263034-8	1993	In the human membranes, 10 pM to 100 nM insulin stimulated [32P]GDP release by 7-10%.	Guanosine Diphosphate	64-67	insulin	Homo sapiens	40-47	
8263034-9	1993	In the rat membranes, 10 nM insulin stimulated [32P]GDP release by 17 and 24% at 2 and 4 min, respectively (P < .05); in the human membranes, 10 nM insulin stimulated [32P]GDP release by about 9% at 2 and 4 min.	Guanosine Diphosphate	52-55	insulin	Homo sapiens	28-35	
8263034-9	1993	In the rat membranes, 10 nM insulin stimulated [32P]GDP release by 17 and 24% at 2 and 4 min, respectively (P < .05); in the human membranes, 10 nM insulin stimulated [32P]GDP release by about 9% at 2 and 4 min.	Guanosine Diphosphate	52-55	insulin	Homo sapiens	151-158	
8263034-9	1993	In the rat membranes, 10 nM insulin stimulated [32P]GDP release by 17 and 24% at 2 and 4 min, respectively (P < .05); in the human membranes, 10 nM insulin stimulated [32P]GDP release by about 9% at 2 and 4 min.	Guanosine Diphosphate	175-178	insulin	Homo sapiens	28-35	
8263034-9	1993	In the rat membranes, 10 nM insulin stimulated [32P]GDP release by 17 and 24% at 2 and 4 min, respectively (P < .05); in the human membranes, 10 nM insulin stimulated [32P]GDP release by about 9% at 2 and 4 min.	Guanosine Diphosphate	175-178	insulin	Homo sapiens	151-158	
31507338-14	2019	The insulin pump therapy can be considered cost-effective in the context of the IMSS when considering a threshold of three GDPs per capita with 43.9% probability.	Guanosine Diphosphate	123-127	insulin	Homo sapiens	4-11	
9609111-3	1998	In the last decade, great progress has been made in understanding the molecular mechanisms which regulate the insulin mediated conversion of Ras from its inactive, GDP-bound state, to the activated GTP-bound form.	Guanosine Diphosphate	164-167	insulin	Homo sapiens	110-117	
34551282-5	2021	Insulin-induced KARATE assembly is controlled via phosphorylation of GTP-bound KRAS4B at S181 and GDP-bound RHOA at S188 by protein kinase A.	Guanosine Diphosphate	98-101	insulin	Homo sapiens	0-7	
3109943-1	1987	Autophosphorylation of the purified human insulin receptor tyrosyl kinase was found to be inhibited by the ras oncogene product p21 in a concentration- and GDP-dependent manner.	Guanosine Diphosphate	156-159	insulin	Homo sapiens	42-49	
8388384-1	1993	Insulin activates the ras proto-oncogene product p21ras (Ras) by stimulating conversion of the inactive GDP-bound form of Ras to the active GTP-bound form.	Guanosine Diphosphate	104-107	insulin	Homo sapiens	0-7	
2956255-1	1987	We have previously reported that the GDP-bound alpha-subunit of the GTP-binding protein transducin, present in outer segments of retinal rod cells (ROS), serves as a high affinity in vitro substrate (Km = 1 microM) for the insulin receptor kinase.	Guanosine Diphosphate	37-40	insulin	Homo sapiens	223-230	
25947911-9	2015	We also demonstrated that the insulin secretagogue glucose converts Rab27a from its GTP- to GDP-bound forms.	Guanosine Diphosphate	92-95	insulin	Homo sapiens	30-37	
31474712-0	2019	GDP-Bound Rab27a Dissociates from the Endocytic Machinery in a Phosphorylation-Dependent Manner after Insulin Secretion.	Guanosine Diphosphate	0-3	insulin	Homo sapiens	102-109	
31474712-3	2019	We have previously shown that in response to high concentrations of glucose, guanosine 5"-diphosphate (GDP)-bound Rab27a is recruited to the plasma membrane where IQ motif-containing guanosine 5"-triphosphatase (GTPase)-activating protein 1 (IQGAP1) is expressed, and that complex formation promotes endocytosis of secretory membranes after insulin secretion.	Guanosine Diphosphate	77-101	insulin	Homo sapiens	341-348	
31474712-3	2019	We have previously shown that in response to high concentrations of glucose, guanosine 5"-diphosphate (GDP)-bound Rab27a is recruited to the plasma membrane where IQ motif-containing guanosine 5"-triphosphatase (GTPase)-activating protein 1 (IQGAP1) is expressed, and that complex formation promotes endocytosis of secretory membranes after insulin secretion.	Guanosine Diphosphate	103-106	insulin	Homo sapiens	341-348	
31474712-9	2019	These results suggest that IQGAP1 phosphorylated by PKCepsilon promotes the dissociation of the IQGAP1-GDP-bound Rab27a complex in pancreatic beta-cells, thereby regulating endocytosis of secretory membranes following insulin secretion.	Guanosine Diphosphate	103-106	insulin	Homo sapiens	218-225