PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1903193-4 1991 The inhibitory GDP/GTP exchange protein for rhoA p21, named GDP dissociation inhibitor (GDI), made a complex with the GDP-bound form of bovine rhoA p21 and thereby inhibited the dissociation of GDP from and the subsequent binding of GTP to it. Guanosine Diphosphate 15-18 ras homolog family member A Bos taurus 49-52 1599487-1 1992 The GDP/GTP exchange reaction of rho p21, a member of ras p21-related small GTP-binding protein superfamily, is regulated by two stimulatory GDP/GTP exchange proteins (GEPs), named smg GDS and rho GDS, and by one inhibitory GEP, named rho GDI. Guanosine Diphosphate 4-7 ras homolog family member A Bos taurus 37-40 1599487-1 1992 The GDP/GTP exchange reaction of rho p21, a member of ras p21-related small GTP-binding protein superfamily, is regulated by two stimulatory GDP/GTP exchange proteins (GEPs), named smg GDS and rho GDS, and by one inhibitory GEP, named rho GDI. Guanosine Diphosphate 4-7 ras homolog family member A Bos taurus 58-61 1599487-2 1992 In bovine aortic smooth muscle, rho GDS and rho GDI were major GEPs for rho p21, and the rho GDI activity on the GDP/GTP exchange reaction of rho p21 was stronger than the rho GDS activity in their simultaneous presence. Guanosine Diphosphate 113-116 ras homolog family member A Bos taurus 146-149 1599487-3 1992 Moreover, in the crude cytosol, the GDP-bound form of rho p21 was complexed with rho GDI but not with rho GDS. Guanosine Diphosphate 36-39 ras homolog family member A Bos taurus 58-61 1518273-4 1992 Both the stimulatory and inhibitory GDP/GTP exchange proteins for bovine rhoA p21 were inactive for bacterial rhoA p21. Guanosine Diphosphate 36-39 ras homolog family member A Bos taurus 73-77 1518273-4 1992 Both the stimulatory and inhibitory GDP/GTP exchange proteins for bovine rhoA p21 were inactive for bacterial rhoA p21. Guanosine Diphosphate 36-39 ras homolog family member A Bos taurus 78-81 1518273-6 1992 These results indicate that the post-translational modifications of the C-terminal region of bovine rhoA p21, which are absent in bacterial rhoA p21, are essential for its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins but not with the GTPase activating protein. Guanosine Diphosphate 234-237 ras homolog family member A Bos taurus 100-104 1518273-6 1992 These results indicate that the post-translational modifications of the C-terminal region of bovine rhoA p21, which are absent in bacterial rhoA p21, are essential for its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins but not with the GTPase activating protein. Guanosine Diphosphate 234-237 ras homolog family member A Bos taurus 105-108 1903193-6 1991 The stimulatory GDP/GTP exchange protein for rhoA p21, named GDP dissociation stimulator (GDS), stimulated the dissociation of GDP from bovine rhoA p21, but was inactive for the bacterial protein. Guanosine Diphosphate 61-64 ras homolog family member A Bos taurus 50-53 1903193-6 1991 The stimulatory GDP/GTP exchange protein for rhoA p21, named GDP dissociation stimulator (GDS), stimulated the dissociation of GDP from bovine rhoA p21, but was inactive for the bacterial protein. Guanosine Diphosphate 61-64 ras homolog family member A Bos taurus 148-151 1903193-6 1991 The stimulatory GDP/GTP exchange protein for rhoA p21, named GDP dissociation stimulator (GDS), stimulated the dissociation of GDP from bovine rhoA p21, but was inactive for the bacterial protein. Guanosine Diphosphate 61-64 ras homolog family member A Bos taurus 50-53 1903193-6 1991 The stimulatory GDP/GTP exchange protein for rhoA p21, named GDP dissociation stimulator (GDS), stimulated the dissociation of GDP from bovine rhoA p21, but was inactive for the bacterial protein. Guanosine Diphosphate 61-64 ras homolog family member A Bos taurus 148-151 1903193-8 1991 These results suggest that the post-translational modifications of the C-terminal region of bovine rhoA p21, most presumably the geranylgeranylation, which are absent in bacterial rhoA p21, play important roles in its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins but not with the GAP. Guanosine Diphosphate 280-283 ras homolog family member A Bos taurus 104-107 1901951-0 1991 Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein. Guanosine Diphosphate 46-49 ras homolog family member A Bos taurus 79-82 1901951-0 1991 Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein. Guanosine Diphosphate 162-165 ras homolog family member A Bos taurus 79-82 1901951-1 1991 We have recently purified to near homogeneity the stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like GTP-binding proteins) from bovine brain cytosol. Guanosine Diphosphate 62-65 ras homolog family member A Bos taurus 95-98 1901951-8 1991 smg p21 GDS has low amino acid sequence homology with the yeast CDC25 and SCD25 proteins, which may regulate the GDP/GTP exchange reaction of the yeast RAS2 protein, but not with ras p21 GTPase-activating protein, the inhibitory GDP/GTP exchange proteins (GDP dissociation inhibitor) for smg p25A and rho p21s, and the beta gamma subunits of heterotrimeric GTP-binding proteins such as Gs and Gi. Guanosine Diphosphate 113-116 ras homolog family member A Bos taurus 4-7 1901951-8 1991 smg p21 GDS has low amino acid sequence homology with the yeast CDC25 and SCD25 proteins, which may regulate the GDP/GTP exchange reaction of the yeast RAS2 protein, but not with ras p21 GTPase-activating protein, the inhibitory GDP/GTP exchange proteins (GDP dissociation inhibitor) for smg p25A and rho p21s, and the beta gamma subunits of heterotrimeric GTP-binding proteins such as Gs and Gi. Guanosine Diphosphate 229-232 ras homolog family member A Bos taurus 4-7 1901951-8 1991 smg p21 GDS has low amino acid sequence homology with the yeast CDC25 and SCD25 proteins, which may regulate the GDP/GTP exchange reaction of the yeast RAS2 protein, but not with ras p21 GTPase-activating protein, the inhibitory GDP/GTP exchange proteins (GDP dissociation inhibitor) for smg p25A and rho p21s, and the beta gamma subunits of heterotrimeric GTP-binding proteins such as Gs and Gi. Guanosine Diphosphate 229-232 ras homolog family member A Bos taurus 4-7 1903193-4 1991 The inhibitory GDP/GTP exchange protein for rhoA p21, named GDP dissociation inhibitor (GDI), made a complex with the GDP-bound form of bovine rhoA p21 and thereby inhibited the dissociation of GDP from and the subsequent binding of GTP to it. Guanosine Diphosphate 15-18 ras homolog family member A Bos taurus 148-151 1903193-4 1991 The inhibitory GDP/GTP exchange protein for rhoA p21, named GDP dissociation inhibitor (GDI), made a complex with the GDP-bound form of bovine rhoA p21 and thereby inhibited the dissociation of GDP from and the subsequent binding of GTP to it. Guanosine Diphosphate 60-63 ras homolog family member A Bos taurus 49-52 1903193-4 1991 The inhibitory GDP/GTP exchange protein for rhoA p21, named GDP dissociation inhibitor (GDI), made a complex with the GDP-bound form of bovine rhoA p21 and thereby inhibited the dissociation of GDP from and the subsequent binding of GTP to it. Guanosine Diphosphate 60-63 ras homolog family member A Bos taurus 148-151 1903193-4 1991 The inhibitory GDP/GTP exchange protein for rhoA p21, named GDP dissociation inhibitor (GDI), made a complex with the GDP-bound form of bovine rhoA p21 and thereby inhibited the dissociation of GDP from and the subsequent binding of GTP to it. Guanosine Diphosphate 60-63 ras homolog family member A Bos taurus 49-52 1903193-4 1991 The inhibitory GDP/GTP exchange protein for rhoA p21, named GDP dissociation inhibitor (GDI), made a complex with the GDP-bound form of bovine rhoA p21 and thereby inhibited the dissociation of GDP from and the subsequent binding of GTP to it. Guanosine Diphosphate 60-63 ras homolog family member A Bos taurus 148-151 1903193-4 1991 The inhibitory GDP/GTP exchange protein for rhoA p21, named GDP dissociation inhibitor (GDI), made a complex with the GDP-bound form of bovine rhoA p21 and thereby inhibited the dissociation of GDP from and the subsequent binding of GTP to it. Guanosine Diphosphate 60-63 ras homolog family member A Bos taurus 49-52 1903193-4 1991 The inhibitory GDP/GTP exchange protein for rhoA p21, named GDP dissociation inhibitor (GDI), made a complex with the GDP-bound form of bovine rhoA p21 and thereby inhibited the dissociation of GDP from and the subsequent binding of GTP to it. Guanosine Diphosphate 60-63 ras homolog family member A Bos taurus 148-151 1903193-5 1991 However, rho GDI neither made a complex with the GDP-bound form of bacterial rhoA p21 nor affected these reactions of the bacterial protein. Guanosine Diphosphate 49-52 ras homolog family member A Bos taurus 82-85 1903193-6 1991 The stimulatory GDP/GTP exchange protein for rhoA p21, named GDP dissociation stimulator (GDS), stimulated the dissociation of GDP from bovine rhoA p21, but was inactive for the bacterial protein. Guanosine Diphosphate 16-19 ras homolog family member A Bos taurus 50-53 1903193-6 1991 The stimulatory GDP/GTP exchange protein for rhoA p21, named GDP dissociation stimulator (GDS), stimulated the dissociation of GDP from bovine rhoA p21, but was inactive for the bacterial protein. Guanosine Diphosphate 16-19 ras homolog family member A Bos taurus 148-151 2123802-4 1990 GDP reduced the light-induced inhibition, while GTP[S] and light inhibited ADP-ribosylation of rho A proteins in a synergistic manner. Guanosine Diphosphate 0-3 ras homolog family member A Bos taurus 95-100 2172971-4 1990 rGEF increased the exchange rate of GDP in normal [Gly12]p21 or oncogenic [Val12]p21 up to 30- to 40-fold under physiological concentrations of Mg2+. Guanosine Diphosphate 36-39 ras homolog family member A Bos taurus 57-60 2172971-4 1990 rGEF increased the exchange rate of GDP in normal [Gly12]p21 or oncogenic [Val12]p21 up to 30- to 40-fold under physiological concentrations of Mg2+. Guanosine Diphosphate 36-39 ras homolog family member A Bos taurus 81-84 2118909-0 1990 Purification and characterization from bovine brain cytosol of proteins that regulate the GDP/GTP exchange reaction of smg p21s, ras p21-like GTP-binding proteins. Guanosine Diphosphate 90-93 ras homolog family member A Bos taurus 123-126 2118909-3 1990 smg p21 GDS1 and -2 also stimulated the binding of [35S]GTP gamma S to the GDP-bound form of smg p21s but not that to the guanine nucleotide-free form. Guanosine Diphosphate 75-78 ras homolog family member A Bos taurus 4-7 2118909-9 1990 These results indicate that bovine brain contains regulatory proteins for smg p21s that stimulate the dissociation of GDP from and thereby the subsequent binding of GTP to smg p21s in addition to smg p21 GAP. Guanosine Diphosphate 118-121 ras homolog family member A Bos taurus 78-81 2118909-9 1990 These results indicate that bovine brain contains regulatory proteins for smg p21s that stimulate the dissociation of GDP from and thereby the subsequent binding of GTP to smg p21s in addition to smg p21 GAP. Guanosine Diphosphate 118-121 ras homolog family member A Bos taurus 176-179 2118909-10 1990 It is likely that the conversion from the GDP-bound inactive form of smg p21s to the GTP-bound active form is regulated by smg p21 GDS and that its reverse reaction is regulated by smg p21 GAP. Guanosine Diphosphate 42-45 ras homolog family member A Bos taurus 73-76 2118909-10 1990 It is likely that the conversion from the GDP-bound inactive form of smg p21s to the GTP-bound active form is regulated by smg p21 GDS and that its reverse reaction is regulated by smg p21 GAP. Guanosine Diphosphate 42-45 ras homolog family member A Bos taurus 127-130 2118909-10 1990 It is likely that the conversion from the GDP-bound inactive form of smg p21s to the GTP-bound active form is regulated by smg p21 GDS and that its reverse reaction is regulated by smg p21 GAP. Guanosine Diphosphate 42-45 ras homolog family member A Bos taurus 127-130 2113382-2 1990 These regulatory proteins, named rho GDP dissociation stimulator (GDS) 1 and -2, stimulate the dissociation of GDP from rhoA p21 and rhoB p20. Guanosine Diphosphate 37-40 ras homolog family member A Bos taurus 125-128 2111820-0 1990 Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein. Guanosine Diphosphate 121-124 ras homolog family member A Bos taurus 183-186 2113382-2 1990 These regulatory proteins, named rho GDP dissociation stimulator (GDS) 1 and -2, stimulate the dissociation of GDP from rhoA p21 and rhoB p20. Guanosine Diphosphate 111-114 ras homolog family member A Bos taurus 125-128 3143720-7 1988 Consistent with these structural properties, smg p21 binds specifically [35S] guanosine 5"-(3-O-thio)triphosphate (GTP gamma S), GTP, and GDP with a Kd value for GTP gamma S of about 40 nM. Guanosine Diphosphate 138-141 ras homolog family member A Bos taurus 49-52 2842690-6 1988 Here, using pure GAP in a kinetic competition assay, we show that GAP interacts preferentially with the active GTP complexes of both normal and oncogenic Harvey (Ha) ras p21 compared with the inactive GDP complexes. Guanosine Diphosphate 201-204 ras homolog family member A Bos taurus 170-173 7999019-0 1994 Role of bound GDP in the stability of the rho A-rho GDI complex purified from neutrophil cytosol. Guanosine Diphosphate 14-17 ras homolog family member A Bos taurus 42-47 7999019-1 1994 The rho A-rho GDI complex purified from bovine neutrophil cytosol was found to contain GDP as the only bound nucleotide at a ratio of 1 mol of GDP per mol of complex. Guanosine Diphosphate 87-90 ras homolog family member A Bos taurus 4-9 7999019-1 1994 The rho A-rho GDI complex purified from bovine neutrophil cytosol was found to contain GDP as the only bound nucleotide at a ratio of 1 mol of GDP per mol of complex. Guanosine Diphosphate 143-146 ras homolog family member A Bos taurus 4-9 7999019-3 1994 Upon dephosphorylation of bound GDP by apyrase, the rho A component of the complex was prone to proteolytic cleavage. Guanosine Diphosphate 32-35 ras homolog family member A Bos taurus 52-57 7999019-5 1994 These data suggest that rho A liganded by GDP in the rho A-rho GDI complex is maintained in a conformation that escapes action of proteases. Guanosine Diphosphate 42-45 ras homolog family member A Bos taurus 24-29 7999019-5 1994 These data suggest that rho A liganded by GDP in the rho A-rho GDI complex is maintained in a conformation that escapes action of proteases. Guanosine Diphosphate 42-45 ras homolog family member A Bos taurus 53-58 8573175-1 1996 The GDP dissociation inhibitor Rho GDI from bovine neutrophil cytosol was purified in association with prenylated Rho A. Guanosine Diphosphate 4-7 ras homolog family member A Bos taurus 114-119