PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10369786-7 1999 Ran-GDP was coupled to the sensor chip and reacted with RCC1 mutants to categorise them into different groups, demonstrating the usefulness of plasmon surface resonance in the study of complex multi-step kinetic processes. Guanosine Diphosphate 4-7 regulator of chromosome condensation 1 Homo sapiens 56-60 11932251-5 2002 This interaction was stimulated by the addition of Ran; moreover, Ran.GDP, Ran.GTP, and Ran without nucleotide could all stimulate complex formation between RanBP3 and RCC1 even though binding of Ran.GDP to RanBP3 alone was undetectable. Guanosine Diphosphate 70-73 regulator of chromosome condensation 1 Homo sapiens 168-172 11932251-5 2002 This interaction was stimulated by the addition of Ran; moreover, Ran.GDP, Ran.GTP, and Ran without nucleotide could all stimulate complex formation between RanBP3 and RCC1 even though binding of Ran.GDP to RanBP3 alone was undetectable. Guanosine Diphosphate 200-203 regulator of chromosome condensation 1 Homo sapiens 168-172 11994165-6 2002 Kti11p is highly conserved from yeast to man, and Kti13p/Ats1p is related to yeast Prp20p and mammalian RCC1, components of the Ran-GTP/GDP cycle. Guanosine Diphosphate 136-139 regulator of chromosome condensation 1 Homo sapiens 104-108 11231159-6 2001 However, addition of antibodies to RCC1 and RanGAP1 shows that Ran-GDP must be converted to Ran-GTP by RCC1 before precursor vesicles are recruited, whereas GTP hydrolysis by Ran stimulated by RanGAP1 promotes vesicle recruitment and is necessary for vesicle fusion to form an intact envelope. Guanosine Diphosphate 67-70 regulator of chromosome condensation 1 Homo sapiens 35-39 11231159-6 2001 However, addition of antibodies to RCC1 and RanGAP1 shows that Ran-GDP must be converted to Ran-GTP by RCC1 before precursor vesicles are recruited, whereas GTP hydrolysis by Ran stimulated by RanGAP1 promotes vesicle recruitment and is necessary for vesicle fusion to form an intact envelope. Guanosine Diphosphate 67-70 regulator of chromosome condensation 1 Homo sapiens 103-107 9889103-9 1998 We conclude that NTF2 functions as a transport receptor for Ran, permitting rapid entry into the nucleus where GTP-GDP exchange mediated by RCC1 [7] converts Ran into its GTP-bound state. Guanosine Diphosphate 115-118 regulator of chromosome condensation 1 Homo sapiens 140-144 9510255-4 1998 Biochemically, RCC1 is a guanine-nucleotide-exchange factor for the nuclear Ras homologue Ran; it increases the dissociation of Ran-bound GDP by 10(5)-fold. Guanosine Diphosphate 138-141 regulator of chromosome condensation 1 Homo sapiens 15-19 9843686-4 1998 In this study, we show that mammalian p10/NTF2 dramatically inhibits the dissociation of [3H]GDP from Ran and the binding of [35S]GTPgammaS to Ran following the dissociation of non-radioactive GDP by RCC1, the only known mammalian guanine nucleotide exchange factor for Ran (Ran-GEF) [7]. Guanosine Diphosphate 93-96 regulator of chromosome condensation 1 Homo sapiens 200-204 9121474-3 1997 Using PRP20, encoding the Ran GTP/GDP exchange factor, we identified YRB1, previously identified as a protein able to interact with human Ran GTP/GDP exchange factor RCC1 in the two-hybrid system. Guanosine Diphosphate 34-37 regulator of chromosome condensation 1 Homo sapiens 166-170 9121474-3 1997 Using PRP20, encoding the Ran GTP/GDP exchange factor, we identified YRB1, previously identified as a protein able to interact with human Ran GTP/GDP exchange factor RCC1 in the two-hybrid system. Guanosine Diphosphate 146-149 regulator of chromosome condensation 1 Homo sapiens 166-170 8889801-2 1996 RCC1 has no preference for GTP or GDP-bound Ran, so that GTP-Ran formation in vivo is regulated by relative concentrations of GTP/GDP and regulatory proteins interacting with RCC1, Ran, and RNA1. Guanosine Diphosphate 130-133 regulator of chromosome condensation 1 Homo sapiens 0-4 26124124-2 2015 An intracellular Ran GTP/Ran GDP gradient created by the distinct subcellular localization of its regulators RCC1 and RanGAP mediates many of its cellular effects. Guanosine Diphosphate 29-32 regulator of chromosome condensation 1 Homo sapiens 109-113 29040603-5 2018 Our structure-guided functional analyses revealed that Mog1 competes with RCC1 for Ran binding in a GTP/GDP-dependent manner. Guanosine Diphosphate 104-107 regulator of chromosome condensation 1 Homo sapiens 74-78 7548002-5 1995 The affinities of RCC1 to Ran.GDP and Ran.GTP are similar (1.3 x 10(5) and 1.8 x 10(5) M-1, respectively) and are high enough to allow formation of the ternary complex under appropriate concentration conditions. Guanosine Diphosphate 30-33 regulator of chromosome condensation 1 Homo sapiens 18-22 7548002-6 1995 In the absence of excess nucleotide and at low Ran concentrations, GDP (or GTP) can be efficiently displaced by excess RCC1 and the ternary complex can be produced. Guanosine Diphosphate 67-70 regulator of chromosome condensation 1 Homo sapiens 119-123 7882974-3 1995 In a search for further members of the RCC1-Ran signal pathway, we have identified proteins of 23, 45 and 300 kDa which tightly bind to Ran-GTP but not Ran-GDP. Guanosine Diphosphate 156-159 regulator of chromosome condensation 1 Homo sapiens 39-43 18469014-2 2008 The cycling of Ran between its GTP- and GDP-bound forms is catalyzed by the chromatin-bound guanine nucleotide exchange factor RCC1 and the cytoplasmic Ran GTPase-activating protein RanGAP. Guanosine Diphosphate 40-43 regulator of chromosome condensation 1 Homo sapiens 127-131 23536659-3 2013 Exogenous GDP and GTP are inhibitory to L-Ran binding, but the guanine-nucleotide exchange factor RCC1 can relieve this inhibition. Guanosine Diphosphate 10-13 regulator of chromosome condensation 1 Homo sapiens 98-102 15807788-2 2005 In vertebrates, these functions are controlled by a three-dimensional gradient of Ran-GTP to Ran-GDP, established by the spatial separation of Ran GTPase-activating protein (RanGAP) and the Ran guanine nucleotide exchange factor RCC1. Guanosine Diphosphate 97-100 regulator of chromosome condensation 1 Homo sapiens 229-233