PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22985415-7 2012 Our data have important implications for the regulatory role of m(7)GDP in mRNA metabolic pathways due to its possible interactions with different cap-binding proteins, such as DcpS or eIF4E. Guanosine Diphosphate 68-71 eukaryotic translation initiation factor 4E Homo sapiens 185-190 11076512-5 2000 To further understand the structural requirements for the specific recognition of an m(7)G mRNA cap, we determined the effects of amino acid substitutions in eIF4E and VP39 cap-binding sites on their affinity for m(7)GDP. Guanosine Diphosphate 217-220 eukaryotic translation initiation factor 4E Homo sapiens 158-163 14675529-1 2003 The structure of the eukaryotic initiation factor eIF4E bound to a cognate domain of eIF4G and m(7)GDP in this issue of Cell shows that these factors undergo coupled folding to form a stable complex with high cap binding activity that promotes efficient ribosomal attachment to mRNA during translation initiation. Guanosine Diphosphate 99-102 eukaryotic translation initiation factor 4E Homo sapiens 50-55 11076512-7 2000 The results suggest that both eIF4E and VP39 require a complicated pattern of both orientation and identity of the stacking aromatic residues to permit the selective binding of m(7)GDP. Guanosine Diphosphate 181-184 eukaryotic translation initiation factor 4E Homo sapiens 30-35 10349744-7 1999 Influence of the structural features of the cap-analogues, especially the type of the second nucleoside in the dinucleotide caps, on their association with eIF4E and biological activities in in vitro protein translation systems has been discussed in light of the known structures of the eIF4E-7-methyl-GDP complexes in crystal and solution. Guanosine Diphosphate 302-305 eukaryotic translation initiation factor 4E Homo sapiens 156-161