PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21346189-4 2011 We observed that an alteration of the Arf6-guanosine 5"-diphosphate/guanosine 5"-triphosphate (GTP/GDP) cycle, by GDP-bound or GTP-bound inactive mutants or by specific Arf6 silencing, inhibited HIV-1 envelope-induced membrane fusion, entry, and infection of T lymphocytes and permissive cells, regardless of viral tropism. Guanosine Diphosphate 99-102 ADP ribosylation factor 6 Homo sapiens 38-42 32103017-4 2020 We demonstrate that the NAD+-dependent deacylase SIRT2 removes the myristoyl group, and our evidence suggests that NMT prefers the GTP-bound while SIRT2 prefers the GDP-bound ARF6. Guanosine Diphosphate 165-168 ADP ribosylation factor 6 Homo sapiens 175-179 25713146-4 2015 Results from pulldown assays show that ARF6 exchanges GDP for GTP in sperm challenged with different exocytic stimuli. Guanosine Diphosphate 54-57 ADP ribosylation factor 6 Homo sapiens 39-43 25713146-9 2015 We show that active ARF6 increases the exchange of GDP for GTP on Rab3A, a prerequisite for secretion. Guanosine Diphosphate 51-54 ADP ribosylation factor 6 Homo sapiens 20-24 25296758-1 2014 ADP-ribosylation factor 6 (ARF6) small GTPase regulates membrane trafficking and cytoskeleton rearrangements at the plasma membrane (PM) by cycling between the GTP-bound active and GDP-bound inactive conformations. Guanosine Diphosphate 181-184 ADP ribosylation factor 6 Homo sapiens 0-25 25296758-1 2014 ADP-ribosylation factor 6 (ARF6) small GTPase regulates membrane trafficking and cytoskeleton rearrangements at the plasma membrane (PM) by cycling between the GTP-bound active and GDP-bound inactive conformations. Guanosine Diphosphate 181-184 ADP ribosylation factor 6 Homo sapiens 27-31 23295182-4 2013 Here we test the hypothesis that ARAP2 promotes the growth of FAs by converting Arf6 GTP to Arf6 GDP thereby preventing the activation of the Rho family GTP-binding protein Rac1. Guanosine Diphosphate 97-100 ADP ribosylation factor 6 Homo sapiens 92-96 27776975-1 2017 The Small GTPase ADP-ribosylation factor 6 (Arf6) functions as the molecular switch in cellular signaling pathways by cycling between GDP-bound inactive and GTP-bound active form, which is precisely regulated by two regulators, guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Guanosine Diphosphate 134-137 ADP ribosylation factor 6 Homo sapiens 17-42 27776975-1 2017 The Small GTPase ADP-ribosylation factor 6 (Arf6) functions as the molecular switch in cellular signaling pathways by cycling between GDP-bound inactive and GTP-bound active form, which is precisely regulated by two regulators, guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Guanosine Diphosphate 134-137 ADP ribosylation factor 6 Homo sapiens 44-48 22226746-6 2012 Human cells expressing a constitutively activated, GTP-bound ARF6 mutant display identical endocytic recycling and cytokinesis defects as those observed upon overexpression of the inactivated, GDP-bound Rab35 mutant. Guanosine Diphosphate 193-196 ADP ribosylation factor 6 Homo sapiens 61-65 22666423-2 2012 ARF6 operates by cycling between GDP-bound (inactive) and GTP-bound (active) forms and is a potential regulator of GPCR-mediated uterine activity during pregnancy and labour. Guanosine Diphosphate 33-36 ADP ribosylation factor 6 Homo sapiens 0-4 21523371-3 2011 In this article, we determined that Arf6 proteins both in the GDP and GTPgammaS bound forms can enter cells when simply added in the cell culture medium without requiring the myristoyl group. Guanosine Diphosphate 62-65 ADP ribosylation factor 6 Homo sapiens 36-40 21523371-4 2011 The GTPgammaS bound can enter cells at a faster rate than the GDP-bound Arf6. Guanosine Diphosphate 62-65 ADP ribosylation factor 6 Homo sapiens 72-76 21346189-4 2011 We observed that an alteration of the Arf6-guanosine 5"-diphosphate/guanosine 5"-triphosphate (GTP/GDP) cycle, by GDP-bound or GTP-bound inactive mutants or by specific Arf6 silencing, inhibited HIV-1 envelope-induced membrane fusion, entry, and infection of T lymphocytes and permissive cells, regardless of viral tropism. Guanosine Diphosphate 114-117 ADP ribosylation factor 6 Homo sapiens 38-42 20709080-0 2010 SAXS and X-ray crystallography suggest an unfolding model for the GDP/GTP conformational switch of the small GTPase Arf6. Guanosine Diphosphate 66-69 ADP ribosylation factor 6 Homo sapiens 116-120 20709080-5 2010 NMR chemical shifts identify this structural disorder in Delta13Arf6-GDP, but not in the closely related Delta17Arf1-GDP, which is consistent with their comparative thermodynamic and hydrodynamic analyses. Guanosine Diphosphate 69-72 ADP ribosylation factor 6 Homo sapiens 57-68 17889949-3 2008 However, recent data, obtained with human ARF-6, a member of the same family of G proteins, revealed that the corresponding mutant T27N was nucleotide-free and that the GDP-blocked form was the T44N mutant. Guanosine Diphosphate 169-172 ADP ribosylation factor 6 Homo sapiens 42-47 19890090-4 2010 The purpose of this article is to provide an overview of current understanding of the identity of small G proteins (e.g., Cdc42, Rac1, and ARF-6) and their corresponding regulatory factors (e.g., GDP/GTP-exchange factors, GDP-dissociation inhibitors) in the pancreatic beta-cell. Guanosine Diphosphate 196-199 ADP ribosylation factor 6 Homo sapiens 139-144 19896381-3 2009 RESULTS: We show that the ARF6 GTP/GDP cycle regulates the release of protease-loaded plasma membrane-derived microvesicles from tumor cells into the surrounding environment. Guanosine Diphosphate 35-38 ADP ribosylation factor 6 Homo sapiens 26-30 17398097-8 2007 First, GULP bound directly to GDP-bound Arf6 via its PTB domain. Guanosine Diphosphate 30-33 ADP ribosylation factor 6 Homo sapiens 40-44 17719203-10 2007 Taken together, these results suggest that the cycling of ARF6 between its GDP-and GTP-bound states coordinates the recruitment of AP-2 and clathrin to activated receptors during the endocytic process. Guanosine Diphosphate 75-78 ADP ribosylation factor 6 Homo sapiens 58-62 17640372-8 2007 CONCLUSION: We show here with over-expressed proteins that the GDP-bound form of Arf6 can bind to the spectrin repeat regions in Kalirin Rho family GEFs thereby recruiting Kalirin to membranes. Guanosine Diphosphate 63-66 ADP ribosylation factor 6 Homo sapiens 81-85 17786213-3 2007 Exchange of GDP for GTP on Arf6 is performed by a variety of guanine nucleotide exchange factors (GEFs), principally of the cytohesin (PSCD) and EFA6 (PSD) families. Guanosine Diphosphate 12-15 ADP ribosylation factor 6 Homo sapiens 27-31 17398097-11 2007 Fourth, GULP, ACAP1, and GDP-bound Arf6 were part of a tripartite complex, suggesting sequestration of ACAP1 as one mechanism of GULP action. Guanosine Diphosphate 25-28 ADP ribosylation factor 6 Homo sapiens 35-39 17122362-5 2007 ARF6-GTP preferentially interacts with Rac1-GDP. Guanosine Diphosphate 44-47 ADP ribosylation factor 6 Homo sapiens 0-4 16527809-2 2006 First, by comparing a fast-cycling mutant (Arf6(T157N)) and a GTPase-deficient mutant (Arf6(Q67L)), we established the necessity for completion of the Arf6 GDP/GTP cycle for recycling of major histocompatibility complex molecules to the plasma membrane. Guanosine Diphosphate 156-159 ADP ribosylation factor 6 Homo sapiens 87-91 16527809-7 2006 Finally, competition experiments conducted in vivo suggest the existence of a membrane receptor for GDP-bound Arf6. Guanosine Diphosphate 100-103 ADP ribosylation factor 6 Homo sapiens 110-114 16737952-2 2006 A key determinant of ARF6 function is the lifetime of the GTP-bound active state, which is orchestrated by GTPase-activating protein (GAP) and GTP-GDP exchanging factor. Guanosine Diphosphate 147-150 ADP ribosylation factor 6 Homo sapiens 21-25 16527809-2 2006 First, by comparing a fast-cycling mutant (Arf6(T157N)) and a GTPase-deficient mutant (Arf6(Q67L)), we established the necessity for completion of the Arf6 GDP/GTP cycle for recycling of major histocompatibility complex molecules to the plasma membrane. Guanosine Diphosphate 156-159 ADP ribosylation factor 6 Homo sapiens 87-91 9314528-1 1997 ADP-ribosylation factor (ARF) 6 localizes to the plasma membrane (PM) in its GTP state and to a tubulovesicular compartment in its GDP state in HeLa cells that express wild-type or mutant forms of this GTPase. Guanosine Diphosphate 131-134 ADP ribosylation factor 6 Homo sapiens 25-31 15126638-0 2004 The GDP-bound form of Arf6 is located at the plasma membrane. Guanosine Diphosphate 4-7 ADP ribosylation factor 6 Homo sapiens 22-26 15126638-1 2004 The function of Arf6 has been investigated largely by using the T27N and the Q67L mutants, which are thought to be blocked in GDP- and GTP-bound states, respectively. Guanosine Diphosphate 126-129 ADP ribosylation factor 6 Homo sapiens 16-20 12920129-1 2003 The ADP-ribosylation factor 6 (ARF6) small GTPase functions as a GDP/GTP-regulated switch in the pathways that stimulate actin reorganization and membrane ruffling. Guanosine Diphosphate 65-68 ADP ribosylation factor 6 Homo sapiens 4-29 12920129-1 2003 The ADP-ribosylation factor 6 (ARF6) small GTPase functions as a GDP/GTP-regulated switch in the pathways that stimulate actin reorganization and membrane ruffling. Guanosine Diphosphate 65-68 ADP ribosylation factor 6 Homo sapiens 31-35 11533043-6 2001 Upon agonist stimulation of the receptor, beta-arrestin also interacts with the GDP-liganded form of ARF6, thereby facilitating ARNO-promoted GTP loading and activation of the G protein. Guanosine Diphosphate 80-83 ADP ribosylation factor 6 Homo sapiens 101-105 11266366-0 2001 The structural GDP/GTP cycle of human Arf6. Guanosine Diphosphate 15-19 ADP ribosylation factor 6 Homo sapiens 38-42 11266366-4 2001 Unlike their GDP-bound forms, the active forms of Arf6 and Arf1 are very similar. Guanosine Diphosphate 13-16 ADP ribosylation factor 6 Homo sapiens 50-54 10881192-3 2000 The crystal structure of Arf6-GDP at 2.3 A shows that it has a conformation similar to that of Arf1-GDP, which cannot bind membranes with high affinity. Guanosine Diphosphate 30-33 ADP ribosylation factor 6 Homo sapiens 25-29 10881192-3 2000 The crystal structure of Arf6-GDP at 2.3 A shows that it has a conformation similar to that of Arf1-GDP, which cannot bind membranes with high affinity. Guanosine Diphosphate 100-103 ADP ribosylation factor 6 Homo sapiens 25-29 15642342-4 2005 We show that HERC1, through its RLD1, stimulates GDP release from ARF6 but, unexpectedly, it inhibits GDP/GTP exchange on ARF6 under conditions where ARNO stimulates it. Guanosine Diphosphate 49-52 ADP ribosylation factor 6 Homo sapiens 66-70 15642342-4 2005 We show that HERC1, through its RLD1, stimulates GDP release from ARF6 but, unexpectedly, it inhibits GDP/GTP exchange on ARF6 under conditions where ARNO stimulates it. Guanosine Diphosphate 102-105 ADP ribosylation factor 6 Homo sapiens 122-126 15509780-5 2004 TRE17 associates directly with Arf6 in its GDP- but not GTP-bound state. Guanosine Diphosphate 43-46 ADP ribosylation factor 6 Homo sapiens 31-35