PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25753113-7 2015 The observed small degree of colocalization of NPs and wildtype Rab5 is consistent with recycling of Rab5-GDP to the plasma membrane and not indicative of NP escape from EEs. Guanosine Diphosphate 106-109 RAB5A, member RAS oncogene family Homo sapiens 101-105 26430212-3 2015 Rab5 and its effector rabaptin5 (Rbpt5, also known as RABEP1) are generally considered the prime example for a positive-feedback loop in which Rab5-GTP recruits Rbpt5 in complex with Rabex5 (also known as RABGEF1), the GDP/GTP exchange factor of Rab5, to early endosomes, thus maintaining the Rab5 membrane identity. Guanosine Diphosphate 219-222 RAB5A, member RAS oncogene family Homo sapiens 0-4 26430212-3 2015 Rab5 and its effector rabaptin5 (Rbpt5, also known as RABEP1) are generally considered the prime example for a positive-feedback loop in which Rab5-GTP recruits Rbpt5 in complex with Rabex5 (also known as RABGEF1), the GDP/GTP exchange factor of Rab5, to early endosomes, thus maintaining the Rab5 membrane identity. Guanosine Diphosphate 219-222 RAB5A, member RAS oncogene family Homo sapiens 143-147 26430212-3 2015 Rab5 and its effector rabaptin5 (Rbpt5, also known as RABEP1) are generally considered the prime example for a positive-feedback loop in which Rab5-GTP recruits Rbpt5 in complex with Rabex5 (also known as RABGEF1), the GDP/GTP exchange factor of Rab5, to early endosomes, thus maintaining the Rab5 membrane identity. Guanosine Diphosphate 219-222 RAB5A, member RAS oncogene family Homo sapiens 143-147 26430212-3 2015 Rab5 and its effector rabaptin5 (Rbpt5, also known as RABEP1) are generally considered the prime example for a positive-feedback loop in which Rab5-GTP recruits Rbpt5 in complex with Rabex5 (also known as RABGEF1), the GDP/GTP exchange factor of Rab5, to early endosomes, thus maintaining the Rab5 membrane identity. Guanosine Diphosphate 219-222 RAB5A, member RAS oncogene family Homo sapiens 143-147 25800849-2 2015 Like other GTPases, Rab5 functions as a molecular switch by alternating between GTP-bound and GDP-bound forms, with the former being biologically active via interactions with multiple effector proteins. Guanosine Diphosphate 94-97 RAB5A, member RAS oncogene family Homo sapiens 20-24 19819222-7 2009 These findings might be of use for revealing the profound mechanism of the displacements of Rab5a switch regions, as well as the mechanism of the GDP dissociation and GTP association. Guanosine Diphosphate 146-149 RAB5A, member RAS oncogene family Homo sapiens 92-97 24520163-6 2014 By contrast, in Rab5 the switch II aspartate is required for Rabex mediated GDP-release. Guanosine Diphosphate 76-79 RAB5A, member RAS oncogene family Homo sapiens 16-20 23382462-5 2013 Here, we demonstrate that Rab-activating guanosine diphosphate/guanosine triphosphate exchange factors (GEFs) display the minimal targeting machinery for recruiting Rabs from the cytosol to the correct membrane using the Rab-GEF pairs Rab5A-Rabex-5, Rab1A-DrrA, and Rab8-Rabin8 as model systems. Guanosine Diphosphate 41-62 RAB5A, member RAS oncogene family Homo sapiens 235-240 20169068-7 2010 These studies show that the indirect pathway constitutes a positive feedback loop for converting Rab5-GDP to Rab5-GTP on the endosomal membrane and allows sensitive regulation of endosome fusion activity by the levels of Rab5 and Rabex-5 in the cell. Guanosine Diphosphate 102-105 RAB5A, member RAS oncogene family Homo sapiens 97-101 20169068-7 2010 These studies show that the indirect pathway constitutes a positive feedback loop for converting Rab5-GDP to Rab5-GTP on the endosomal membrane and allows sensitive regulation of endosome fusion activity by the levels of Rab5 and Rabex-5 in the cell. Guanosine Diphosphate 102-105 RAB5A, member RAS oncogene family Homo sapiens 109-113 20169068-7 2010 These studies show that the indirect pathway constitutes a positive feedback loop for converting Rab5-GDP to Rab5-GTP on the endosomal membrane and allows sensitive regulation of endosome fusion activity by the levels of Rab5 and Rabex-5 in the cell. Guanosine Diphosphate 102-105 RAB5A, member RAS oncogene family Homo sapiens 109-113 21586568-1 2011 The small GTPase Rab5, which cycles between GDP-bound inactive and GTP-bound active forms, plays essential roles in membrane budding and trafficking in the early endocytic pathway. Guanosine Diphosphate 44-47 RAB5A, member RAS oncogene family Homo sapiens 17-21 12432064-10 2002 Finally, all SARA-mediated phenotypic changes can be counteracted by overexpression Rab5:GDP mutant Rab5S34N. Guanosine Diphosphate 89-92 RAB5A, member RAS oncogene family Homo sapiens 84-88 17987124-1 2007 BACKGROUND: Small GTPases of the Rab family can cycle between a GTP- and a GDP-bound state and also between membrane and cytosol. Guanosine Diphosphate 75-78 RAB5A, member RAS oncogene family Homo sapiens 33-36 17987124-2 2007 The latter cycle is mediated by the Guanine Nucleotide Dissociation Inhibitor GDI, which can selectively extract GDP-bound Rab proteins from donor membranes, and then reload them on target membranes. Guanosine Diphosphate 113-116 RAB5A, member RAS oncogene family Homo sapiens 123-126 17473071-0 2007 Thyrotropin activates guanosine 5"-diphosphate/guanosine 5"-triphosphate exchange on the rate-limiting endocytic catalyst, Rab5a, in human thyrocytes in vivo and in vitro. Guanosine Diphosphate 22-46 RAB5A, member RAS oncogene family Homo sapiens 123-128 17395284-5 2007 Droplet Rabs are removed by Rab GDP-dissociation inhibitor (RabGDI) in a GDP-dependent reaction, and are recruited to Rab-depleted droplets from cytosol in a GTP-dependent reaction. Guanosine Diphosphate 32-35 RAB5A, member RAS oncogene family Homo sapiens 8-12 17395284-9 2007 Finally, we show that when GTP bound active or GDP bound inactive Rab5 is targeted to the droplet, the active form recruits EEA1. Guanosine Diphosphate 47-50 RAB5A, member RAS oncogene family Homo sapiens 66-70 16473603-1 2005 The small GTPase Rab5 is one of the key regulators of early endocytic traffic and, like other GTPases, cycles between GTP- and GDP-bound states as well as between membrane and cytosol. Guanosine Diphosphate 127-130 RAB5A, member RAS oncogene family Homo sapiens 17-21 16473603-3 2005 GDI extracts from membranes the inactive GDP-bound form of the Rab. Guanosine Diphosphate 41-44 RAB5A, member RAS oncogene family Homo sapiens 63-66 14600265-5 2003 Although the plasma membrane-localized activity of Rab5 was not detected by light microscopy, overexpression of a GDP-bound mutant of CFP-Rab5(S34N) inhibited internalization of the epidermal growth factor receptor by retaining receptors in clathrin-coated pits. Guanosine Diphosphate 114-117 RAB5A, member RAS oncogene family Homo sapiens 138-142 12972505-1 2003 The small GTPase Rab5, which cycles between active (GTP-bound) and inactive (GDP-bound) states, plays essential roles in membrane budding and trafficking in the early endocytic pathway. Guanosine Diphosphate 77-80 RAB5A, member RAS oncogene family Homo sapiens 17-21 19372461-5 2009 Expression of GTP or GDP-bound Rab5a mutants block activated VEGFR2 trafficking and degradation. Guanosine Diphosphate 21-24 RAB5A, member RAS oncogene family Homo sapiens 31-36 18957427-8 2008 Moreover, the expression of dominant-negative Rab5, unable to exchange GDP for GTP, interfered with the agonist-induced dissociation of Rab5 from the syndecan-1 cytoplasmic domain and significantly inhibited syndecan-1 shedding induced by several distinct agonists. Guanosine Diphosphate 71-74 RAB5A, member RAS oncogene family Homo sapiens 46-50 18957427-9 2008 Based on these data, we propose that Rab5 is a critical regulator of syndecan-1 shedding that serves as an on-off molecular switch through its alternation between the GDP-bound and GTP-bound forms. Guanosine Diphosphate 167-170 RAB5A, member RAS oncogene family Homo sapiens 37-41 18425118-7 2008 Finally, we have also identified a previously undescribed biochemical complex containing Vps34, dynamin and Rab5(GDP), thus providing a mechanism for Rab5 recruitment to the nascent phagosome. Guanosine Diphosphate 113-116 RAB5A, member RAS oncogene family Homo sapiens 108-112 18425118-7 2008 Finally, we have also identified a previously undescribed biochemical complex containing Vps34, dynamin and Rab5(GDP), thus providing a mechanism for Rab5 recruitment to the nascent phagosome. Guanosine Diphosphate 113-116 RAB5A, member RAS oncogene family Homo sapiens 150-154 16410077-4 2006 We show that the Vps9 domain is sufficient for the interaction of RAP6 with GDP-bound Rab5 and that RAP6 stimulates Rab5 guanine nucleotide exchange. Guanosine Diphosphate 76-79 RAB5A, member RAS oncogene family Homo sapiens 86-90 10432006-11 1999 The RAB5A gene is a member of RAS superfamily, which can transcribe GTP-binding protein that plays an important role in signal transduction of protein trafficking at the cell surface and GDP/GTP cycle in the regulation of endocytotic membrane traffic. Guanosine Diphosphate 187-190 RAB5A, member RAS oncogene family Homo sapiens 4-9 11733506-1 2002 The small GTPase Rab family, which cycles between GTP-bound active and GDP-bound inactive states, plays an important role in membrane trafficking. Guanosine Diphosphate 71-74 RAB5A, member RAS oncogene family Homo sapiens 17-20 11703925-3 2001 Here, we show that this region is necessary and sufficient for RIN1 interaction with the GDP-bound Rabs, Vps21p, and Rab5A. Guanosine Diphosphate 89-92 RAB5A, member RAS oncogene family Homo sapiens 117-122 11239470-1 2001 Early endocytic membrane traffic is regulated by the small GTPase Rab5, which cycles between GTP- and GDP-bound states as well as between membrane and cytosol. Guanosine Diphosphate 102-105 RAB5A, member RAS oncogene family Homo sapiens 66-70 9524116-6 1998 Rabaptin-5beta does not heterodimerize with Rabaptin-5, and forms a distinct complex with Rabex-5, the GDP/GTP exchange factor for Rab5. Guanosine Diphosphate 103-106 RAB5A, member RAS oncogene family Homo sapiens 131-135 8702787-1 1996 We describe here the kinetics of the interaction of GTP and GDP with the small GTP-binding proteins Rab5 and Rab7. Guanosine Diphosphate 60-63 RAB5A, member RAS oncogene family Homo sapiens 100-104 9323142-2 1997 Rab GDP dissociation inhibitor delivers Rab5 to the membrane, where a nucleotide exchange activity allows recruitment of an effector protein, Rabaptin-5. Guanosine Diphosphate 4-7 RAB5A, member RAS oncogene family Homo sapiens 40-44 9323142-6 1997 Rabex-5 displays GDP/GTP exchange activity on Rab5 upon delivery of the GTPase to the membrane. Guanosine Diphosphate 17-20 RAB5A, member RAS oncogene family Homo sapiens 46-50 8769123-2 1996 Rab-GDP dissociation inhibitor prevents dissociation of GDP from Rab proteins and extracts Rab proteins from cell membranes in vitro. Guanosine Diphosphate 4-7 RAB5A, member RAS oncogene family Homo sapiens 0-3 8769123-2 1996 Rab-GDP dissociation inhibitor prevents dissociation of GDP from Rab proteins and extracts Rab proteins from cell membranes in vitro. Guanosine Diphosphate 4-7 RAB5A, member RAS oncogene family Homo sapiens 65-68 8769123-2 1996 Rab-GDP dissociation inhibitor prevents dissociation of GDP from Rab proteins and extracts Rab proteins from cell membranes in vitro. Guanosine Diphosphate 56-59 RAB5A, member RAS oncogene family Homo sapiens 0-3 8769123-2 1996 Rab-GDP dissociation inhibitor prevents dissociation of GDP from Rab proteins and extracts Rab proteins from cell membranes in vitro. Guanosine Diphosphate 56-59 RAB5A, member RAS oncogene family Homo sapiens 65-68 7890612-3 1995 The single-step catalytic rate of Rab5 WT exceeded that of Q79L 12.2-fold, but the steady-state GTPase rate was only 2.8-fold greater because GDP dissociation was rate-limiting and GDP dissociation was 3.6-fold slower than for Q79L. Guanosine Diphosphate 181-184 RAB5A, member RAS oncogene family Homo sapiens 34-38 7592625-2 1995 When excited at 290 nm, Rab5 displays emission maxima at 339.7 nm for the GDP-bound and 336.7 nm for the GTP gamma S-bound forms. Guanosine Diphosphate 74-77 RAB5A, member RAS oncogene family Homo sapiens 24-28 8576119-2 1996 Thus, inhibition of GDP release is apparently exerted via coordination of Mg2+ between Rab5 and GDP. Guanosine Diphosphate 20-23 RAB5A, member RAS oncogene family Homo sapiens 87-91 8576119-5 1996 The correlation between Mg2+ effects on nucleotide exchange and the fluorescence properties of Rab5 suggests that a conformation promoted through Mg2+ coordination with Ser34 also contributes to inhibition of GDP release. Guanosine Diphosphate 209-212 RAB5A, member RAS oncogene family Homo sapiens 95-99 7592935-0 1995 GDP dissociation inhibitor serves as a cytosolic acceptor for newly synthesized and prenylated Rab5. Guanosine Diphosphate 0-3 RAB5A, member RAS oncogene family Homo sapiens 95-99 7890612-8 1995 Rab5 N133I underwent no apparent proteolysis with 10 mM GTP or GDP, suggesting a "triphosphate" conformation may be induced in Rab5 N133I by either GTP or GDP. Guanosine Diphosphate 155-158 RAB5A, member RAS oncogene family Homo sapiens 0-4 7890612-8 1995 Rab5 N133I underwent no apparent proteolysis with 10 mM GTP or GDP, suggesting a "triphosphate" conformation may be induced in Rab5 N133I by either GTP or GDP. Guanosine Diphosphate 155-158 RAB5A, member RAS oncogene family Homo sapiens 127-131 8139660-3 1994 In vitro, Rab proteins are removed from membranes by a protein that inhibits GDP dissociation (rabGDI), which leads to formation of a cytosolic complex of Rab with the inhibitor protein. Guanosine Diphosphate 77-80 RAB5A, member RAS oncogene family Homo sapiens 155-158 8137813-8 1994 A different mutant, rab5 S34N, was found, like the inhibitory p21-ras S17N mutant, to have a preferential affinity for GDP. Guanosine Diphosphate 119-122 RAB5A, member RAS oncogene family Homo sapiens 20-24 8139660-0 1994 Membrane association of Rab5 mediated by GDP-dissociation inhibitor and accompanied by GDP/GTP exchange. Guanosine Diphosphate 41-44 RAB5A, member RAS oncogene family Homo sapiens 24-28 8139660-0 1994 Membrane association of Rab5 mediated by GDP-dissociation inhibitor and accompanied by GDP/GTP exchange. Guanosine Diphosphate 87-90 RAB5A, member RAS oncogene family Homo sapiens 24-28 8139660-2 1994 The GTP/GDP cycle is believed to control shuttling of Rab proteins between the cytosol and organelle membranes. Guanosine Diphosphate 8-11 RAB5A, member RAS oncogene family Homo sapiens 54-57 8139660-3 1994 In vitro, Rab proteins are removed from membranes by a protein that inhibits GDP dissociation (rabGDI), which leads to formation of a cytosolic complex of Rab with the inhibitor protein. Guanosine Diphosphate 77-80 RAB5A, member RAS oncogene family Homo sapiens 10-13 32104603-2 2020 Rab proteins alternate between an activated (GTP-bound) state and an inactivated (GDP-bound) state. Guanosine Diphosphate 82-85 RAB5A, member RAS oncogene family Homo sapiens 0-3 8226999-12 1993 The S35N mutation, which is immediately downstream of the first GTP/GDP binding motif, decreased guanine nucleotide binding by approximately 4-fold and partially inactivated rab5. Guanosine Diphosphate 68-71 RAB5A, member RAS oncogene family Homo sapiens 174-178 33335690-2 2020 Rapid GDP/GTP exchange in the packet of Rab5 sustains its high activity for promoting cancer progression. Guanosine Diphosphate 6-9 RAB5A, member RAS oncogene family Homo sapiens 40-44 33335690-4 2020 Herein, we reported the discovery of a novel Rab5 inhibitor, neoandrographolide (NAP), by using high-throughput virtual screening with a natural product library containing 7459 compounds, which can occupy the surface groove of Rab5, competing with GDP/GTP for the binding. Guanosine Diphosphate 248-251 RAB5A, member RAS oncogene family Homo sapiens 45-49 33335690-4 2020 Herein, we reported the discovery of a novel Rab5 inhibitor, neoandrographolide (NAP), by using high-throughput virtual screening with a natural product library containing 7459 compounds, which can occupy the surface groove of Rab5, competing with GDP/GTP for the binding. Guanosine Diphosphate 248-251 RAB5A, member RAS oncogene family Homo sapiens 227-231 33335690-5 2020 Ser34 is the most important residue in the groove of Rab5, as it forms most hydrogen-bond interactions with GDP/GTP or NAP, and in silico mutation of Ser34 decreased the stabilization of Rab5. Guanosine Diphosphate 108-111 RAB5A, member RAS oncogene family Homo sapiens 53-57 33335690-5 2020 Ser34 is the most important residue in the groove of Rab5, as it forms most hydrogen-bond interactions with GDP/GTP or NAP, and in silico mutation of Ser34 decreased the stabilization of Rab5. Guanosine Diphosphate 108-111 RAB5A, member RAS oncogene family Homo sapiens 187-191 33335690-8 2020 This finding firstly identifies NAP as a novel inhibitor of Rab5, which directly binds with Rab5 by occupying the GDP/GTP binding groove to suppress its functions, highlighting a great potential of NAP to be developed as a chemotherapeutic agent in cancer therapy. Guanosine Diphosphate 114-117 RAB5A, member RAS oncogene family Homo sapiens 60-64 33335690-8 2020 This finding firstly identifies NAP as a novel inhibitor of Rab5, which directly binds with Rab5 by occupying the GDP/GTP binding groove to suppress its functions, highlighting a great potential of NAP to be developed as a chemotherapeutic agent in cancer therapy. Guanosine Diphosphate 114-117 RAB5A, member RAS oncogene family Homo sapiens 92-96 8226909-4 1993 Rab5N133I, a point mutant that has impaired ability to bind GTP or GDP, undergoes modification to a limited extent and at a severely reduced rate when compared to cognate Rab5. Guanosine Diphosphate 67-70 RAB5A, member RAS oncogene family Homo sapiens 0-4 8226909-6 1993 Since the latter mutation results in defective GTPase activity, these combined observations indicate that guanine nucleotide binding plays an important role in the geranylgeranylation reaction and suggest that the GDP-bound form of Rab5 is the preferred conformation for interaction with Rab prenyltransferase. Guanosine Diphosphate 214-217 RAB5A, member RAS oncogene family Homo sapiens 232-236 31292193-8 2019 Moreover, expression of a GDP-bound Rab5 mutant (Rab5/S34N) or shRNA-mediated knockdown of endogenous Rab5 prevented FAK-induced A549 cell migration, whereas expression of WT or GTP-bound Rab5 (Rab5/Q79L), but not Rab5/S34N, promoted cell migration in FAK-null fibroblasts. Guanosine Diphosphate 26-29 RAB5A, member RAS oncogene family Homo sapiens 36-40 31811856-4 2020 Similarly, paroxetine and expression of the DN-GRK2 or the GDP-Rab5 mutants markedly decreased receptor internalization, alpha1B-adrenergic receptor phosphorylation, and attenuated the ability of the adrenergic agonist to induce homologous desensitization (calcium signaling). Guanosine Diphosphate 59-62 RAB5A, member RAS oncogene family Homo sapiens 63-67 31811856-7 2020 The possibility that Rab5 might form part of a signaling complex is suggested, as well as that GDP-Rab5 might interfere with the ability of GRK2 to catalyze alpha1B-adrenergic receptor phosphorylation. Guanosine Diphosphate 95-98 RAB5A, member RAS oncogene family Homo sapiens 99-103 31292193-8 2019 Moreover, expression of a GDP-bound Rab5 mutant (Rab5/S34N) or shRNA-mediated knockdown of endogenous Rab5 prevented FAK-induced A549 cell migration, whereas expression of WT or GTP-bound Rab5 (Rab5/Q79L), but not Rab5/S34N, promoted cell migration in FAK-null fibroblasts. Guanosine Diphosphate 26-29 RAB5A, member RAS oncogene family Homo sapiens 49-53 31292193-8 2019 Moreover, expression of a GDP-bound Rab5 mutant (Rab5/S34N) or shRNA-mediated knockdown of endogenous Rab5 prevented FAK-induced A549 cell migration, whereas expression of WT or GTP-bound Rab5 (Rab5/Q79L), but not Rab5/S34N, promoted cell migration in FAK-null fibroblasts. Guanosine Diphosphate 26-29 RAB5A, member RAS oncogene family Homo sapiens 49-53 31292193-8 2019 Moreover, expression of a GDP-bound Rab5 mutant (Rab5/S34N) or shRNA-mediated knockdown of endogenous Rab5 prevented FAK-induced A549 cell migration, whereas expression of WT or GTP-bound Rab5 (Rab5/Q79L), but not Rab5/S34N, promoted cell migration in FAK-null fibroblasts. Guanosine Diphosphate 26-29 RAB5A, member RAS oncogene family Homo sapiens 49-53 31292193-8 2019 Moreover, expression of a GDP-bound Rab5 mutant (Rab5/S34N) or shRNA-mediated knockdown of endogenous Rab5 prevented FAK-induced A549 cell migration, whereas expression of WT or GTP-bound Rab5 (Rab5/Q79L), but not Rab5/S34N, promoted cell migration in FAK-null fibroblasts. Guanosine Diphosphate 26-29 RAB5A, member RAS oncogene family Homo sapiens 49-53 31292193-8 2019 Moreover, expression of a GDP-bound Rab5 mutant (Rab5/S34N) or shRNA-mediated knockdown of endogenous Rab5 prevented FAK-induced A549 cell migration, whereas expression of WT or GTP-bound Rab5 (Rab5/Q79L), but not Rab5/S34N, promoted cell migration in FAK-null fibroblasts. Guanosine Diphosphate 26-29 RAB5A, member RAS oncogene family Homo sapiens 49-53 28968219-9 2017 We propose a regulatory mechanism of Rab5 where monoubiquitination downregulates effector recruitment and GDP/GTP conversion in a site-specific manner. Guanosine Diphosphate 106-109 RAB5A, member RAS oncogene family Homo sapiens 37-41 29065764-3 2019 The GDP dissociation inhibitor (GDI) recognizes membrane-associated Rab5(GDP) and serves to release it into the cytoplasm where it is kept in a soluble state. Guanosine Diphosphate 4-7 RAB5A, member RAS oncogene family Homo sapiens 68-72 29065764-4 2019 A detailed new structural and dynamic model for human Rab5(GDP) recognition and binding with human GDI at the early endosome membrane and in its dissociated state is presented. Guanosine Diphosphate 59-62 RAB5A, member RAS oncogene family Homo sapiens 54-58 29065764-6 2019 In solution, two different binding modes of the isoprenoid chains inserted into the hydrophobic pocket of the Rab5(GDP):GDI complex can be identified. Guanosine Diphosphate 115-118 RAB5A, member RAS oncogene family Homo sapiens 110-114 29743547-7 2018 We show that PAR2 stimulation promotes AKT phosphorylation which activates Rab5a by converting inactive Rab5a-GDP to active Rab5a-GTP. Guanosine Diphosphate 110-113 RAB5A, member RAS oncogene family Homo sapiens 75-80 29743547-7 2018 We show that PAR2 stimulation promotes AKT phosphorylation which activates Rab5a by converting inactive Rab5a-GDP to active Rab5a-GTP. Guanosine Diphosphate 110-113 RAB5A, member RAS oncogene family Homo sapiens 104-109 29743547-7 2018 We show that PAR2 stimulation promotes AKT phosphorylation which activates Rab5a by converting inactive Rab5a-GDP to active Rab5a-GTP. Guanosine Diphosphate 110-113 RAB5A, member RAS oncogene family Homo sapiens 104-109 28779233-4 2017 An in-depth structural comparison of APMV Rab with each other and with mammalian Rab homologues led to an atomic-level elucidation of the inactive-active conformational change upon GDP/GTP exchange. Guanosine Diphosphate 181-184 RAB5A, member RAS oncogene family Homo sapiens 42-45 28779233-4 2017 An in-depth structural comparison of APMV Rab with each other and with mammalian Rab homologues led to an atomic-level elucidation of the inactive-active conformational change upon GDP/GTP exchange. Guanosine Diphosphate 181-184 RAB5A, member RAS oncogene family Homo sapiens 81-84 27841328-1 2016 The role of GDP dissociation inhibitor (GDI) protein in regulation of Rab cycle in Leishmania is not known. Guanosine Diphosphate 12-15 RAB5A, member RAS oncogene family Homo sapiens 70-73 27841328-3 2016 Our results have shown that LdGDI:WT along with GDP removes the Rab5 from purified endosomes and inhibits the homotypic fusion between early endosomes. Guanosine Diphosphate 48-51 RAB5A, member RAS oncogene family Homo sapiens 64-68 27335171-6 2016 We report here that inhibition of V-ATPase with bafilomycin A1 as well as inactivation of the GTP-GDP cycle of Rab5a GTPase phenotypically rescued or completely precluded the cytoplasmic vacuolization despite the continued presence of inactivated PIKfyve or Vps34. Guanosine Diphosphate 98-101 RAB5A, member RAS oncogene family Homo sapiens 111-116