PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33125148-1 2020 Ras p21 protein activator 1 (RASA1) is a regulator of Ras GDP and GTP and is involved in numerous physiological processes such as angiogenesis, cell proliferation, and apoptosis. Guanosine Diphosphate 58-61 RAS p21 protein activator 1 Homo sapiens 0-27 33125148-1 2020 Ras p21 protein activator 1 (RASA1) is a regulator of Ras GDP and GTP and is involved in numerous physiological processes such as angiogenesis, cell proliferation, and apoptosis. Guanosine Diphosphate 58-61 RAS p21 protein activator 1 Homo sapiens 29-34 25820867-1 2015 The free energy profiles for the chemical reaction of the guanosine triphosphate hydrolysis GTP + H2O GDP + Pi by Ras-GAP for the wild-type and G13V mutated Ras were computed by using molecular dynamics protocols with the QM(ab initio)/MM potentials. Guanosine Diphosphate 104-107 RAS p21 protein activator 1 Homo sapiens 116-123 22664862-7 2012 This is the first report demonstrating that PAG inhibits the proliferation and invasion potential of prostate cancer cells via the interaction with RasGAP to recruit RasGAP to the cell membrane, where RasGAP hydrolyzes GTP to GDP, reduces the level of activated Ras, and ultimately suppresses the activation of ERK1/2, cyclin D1 and other effectors of the Ras signaling pathway. Guanosine Diphosphate 262-265 RAS p21 protein activator 1 Homo sapiens 172-178 23181905-0 2012 Detailed structure of the H2PO4(-)-guanosine diphosphate intermediate in Ras-GAP decoded from FTIR experiments by biomolecular simulations. Guanosine Diphosphate 31-56 RAS p21 protein activator 1 Homo sapiens 73-80 18682833-1 2008 The Ras GTPase-activating protein RasGAP catalyzes the conversion of active GTP-bound Ras into inactive GDP-bound Ras. Guanosine Diphosphate 104-107 RAS p21 protein activator 1 Homo sapiens 34-40 9312123-9 1997 As a consequence of this inhibition, presence of p120-GAP enhanced the regeneration of Ha-Ras.GTPgammaS by GEF at a GDP:GTPgammaS ratio mimicking the in vivo GDP:GTP ratio. Guanosine Diphosphate 116-119 RAS p21 protein activator 1 Homo sapiens 49-57 16052311-1 2005 The structures of the complexes between Ras*GDP bound to RasGAP in the presence of three probable gamma-phosphate analogs (AlF3, AlF4- and MgF3-) for the transition state (TS) of the hydrolysis of guanosine triphosphate (GTP) by the Ras-RasGAP enzymes have been modeled by quantum mechanical-molecular mechanical (QM/MM) calculations. Guanosine Diphosphate 44-47 RAS p21 protein activator 1 Homo sapiens 57-63 15906320-4 2005 At the first stage, a unified motion of Arg789 of GAP, Gln61, Thr35 of Ras, and the lytic water molecule results in a substantial spatial separation of the gamma-phosphate group of GTP from the rest of the molecule (GDP). Guanosine Diphosphate 216-219 RAS p21 protein activator 1 Homo sapiens 50-53 15917201-7 2005 RASA1 reverts active GTP-bound Ras into inactive GDP-bound form. Guanosine Diphosphate 49-52 RAS p21 protein activator 1 Homo sapiens 0-5 9312123-11 1997 This constrain is likely involved in the regulation of the physiological GDP/GTP cycle of Ras and in the action of p120-GAP as downstream effector of Ras. Guanosine Diphosphate 73-76 RAS p21 protein activator 1 Homo sapiens 115-123 8658179-2 1996 However, the product of the proto-oncogene ras in its guanosine diphosphate (GDP)-bound form interacted with AIF4 - in the presence of stoichiometric amounts of either of the guanosine triphosphatase (GTPase)-activating proteins (GAPs) p120GAP and neurofibromin. Guanosine Diphosphate 54-75 RAS p21 protein activator 1 Homo sapiens 236-243 9219684-1 1997 The three-dimensional structure of the complex between human H-Ras bound to guanosine diphosphate and the guanosine triphosphatase (GTPase)-activating domain of the human GTPase-activating protein p120GAP (GAP-334) in the presence of aluminum fluoride was solved at a resolution of 2.5 angstroms. Guanosine Diphosphate 76-97 RAS p21 protein activator 1 Homo sapiens 197-204 9255347-4 1997 Proteins that can stimulate the GTPase activity of Ras (GAPs) ensure that following mitogenic stimulations, they return to their inactive GDP-bound state; amongst these proteins are p120-GAP, neurofibomin (the product of the susceptibility gene to type I neurofibromatosis), as well as the inositol 1,3,4,5-tetrakisphosphate-dependent GAPIP4BF. Guanosine Diphosphate 138-141 RAS p21 protein activator 1 Homo sapiens 182-190 8658179-2 1996 However, the product of the proto-oncogene ras in its guanosine diphosphate (GDP)-bound form interacted with AIF4 - in the presence of stoichiometric amounts of either of the guanosine triphosphatase (GTPase)-activating proteins (GAPs) p120GAP and neurofibromin. Guanosine Diphosphate 77-80 RAS p21 protein activator 1 Homo sapiens 236-243 8909796-2 1996 GTPase activating proteins (p120GAP, neurofibromin and GAP1) are negative regulators that stimulate hydrolysis of bound GTP to GDP, and guanine nucleotide exchange factors (Sos and Ras-GRF) are positive regulators that stimulate the exchange of GDP bound to Ras for fresh GTP from the cytosol. Guanosine Diphosphate 127-130 RAS p21 protein activator 1 Homo sapiens 28-35 8909796-2 1996 GTPase activating proteins (p120GAP, neurofibromin and GAP1) are negative regulators that stimulate hydrolysis of bound GTP to GDP, and guanine nucleotide exchange factors (Sos and Ras-GRF) are positive regulators that stimulate the exchange of GDP bound to Ras for fresh GTP from the cytosol. Guanosine Diphosphate 245-248 RAS p21 protein activator 1 Homo sapiens 28-35