PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35001550-2 2022 Perylenebisimide (PBI) chromophore tagged fluorescent ABC-triblock polycaprolactone (PCL) nanoscaffold was engineered having carboxylic acid blocks for the chemical conjugation of cisplatin at the core and hydrophilic PEG blocks at the periphery. Polyethylene Glycols 218-221 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 54-57 35217484-2 2022 However, linear PEG-modified nanocarriers have been found to induce anti-PEG IgM at the first injection, which triggers the accelerated blood clearance (ABC) phenomenon upon repeated injections. Polyethylene Glycols 16-19 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 153-156 35217484-2 2022 However, linear PEG-modified nanocarriers have been found to induce anti-PEG IgM at the first injection, which triggers the accelerated blood clearance (ABC) phenomenon upon repeated injections. Polyethylene Glycols 73-76 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 153-156 30378014-9 2019 Based on our findings, we suggest that there is a positive linear relationship between stability of PEG-modified micelles and susceptibility to the ABC phenomenon. Polyethylene Glycols 100-103 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 148-151 34008617-6 2021 Polyethylene glycol (PEG) modification has been widely used to stabilize hydrophobic prodrug nanoparticles and prolong the circulation time, but the PEGylated nanoparticles always suffer from accelerated blood clearance (ABC), a phenomenon which restricts their application severely. Polyethylene Glycols 0-19 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 221-224 34008617-6 2021 Polyethylene glycol (PEG) modification has been widely used to stabilize hydrophobic prodrug nanoparticles and prolong the circulation time, but the PEGylated nanoparticles always suffer from accelerated blood clearance (ABC), a phenomenon which restricts their application severely. Polyethylene Glycols 21-24 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 221-224 31275462-4 2019 ABC involves the production of antibodies toward nanocarrier components, including PEG, which reduces the safety and effectiveness of encapsulated therapeutic agents. Polyethylene Glycols 83-86 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 0-3 32104322-2 2017 However, PEG-modified liposomes can induce accelerated blood clearance (ABC) upon repeated administration, and the extent of ABC phenomenon on the cytotoxic drugs-containing PEGylated liposomes is related to the dose of the cytotoxic drugs. Polyethylene Glycols 9-12 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 72-75 23727909-5 2013 On the other hand, accelerated blood clearance (ABC) phenomenon is a well-known immunological response of PEG-coated liposomes. Polyethylene Glycols 106-109 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 48-51 23933235-1 2013 Despite the clinical introduction of an increasing number of polyethylene glycol (PEG)-conjugated substances, PEG has been named as the cause of an unexpected immunogenic response known as the "accelerated blood clearance (ABC) phenomenon." Polyethylene Glycols 61-80 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 223-226 23933235-1 2013 Despite the clinical introduction of an increasing number of polyethylene glycol (PEG)-conjugated substances, PEG has been named as the cause of an unexpected immunogenic response known as the "accelerated blood clearance (ABC) phenomenon." Polyethylene Glycols 110-113 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 223-226 23933235-4 2013 In addition, the clinical implications of the ABC phenomenon on the therapeutic efficacy of PEG-conjugated substances/PEGylated nanocarriers, along with the new approaches that can be applied to manage and/or abrogate the induction of the ABC phenomenon, are also discussed. Polyethylene Glycols 92-95 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 46-49 23933235-4 2013 In addition, the clinical implications of the ABC phenomenon on the therapeutic efficacy of PEG-conjugated substances/PEGylated nanocarriers, along with the new approaches that can be applied to manage and/or abrogate the induction of the ABC phenomenon, are also discussed. Polyethylene Glycols 92-95 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 239-242 23727909-6 2013 Since the ABC phenomenon greatly influences targeting functions of carrier systems, elaborative studies on polymeric micelles" ABC phenomenon have been done, and revealed different behaviors of the polymeric micelle systems from those of PEG-coated liposomes. Polyethylene Glycols 238-241 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 10-13 19209424-1 2009 This work deals with the self-assembly in water of ABC miktoarm star terpolymers consisting of hydrophobic poly(-caprolactone), hydrophilic poly(ethylene oxide) (PEO), and pH-sensitive poly(2-vinylpyridine) (P2VP). Polyethylene Glycols 140-160 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 51-54 21277920-4 2011 Doxorubicin (DOX), an anthracycline antibiotic commonly used in cancer chemotherapy and substrate for ABC-mediated drug efflux, was covalently bound to polyethylenimine via a pH sensitive hydrazone linkage and conjugated to an iron oxide nanoparticle coated with amine terminated polyethylene glycol. Polyethylene Glycols 280-299 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 102-105 19952519-5 2009 The induction of ABC phenomenon is related to the production of anti-PEG IgM from splenic B cells. Polyethylene Glycols 69-72 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 17-20 19952519-8 2009 Finally, the size-dependency of ABC phenomenon was investigated by use of variously sized PEGylated liposomes and polymeric micelles having PEG chains. Polyethylene Glycols 90-93 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 32-35 19239225-8 2009 In aqueous solution, PEG(-b-PMAA)-b-PDEA zwitterionic ABC miktoarm star terpolymers can self-assemble into three types of micellar aggregates by simply adjusting solution pH at room temperature. Polyethylene Glycols 21-24 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 54-57 19209424-1 2009 This work deals with the self-assembly in water of ABC miktoarm star terpolymers consisting of hydrophobic poly(-caprolactone), hydrophilic poly(ethylene oxide) (PEO), and pH-sensitive poly(2-vinylpyridine) (P2VP). Polyethylene Glycols 162-165 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 51-54 18239370-2 2008 Recently, it was demonstrated by our group that anti-PEG IgM, induced by the first dose of PEGylated liposomes, is responsible for the ABC phenomenon. Polyethylene Glycols 53-56 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 135-138 17358044-4 2007 The ABC triblock copolymer is based on poly(ethylene glycol) (PEG), poly(propylene sulfide) (PPS), and a positively charged peptide (PEG-PPS-peptide). Polyethylene Glycols 39-60 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 4-7 17358044-4 2007 The ABC triblock copolymer is based on poly(ethylene glycol) (PEG), poly(propylene sulfide) (PPS), and a positively charged peptide (PEG-PPS-peptide). Polyethylene Glycols 62-65 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 4-7 15835996-1 2005 A new type of amphiphilic ABC triblock copolymer, poly(acrylic acid)(33)-poly(styrene)(47)-poly(ethylene oxide)(113) (PAA(33)-PS(47)-PEO(113)), was designed to assist the synthesis of core/shell structured CdTe nanowires via a one-step synthetic route. Polyethylene Glycols 91-111 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 26-29 34896215-4 2022 Previous studies have focused on PEG molecular weight and PEG alternative materials, but there has never been any research on the effect of different PEG chain types on the ABC phenomenon. Polyethylene Glycols 150-153 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 173-176 17399838-3 2007 Interestingly, we found that under certain circumstances administration of conventional liposomes without PEG-coating also caused a strong ABC response upon injection of a second dose of PEGylated liposomes, but not of conventional liposomes. Polyethylene Glycols 106-109 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 139-142 17399838-7 2007 Taken together, our results demonstrate that the ABC phenomenon is fully attributable to production of anti-PEG IgM by the first dose of liposomes and the subsequent complement activation upon a second dose of PEGylated but not conventional liposomes. Polyethylene Glycols 108-111 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 49-52