PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24560660-0 2014 Nod2 deficiency protects mice from cholestatic liver disease by increasing renal excretion of bile acids. Bile Acids and Salts 94-104 nucleotide-binding oligomerization domain containing 2 Mus musculus 0-4 24560660-6 2014 Most notably, the hepatic bile acid concentration was lower in Nod2(-/-) mice than wild type mice following bile duct ligation for 3 weeks. Bile Acids and Salts 26-35 nucleotide-binding oligomerization domain containing 2 Mus musculus 63-67 24560660-7 2014 In contrast to wild type mice, Nod2(-/-) mice had increased urinary excretion of bile acids, including sulfated bile acids, and an upregulation of the bile acid efflux transporters MRP2 and MRP4 in tubular epithelial cells of the kidney. Bile Acids and Salts 81-91 nucleotide-binding oligomerization domain containing 2 Mus musculus 31-35 24560660-7 2014 In contrast to wild type mice, Nod2(-/-) mice had increased urinary excretion of bile acids, including sulfated bile acids, and an upregulation of the bile acid efflux transporters MRP2 and MRP4 in tubular epithelial cells of the kidney. Bile Acids and Salts 112-122 nucleotide-binding oligomerization domain containing 2 Mus musculus 31-35 24560660-7 2014 In contrast to wild type mice, Nod2(-/-) mice had increased urinary excretion of bile acids, including sulfated bile acids, and an upregulation of the bile acid efflux transporters MRP2 and MRP4 in tubular epithelial cells of the kidney. Bile Acids and Salts 81-90 nucleotide-binding oligomerization domain containing 2 Mus musculus 31-35 24560660-9 2014 CONCLUSIONS: Our findings indicate that Nod2 deficiency protects mice from cholestatic liver injury and fibrosis through enhancing renal excretion of bile acids that in turn contributes to decreased concentration of bile acids in the hepatocyte. Bile Acids and Salts 150-160 nucleotide-binding oligomerization domain containing 2 Mus musculus 40-44 24560660-9 2014 CONCLUSIONS: Our findings indicate that Nod2 deficiency protects mice from cholestatic liver injury and fibrosis through enhancing renal excretion of bile acids that in turn contributes to decreased concentration of bile acids in the hepatocyte. Bile Acids and Salts 216-226 nucleotide-binding oligomerization domain containing 2 Mus musculus 40-44