PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17560000-8	2007	Hydrophobic bile acids activate c-Jun-NH(2)-terminal kinase (JNK), p38 mitogen-activated protein kinases (MAPK), and extracellular signal-regulated kinase 1/2, and PF2401-SF inhibited the phosphorylation of JNK and p38.	Bile Acids and Salts	12-22	mitogen-activated protein kinase 8	Rattus norvegicus	61-64	
18550202-0	2008	Activation of focal adhesion kinase and JNK contributes to the extracellular matrix and cAMP-GEF mediated survival from bile acid induced apoptosis in rat hepatocytes.	Bile Acids and Salts	120-129	mitogen-activated protein kinase 8	Rattus norvegicus	40-43	
18550202-7	2008	SP-600125, a JNK inhibitor, prevented LM and PL potentiation of bile acid apoptosis.	Bile Acids and Salts	64-73	mitogen-activated protein kinase 8	Rattus norvegicus	13-16	
17560000-8	2007	Hydrophobic bile acids activate c-Jun-NH(2)-terminal kinase (JNK), p38 mitogen-activated protein kinases (MAPK), and extracellular signal-regulated kinase 1/2, and PF2401-SF inhibited the phosphorylation of JNK and p38.	Bile Acids and Salts	12-22	mitogen-activated protein kinase 8	Rattus norvegicus	207-210	
12949729-3	2003	RESULTS: Within 1 minute, the proapoptotic bile salts taurolithocholate-3-sulfate and glycochenodeoxycholate induced oxidative stress and EGF receptor (EGF-R) tyrosine phosphorylation followed by rapid c-Jun-N-terminal kinase (JNK) activation.	Bile Acids and Salts	43-53	mitogen-activated protein kinase 8	Rattus norvegicus	202-225	
17592815-0	2007	Butein suppresses bile acid-induced hepatocyte apoptosis through a JNK-dependent but ERK-independent pathway.	Bile Acids and Salts	18-27	mitogen-activated protein kinase 8	Rattus norvegicus	67-70	
14660582-2	2004	We have shown previously that bile acids can activate the JNK pathway and down-regulate cholesterol 7alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in the neutral pathway of bile acid biosynthesis.	Bile Acids and Salts	30-40	mitogen-activated protein kinase 8	Rattus norvegicus	58-61	
14660582-2	2004	We have shown previously that bile acids can activate the JNK pathway and down-regulate cholesterol 7alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in the neutral pathway of bile acid biosynthesis.	Bile Acids and Salts	30-39	mitogen-activated protein kinase 8	Rattus norvegicus	58-61	
12949729-3	2003	RESULTS: Within 1 minute, the proapoptotic bile salts taurolithocholate-3-sulfate and glycochenodeoxycholate induced oxidative stress and EGF receptor (EGF-R) tyrosine phosphorylation followed by rapid c-Jun-N-terminal kinase (JNK) activation.	Bile Acids and Salts	43-53	mitogen-activated protein kinase 8	Rattus norvegicus	227-230	
11984527-8	2002	The apoptotic potency of other bile acids paralleled their ability to induce sustained JNK activation.	Bile Acids and Salts	31-41	mitogen-activated protein kinase 8	Rattus norvegicus	87-90	
12947330-10	2003	CONCLUSIONS: These data show that pharmacologic inhibition of JNK activity reduces bile salt or TNF-alpha-induced apoptosis by maintaining expression of anti-apoptotic proteins.	Bile Acids and Salts	83-92	mitogen-activated protein kinase 8	Rattus norvegicus	62-65	
11984527-10	2002	JNK activation may be important for bile acid-induced apoptosis by triggering ligand-independent CD95 surface trafficking and activation of apoptosis.	Bile Acids and Salts	36-45	mitogen-activated protein kinase 8	Rattus norvegicus	0-3	
20675006-16	2010	Bile salt-induced hepatocyte apoptosis is partly mediated via a PI3K p110gamma dependent signaling pathway, potentially involving JNK.	Bile Acids and Salts	0-9	mitogen-activated protein kinase 8	Rattus norvegicus	130-133	
11278771-4	2001	In this study, we provide evidence that bile acids rapidly down-regulate CYP7A1 transcription via activation of the JNK/c-Jun pathway.	Bile Acids and Salts	40-50	mitogen-activated protein kinase 8	Rattus norvegicus	116-119	
11278771-12	2001	These results indicate that the bile acid-activated JNK pathway plays a pivotal role in regulating CYP7A1 levels in primary rat hepatocytes.	Bile Acids and Salts	32-41	mitogen-activated protein kinase 8	Rattus norvegicus	52-55