PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29933103-0 2018 Human OATP1B1 (SLCO1B1) transports sulfated bile acids and bile salts with particular efficiency. Bile Acids and Salts 44-54 solute carrier organic anion transporter family member 1B1 Homo sapiens 6-13 33860121-3 2021 How this OATP1B1/1B3 defect disturbs bile acid (BA) metabolism is largely unknown. Bile Acids and Salts 37-46 solute carrier organic anion transporter family member 1B1 Homo sapiens 9-20 33860121-3 2021 How this OATP1B1/1B3 defect disturbs bile acid (BA) metabolism is largely unknown. Bile Acids and Salts 48-50 solute carrier organic anion transporter family member 1B1 Homo sapiens 9-20 33860121-8 2021 The cycling pathway of BA-3G, consisting of excretion from upstream hepatocytes and uptake by downstream hepatocytes by OATP1B1/1B3 may exist to reduce the burden on upstream hepatocytes. Bile Acids and Salts 23-25 solute carrier organic anion transporter family member 1B1 Homo sapiens 120-131 32407928-5 2020 OATP1B1 and OATP1B3 also play important roles in the hepatic uptake of many endogenous molecules, such as bile acids, bilirubin, and coproporphyrins. Bile Acids and Salts 106-116 solute carrier organic anion transporter family member 1B1 Homo sapiens 0-7 29933103-0 2018 Human OATP1B1 (SLCO1B1) transports sulfated bile acids and bile salts with particular efficiency. Bile Acids and Salts 44-54 solute carrier organic anion transporter family member 1B1 Homo sapiens 15-22 29933103-0 2018 Human OATP1B1 (SLCO1B1) transports sulfated bile acids and bile salts with particular efficiency. Bile Acids and Salts 59-69 solute carrier organic anion transporter family member 1B1 Homo sapiens 6-13 29933103-0 2018 Human OATP1B1 (SLCO1B1) transports sulfated bile acids and bile salts with particular efficiency. Bile Acids and Salts 59-69 solute carrier organic anion transporter family member 1B1 Homo sapiens 15-22 29933103-4 2018 All bile acid derivatives except for CDC showed an efficient transport by OATP1B1. Bile Acids and Salts 4-13 solute carrier organic anion transporter family member 1B1 Homo sapiens 74-81 29933103-7 2018 In summary, human OATP1B1 transports sulfate esters of bile acids and bile salts more efficiently than monovalent bile salts. Bile Acids and Salts 55-65 solute carrier organic anion transporter family member 1B1 Homo sapiens 18-25 29933103-7 2018 In summary, human OATP1B1 transports sulfate esters of bile acids and bile salts more efficiently than monovalent bile salts. Bile Acids and Salts 70-80 solute carrier organic anion transporter family member 1B1 Homo sapiens 18-25 28060902-0 2017 Preference of Conjugated Bile Acids over Unconjugated Bile Acids as Substrates for OATP1B1 and OATP1B3. Bile Acids and Salts 25-35 solute carrier organic anion transporter family member 1B1 Homo sapiens 83-90 28060902-8 2017 However, all the conjugated bile acids were taken up rapidly by OATP1B1 and OATP1B3. Bile Acids and Salts 28-38 solute carrier organic anion transporter family member 1B1 Homo sapiens 64-71 28060902-9 2017 Kinetic analyses revealed the involvement of saturable OATP1B1- and OATP1B3-mediated transport of bile acids. Bile Acids and Salts 98-108 solute carrier organic anion transporter family member 1B1 Homo sapiens 55-62 28060902-10 2017 The apparent Km values for OATP1B1 and OATP1B3 of the conjugated bile acids were similar (0.74-14.7 muM for OATP1B1 and 0.47-15.3 muM for OATP1B3). Bile Acids and Salts 65-75 solute carrier organic anion transporter family member 1B1 Homo sapiens 27-34 28060902-10 2017 The apparent Km values for OATP1B1 and OATP1B3 of the conjugated bile acids were similar (0.74-14.7 muM for OATP1B1 and 0.47-15.3 muM for OATP1B3). Bile Acids and Salts 65-75 solute carrier organic anion transporter family member 1B1 Homo sapiens 108-115 28060902-12 2017 Our results suggest that conjugated bile acids (glycine and taurine) are preferred to unconjugated bile acids as substrates for OATP1B1 and OATP1B3. Bile Acids and Salts 36-46 solute carrier organic anion transporter family member 1B1 Homo sapiens 128-135 28060902-12 2017 Our results suggest that conjugated bile acids (glycine and taurine) are preferred to unconjugated bile acids as substrates for OATP1B1 and OATP1B3. Bile Acids and Salts 99-109 solute carrier organic anion transporter family member 1B1 Homo sapiens 128-135 29749252-1 2018 AIM: Selected bile acids (BAs) in plasma have been proposed as endogenous probes for assessing drug-drug interactions involving hepatic drug transporters such as the organic anion-transporting polypeptides (OATP1B1 and OATP1B3). Bile Acids and Salts 14-24 solute carrier organic anion transporter family member 1B1 Homo sapiens 207-214 28868654-1 2017 WHAT IS KNOWN AND OBJECTIVE: OATP1B1 mediates the transport of a diverse range of amphiphilic organic compounds that include bile acids, steroid conjugates and hormones. Bile Acids and Salts 125-135 solute carrier organic anion transporter family member 1B1 Homo sapiens 29-36 28060902-0 2017 Preference of Conjugated Bile Acids over Unconjugated Bile Acids as Substrates for OATP1B1 and OATP1B3. Bile Acids and Salts 54-64 solute carrier organic anion transporter family member 1B1 Homo sapiens 83-90 28060902-3 2017 Human organic anion-transporting polypeptides (OATP) 1B1 and OATP1B3 contribute to hepatic uptake of bile acids such as taurocholic acid. Bile Acids and Salts 101-111 solute carrier organic anion transporter family member 1B1 Homo sapiens 6-56 20827719-9 2010 CONCLUSION: We note that OATP1B1 transcriptional regulation is under dual nuclear receptor control through the oxysterol sensing LXRalpha and the bile acid sensor FXR. Bile Acids and Salts 146-155 solute carrier organic anion transporter family member 1B1 Homo sapiens 25-32 27174168-9 2016 Importantly, CDCA affected distinct microRNAs, including miR-34a, -505, -885, -1260 and -552 that systematically correlated in expression with gene clusters responsible for bile acid, lipid and drug homeostasis incorporating genes, such as e.g. SLCO1B1, SLC22A7, FGF19, CYP2E1, CYP1A2, APO family members and FOXO3. Bile Acids and Salts 173-182 solute carrier organic anion transporter family member 1B1 Homo sapiens 245-252 23311897-1 2013 BACKGROUND: Organic anion transporting polypeptide (OATP) 1B1, OATP1B3, and OATP2B1 (encoded by SLCO1B1, SLCO1B3, SLCO2B1) mediate the hepatic uptake of endogenous compounds like bile acids and of drugs, for example, the lipid-lowering atorvastatin, thereby influencing hepatobiliary elimination. Bile Acids and Salts 179-189 solute carrier organic anion transporter family member 1B1 Homo sapiens 12-61 23311897-1 2013 BACKGROUND: Organic anion transporting polypeptide (OATP) 1B1, OATP1B3, and OATP2B1 (encoded by SLCO1B1, SLCO1B3, SLCO2B1) mediate the hepatic uptake of endogenous compounds like bile acids and of drugs, for example, the lipid-lowering atorvastatin, thereby influencing hepatobiliary elimination. Bile Acids and Salts 179-189 solute carrier organic anion transporter family member 1B1 Homo sapiens 96-103 22562052-1 2012 The organic anion transporting polypeptide 1B1 (OATP1B1, encoded by SLCO1B1) plays an important role in the transport of endogenous and xenobiotic compounds, such as bile acids and rifampin. Bile Acids and Salts 166-176 solute carrier organic anion transporter family member 1B1 Homo sapiens 4-46 22562052-1 2012 The organic anion transporting polypeptide 1B1 (OATP1B1, encoded by SLCO1B1) plays an important role in the transport of endogenous and xenobiotic compounds, such as bile acids and rifampin. Bile Acids and Salts 166-176 solute carrier organic anion transporter family member 1B1 Homo sapiens 48-55 22562052-1 2012 The organic anion transporting polypeptide 1B1 (OATP1B1, encoded by SLCO1B1) plays an important role in the transport of endogenous and xenobiotic compounds, such as bile acids and rifampin. Bile Acids and Salts 166-176 solute carrier organic anion transporter family member 1B1 Homo sapiens 68-75 22562052-5 2012 Functional analyses were conducted to determine whether the inhibition of bile acids by rifampin was associated with OATP1B1 variants. Bile Acids and Salts 74-84 solute carrier organic anion transporter family member 1B1 Homo sapiens 117-124 22562052-11 2012 Functional assessment of the OATP1B1 *15 haplotype revealed that the activity of bile acid uptake was markedly reduced compared to the three other haplotypes. Bile Acids and Salts 81-90 solute carrier organic anion transporter family member 1B1 Homo sapiens 29-36 20973885-1 2011 AIM: Gallstone disease is an important cause of abdominal morbidity Organic anion transport protein 1B1 (OATP1B1) (encoded by SLCO1B1) is a major transporter protein for bile salt uptake in enterohepatic circulation of bile salts. Bile Acids and Salts 172-181 solute carrier organic anion transporter family member 1B1 Homo sapiens 70-105 20973885-1 2011 AIM: Gallstone disease is an important cause of abdominal morbidity Organic anion transport protein 1B1 (OATP1B1) (encoded by SLCO1B1) is a major transporter protein for bile salt uptake in enterohepatic circulation of bile salts. Bile Acids and Salts 172-181 solute carrier organic anion transporter family member 1B1 Homo sapiens 107-114 20973885-1 2011 AIM: Gallstone disease is an important cause of abdominal morbidity Organic anion transport protein 1B1 (OATP1B1) (encoded by SLCO1B1) is a major transporter protein for bile salt uptake in enterohepatic circulation of bile salts. Bile Acids and Salts 172-181 solute carrier organic anion transporter family member 1B1 Homo sapiens 128-135 20973885-1 2011 AIM: Gallstone disease is an important cause of abdominal morbidity Organic anion transport protein 1B1 (OATP1B1) (encoded by SLCO1B1) is a major transporter protein for bile salt uptake in enterohepatic circulation of bile salts. Bile Acids and Salts 221-231 solute carrier organic anion transporter family member 1B1 Homo sapiens 70-105 20973885-1 2011 AIM: Gallstone disease is an important cause of abdominal morbidity Organic anion transport protein 1B1 (OATP1B1) (encoded by SLCO1B1) is a major transporter protein for bile salt uptake in enterohepatic circulation of bile salts. Bile Acids and Salts 221-231 solute carrier organic anion transporter family member 1B1 Homo sapiens 107-114 20973885-1 2011 AIM: Gallstone disease is an important cause of abdominal morbidity Organic anion transport protein 1B1 (OATP1B1) (encoded by SLCO1B1) is a major transporter protein for bile salt uptake in enterohepatic circulation of bile salts. Bile Acids and Salts 221-231 solute carrier organic anion transporter family member 1B1 Homo sapiens 128-135 22352740-1 2012 The human organic anion-transporting polypeptides OATP1B1 (SLCO1B1) and OATP1B3 (SLCO1B3) are liver-enriched membrane transporters of major importance to hepatic uptake of numerous endogenous compounds, including bile acids, steroid conjugates, hormones, and drugs, including the 3-hydroxy-3-methylglutaryl Co-A reductase inhibitor (statin) family of cholesterol-lowering compounds. Bile Acids and Salts 213-223 solute carrier organic anion transporter family member 1B1 Homo sapiens 50-57 22352740-1 2012 The human organic anion-transporting polypeptides OATP1B1 (SLCO1B1) and OATP1B3 (SLCO1B3) are liver-enriched membrane transporters of major importance to hepatic uptake of numerous endogenous compounds, including bile acids, steroid conjugates, hormones, and drugs, including the 3-hydroxy-3-methylglutaryl Co-A reductase inhibitor (statin) family of cholesterol-lowering compounds. Bile Acids and Salts 213-223 solute carrier organic anion transporter family member 1B1 Homo sapiens 59-66 21902813-1 2012 Cholesterol 7alpha-hydroxylase (CYP7A1) is the rate-limiting enzyme of bile acid production in human beings, and organic anion-transporting polypeptide 1B1 (OATP1B1) may influence bile acid hepatic uptake and cholesterol and bile acid synthesis rate. Bile Acids and Salts 71-80 solute carrier organic anion transporter family member 1B1 Homo sapiens 157-164 21902813-1 2012 Cholesterol 7alpha-hydroxylase (CYP7A1) is the rate-limiting enzyme of bile acid production in human beings, and organic anion-transporting polypeptide 1B1 (OATP1B1) may influence bile acid hepatic uptake and cholesterol and bile acid synthesis rate. Bile Acids and Salts 180-189 solute carrier organic anion transporter family member 1B1 Homo sapiens 113-155 21902813-1 2012 Cholesterol 7alpha-hydroxylase (CYP7A1) is the rate-limiting enzyme of bile acid production in human beings, and organic anion-transporting polypeptide 1B1 (OATP1B1) may influence bile acid hepatic uptake and cholesterol and bile acid synthesis rate. Bile Acids and Salts 180-189 solute carrier organic anion transporter family member 1B1 Homo sapiens 157-164 21902813-1 2012 Cholesterol 7alpha-hydroxylase (CYP7A1) is the rate-limiting enzyme of bile acid production in human beings, and organic anion-transporting polypeptide 1B1 (OATP1B1) may influence bile acid hepatic uptake and cholesterol and bile acid synthesis rate. Bile Acids and Salts 180-189 solute carrier organic anion transporter family member 1B1 Homo sapiens 113-155 21902813-1 2012 Cholesterol 7alpha-hydroxylase (CYP7A1) is the rate-limiting enzyme of bile acid production in human beings, and organic anion-transporting polypeptide 1B1 (OATP1B1) may influence bile acid hepatic uptake and cholesterol and bile acid synthesis rate. Bile Acids and Salts 180-189 solute carrier organic anion transporter family member 1B1 Homo sapiens 157-164 21902813-2 2012 Our purpose was to investigate the effects of gender and CYP7A1 and SLCO1B1 polymorphisms on the fasting plasma concentrations of bile acids, bile acid synthesis marker and total cholesterol in a Finnish population. Bile Acids and Salts 130-140 solute carrier organic anion transporter family member 1B1 Homo sapiens 68-75 21902813-2 2012 Our purpose was to investigate the effects of gender and CYP7A1 and SLCO1B1 polymorphisms on the fasting plasma concentrations of bile acids, bile acid synthesis marker and total cholesterol in a Finnish population. Bile Acids and Salts 130-139 solute carrier organic anion transporter family member 1B1 Homo sapiens 68-75 19400585-2 2009 Members of this family include human OATP1B1 and OATP1B3, which have been widely studied and shown to be involved in the hepatic uptake of hormones, bile acids, and many clinically used drugs. Bile Acids and Salts 149-159 solute carrier organic anion transporter family member 1B1 Homo sapiens 37-44 19293444-1 2009 BACKGROUND & OBJECTIVES: Organic anion transport protein 1B1 (OATP1B1) is a major transporter protein for bile salt uptake in the enterohepatic circulation of bile salts. Bile Acids and Salts 110-119 solute carrier organic anion transporter family member 1B1 Homo sapiens 29-64 19387419-0 2009 Effect of SLCO1B1 polymorphism on the plasma concentrations of bile acids and bile acid synthesis marker in humans. Bile Acids and Salts 63-73 solute carrier organic anion transporter family member 1B1 Homo sapiens 10-17 19387419-0 2009 Effect of SLCO1B1 polymorphism on the plasma concentrations of bile acids and bile acid synthesis marker in humans. Bile Acids and Salts 63-72 solute carrier organic anion transporter family member 1B1 Homo sapiens 10-17 19387419-2 2009 Our aim was to characterize the role of OATP1B1 in the hepatic uptake of bile acids in vivo. Bile Acids and Salts 73-83 solute carrier organic anion transporter family member 1B1 Homo sapiens 40-47 19387419-9 2009 CONCLUSION: SLCO1B1 polymorphism considerably affects the disposition of several endogenous bile acids and bile acid synthesis marker, indicating that OATP1B1 plays an important role in the hepatic uptake of bile acids in vivo in humans. Bile Acids and Salts 92-102 solute carrier organic anion transporter family member 1B1 Homo sapiens 12-19 19387419-9 2009 CONCLUSION: SLCO1B1 polymorphism considerably affects the disposition of several endogenous bile acids and bile acid synthesis marker, indicating that OATP1B1 plays an important role in the hepatic uptake of bile acids in vivo in humans. Bile Acids and Salts 92-102 solute carrier organic anion transporter family member 1B1 Homo sapiens 151-158 19387419-9 2009 CONCLUSION: SLCO1B1 polymorphism considerably affects the disposition of several endogenous bile acids and bile acid synthesis marker, indicating that OATP1B1 plays an important role in the hepatic uptake of bile acids in vivo in humans. Bile Acids and Salts 92-101 solute carrier organic anion transporter family member 1B1 Homo sapiens 12-19 19387419-9 2009 CONCLUSION: SLCO1B1 polymorphism considerably affects the disposition of several endogenous bile acids and bile acid synthesis marker, indicating that OATP1B1 plays an important role in the hepatic uptake of bile acids in vivo in humans. Bile Acids and Salts 92-101 solute carrier organic anion transporter family member 1B1 Homo sapiens 151-158 19387419-9 2009 CONCLUSION: SLCO1B1 polymorphism considerably affects the disposition of several endogenous bile acids and bile acid synthesis marker, indicating that OATP1B1 plays an important role in the hepatic uptake of bile acids in vivo in humans. Bile Acids and Salts 208-218 solute carrier organic anion transporter family member 1B1 Homo sapiens 12-19 19387419-9 2009 CONCLUSION: SLCO1B1 polymorphism considerably affects the disposition of several endogenous bile acids and bile acid synthesis marker, indicating that OATP1B1 plays an important role in the hepatic uptake of bile acids in vivo in humans. Bile Acids and Salts 208-218 solute carrier organic anion transporter family member 1B1 Homo sapiens 151-158 19293444-1 2009 BACKGROUND & OBJECTIVES: Organic anion transport protein 1B1 (OATP1B1) is a major transporter protein for bile salt uptake in the enterohepatic circulation of bile salts. Bile Acids and Salts 110-119 solute carrier organic anion transporter family member 1B1 Homo sapiens 66-73 19293444-1 2009 BACKGROUND & OBJECTIVES: Organic anion transport protein 1B1 (OATP1B1) is a major transporter protein for bile salt uptake in the enterohepatic circulation of bile salts. Bile Acids and Salts 163-173 solute carrier organic anion transporter family member 1B1 Homo sapiens 29-64 19293444-1 2009 BACKGROUND & OBJECTIVES: Organic anion transport protein 1B1 (OATP1B1) is a major transporter protein for bile salt uptake in the enterohepatic circulation of bile salts. Bile Acids and Salts 163-173 solute carrier organic anion transporter family member 1B1 Homo sapiens 66-73 17641954-1 2008 INTRODUCTION: The human organic anion transporting polypeptide C (OATPC) is one of the major transport proteins involved in the enterohepatic circulation of bile salts and plays an important role in vectorial transport of organic anions and drugs across hepatocytes. Bile Acids and Salts 157-167 solute carrier organic anion transporter family member 1B1 Homo sapiens 24-64 18185926-1 2008 BACKGROUND: OATP1B1 is one of the key hepatocellular uptake transporters providing extraction of diverse compounds, including bile acids, xenobiotics, and a variety of drugs, from portal venous blood into the liver. Bile Acids and Salts 126-136 solute carrier organic anion transporter family member 1B1 Homo sapiens 12-19 17641954-1 2008 INTRODUCTION: The human organic anion transporting polypeptide C (OATPC) is one of the major transport proteins involved in the enterohepatic circulation of bile salts and plays an important role in vectorial transport of organic anions and drugs across hepatocytes. Bile Acids and Salts 157-167 solute carrier organic anion transporter family member 1B1 Homo sapiens 66-71 16534140-7 2006 NBD-labeled bile acids, including cholic acid, deoxycholic acid, lithocholic acid, and ursodeoxycholic acid, were all transported by OATP1B1 and OATP1B3. Bile Acids and Salts 12-22 solute carrier organic anion transporter family member 1B1 Homo sapiens 133-140 16534140-8 2006 CDCA-NBD exhibited the highest rate of transport of the five NBD-labeled bile acids examined in OATP1B1- and OATP1B3-expressing cells. Bile Acids and Salts 73-83 solute carrier organic anion transporter family member 1B1 Homo sapiens 96-103 15841457-11 2005 Several mechanisms may contribute to elevated plasma bile salts in PFIC: reduced bile salt uptake via NTCP, OATP1B1, and OATP1B3, decreased BSEP-dependent secretion into bile, and increased transport back into plasma by MRP4. Bile Acids and Salts 53-63 solute carrier organic anion transporter family member 1B1 Homo sapiens 108-115 16637898-6 2006 Real-time reverse transcription polymerase chain reaction was used to establish whether transcripts of genes that may influence bile acid transport are present in the culture (NTCP, BSEP, MDR3, FIC1, MRP2, MRP3, OATP-A, OATP-C, OATP-D, OATP-E) and whether taurocholate administration alters messenger RNA (mRNA) expression. Bile Acids and Salts 128-137 solute carrier organic anion transporter family member 1B1 Homo sapiens 220-226 15841457-11 2005 Several mechanisms may contribute to elevated plasma bile salts in PFIC: reduced bile salt uptake via NTCP, OATP1B1, and OATP1B3, decreased BSEP-dependent secretion into bile, and increased transport back into plasma by MRP4. Bile Acids and Salts 53-62 solute carrier organic anion transporter family member 1B1 Homo sapiens 108-115 14699511-5 2004 SHP is a transcriptional repressor that mediates bile acid-induced repression of the bile salt uptake systems rat Ntcp and human OATP-C. Bile Acids and Salts 49-58 solute carrier organic anion transporter family member 1B1 Homo sapiens 129-135 14699511-5 2004 SHP is a transcriptional repressor that mediates bile acid-induced repression of the bile salt uptake systems rat Ntcp and human OATP-C. Bile Acids and Salts 85-94 solute carrier organic anion transporter family member 1B1 Homo sapiens 129-135 12763363-8 2003 OATP2 and MRP2 expression correlated inversely with hepatic levels of hydrophobic bile acids, while positively correlating with hepatic enrichment with ursodeoxycholic acid. Bile Acids and Salts 82-92 solute carrier organic anion transporter family member 1B1 Homo sapiens 0-5 12601360-3 2003 In cholestatic liver disease, hepatic bile acid concentrations are elevated and expression of the major Na+-independent bile acid uptake system, organic anion transporting polypeptide (OATP)-C (solute carrier gene family SLC21A6), is markedly decreased. Bile Acids and Salts 120-129 solute carrier organic anion transporter family member 1B1 Homo sapiens 145-192 12601360-4 2003 Because the OATP-C gene is transcriptionally dependent on the hepatocyte nuclear factor (HNF) 1 alpha, we hypothesized that bile acids decrease OATP-C expression through direct repression of HNF1 alpha. Bile Acids and Salts 124-134 solute carrier organic anion transporter family member 1B1 Homo sapiens 12-18 12601360-4 2003 Because the OATP-C gene is transcriptionally dependent on the hepatocyte nuclear factor (HNF) 1 alpha, we hypothesized that bile acids decrease OATP-C expression through direct repression of HNF1 alpha. Bile Acids and Salts 124-134 solute carrier organic anion transporter family member 1B1 Homo sapiens 144-150 12601360-13 2003 This explains the suppressive effect of bile acids on the OATP-C gene promoter, leading to decreased expression in cholestatic liver disease. Bile Acids and Salts 40-50 solute carrier organic anion transporter family member 1B1 Homo sapiens 58-64 11826283-2 2002 Hepatocellular bile salt uptake is mediated predominantly by the Na(+)-taurocholate cotransport proteins Ntcp (rodents) and NTCP (humans) and by the Na(+)-independent organic anion-transporting polypeptides Oatp1, Oatp2, and Oatp4 (rodents) and OATP-C (humans). Bile Acids and Salts 15-24 solute carrier organic anion transporter family member 1B1 Homo sapiens 214-219 11826283-2 2002 Hepatocellular bile salt uptake is mediated predominantly by the Na(+)-taurocholate cotransport proteins Ntcp (rodents) and NTCP (humans) and by the Na(+)-independent organic anion-transporting polypeptides Oatp1, Oatp2, and Oatp4 (rodents) and OATP-C (humans). Bile Acids and Salts 15-24 solute carrier organic anion transporter family member 1B1 Homo sapiens 245-251 11483603-1 2001 OATP-C (SLC21A6) is the predominant Na(+)-independent uptake system for bile salts and bilirubin of human liver and is expressed exclusively at the basolateral (sinusoidal) hepatocyte membrane. Bile Acids and Salts 72-82 solute carrier organic anion transporter family member 1B1 Homo sapiens 0-6 11483603-1 2001 OATP-C (SLC21A6) is the predominant Na(+)-independent uptake system for bile salts and bilirubin of human liver and is expressed exclusively at the basolateral (sinusoidal) hepatocyte membrane. Bile Acids and Salts 72-82 solute carrier organic anion transporter family member 1B1 Homo sapiens 8-15 33782042-8 2021 Whereas the fluorescent bile acid derivatives themselves were transported across the membrane by OATP1B1, OATP1B3 and OATP2B1 they were not transport substrates for NTCP, ASBT, BSEP and multidrug resistance-related protein 2 (MRP2). Bile Acids and Salts 24-33 solute carrier organic anion transporter family member 1B1 Homo sapiens 97-104 33782042-10 2021 Significance Statement Synthetic modification of common bile acids by attachment of small organic fluorescent dyes to the bile acid side chain resulted in bright, fluorescent probes that interact with hepatic and intestinal organic anion (OATP1B1, OATP1B3, OATP2B1), bile salt uptake (NTCP, ASBT) and bile salt efflux (BSEP, MRP2) transporters. Bile Acids and Salts 56-66 solute carrier organic anion transporter family member 1B1 Homo sapiens 239-246 33782042-10 2021 Significance Statement Synthetic modification of common bile acids by attachment of small organic fluorescent dyes to the bile acid side chain resulted in bright, fluorescent probes that interact with hepatic and intestinal organic anion (OATP1B1, OATP1B3, OATP2B1), bile salt uptake (NTCP, ASBT) and bile salt efflux (BSEP, MRP2) transporters. Bile Acids and Salts 56-65 solute carrier organic anion transporter family member 1B1 Homo sapiens 239-246