PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31948749-4 2020 In addition, we observed that WDR5 promoted the binding of Myc to CARM1 promoter by interacting with Myc and inducing histone 3 lysine 4 trimethylation (H3K4me3). Lysine 128-134 MYC proto-oncogene, bHLH transcription factor Homo sapiens 59-62 30140938-5 2018 Furthermore, the tri-methylation of histone 3 on the ninth lysine (H3K9me3)-heterochromatin protein 1 alpha (HP1alpha) complex is increased when the complex occupancy ability on the C-myc promoter region is raised, recruiting CREB, P300, and RNApolII to the special position that results in C-myc high abundance. Lysine 59-65 MYC proto-oncogene, bHLH transcription factor Homo sapiens 182-187 31196146-0 2019 Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation. Lysine 95-101 MYC proto-oncogene, bHLH transcription factor Homo sapiens 44-47 31196146-4 2019 Here, we demonstrate that cardiac glycoside proscillaridin A specifically targets MYC overexpressing leukemia cells and leukemia stem cells by causing MYC degradation, epigenetic reprogramming and leukemia differentiation through loss of lysine acetylation. Lysine 238-244 MYC proto-oncogene, bHLH transcription factor Homo sapiens 82-85 30140938-5 2018 Furthermore, the tri-methylation of histone 3 on the ninth lysine (H3K9me3)-heterochromatin protein 1 alpha (HP1alpha) complex is increased when the complex occupancy ability on the C-myc promoter region is raised, recruiting CREB, P300, and RNApolII to the special position that results in C-myc high abundance. Lysine 59-65 MYC proto-oncogene, bHLH transcription factor Homo sapiens 291-296 28806398-0 2017 Lysine-52 stabilizes the MYC oncoprotein through an SCFFbxw7-independent mechanism. Lysine 0-6 MYC proto-oncogene, bHLH transcription factor Homo sapiens 25-28 29653269-2 2018 c-Myc epigenetically silences tumor suppressors by recruiting PRC2 and inducing methylation of histone H3 lysine 27. Lysine 106-112 MYC proto-oncogene, bHLH transcription factor Homo sapiens 0-5 29511348-3 2018 BET bromodomains recognize acetylated lysine residues and often promote and maintain MYC transcription. Lysine 38-44 MYC proto-oncogene, bHLH transcription factor Homo sapiens 85-88 30526305-6 2018 Although coexpression with MYC reduced certain RAS-induced senescence markers (histone H3 lysine 9 trimethylation and senescence-associated beta-GAL activity), the induction of the senescence marker p16INK4A was further enhanced and the culture ceased to proliferate within a few days, revealing that MYC could not fully suppress RAS-induced senescence. Lysine 90-96 MYC proto-oncogene, bHLH transcription factor Homo sapiens 27-30 29996811-2 2018 A new small molecular inhibitor, JQ1, targeting BRD4, which recognizes the acetylated lysine residues, has been shown to induce cell cycle arrest in different cancers by inhibiting MYC oncogene. Lysine 86-92 MYC proto-oncogene, bHLH transcription factor Homo sapiens 181-184 28806398-5 2017 Here we provide evidence for an SCFFbxw7-independent regulatory mechanism centred on the highly conserved lysine-52 (K52) within MYC Box I. Lysine 106-112 MYC proto-oncogene, bHLH transcription factor Homo sapiens 129-132 28653878-1 2017 Sirtuin 6, a member of sirtuin family, is generally regarded as a tumor suppressor as it participates in suppressing hypoxia-inducible factor 1alpha and MYC transcription activity by deacetylating H3K9 (histone H3 lysine 9) and H3K56 (histone H3 lysine) at promoters of target genes, leading to the aerobic glycolysis inhibition and cell growth suppression. Lysine 214-220 MYC proto-oncogene, bHLH transcription factor Homo sapiens 153-156 28653878-1 2017 Sirtuin 6, a member of sirtuin family, is generally regarded as a tumor suppressor as it participates in suppressing hypoxia-inducible factor 1alpha and MYC transcription activity by deacetylating H3K9 (histone H3 lysine 9) and H3K56 (histone H3 lysine) at promoters of target genes, leading to the aerobic glycolysis inhibition and cell growth suppression. Lysine 246-252 MYC proto-oncogene, bHLH transcription factor Homo sapiens 153-156 25977460-10 2015 JVZ-007-c-myc-his was conjugated to 2-(4-isothiocyanatobenzyl)-diethylenetriaminepentaacetic acid (p-SCN-DTPA) via the lysines, whereas JVZ-007-cys was conjugated to maleimide-DTPA via the C-terminal cysteine. Lysine 119-126 MYC proto-oncogene, bHLH transcription factor Homo sapiens 8-13 27358484-4 2017 Upon HDACi treatment, c-Myc is acetylated at lysine 323 and its expression decreases, leading to TRAIL activation and apoptosis. Lysine 45-51 MYC proto-oncogene, bHLH transcription factor Homo sapiens 22-27 27159579-1 2016 Bromodomain-containing proteins of the BET family recognize histone lysine acetylation and mediate transcriptional activation of target genes such as the MYC oncogene. Lysine 68-74 MYC proto-oncogene, bHLH transcription factor Homo sapiens 154-157 26159421-6 2015 LSD depletion increases trimethylation of histone 3 lysine 4 at the avian myelocytomatosis viral oncogene homolog (MYC) locus, which elevates MYC expression. Lysine 52-58 MYC proto-oncogene, bHLH transcription factor Homo sapiens 115-118 26159421-6 2015 LSD depletion increases trimethylation of histone 3 lysine 4 at the avian myelocytomatosis viral oncogene homolog (MYC) locus, which elevates MYC expression. Lysine 52-58 MYC proto-oncogene, bHLH transcription factor Homo sapiens 142-145 26199140-3 2015 DOT1L recognizes SNAIL, ZEB1 and ZEB2 promoters via interacting with the c-Myc-p300 complex and facilitates lysine-79 methylation and acetylation towards histone H3, leading to the dissociation of HDAC1 and DNMT1 in the regions. Lysine 108-114 MYC proto-oncogene, bHLH transcription factor Homo sapiens 73-78 28209620-2 2017 Histone H3 lysine 79 (H3K79) methylation at Myc-responsive elements of target gene promoters is a strict prerequisite for Myc-induced transcriptional activation, and DOT1L is the only known histone methyltransferase that catalyzes H3K79 methylation. Lysine 11-17 MYC proto-oncogene, bHLH transcription factor Homo sapiens 44-47 28209620-2 2017 Histone H3 lysine 79 (H3K79) methylation at Myc-responsive elements of target gene promoters is a strict prerequisite for Myc-induced transcriptional activation, and DOT1L is the only known histone methyltransferase that catalyzes H3K79 methylation. Lysine 11-17 MYC proto-oncogene, bHLH transcription factor Homo sapiens 122-125 27349498-0 2016 Reversible lysine-specific demethylase 1 antagonist HCI-2509 inhibits growth and decreases c-MYC in castration- and docetaxel-resistant prostate cancer cells. Lysine 11-17 MYC proto-oncogene, bHLH transcription factor Homo sapiens 91-96 25977460-16 2015 Renal uptake of (111)In-JVZ-007-c-myc-his was initially high but was efficiently reduced by coinjection of gelofusine and lysine. Lysine 122-128 MYC proto-oncogene, bHLH transcription factor Homo sapiens 32-37 25995743-0 2015 Galactosylated poly-L-lysine targeted microbubbles for ultrasound mediated antisense c-myc gene transfection in hepatocellular carcinoma cells. Lysine 15-28 MYC proto-oncogene, bHLH transcription factor Homo sapiens 85-90 25944903-5 2015 Mutation of the lysine 326 in c-Myc reduces c-Myc ubiquitination and prevents the c-Myc degradation induced by FBXO32. Lysine 16-22 MYC proto-oncogene, bHLH transcription factor Homo sapiens 30-35 25944903-5 2015 Mutation of the lysine 326 in c-Myc reduces c-Myc ubiquitination and prevents the c-Myc degradation induced by FBXO32. Lysine 16-22 MYC proto-oncogene, bHLH transcription factor Homo sapiens 44-49 25944903-5 2015 Mutation of the lysine 326 in c-Myc reduces c-Myc ubiquitination and prevents the c-Myc degradation induced by FBXO32. Lysine 16-22 MYC proto-oncogene, bHLH transcription factor Homo sapiens 44-49 25569455-4 2015 Herein we demonstrate that p30(II) induces lysine-acetylation of the c-MYC oncoprotein. Lysine 43-49 MYC proto-oncogene, bHLH transcription factor Homo sapiens 69-74 25895136-13 2015 Intriguingly, mutating all 10 SUMO acceptor lysines did not reduce c-Myc SUMOylation, suggesting that SUMO acceptor lysines in c-Myc act promiscuously. Lysine 116-123 MYC proto-oncogene, bHLH transcription factor Homo sapiens 127-132 23435422-0 2014 MYC activity is negatively regulated by a C-terminal lysine cluster. Lysine 53-59 MYC proto-oncogene, bHLH transcription factor Homo sapiens 0-3 24435446-1 2014 The bromodomain and extra-terminal (BET) protein family members, including BRD4, bind to acetylated lysines on histones and regulate the expression of important oncogenes, for example, c-MYC and BCL2. Lysine 100-107 MYC proto-oncogene, bHLH transcription factor Homo sapiens 185-190 24608896-3 2014 Here we show that c- and N-Myc are conjugated to SUMO proteins at conserved lysines in their C-terminal domain. Lysine 76-83 MYC proto-oncogene, bHLH transcription factor Homo sapiens 27-30 23435422-5 2014 In this manuscript, we have extensively characterized a MYC signalling mutant in which six lysine residues near the highly conserved MYC homology box IV and basic region have been substituted to arginines (6KR). Lysine 91-97 MYC proto-oncogene, bHLH transcription factor Homo sapiens 56-59 23435422-5 2014 In this manuscript, we have extensively characterized a MYC signalling mutant in which six lysine residues near the highly conserved MYC homology box IV and basic region have been substituted to arginines (6KR). Lysine 91-97 MYC proto-oncogene, bHLH transcription factor Homo sapiens 133-136 23435422-10 2014 Combined, our data identify this region and these six lysines as important residues for the negative regulation of MYC-induced transformation. Lysine 54-61 MYC proto-oncogene, bHLH transcription factor Homo sapiens 115-118 22683437-2 2012 Other individual reports identified lysine acetylation as a PTM regulating transcription factors and co-activators including p53, c-Myc, PGC1alpha and Ku70. Lysine 36-42 MYC proto-oncogene, bHLH transcription factor Homo sapiens 130-135 23296385-6 2013 We found that P493-6 cells with High Myc expression increased their specific uptake of glutamine, arginine, serine, lysine, and branched-chain amino acids by two- to threefold in comparison to low Myc cells, but exhibited only modest increases in glucose uptake and lactate excretion. Lysine 116-122 MYC proto-oncogene, bHLH transcription factor Homo sapiens 37-40 22711821-5 2012 Mapping of translocation breakpoints using an acetylated histone H3 lysine 9 chromatin immunoprecipitation sequencing approach reveals Igh fusions up to ~350 kb upstream of Myc or the related oncogene Mycn. Lysine 68-74 MYC proto-oncogene, bHLH transcription factor Homo sapiens 173-176 20940306-5 2010 Continued Myc expression prevented deacetylation of several lysine residues in histones H3 and H4 that are normally deacetylated during erythroid maturation. Lysine 60-66 MYC proto-oncogene, bHLH transcription factor Homo sapiens 10-13 22190494-12 2012 Depletion/inhibition of SIRT1 correlated with reduced lysine 63-linked polyubiquitination of c-Myc, which presumably destabilizes c-MYC by supporting degradative lysine 48-linked polyubiquitination. Lysine 54-60 MYC proto-oncogene, bHLH transcription factor Homo sapiens 93-98 22190494-12 2012 Depletion/inhibition of SIRT1 correlated with reduced lysine 63-linked polyubiquitination of c-Myc, which presumably destabilizes c-MYC by supporting degradative lysine 48-linked polyubiquitination. Lysine 54-60 MYC proto-oncogene, bHLH transcription factor Homo sapiens 130-135 22190494-12 2012 Depletion/inhibition of SIRT1 correlated with reduced lysine 63-linked polyubiquitination of c-Myc, which presumably destabilizes c-MYC by supporting degradative lysine 48-linked polyubiquitination. Lysine 162-168 MYC proto-oncogene, bHLH transcription factor Homo sapiens 93-98 21642861-10 2011 Furthermore, c-myc down-regulation and apoptotic cell death coinduced by IR and HDACI were suppressed in cells transfected with mutant K382R p53 and C135Y p53 displaying loss of acetylation at lysine 382 and DNA-binding activity, respectively. Lysine 193-199 MYC proto-oncogene, bHLH transcription factor Homo sapiens 13-18 21969221-2 2011 Myc binding to its targets depends on the presence of the E-box binding sequence and by a chromatin context in which histone H3K4me3 lysine methylation favors Myc binding. Lysine 133-139 MYC proto-oncogene, bHLH transcription factor Homo sapiens 0-3 21969221-2 2011 Myc binding to its targets depends on the presence of the E-box binding sequence and by a chromatin context in which histone H3K4me3 lysine methylation favors Myc binding. Lysine 133-139 MYC proto-oncogene, bHLH transcription factor Homo sapiens 159-162 20691906-2 2010 Here we report the identification of Myc-nick, a cytoplasmic form of Myc generated by calpain-dependent proteolysis at lysine 298 of full-length Myc. Lysine 119-125 MYC proto-oncogene, bHLH transcription factor Homo sapiens 37-40 20691906-2 2010 Here we report the identification of Myc-nick, a cytoplasmic form of Myc generated by calpain-dependent proteolysis at lysine 298 of full-length Myc. Lysine 119-125 MYC proto-oncogene, bHLH transcription factor Homo sapiens 69-72 20691906-2 2010 Here we report the identification of Myc-nick, a cytoplasmic form of Myc generated by calpain-dependent proteolysis at lysine 298 of full-length Myc. Lysine 119-125 MYC proto-oncogene, bHLH transcription factor Homo sapiens 69-72 16287840-4 2005 We show that p300 associates with Myc in mammalian cells and in vitro through direct interactions with Myc TAD residues 1 to 110 and acetylates Myc in a TAD-dependent manner in vivo at several lysine residues located between the TAD and DNA-binding domain. Lysine 193-199 MYC proto-oncogene, bHLH transcription factor Homo sapiens 34-37 20714214-4 2010 Myc binding to targets genes depends on the presence of the E-box binding motif and the presence of histone H3K4me3 lysines. Lysine 116-123 MYC proto-oncogene, bHLH transcription factor Homo sapiens 0-3 19047142-2 2008 Strikingly, 90% to 95% of the total genomic euchromatic marks histone H3 acetylated at lysine 9 and methylated at lysine 4 is N-Myc-dependent. Lysine 87-93 MYC proto-oncogene, bHLH transcription factor Homo sapiens 128-131 19047142-2 2008 Strikingly, 90% to 95% of the total genomic euchromatic marks histone H3 acetylated at lysine 9 and methylated at lysine 4 is N-Myc-dependent. Lysine 114-120 MYC proto-oncogene, bHLH transcription factor Homo sapiens 128-131 17712411-5 2007 Myc-induced exit from the stem cell niche correlated with increased acetylation at histone H4 and transiently increased mono-methylation at lysine 20. Lysine 140-146 MYC proto-oncogene, bHLH transcription factor Homo sapiens 0-3 20418916-0 2010 LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription. Lysine 42-48 MYC proto-oncogene, bHLH transcription factor Homo sapiens 60-63 20418916-2 2010 We find that on Myc binding to chromatin, the lysine-demethylating enzyme, LSD1, triggers a transient demethylation of lysine 4 in the histone H3. Lysine 46-52 MYC proto-oncogene, bHLH transcription factor Homo sapiens 16-19 20418916-2 2010 We find that on Myc binding to chromatin, the lysine-demethylating enzyme, LSD1, triggers a transient demethylation of lysine 4 in the histone H3. Lysine 119-125 MYC proto-oncogene, bHLH transcription factor Homo sapiens 16-19 18985155-4 2008 Among other mechanisms, Myc recruits histone acetyl-transferases to target chromatin and locally promotes hyper-acetylation of multiple lysines on histones H3 and H4, although the identity and combination of the modified lysines is unknown. Lysine 136-143 MYC proto-oncogene, bHLH transcription factor Homo sapiens 24-27 18985155-4 2008 Among other mechanisms, Myc recruits histone acetyl-transferases to target chromatin and locally promotes hyper-acetylation of multiple lysines on histones H3 and H4, although the identity and combination of the modified lysines is unknown. Lysine 221-228 MYC proto-oncogene, bHLH transcription factor Homo sapiens 24-27 18985155-6 2008 Here, we used quantitative chromatin immunoprecipitation (qChIP) to profile a total of 24 lysine-acetylation and -methylation marks modulated by Myc at target promoters in a human B-cell line with a regulatable c-myc transgene. Lysine 90-96 MYC proto-oncogene, bHLH transcription factor Homo sapiens 145-148 18985155-7 2008 Myc binding promoted acetylation of multiple lysines, primarily of H3K9, H3K14, H3K18, H4K5 and H4K12, but significantly also of H4K8, H4K91 and H2AK5. Lysine 45-52 MYC proto-oncogene, bHLH transcription factor Homo sapiens 0-3 16287840-4 2005 We show that p300 associates with Myc in mammalian cells and in vitro through direct interactions with Myc TAD residues 1 to 110 and acetylates Myc in a TAD-dependent manner in vivo at several lysine residues located between the TAD and DNA-binding domain. Lysine 193-199 MYC proto-oncogene, bHLH transcription factor Homo sapiens 103-106 16287840-4 2005 We show that p300 associates with Myc in mammalian cells and in vitro through direct interactions with Myc TAD residues 1 to 110 and acetylates Myc in a TAD-dependent manner in vivo at several lysine residues located between the TAD and DNA-binding domain. Lysine 193-199 MYC proto-oncogene, bHLH transcription factor Homo sapiens 103-106 16269333-2 2005 Here we show that the E3 ubiquitin ligase HectH9 ubiquitinates Myc in vivo and in vitro, forming a lysine 63-linked polyubiquitin chain. Lysine 99-105 MYC proto-oncogene, bHLH transcription factor Homo sapiens 63-66 10807912-9 2000 Degradation of both wild type and lysine-less protein is sensitive to fusion of a Myc tag to the N terminus of LMP1. Lysine 34-40 MYC proto-oncogene, bHLH transcription factor Homo sapiens 82-85 16126174-0 2005 Six lysine residues on c-Myc are direct substrates for acetylation by p300. Lysine 4-10 MYC proto-oncogene, bHLH transcription factor Homo sapiens 23-28 16126174-6 2005 These analyses identify six lysine residues in human Myc (K143, K157, K275, K317, K323, and K371) as direct substrates for p300. Lysine 28-34 MYC proto-oncogene, bHLH transcription factor Homo sapiens 53-56 14645543-2 2003 By comparing the pattern of histone modifications at the mouse and human c-myc alleles, we identified an evolutionarily conserved boundary at which the c-myc transcription unit is separated from the flanking condensed chromatin enriched in lysine 9-methylated histone H3. Lysine 240-246 MYC proto-oncogene, bHLH transcription factor Homo sapiens 73-78 14645543-2 2003 By comparing the pattern of histone modifications at the mouse and human c-myc alleles, we identified an evolutionarily conserved boundary at which the c-myc transcription unit is separated from the flanking condensed chromatin enriched in lysine 9-methylated histone H3. Lysine 240-246 MYC proto-oncogene, bHLH transcription factor Homo sapiens 152-157 12397066-6 2003 Addition of a 6x Myc tag to the N terminus of MyoD can force degradation through the lysine-dependent pathway by preventing ubiquitination at the N-terminal site. Lysine 85-91 MYC proto-oncogene, bHLH transcription factor Homo sapiens 17-20 34406978-10 2021 Inhibition of circRHOT1 reduced the enrichment of transcription active marker histone H3 lysine 27 acetylation (H3K27ac) and RNA polymerase II on the promoter of c-MYC. Lysine 89-95 MYC proto-oncogene, bHLH transcription factor Homo sapiens 162-167