PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25907794-4 2015 Here, we generate milligram quantities of pure human Dvl2 DIX domain mono-ubiquitinated at two lysines (K54 and K58) by genetically encoded orthogonal protection with activated ligation (GOPAL), to investigate their effect on DIX polymerization. Lysine 95-102 dishevelled segment polarity protein 2 Homo sapiens 53-57 24616100-7 2014 Biochemical analyses revealed that IRS1/2 decreased Lys-63-linked ubiquitination of Dvl2 and stabilized Dvl2 protein via suppressing its autophagy-mediated degradation. Lysine 52-55 dishevelled segment polarity protein 2 Homo sapiens 84-88