PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19879767-0 2009 Spare interactions of highly potent [Arg(14),Lys(15)]nociceptin for cooperative induction of ORL1 receptor activation. Lysine 45-48 opioid related nociceptin receptor 1 Homo sapiens 93-97 19879767-1 2009 [Arg(14),Lys(15)]Nociceptin is a very potent for ORL1 receptor, showing a few times stronger binding activity and much more enhanced biological activity than endogenous nociceptin. Lysine 9-12 opioid related nociceptin receptor 1 Homo sapiens 49-53 19879767-4 2009 The mutant receptor Gln205Ala was found to be as active as wild-type ORL1 for both nociceptin and [Arg(14),Lys(15)]nociceptin. Lysine 107-110 opioid related nociceptin receptor 1 Homo sapiens 69-73 19577933-8 2009 The results indicate that specific interactions feasible for Arg/Lys and Trp in common must be there for aromatic residues in ORL1, thus forming a cation/pi interaction or pi/pi hydrophobic interaction. Lysine 65-68 opioid related nociceptin receptor 1 Homo sapiens 126-130 16814543-2 2006 Chimera peptides with long spacers (a Lys and five or eight Gly residues) showed synergistically improved affinity for both the mu-opioid receptor and ORL1 receptor, while the chimera peptides with short spacers (Lys residue only) showed decreased or similar affinity compared to the monomeric receptor ligands. Lysine 38-41 opioid related nociceptin receptor 1 Homo sapiens 151-155