PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26204832-4	2015	The results of zymography assay showed that sinulariolide suppressed the activities of matrix metalloproteinase (MMP)-2 and MMP-9.	sinulariolide	44-57	matrix metallopeptidase 9	Homo sapiens	124-129	
28767067-5	2017	Furthermore, the protein expressions of matrix metalloproteinases (MMPs) MMP-2 and MMP-9, as well as urokinase, were significantly decreased after 24-h sinulariolide treatment.	sinulariolide	152-165	matrix metallopeptidase 9	Homo sapiens	83-88	
26204832-5	2015	Moreover, protein levels of MMP-2, MMP-9, and urokinase-type plasminogen activator (uPA) were reduced by sinulariolide in a concentration-dependent manner.	sinulariolide	105-118	matrix metallopeptidase 9	Homo sapiens	35-40	
26204832-7	2015	Taken together, these results demonstrated that sinulariolide could inhibit hepatocellular carcinoma cell migration and invasion and alter HA22T cell metastasis by reduction of MMP-2, MMP-9, and uPA expression through the suppression of MAPKs, PI3K/Akt, and the FAK/GRB2 signaling pathway.	sinulariolide	48-61	matrix metallopeptidase 9	Homo sapiens	184-189	
31783709-6	2019	Immunostaining analysis showed that sinulariolide significantly reduced the protein expressions of MMP-2, MMP-9, and uPA, but the expressions of TIMP-1 and TIMP-2 were increased, while FAK, phosphorylated PI3K, phosphorylated AKT, phosphorylated mTOR, phosphorylated JNK, phosphorylated p38MAPK, and phosphorylated ERK decreased in expression with increasing sinulariolide concentration.	sinulariolide	36-49	matrix metallopeptidase 9	Homo sapiens	106-111	
31783709-7	2019	From the results, we inferred that sinulariolide treatment in AGS and NCI-N87 cells reduced the activities of MMP-2 and MMP-9 via the FAK/PI3K/AKT/mTOR and MAPKs signaling pathways, further inhibiting the invasion and migration of these cells.	sinulariolide	35-48	matrix metallopeptidase 9	Homo sapiens	120-125