PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34739541-3 2021 Some denervated mice were treated with Ang 1-7 or diminazene aceturate (DIZE), an ACE2 activator, to increase Ang 1-7 levels. diminazene aceturate 50-70 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 82-86 34739541-3 2021 Some denervated mice were treated with Ang 1-7 or diminazene aceturate (DIZE), an ACE2 activator, to increase Ang 1-7 levels. diminazene aceturate 72-76 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 82-86 34529881-4 2021 We found that repeated lipopolysaccharide (LPS) treatment shifted the balance between ACE/Ang II/AT1 and ACE2/Ang(1-7)/MasR axis to the deleterious side and treatment with either MasR agonist, AVE0991 (AVE) or ACE2 activator, diminazene aceturate, exhibited strong neuroprotective actions. diminazene aceturate 226-246 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 210-214 34070749-4 2021 Therefore, the aim of our study was to comprehensively evaluate the influence of prolonged treatment with ACE2 activator, diminazene aceturate (DIZE) on the development of atherosclerotic lesions and hepatic steatosis in apoE-/- mice fed a high-fat diet (HFD). diminazene aceturate 122-142 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 106-110 34070749-4 2021 Therefore, the aim of our study was to comprehensively evaluate the influence of prolonged treatment with ACE2 activator, diminazene aceturate (DIZE) on the development of atherosclerotic lesions and hepatic steatosis in apoE-/- mice fed a high-fat diet (HFD). diminazene aceturate 144-148 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 106-110 35347063-5 2022 ACE2 activator diminazene aceturate (DIZE) significantly reduced pulmonary fibrosis, decreased alpha-SMA expression, collagen I, hydroxyproline, and TGF-beta1 in the lung. diminazene aceturate 15-35 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 0-4 35347063-5 2022 ACE2 activator diminazene aceturate (DIZE) significantly reduced pulmonary fibrosis, decreased alpha-SMA expression, collagen I, hydroxyproline, and TGF-beta1 in the lung. diminazene aceturate 37-41 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 0-4 35536587-11 2022 In addition, we observed that GW4869 (an inhibitor of sEV release) or diminazene aceturate (DIZE, an activator of ACE2) treatment could attenuate PM2.5 -induced cardiac dysfunction in vivo. diminazene aceturate 70-90 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 114-118 35536587-11 2022 In addition, we observed that GW4869 (an inhibitor of sEV release) or diminazene aceturate (DIZE, an activator of ACE2) treatment could attenuate PM2.5 -induced cardiac dysfunction in vivo. diminazene aceturate 92-96 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 114-118 32652140-2 2020 Given that diminazene aceturate (DMZ) shares trypanocidal, angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) stimulatory effects, we investigated the impact of DMZ on cardiomyocytes infection in vitro, renin-angiotensin system, Chagas cardiomyopathy and skeletal myositis in vivo. diminazene aceturate 11-31 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 92-96 32652140-2 2020 Given that diminazene aceturate (DMZ) shares trypanocidal, angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) stimulatory effects, we investigated the impact of DMZ on cardiomyocytes infection in vitro, renin-angiotensin system, Chagas cardiomyopathy and skeletal myositis in vivo. diminazene aceturate 33-36 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 92-96 32652140-6 2020 DMZ increased ACE2 activity and angiotensin-(1-7) plasma levels but exerted no interference on angiotensin-converting enzyme (ACE) activity, ACE, ACE2 and angiotensin II levels in uninfected and infected mice. diminazene aceturate 0-3 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 14-18 32701063-0 2020 ACE2 activator diminazene aceturate ameliorates Alzheimer"s disease-like neuropathology and rescues cognitive impairment in SAMP8 mice. diminazene aceturate 15-35 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 0-4 32701063-4 2020 Since Ang-(1-7) is generated by its metabolic enzyme ACE2, we then tested the efficacy of an ACE2 activator diminazene aceturate (DIZE) on AD-like neuropathology and cognitive impairment in senescence-accelerated mouse prone substrain 8 (SAMP8) mice, an animal model of sporadic AD. diminazene aceturate 108-128 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 93-97 32701063-4 2020 Since Ang-(1-7) is generated by its metabolic enzyme ACE2, we then tested the efficacy of an ACE2 activator diminazene aceturate (DIZE) on AD-like neuropathology and cognitive impairment in senescence-accelerated mouse prone substrain 8 (SAMP8) mice, an animal model of sporadic AD. diminazene aceturate 130-134 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 93-97 32701063-11 2020 These beneficial effects of DIZE may be achieved by activating brain ACE2/Ang-(1-7)/MAS1 axis. diminazene aceturate 28-32 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 69-73 32368013-11 2020 Conclusion: The overexpression of ACE2 and treatment with DIZE can ameliorate EMT in silicotic mice via activation of the ACE2-Ang-(1-7)-Mas receptor axis, and these changes are accompanied by suppression of the ACE-Ang II-AT1 receptor axis. diminazene aceturate 58-62 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 122-126 31987711-3 2020 Here, we examined whether the ACE2 activator diminazene aceturate (DIZE) can prevent the formalin-induced nociception in mice. diminazene aceturate 45-65 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 30-34 31987711-3 2020 Here, we examined whether the ACE2 activator diminazene aceturate (DIZE) can prevent the formalin-induced nociception in mice. diminazene aceturate 67-71 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 30-34 31982938-5 2020 We now show that enhancement of brain ACE2 activity, a major effector of rRAS, by intraperitoneal administration of diminazene aceturate (DIZE), an established activator of ACE2, lowered hippocampal Abeta and restored cognition in mid-aged (13-14-month-old) symptomatic Tg2576 mice. diminazene aceturate 116-136 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 38-42 31982938-5 2020 We now show that enhancement of brain ACE2 activity, a major effector of rRAS, by intraperitoneal administration of diminazene aceturate (DIZE), an established activator of ACE2, lowered hippocampal Abeta and restored cognition in mid-aged (13-14-month-old) symptomatic Tg2576 mice. diminazene aceturate 116-136 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 173-177 31982938-5 2020 We now show that enhancement of brain ACE2 activity, a major effector of rRAS, by intraperitoneal administration of diminazene aceturate (DIZE), an established activator of ACE2, lowered hippocampal Abeta and restored cognition in mid-aged (13-14-month-old) symptomatic Tg2576 mice. diminazene aceturate 138-142 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 38-42 31982938-5 2020 We now show that enhancement of brain ACE2 activity, a major effector of rRAS, by intraperitoneal administration of diminazene aceturate (DIZE), an established activator of ACE2, lowered hippocampal Abeta and restored cognition in mid-aged (13-14-month-old) symptomatic Tg2576 mice. diminazene aceturate 138-142 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 173-177 31393582-2 2019 METHODS: Adult mice were exposed to 95% O2 for 72 h to induce hyperoxic lung injury, and simultaneously treated with ACE2 agonist diminazene aceturate (DIZE) or inhibitor MLN-4760. diminazene aceturate 130-150 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 117-121 31393582-2 2019 METHODS: Adult mice were exposed to 95% O2 for 72 h to induce hyperoxic lung injury, and simultaneously treated with ACE2 agonist diminazene aceturate (DIZE) or inhibitor MLN-4760. diminazene aceturate 152-156 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 117-121 29691582-1 2018 This study was aimed to explore the effect of angiotensin converting enzyme 2 (ACE2) agonist diminazene aceturate (DIZE) on acute lung injury (ALI) induced by limb ischemia-reperfusion (LIR) in mice. diminazene aceturate 93-113 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 46-77 29691582-1 2018 This study was aimed to explore the effect of angiotensin converting enzyme 2 (ACE2) agonist diminazene aceturate (DIZE) on acute lung injury (ALI) induced by limb ischemia-reperfusion (LIR) in mice. diminazene aceturate 93-113 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 79-83 29691582-1 2018 This study was aimed to explore the effect of angiotensin converting enzyme 2 (ACE2) agonist diminazene aceturate (DIZE) on acute lung injury (ALI) induced by limb ischemia-reperfusion (LIR) in mice. diminazene aceturate 115-119 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 46-77 29691582-1 2018 This study was aimed to explore the effect of angiotensin converting enzyme 2 (ACE2) agonist diminazene aceturate (DIZE) on acute lung injury (ALI) induced by limb ischemia-reperfusion (LIR) in mice. diminazene aceturate 115-119 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 79-83 27592222-5 2016 As the activator of ACE2, diminazene aceturate (DIZE) inhibited increase of blood pressure, collagen deposition, and KCa3.1 protein expression in myocardium of WT mice induced by Ang II. diminazene aceturate 26-46 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 20-24 27592222-5 2016 As the activator of ACE2, diminazene aceturate (DIZE) inhibited increase of blood pressure, collagen deposition, and KCa3.1 protein expression in myocardium of WT mice induced by Ang II. diminazene aceturate 48-52 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 20-24 25867182-5 2015 Diminazene aceturate treatment (15 mg/kg/day) activated ACE2, increased the circulating Ang (1-7) level, and augmented EDR and FMD in db/db mouse arteries. diminazene aceturate 0-20 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 56-60 25666042-3 2015 In this study, 12 weeks old male mice were treated with the ACE 2 activator (diminazene aceturate, DIZE, 1 mg/kg/day, gavage) or saline (control) for 30 days followed by glucose tolerance tests, insulin sensitivity tests, and blood analysis. diminazene aceturate 77-97 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 60-65 25301841-9 2014 ACE2 activation by administration of diminazene aceturate (30 mg/kg per day) to Ldlr(-/-) mice increased kidney ACE2 mRNA abundance and activity and elevated plasma Ang-(1-7) concentrations. diminazene aceturate 37-57 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 0-4 25301841-9 2014 ACE2 activation by administration of diminazene aceturate (30 mg/kg per day) to Ldlr(-/-) mice increased kidney ACE2 mRNA abundance and activity and elevated plasma Ang-(1-7) concentrations. diminazene aceturate 37-57 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 112-116 24854854-0 2014 Angiotensin-converting enzyme 2 (ACE2) activator diminazene aceturate ameliorates endotoxin-induced uveitis in mice. diminazene aceturate 49-69 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 0-31 24854854-0 2014 Angiotensin-converting enzyme 2 (ACE2) activator diminazene aceturate ameliorates endotoxin-induced uveitis in mice. diminazene aceturate 49-69 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 33-37 24854854-5 2014 METHODS: ACE2 activator diminazene aceturate (DIZE) was administered both systemically and locally. diminazene aceturate 24-44 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 9-13 24854854-5 2014 METHODS: ACE2 activator diminazene aceturate (DIZE) was administered both systemically and locally. diminazene aceturate 46-50 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Mus musculus 9-13