PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6185830-3 1982 When both animals are fed a 1% D/L-ethionine diet, only the rat responds with increased levels of hepatic alpha-fetoprotein synthesis as shown by radioimmunoassay studies. Ethionine 35-44 alpha-fetoprotein Rattus norvegicus 106-123 6187744-4 1983 The increase in the proportion of AFP mRNA in polysomal RNA is relatively small during liver regeneration (2-4-fold) but is larger (30-50-fold) in preneoplastic livers of rats fed a choline-deficient diet containing 0.1% ethionine. Ethionine 221-230 alpha-fetoprotein Rattus norvegicus 34-37 85804-3 1979 Elevations of AFP occur after administration of hepatotoxic agents during the stage of restitutive proliferation and after exposure to the hepatocarcinogen ethionine, but not after croton oil. Ethionine 156-165 alpha-fetoprotein Rattus norvegicus 14-17 6174466-2 1982 These biphasic elevations of serum AFP concentrations in rats fed a 0.25% ethionine-containing diet decreased abruptly an significantly following a change to the basal diet either supplemented with or without 0.7% methionine. Ethionine 74-83 alpha-fetoprotein Rattus norvegicus 35-38 6174466-0 1982 Regulation of rat alpha-fetoprotein production by methionine during ethionine-hepatocarcinogenesis. Ethionine 51-60 alpha-fetoprotein Rattus norvegicus 18-35 6177022-0 1982 Influence of methionine administration on serum alpha-fetoprotein levels in ethionine-injured rats. Ethionine 14-23 alpha-fetoprotein Rattus norvegicus 48-65 6177022-1 1982 Serum alpha-fetoprotein (AFP) concentrations increased promptly 2 days following a single injection of DL-ethionine (ethionine) in adult female rats. Ethionine 106-115 alpha-fetoprotein Rattus norvegicus 6-23 6177022-1 1982 Serum alpha-fetoprotein (AFP) concentrations increased promptly 2 days following a single injection of DL-ethionine (ethionine) in adult female rats. Ethionine 106-115 alpha-fetoprotein Rattus norvegicus 25-28 6177022-2 1982 Continuous elevation of serum AFP was also observed on feeding a diet containing 1% ethionine for at least 2-3 weeks. Ethionine 84-93 alpha-fetoprotein Rattus norvegicus 30-33 6177022-4 1982 Furthermore, in rats fed on 1% ethionine for 2 weeks, dietary change to the laboratory chow supplemented with and without 2.8% methionine produced a decrease of increased serum AFP levels. Ethionine 31-40 alpha-fetoprotein Rattus norvegicus 177-180 6179139-0 1982 Alpha-fetoprotein dynamics during ethionine-induced hepatocarcinogenesis in rat. Ethionine 34-43 alpha-fetoprotein Rattus norvegicus 0-17 6179139-1 1982 Rats fed on a diet containing 0.25% DL-ethionine (ethionine), which has been usually used as carcinogenic dose, demonstrated the early elevations of serum alpha-fetoprotein (AFP) approximately in week 6 of the feedings. Ethionine 39-48 alpha-fetoprotein Rattus norvegicus 155-172 6179139-1 1982 Rats fed on a diet containing 0.25% DL-ethionine (ethionine), which has been usually used as carcinogenic dose, demonstrated the early elevations of serum alpha-fetoprotein (AFP) approximately in week 6 of the feedings. Ethionine 39-48 alpha-fetoprotein Rattus norvegicus 174-177 6179139-4 1982 Furthermore, in ethionine-induced hepatoma-bearing rats, AFP levels in the tumors were rather low as compared to those in the nontumorous portions of the liver surrounding the tumors. Ethionine 16-25 alpha-fetoprotein Rattus norvegicus 57-60 88859-1 1979 The role of alpha-fetoprotein (AFP)-suppressing factor(s) in the increased production of AFP in liver injury was investigated with carbon tetrachloride and ethionine-treated rats. Ethionine 156-165 alpha-fetoprotein Rattus norvegicus 31-34 88859-1 1979 The role of alpha-fetoprotein (AFP)-suppressing factor(s) in the increased production of AFP in liver injury was investigated with carbon tetrachloride and ethionine-treated rats. Ethionine 156-165 alpha-fetoprotein Rattus norvegicus 89-92 76508-4 1978 In rats fed the CD plus ethionine diets concomitant with the proliferation of oval cells, there was a marked elevation in the content of alpha1-fetoprotein in both liver and plasma. Ethionine 24-33 alpha-fetoprotein Rattus norvegicus 137-155 58843-0 1976 Prompt elevation of rat serum alpha-fetoprotein by acute liver injury following a single injection of ethionine. Ethionine 102-111 alpha-fetoprotein Rattus norvegicus 30-47 58843-1 1976 The mechanism of increased alpha-fetoprotein (AFP) production following a single injection of ethionine was investigated by using rats aged 5 weeks at the time of killing. Ethionine 94-103 alpha-fetoprotein Rattus norvegicus 27-44 58843-1 1976 The mechanism of increased alpha-fetoprotein (AFP) production following a single injection of ethionine was investigated by using rats aged 5 weeks at the time of killing. Ethionine 94-103 alpha-fetoprotein Rattus norvegicus 46-49 58843-2 1976 Marked elevations of serum AFP concentrations occurred within 4 days in both male and female rats after administration of DL-ethionine or L-ethionine, although the increased levels of serum AFP and liver triglyceride in the adults were less marked in the male than in the female. Ethionine 123-134 alpha-fetoprotein Rattus norvegicus 27-30 58843-4 1976 Frequent administrations of adenosine triphosphate after a single dose of ethionine prevented the increases in liver triglyceride and serum AFP levels. Ethionine 74-83 alpha-fetoprotein Rattus norvegicus 140-143 58843-6 1976 The serum AFP from ethionine-treated rats was immunologically and electrophoretically indistinguishable from that of fetal, carbontetrachloride-treated or hepatoma-bearing rats. Ethionine 19-28 alpha-fetoprotein Rattus norvegicus 10-13 58843-7 1976 These observations suggest that the increased production of AFP in ethionine-treated rats is closely associated with hepatic injury and is not the consequence of liver cell regeneration. Ethionine 67-76 alpha-fetoprotein Rattus norvegicus 60-63 61145-2 1976 Marked elevation of serum AFP concentrations occurred in rats treated with carbon tetrachloride, thioacetamide, D-galactosamine, allyl alcohol, allyl formate, and ethionine in 4 days of these treatments. Ethionine 163-172 alpha-fetoprotein Rattus norvegicus 26-29 61145-7 1976 On the other hand, the administration of ethionine, which caused little necrosis of liver cells, produced increase in both serum AFP and liver G-6-PD levels with an only small increase of hepatic DNA synthesis compared to those following thioacetamide as well as CC14. Ethionine 41-50 alpha-fetoprotein Rattus norvegicus 129-132