PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21091643-5 2011 KEY RESULTS: Delta9-THC decreased responding for both food presentation and stimulus-shock termination; these effects were antagonized by the CB1 antagonist rimonabant. Dronabinol 13-23 cannabinoid receptor 1 Macaca mulatta 142-145 22718500-4 2012 One potential explanation for atypical effects is CB1 receptor agonist efficacy, which is reportedly higher for JWH-018 and JWH-073 compared with Delta9-THC. Dronabinol 146-156 cannabinoid receptor 1 Macaca mulatta 50-53 22718500-8 2012 (1R,3R,4R)-3-[2-Hydroxy-4-(1,1-dimethylheptyl) phenyl]-4-(3-hydroxypropyl)cyclohexan-1-ol (CP-55,940), a prototype high-efficacy CB1 receptor agonist, JWH-018, and JWH-073 substituted for the discriminative stimulus effects of Delta9-THC. Dronabinol 227-237 cannabinoid receptor 1 Macaca mulatta 129-132 22718500-12 2012 The greater loss of sensitivity to Delta9-THC relative to CP-55,940 and JWH-018 suggests that differences in CB1 receptor agonist efficacy are important in vivo and might underlie differences in the dependence liability and adverse effects of synthetic CBs versus cannabis. Dronabinol 35-45 cannabinoid receptor 1 Macaca mulatta 109-112 21091643-11 2011 CONCLUSIONS AND IMPLICATIONS: In Delta9-THC-treated monkeys, the magnitude of tolerance and cross-tolerance to other CB1 receptor agonists varied inversely with agonist efficacy, suggesting that CB1 agonist efficacy is an important determinant of behavioural effects. Dronabinol 40-43 cannabinoid receptor 1 Macaca mulatta 117-120 21091643-11 2011 CONCLUSIONS AND IMPLICATIONS: In Delta9-THC-treated monkeys, the magnitude of tolerance and cross-tolerance to other CB1 receptor agonists varied inversely with agonist efficacy, suggesting that CB1 agonist efficacy is an important determinant of behavioural effects. Dronabinol 40-43 cannabinoid receptor 1 Macaca mulatta 195-198 16953389-0 2006 Discriminative stimulus effects of the cannabinoid CB1 antagonist SR 141716A in rhesus monkeys pretreated with Delta9-tetrahydrocannabinol. Dronabinol 111-138 cannabinoid receptor 1 Macaca mulatta 51-54 16148440-1 2005 The prototypic cannabinoid CB1 antagonist SR 141716A is one important pharmacologic tool for examining CB1 receptors that mediate the behavioral and physiologic effects of delta9-tetrahydrocannabinol (delta9-THC). Dronabinol 172-199 cannabinoid receptor 1 Macaca mulatta 27-30 16148440-1 2005 The prototypic cannabinoid CB1 antagonist SR 141716A is one important pharmacologic tool for examining CB1 receptors that mediate the behavioral and physiologic effects of delta9-tetrahydrocannabinol (delta9-THC). Dronabinol 172-199 cannabinoid receptor 1 Macaca mulatta 103-106 16148440-1 2005 The prototypic cannabinoid CB1 antagonist SR 141716A is one important pharmacologic tool for examining CB1 receptors that mediate the behavioral and physiologic effects of delta9-tetrahydrocannabinol (delta9-THC). Dronabinol 201-211 cannabinoid receptor 1 Macaca mulatta 27-30 16148440-1 2005 The prototypic cannabinoid CB1 antagonist SR 141716A is one important pharmacologic tool for examining CB1 receptors that mediate the behavioral and physiologic effects of delta9-tetrahydrocannabinol (delta9-THC). Dronabinol 201-211 cannabinoid receptor 1 Macaca mulatta 103-106 10780256-10 1999 In summary, CB1-receptor agonists such as delta 9-THC and WIN 55,212-2 were more disruptive to the rate and accuracy of learning in old-world monkeys than the CB1-receptor antagonist SR141716A or cannabidiol. Dronabinol 42-53 cannabinoid receptor 1 Macaca mulatta 12-15