PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15203120-9 2004 Altogether our data suggest that part of the biological activities of suramin might be related to alpha-thrombin inhibition at extra-vascular sites. Suramin 70-77 coagulation factor II, thrombin Homo sapiens 104-112 4788038-5 1973 Part of the anticoagulant effect of suramin is due to inhibition of the action of thrombin on fibrinogen.4. Suramin 36-43 coagulation factor II, thrombin Homo sapiens 82-90 22342888-0 2012 Allosteric activation of human alpha-thrombin through exosite 2 by suramin analogs. Suramin 67-74 coagulation factor II, thrombin Homo sapiens 37-45 22342888-2 2012 We have recently elucidated the crystal structure of thrombin in complex with suramin, evidencing the interaction through the anion binding exosite 2. Suramin 78-85 coagulation factor II, thrombin Homo sapiens 53-61 22342888-3 2012 Here, we show that the activity of thrombin toward natural and synthetic substrates is enhanced by suramin as well as analogs of suramin at a low micromolar range prior to an inhibitory component at higher concentrations. Suramin 99-106 coagulation factor II, thrombin Homo sapiens 35-43 22342888-3 2012 Here, we show that the activity of thrombin toward natural and synthetic substrates is enhanced by suramin as well as analogs of suramin at a low micromolar range prior to an inhibitory component at higher concentrations. Suramin 129-136 coagulation factor II, thrombin Homo sapiens 35-43 19332154-0 2009 Structural and thermodynamic analysis of thrombin:suramin interaction in solution and crystal phases. Suramin 50-57 coagulation factor II, thrombin Homo sapiens 41-49 19332154-1 2009 Suramin is a hexasulfonated naphthylurea which has been recently characterized as a non-competitive inhibitor of human alpha-thrombin activity over fibrinogen, although its binding site and mode of interaction with the enzyme remain elusive. Suramin 0-7 coagulation factor II, thrombin Homo sapiens 125-133 19332154-2 2009 Here, we determined two X-ray structure of the thrombin:suramin complex, refined at 2.4 A resolution. Suramin 56-63 coagulation factor II, thrombin Homo sapiens 47-55 19332154-3 2009 While a single thrombin:suramin complex was found in the asymmetric unit cell of the crystal, some of the crystallographic contacts with symmetrically related molecules are mediated by both the enzyme and the ligand. Suramin 24-31 coagulation factor II, thrombin Homo sapiens 15-23 19332154-7 2009 Collectively, close understanding on the structural basis for interaction is given which might establish a basis for design of suramin analogues targeting thrombin. Suramin 127-134 coagulation factor II, thrombin Homo sapiens 155-163 15203120-0 2004 Suramin interaction with human alpha-thrombin: inhibitory effects and binding studies. Suramin 0-7 coagulation factor II, thrombin Homo sapiens 37-45 15203120-2 2004 Here we show that suramin binds to human alpha-thrombin inhibiting both the hydrolysis of the synthetic substrate S-2238 (IC50 = 40 microM), and the thrombin-induced fibrinogen clotting (IC50 = 20 microM). Suramin 18-25 coagulation factor II, thrombin Homo sapiens 47-55 15203120-2 2004 Here we show that suramin binds to human alpha-thrombin inhibiting both the hydrolysis of the synthetic substrate S-2238 (IC50 = 40 microM), and the thrombin-induced fibrinogen clotting (IC50 = 20 microM). Suramin 18-25 coagulation factor II, thrombin Homo sapiens 149-157 15203120-5 2004 Calorimetric studies revealed two distinct binding sites for suramin in alpha-thrombin. Suramin 61-68 coagulation factor II, thrombin Homo sapiens 78-86 15203120-6 2004 In addition, circular dichroism studies showed that suramin causes significant changes in alpha-thrombin tertiary structure, without affecting the secondary structure content. Suramin 52-59 coagulation factor II, thrombin Homo sapiens 96-104 9848889-7 1998 Certain polyanions, eg, heparin, pentosan polysulfate, dextran sulfate, and suramin, bind to adsorbed fibrin(ogen) and prevent thrombin-dependent adhesion of fibrinogen-coated surfaces. Suramin 76-83 coagulation factor II, thrombin Homo sapiens 127-135 9820121-0 1998 Effects of suramin on human platelet aggregation and Ca2+ mobilization induced by thrombin and other agonists. Suramin 11-18 coagulation factor II, thrombin Homo sapiens 82-90 9820121-2 1998 Our results show that suramin completely inhibited aggregation by thrombin, platelet activating factor (PAF), alkyllysophosphatidic acid (ALPA), or arachidonic acid in a concentration-dependent manner. Suramin 22-29 coagulation factor II, thrombin Homo sapiens 66-74 9820121-3 1998 The IC50 values of suramin for inhibition of aggregation by PAF, arachidonic acid, and thrombin were 76.7, 239, and 1.49 microg/ml, respectively. Suramin 19-26 coagulation factor II, thrombin Homo sapiens 87-95 9820121-4 1998 Ca2+ mobilization induced by thrombin was inhibited by suramin with an approximate IC50 value of 20 microg/ml. Suramin 55-62 coagulation factor II, thrombin Homo sapiens 29-37