PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27677339-9 2016 Pre-treatment with suramin also significantly reduced the expression and amount of extracellular EGFR ligands and the phosphorylation of EGFR and ERK in poly(I:C)-treated cells. Suramin 19-26 epidermal growth factor receptor Homo sapiens 97-101 27677339-9 2016 Pre-treatment with suramin also significantly reduced the expression and amount of extracellular EGFR ligands and the phosphorylation of EGFR and ERK in poly(I:C)-treated cells. Suramin 19-26 epidermal growth factor receptor Homo sapiens 137-141 9075785-5 1997 In this study, we analyzed the antitumor effect of suramin using two lines of lung cancer cells (A549 and PC-13), which express EGF-R, and a variety of assays. Suramin 51-58 epidermal growth factor receptor Homo sapiens 128-133 21029725-3 2010 Suramin, a polysulfonated naphthylurea that acts as a growth factor blocker, exhibits antiproliferative activity against non-small cell lung cancer (NSCLC) cells that overexpress EGFR on the cell surface. Suramin 0-7 epidermal growth factor receptor Homo sapiens 179-183 16616945-12 2006 The EGFR inhibitors AG1478 and suramin protected against the ciglitazone-induced cell death. Suramin 31-38 epidermal growth factor receptor Homo sapiens 4-8 26505315-12 2016 Phosphorylation of ERK was attenuated in cells pretreated with suramin or BAPTA/AM ([Ca(2+)]i chelator), and partially with AG1478 (EGFR inhibitor). Suramin 63-70 epidermal growth factor receptor Homo sapiens 132-136 15350362-8 2004 The proliferative response to suramin could be inhibited with EGFR antagonists. Suramin 30-37 epidermal growth factor receptor Homo sapiens 62-66 15350362-11 2004 Unexpectedly, the antineoplastic agent suramin increased growth of ER positive ovarian carcinoma cells in an EGFR-dependent manner. Suramin 39-46 epidermal growth factor receptor Homo sapiens 109-113 10836098-4 2000 In this study we aimed to verify this hypothesis by evaluating the presence of mRNA of EGF and EGF receptor (EGF-R) and of their translation products in U285 cells, before and after the treatment with suramin and exogenous EGF. Suramin 201-208 epidermal growth factor receptor Homo sapiens 95-114 10071987-6 1999 The effect of suramin on epidermal growth factor receptor (EGFR) was determined by analyzing receptor phosphorylation and dimerization. Suramin 14-21 epidermal growth factor receptor Homo sapiens 25-57 10071987-6 1999 The effect of suramin on epidermal growth factor receptor (EGFR) was determined by analyzing receptor phosphorylation and dimerization. Suramin 14-21 epidermal growth factor receptor Homo sapiens 59-63 10071987-10 1999 PPADS had no effect on the growth stimulation by suramin; however suramin treatment resulted in rapid phosphorylation and dimerization of EGFR. Suramin 66-73 epidermal growth factor receptor Homo sapiens 138-142 10071987-13 1999 Rather, it appears that suramin acts via an interaction with EGFR, but not with purinergic receptors. Suramin 24-31 epidermal growth factor receptor Homo sapiens 61-65 9282976-2 1997 Since human esophageal squamous cell carcinoma expresses abundant epidermal growth factor receptors (EGFR) and proliferates in an autocrine and paracrine manner, it was expected that suramin inhibits tumor growth by disrupting EGFR. Suramin 183-190 epidermal growth factor receptor Homo sapiens 66-99 9282976-2 1997 Since human esophageal squamous cell carcinoma expresses abundant epidermal growth factor receptors (EGFR) and proliferates in an autocrine and paracrine manner, it was expected that suramin inhibits tumor growth by disrupting EGFR. Suramin 183-190 epidermal growth factor receptor Homo sapiens 101-105 9282976-2 1997 Since human esophageal squamous cell carcinoma expresses abundant epidermal growth factor receptors (EGFR) and proliferates in an autocrine and paracrine manner, it was expected that suramin inhibits tumor growth by disrupting EGFR. Suramin 183-190 epidermal growth factor receptor Homo sapiens 227-231 9282976-5 1997 Since autophosphorylation of EGFR was stronger at the low concentration and weaker at the high concentration of suramin compared with the control, the effect of suramin was thought to be via phosphorylation of receptors. Suramin 112-119 epidermal growth factor receptor Homo sapiens 29-33 9282976-5 1997 Since autophosphorylation of EGFR was stronger at the low concentration and weaker at the high concentration of suramin compared with the control, the effect of suramin was thought to be via phosphorylation of receptors. Suramin 161-168 epidermal growth factor receptor Homo sapiens 29-33 9075785-0 1997 Suramin inhibits the growth of non-small-cell lung cancer cells that express the epidermal growth factor receptor. Suramin 0-7 epidermal growth factor receptor Homo sapiens 81-113 9075785-4 1997 Several investigators have reported that suramin has antiproliferative activity against cancer cells that express EGF receptors (EGF-R), and that it acts by blocking the binding of the ligand to its receptor. Suramin 41-48 epidermal growth factor receptor Homo sapiens 114-127 9075785-4 1997 Several investigators have reported that suramin has antiproliferative activity against cancer cells that express EGF receptors (EGF-R), and that it acts by blocking the binding of the ligand to its receptor. Suramin 41-48 epidermal growth factor receptor Homo sapiens 129-134 7923365-5 1994 Indeed, UVC induces the suramin-inhibitable immediate tyrosine phosphorylation of the EGF receptor. Suramin 24-31 epidermal growth factor receptor Homo sapiens 86-98 2170005-11 1990 Additionally, we confirm the inhibitory effects of suramin on epidermal growth factor receptor binding in a human intestinal cell line. Suramin 51-58 epidermal growth factor receptor Homo sapiens 62-94 1592534-5 1992 A suramin concentration of 100 micrograms/ml brought about a 100% stimulation of the proliferation of ZR/HERc cells, ZR 75.1 cells ectopically expressing a human epidermal growth factor receptor (EGF-R) cDNA. Suramin 2-9 epidermal growth factor receptor Homo sapiens 162-194 1592534-5 1992 A suramin concentration of 100 micrograms/ml brought about a 100% stimulation of the proliferation of ZR/HERc cells, ZR 75.1 cells ectopically expressing a human epidermal growth factor receptor (EGF-R) cDNA. Suramin 2-9 epidermal growth factor receptor Homo sapiens 196-201