PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8914844-0	1996	Potent inhibition of human folylpolyglutamate synthetase by suramin.	Suramin	60-67	folylpolyglutamate synthase	Homo sapiens	27-56	
8914844-1	1996	Suramin, a bis-hexasulfonated napthylurea, was studied as an inhibitor of human folylpolyglutamate synthetase (FPGS), a crucial enzyme in folate metabolism.	Suramin	0-7	folylpolyglutamate synthase	Homo sapiens	80-109	
8914844-1	1996	Suramin, a bis-hexasulfonated napthylurea, was studied as an inhibitor of human folylpolyglutamate synthetase (FPGS), a crucial enzyme in folate metabolism.	Suramin	0-7	folylpolyglutamate synthase	Homo sapiens	111-115	
8914844-2	1996	Suramin is a more potent (IC50, 0.9 microM) inhibitor of FPGS partially purified from CCRF-CEM human leukemia cells than is bromosulfophthalein (IC50, 17 microM), the first reported nonsubstrate-analog inhibitor of FPGS (J. J. McGuire et al., Adv.	Suramin	0-7	folylpolyglutamate synthase	Homo sapiens	57-61	
8914844-2	1996	Suramin is a more potent (IC50, 0.9 microM) inhibitor of FPGS partially purified from CCRF-CEM human leukemia cells than is bromosulfophthalein (IC50, 17 microM), the first reported nonsubstrate-analog inhibitor of FPGS (J. J. McGuire et al., Adv.	Suramin	0-7	folylpolyglutamate synthase	Homo sapiens	215-219	
8914844-7	1996	FPGS inhibition by suramin is reversed by bovine serum albumin (which binds suramin).	Suramin	19-26	folylpolyglutamate synthase	Homo sapiens	0-4	
8914844-7	1996	FPGS inhibition by suramin is reversed by bovine serum albumin (which binds suramin).	Suramin	76-83	folylpolyglutamate synthase	Homo sapiens	0-4	
8914844-8	1996	Suramin is a noncompetitive inhibitor with aminopterin (K(ii) = 0.9 microM; K(is) = 1.1 microM) and glutamic acid (K(ii) = 1.0 microM; K(is) = 5.2 microM) as the variable substrates; suramin inhibition tends toward being competitive with respect to the third FPGS substrate, ATP (K(ii) = 3.4 microM; K(is) = 0.35 microM), since the major effect is on its K(m).	Suramin	0-7	folylpolyglutamate synthase	Homo sapiens	259-263