PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9468299-4	1998	Here we report on a differential effect of suramin on PKCmu and various PKC isoforms representing the cPKC, nPKC, and aPKC group of the PKC family.	Suramin	43-50	protein kinase C zeta	Homo sapiens	54-57	
9468299-5	1998	In the absence of any cofactors suramin activates all PKC isoforms in the order of aPKCzeta >> PKCmu > cPKC, nPKCdelta.	Suramin	32-39	protein kinase C zeta	Homo sapiens	54-57	
9468299-6	1998	As judged by the Vmax/KM ratios (0.5 for PKCmu and 2.2 for PKCzeta) the substrate syntide 2 is phosphorylated by suramin-activated PKCzeta around four times more effectively than by suramin-activated PKCmu.	Suramin	113-120	protein kinase C zeta	Homo sapiens	59-66	
9468299-6	1998	As judged by the Vmax/KM ratios (0.5 for PKCmu and 2.2 for PKCzeta) the substrate syntide 2 is phosphorylated by suramin-activated PKCzeta around four times more effectively than by suramin-activated PKCmu.	Suramin	113-120	protein kinase C zeta	Homo sapiens	131-138	
9468299-6	1998	As judged by the Vmax/KM ratios (0.5 for PKCmu and 2.2 for PKCzeta) the substrate syntide 2 is phosphorylated by suramin-activated PKCzeta around four times more effectively than by suramin-activated PKCmu.	Suramin	182-189	protein kinase C zeta	Homo sapiens	131-138	
9468299-7	1998	Suramin-activated PKCmu behaves like that activated by phosphatidylserine and the phorbol ester TPA regarding autophosphorylation and differential inhibition by the PKC inhibitors Go 6976 and Go 6983.	Suramin	0-7	protein kinase C zeta	Homo sapiens	18-21	
9468299-8	1998	In the presence of activating cofactors, such as phosphatidylserine and TPA or cholesterol sulfate (for PKCzeta), the activity of the aPKCzeta is further stimulated, PKCmu is not significantly affected, and the cPKCs and the nPKCdelta are strongly inhibited by suramin.	Suramin	261-268	protein kinase C zeta	Homo sapiens	104-111	
9468299-9	1998	The differential action of suramin on PKC isoenzymes might play a role in some of its biological effects, as for instance inhibition of proliferation and tumor development.	Suramin	27-34	protein kinase C zeta	Homo sapiens	38-41	
9468299-10	1998	Moreover, due to this property suramin will possibly be a valuable tool for discriminating the activities of PKC isoenzymes in vitro and in vivo.	Suramin	31-38	protein kinase C zeta	Homo sapiens	109-112