PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10667230-8	1999	Suramin inhibited the anchorage-independent growth induced by IGF-1 or TGF alpha only at an IC50 of 100 micrograms/ml.	Suramin	0-7	transforming growth factor alpha	Homo sapiens	71-80	
1524218-5	1992	Suramin inhibited [125I]-TGF alpha binding (IC50 = 0.20 mM).	Suramin	0-7	transforming growth factor alpha	Homo sapiens	25-34	
7511269-5	1993	The polyanionic compounds suramin and dextran sulfates which have been shown to inactivate a variety of growth factors e.g. EGF/TGF alpha inhibit growth of LNCaP cells and DU 145 cells in a dose dependent and reversible fashion.	Suramin	26-33	transforming growth factor alpha	Homo sapiens	128-137	
2056586-0	1991	Inhibition of prostatic tumor cell proliferation by suramin: alterations in TGF alpha-mediated autocrine growth regulation and cell cycle distribution.	Suramin	52-59	transforming growth factor alpha	Homo sapiens	76-85	
2056586-3	1991	The present studies were designed to evaluate the ability of suramin to inhibit PC3 and DU145 proliferation by interfering with TGFa-mediated autocrine growth.	Suramin	61-68	transforming growth factor alpha	Homo sapiens	128-132	
2056586-7	1991	Suramin also interfered with TGFa-mediated growth mechanisms.	Suramin	0-7	transforming growth factor alpha	Homo sapiens	29-33	
2056586-8	1991	Specifically, suramin reduced the specific binding of TGFa to PC3 and DU145 cells.	Suramin	14-21	transforming growth factor alpha	Homo sapiens	54-58	
2056586-9	1991	Additionally, the inhibitory effect of suramin on DU145 was reversed by cultivation of cells in the presence of excess TGFa.	Suramin	39-46	transforming growth factor alpha	Homo sapiens	119-123	
2056586-11	1991	These studies show that the inhibitory effect of suramin on PC3 and DU145 cell growth is mediated, in part, by alteration of TGFa-mediated autocrine growth mechanisms and cell cycle kinetics.	Suramin	49-56	transforming growth factor alpha	Homo sapiens	125-129