PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25277183-3 2014 Herein, we reported that 3,3"-diselenodipropionic acid (DSeA), a Selenocysteine derivative, could synergistically enhance the growth inhibitory effect of TRAIL on A375 melanoma cells though induction of ROS-dependent apoptosis with involvement of PTEN-mediated Akt inactivation and DNA damage-mediated p53 phosphorylation, which subsequently activated mitochondrial and death receptor apoptotic pathways. 3,3'-diselenodipropionic acid 25-54 AKT serine/threonine kinase 1 Homo sapiens 261-264 25277183-3 2014 Herein, we reported that 3,3"-diselenodipropionic acid (DSeA), a Selenocysteine derivative, could synergistically enhance the growth inhibitory effect of TRAIL on A375 melanoma cells though induction of ROS-dependent apoptosis with involvement of PTEN-mediated Akt inactivation and DNA damage-mediated p53 phosphorylation, which subsequently activated mitochondrial and death receptor apoptotic pathways. 3,3'-diselenodipropionic acid 56-60 AKT serine/threonine kinase 1 Homo sapiens 261-264