PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1322161-0 1992 Low sodium intake enhances sensitivity of 11-deoxycortisol and deoxycorticosterone to ACTH in ACTH-suppressed normal subjects. Desoxycorticosterone 63-82 proopiomelanocortin Homo sapiens 86-90 1322161-0 1992 Low sodium intake enhances sensitivity of 11-deoxycortisol and deoxycorticosterone to ACTH in ACTH-suppressed normal subjects. Desoxycorticosterone 63-82 proopiomelanocortin Homo sapiens 94-98 2166067-1 1990 Short term suppression of ACTH by dexamethasone effects limited reduction in plasma deoxycorticosterone (DOC) while cortisol levels are almost completely suppressed in normal control subjects. Desoxycorticosterone 84-103 proopiomelanocortin Homo sapiens 26-30 1531483-7 1992 An increase in deoxycorticosterone was observed after fadrozole treatment compared with pretreatment values (P less than 0.01) and after stimulation with ACTH compared with placebo (P less than 0.05). Desoxycorticosterone 15-34 proopiomelanocortin Homo sapiens 154-158 2166067-1 1990 Short term suppression of ACTH by dexamethasone effects limited reduction in plasma deoxycorticosterone (DOC) while cortisol levels are almost completely suppressed in normal control subjects. Desoxycorticosterone 105-108 proopiomelanocortin Homo sapiens 26-30 35263051-3 2022 We highlight the presence of a "mineralocorticoid (MC) pathway of zona fasciculata (ZF)", where most circulating corticosterone and deoxycorticosterone (DOC) originate together with 18OHDOC, under ACTH control, a claim based on functional studies in normal subjects and in patients with 11beta-, and 17alpha-hydroxylase deficiencies. Desoxycorticosterone 132-151 proopiomelanocortin Homo sapiens 197-201 34483146-10 2022 Rapid ACTH injection resulted in elevations in the deoxycorticosterone, corticosterone, aldosterone, and 17-hydroxypregnenolone levels, but not in the cortisol level. Desoxycorticosterone 51-70 proopiomelanocortin Homo sapiens 6-10 35263051-3 2022 We highlight the presence of a "mineralocorticoid (MC) pathway of zona fasciculata (ZF)", where most circulating corticosterone and deoxycorticosterone (DOC) originate together with 18OHDOC, under ACTH control, a claim based on functional studies in normal subjects and in patients with 11beta-, and 17alpha-hydroxylase deficiencies. Desoxycorticosterone 153-156 proopiomelanocortin Homo sapiens 197-201 7056849-3 1982 The blocking effect of met-enkephalin on the rate of aldosterone, deoxycorticosterone, and corticosterone release was significant at a concentration as low as 10(-11) M (P less than 0.001, P less than 0.01, and P less than 0.001, respectively). Desoxycorticosterone 66-85 proopiomelanocortin Homo sapiens 23-37 3023428-4 1987 The episodes were caused by mineralocorticoid actions of large ACTH-induced increases in cortisol and deoxycorticosterone secretion. Desoxycorticosterone 102-121 proopiomelanocortin Homo sapiens 63-67 3034556-6 1986 Plasma deoxycorticosterone (DOC), B and 18-OH-B as well as cortisol remarkable increased after ACTH injection, but the increase in plasma ALD was very small. Desoxycorticosterone 7-26 proopiomelanocortin Homo sapiens 95-99 3034556-6 1986 Plasma deoxycorticosterone (DOC), B and 18-OH-B as well as cortisol remarkable increased after ACTH injection, but the increase in plasma ALD was very small. Desoxycorticosterone 28-31 proopiomelanocortin Homo sapiens 95-99 3015796-8 1986 Infusion of adrenocorticotropic hormone (ACTH) caused exaggerated increases of aldosterone, 11-deoxycorticosterone, and 18-hydroxycortisol; cortisol response was normal. Desoxycorticosterone 92-114 proopiomelanocortin Homo sapiens 12-39 2982239-7 1985 The fasciculata steroids cortisol, 11-deoxycorticosterone and corticosterone were continuously stimulated by ACTH. Desoxycorticosterone 35-57 proopiomelanocortin Homo sapiens 109-113 6328122-0 1984 ACTH sensitivity of isolated human pathological adrenocortical cells: variability of responses in aldosterone, corticosterone, deoxycorticosterone and cortisol production. Desoxycorticosterone 127-146 proopiomelanocortin Homo sapiens 0-4 6325055-2 1984 ACTH administration produced hypokalaemia, initial urinary sodium retention, a fall in active plasma renin concentration, a transient rise in plasma aldosterone concentration and sustained rises in plasma deoxycorticosterone concentration and urinary kallikrein activity. Desoxycorticosterone 205-224 proopiomelanocortin Homo sapiens 0-4 6325055-4 1984 The effects of ACTH on urinary kallikrein excretion appeared to be independent of aldosterone and correlated most closely with deoxycorticosterone concentrations. Desoxycorticosterone 127-146 proopiomelanocortin Homo sapiens 15-19 7056849-4 1982 Dose-dependent inhibition of steroid biosynthesis became more apparent with increasing amounts of met-enkephalin in the incubation medium (10(-11)-10(-5) M); at a concentration of 10(-5) M, met-enkephalin decreased the production of aldosterone by 45%, that of deoxycorticosterone by 51%, and that of corticosterone by 44%. Desoxycorticosterone 261-280 proopiomelanocortin Homo sapiens 98-112 7056849-6 1982 In a concentration of 10(-5) M, met-enkephalin produced significant decreases in aldosterone (P less than 0.001), deoxycorticosterone (P less than 0.05), and corticosterone (P less than 0.001) production compared to the peak values obtained after stimulation with 0.85 X 10(-10) M ACTH-(1-24). Desoxycorticosterone 114-133 proopiomelanocortin Homo sapiens 32-46 6291816-3 1982 Few peaks of ACTH and cortisol were simultaneous and rare secretory impulses of corticosterone, and deoxycorticosterone were in synchrony with those of ACTH or cortisol. Desoxycorticosterone 100-119 proopiomelanocortin Homo sapiens 13-17 6291816-7 1982 appear to be essential in order to distinguish pituitary-dependent Cushing"s syndrome from normal; 2) In conditions of ACTH excess, DOC and corticosterone secretion seems to become progressively less ACTH-dependent as we proceed down the biosynthetic chain towards aldosterone, which is suppressed in most cases. Desoxycorticosterone 132-135 proopiomelanocortin Homo sapiens 119-123 6257748-3 1981 Plasma 18-OH-DOC and B demonstrated quantitatively the greatest responses to ACTH, while DOC and 18-OHB responses were intermediate. Desoxycorticosterone 13-16 proopiomelanocortin Homo sapiens 77-81 6303639-6 1983 Plasma cortisol, 11-deoxycortisol, corticosterone, deoxycorticosterone, 17 alpha-hydroxyprogesterone and 17-hydroxy, 20-dihydroprogesterone were all increased by ACTH treatment. Desoxycorticosterone 51-70 proopiomelanocortin Homo sapiens 162-166 6274570-12 1981 ACTH produced increases in plasma cortisol, 11-deoxycortisol, corticosterone, deoxycorticosterone, aldosterone, 17 alpha-hydroxyprogesterone and 17 alpha,20 alpha-dihydroxyprogesterone. Desoxycorticosterone 78-97 proopiomelanocortin Homo sapiens 0-4 6267148-5 1981 Plasma levels of steroids distal to progesterone, i.e., DOC, corticosterone, 18 OH-B, and aldosterone, are relatively higher after small amounts of ACTH in patients with adenomas than in normal subjects or those with adrenal hyperplasia. Desoxycorticosterone 56-59 proopiomelanocortin Homo sapiens 148-152 7409273-3 1980 DOC and cortisol which were contained in the adenomas were also stimulated more significantly by ACTH than by angiotensin II and III. Desoxycorticosterone 0-3 proopiomelanocortin Homo sapiens 97-101 7354720-6 1980 Correlations of free DOC and aldosterone excretion with free cortisol excretion, and their responses to the administration of metyrapone and dexamethasone were compatible with ACTH dependency in adrenal hyperplasia, autonomous production of steroids in adrenal adenomas and a chaotic steroidogenesis in adrenal carcinoma. Desoxycorticosterone 21-24 proopiomelanocortin Homo sapiens 176-180 6259660-1 1980 Chronic oversecretion of adrenocorticotropin (ACTH) in Cushing"s disease and partial adrenal insufficiency results in a plasma pattern of mineralocorticoid hormones (MCHs) in which deoxycorticosterone, 18-hydroxycorticosterone and aldosterone remain within normal limits. Desoxycorticosterone 181-200 proopiomelanocortin Homo sapiens 46-50 232023-2 1979 Adrenocorticotropin (ACTH)-induced steroidogenesis, obtained by continuous administration of ACTH for 3 days, produces in man (a) sustained elevations of plasma deoxycorticosterone and cortisol concentrations, (b) transient elevations of plasma aldosterone and 18-hydroxycorticosterone concentrations that return to near-control values, and (c) brisk initial increases in plasma 18-hydroxydeoxycorticosterone and corticosterone concentrations that fall to 20-68% of peak values 30 h thereafter. Desoxycorticosterone 161-180 proopiomelanocortin Homo sapiens 21-25 232023-2 1979 Adrenocorticotropin (ACTH)-induced steroidogenesis, obtained by continuous administration of ACTH for 3 days, produces in man (a) sustained elevations of plasma deoxycorticosterone and cortisol concentrations, (b) transient elevations of plasma aldosterone and 18-hydroxycorticosterone concentrations that return to near-control values, and (c) brisk initial increases in plasma 18-hydroxydeoxycorticosterone and corticosterone concentrations that fall to 20-68% of peak values 30 h thereafter. Desoxycorticosterone 161-180 proopiomelanocortin Homo sapiens 93-97 218456-5 1979 Since urinary tetrahydrodesoxycorticosterone increased substantially, sodium retention resulting from ACTH was ascribed to enhanced DOC secretion. Desoxycorticosterone 132-135 proopiomelanocortin Homo sapiens 102-106 218456-8 1979 As a result of ACTH, plasma cortisol and the free cortisol index increased strikingly; the plasma free DOC index rose markedly in those subjects in whom the total plasma DOC level was not altered appreciably and was unchanged or even increased slightly in the few subjects in whom the total DOC level decreased. Desoxycorticosterone 170-173 proopiomelanocortin Homo sapiens 15-19 218456-8 1979 As a result of ACTH, plasma cortisol and the free cortisol index increased strikingly; the plasma free DOC index rose markedly in those subjects in whom the total plasma DOC level was not altered appreciably and was unchanged or even increased slightly in the few subjects in whom the total DOC level decreased. Desoxycorticosterone 170-173 proopiomelanocortin Homo sapiens 15-19 218456-9 1979 The results support the proposition that the plasma free DOC fraction is increased because of displacement from corticosteroid-binding globulin by the ACTH-induced increment in cortisol. Desoxycorticosterone 57-60 proopiomelanocortin Homo sapiens 151-155 212954-9 1978 The loss of responsiveness of DOC to ACTH in the third trimester suggests that the maternal adrenals have undergone an alteration in their steroidogenic response to ACTH, but also may indicate that their output of DOC has reached a maximal rate. Desoxycorticosterone 30-33 proopiomelanocortin Homo sapiens 37-41 212954-9 1978 The loss of responsiveness of DOC to ACTH in the third trimester suggests that the maternal adrenals have undergone an alteration in their steroidogenic response to ACTH, but also may indicate that their output of DOC has reached a maximal rate. Desoxycorticosterone 30-33 proopiomelanocortin Homo sapiens 165-169 212954-9 1978 The loss of responsiveness of DOC to ACTH in the third trimester suggests that the maternal adrenals have undergone an alteration in their steroidogenic response to ACTH, but also may indicate that their output of DOC has reached a maximal rate. Desoxycorticosterone 214-217 proopiomelanocortin Homo sapiens 37-41 190252-7 1977 Estimations of adrenal 11beta-hydroxylating efficiency in response to ACTH in patients and controls by plasma steroid ratios revealed significantly lower B/DOC ratios in both low and normal renin patients compared to controls, supported by somewhat lower F/S ratios in these patients, especially those in the low renin subgroup. Desoxycorticosterone 156-159 proopiomelanocortin Homo sapiens 70-74 210631-0 1977 Prevention of the ACTH-induced hypertension by deoxycorticosterone antibody ... Desoxycorticosterone 47-66 proopiomelanocortin Homo sapiens 18-22 231371-4 1979 In agreement with the results in the in vivo study, the in vitro study also revealed ACTH stimulated aldosterone and deoxycorticosterone (DOC) from the adenoma more markedly than angiotensin II or III. Desoxycorticosterone 117-136 proopiomelanocortin Homo sapiens 85-89 231371-4 1979 In agreement with the results in the in vivo study, the in vitro study also revealed ACTH stimulated aldosterone and deoxycorticosterone (DOC) from the adenoma more markedly than angiotensin II or III. Desoxycorticosterone 138-141 proopiomelanocortin Homo sapiens 85-89 225716-4 1979 DOC (11-deoxycorticosterone) was found in saliva only during ACTH administration. Desoxycorticosterone 0-3 proopiomelanocortin Homo sapiens 61-65 225716-4 1979 DOC (11-deoxycorticosterone) was found in saliva only during ACTH administration. Desoxycorticosterone 5-27 proopiomelanocortin Homo sapiens 61-65 212954-3 1978 Although DOC secretion in nongravid women has been assumed to be dependent mainly on adrenocorticotropic hormone (ACTH), in a previous study of women in the third trimester of pregnancy it was found to be unresponsive to ACTH, dexamethasone, and variations in salt intake. Desoxycorticosterone 9-12 proopiomelanocortin Homo sapiens 85-112 212954-3 1978 Although DOC secretion in nongravid women has been assumed to be dependent mainly on adrenocorticotropic hormone (ACTH), in a previous study of women in the third trimester of pregnancy it was found to be unresponsive to ACTH, dexamethasone, and variations in salt intake. Desoxycorticosterone 9-12 proopiomelanocortin Homo sapiens 114-118 198594-8 1977 Effects of ACTH upon plasma DOC and cortisol were not inhibited by angiotenesin III analogue, but the effect of ACTH upon aldosterone was blunted slightly. Desoxycorticosterone 28-31 proopiomelanocortin Homo sapiens 11-15 199474-0 1977 [Effect of ACTH on plasma renin activity, aldosterone level and deoxycorticosterone level in humans (author"s transl)]. Desoxycorticosterone 64-83 proopiomelanocortin Homo sapiens 11-15 187612-8 1976 These studies suggest that a steroid other than aldosterone, 18-OH-DOC, or DOC may be the cause of the ACTH-induced hypertension in this patient. Desoxycorticosterone 67-70 proopiomelanocortin Homo sapiens 103-107 168695-5 1975 Serum deoxycorticosterone rose in healthy subjects upon injection of ACTH, after induction of insulin hypoglycemia and after administration of metyrapone, while the rise was absent or blunted in patients with Addison"s disease and in patients with pituitary failure. Desoxycorticosterone 6-25 proopiomelanocortin Homo sapiens 69-73 28487303-4 2017 The consequent cortisol deficiency results in a compensatory increase in adrenocorticotropic hormone (ACTH) drive, which stimulates the production of deoxycorticosterone and corticosterone leading to hypertension and hypokalaemia. Desoxycorticosterone 150-169 proopiomelanocortin Homo sapiens 73-100 180044-9 1976 We suggest that competitive interactions in the protein binding properties of various steroids account for the selective effect of ACTH on the MCR of aldosterone, cortisol, and DOC. Desoxycorticosterone 177-180 proopiomelanocortin Homo sapiens 131-135 4336939-8 1972 In contrast, small doses of ACTH given under similar conditions never induced increases in plasma deoxycorticosterone without simultaneously inducing large increases in plasma deoxycortisol. Desoxycorticosterone 98-117 proopiomelanocortin Homo sapiens 28-32 14927717-0 1952 Inhibition of desoxycorticosterone-induced pathologic changes by adrenocorticotropic hormone and cortisone. Desoxycorticosterone 14-34 proopiomelanocortin Homo sapiens 65-92 28487303-4 2017 The consequent cortisol deficiency results in a compensatory increase in adrenocorticotropic hormone (ACTH) drive, which stimulates the production of deoxycorticosterone and corticosterone leading to hypertension and hypokalaemia. Desoxycorticosterone 150-169 proopiomelanocortin Homo sapiens 102-106 26525354-11 2015 In infancy and childhood adrenal androgen overproduction results in peripheral precocious puberty in boys and various degrees of virilization in girls.Accumulation of 11-deoxycorticosterone and its metabolites causes hypertension in about two thirds of patients.Diagnosis lies upon elevated 11-deoxycortisol and DOC plus upstream precursors, such as 17alpha-hydroxyprogesterone and Delta4-androstenedione.The established treatment of steroid 11beta-OHD is similar to that of steroid 21-hydroxylase deficiency and consists of glucocorticoid administration in order to reduce ACTH-driven DOC overproduction resulting in hypertension remission and improvement of the virilization symptoms. Desoxycorticosterone 167-189 proopiomelanocortin Homo sapiens 574-578 12040893-5 2002 Also, the therapeutic activity of ACTH in infantile spasms could partially relate to its stimulatory effects on the synthesis of DOC, which then undergoes biotransformation to neurosteroids. Desoxycorticosterone 129-132 proopiomelanocortin Homo sapiens 34-38 10454460-6 1999 Plasma deoxycorticosterone levels were lower in blacks than in whites both at baseline (247+/-161 versus 381+/-270 pmol/L, P=0.048) and after stimulation with adrenocorticotropic hormone (822+/-294 versus 1127+/-628 pmol/L at 30 minutes, P=0.047; 925+/-366 versus 1440+/-834 pmol/L at 60 minutes, P=0.013). Desoxycorticosterone 7-26 proopiomelanocortin Homo sapiens 159-186 1337504-13 1992 In ectopic ACTH syndrome the characteristic mineralocorticoid excess can be accounted for by a combination of increased secretion of cortisol, corticosterone and of 11-deoxycorticosterone and decreased inactivation of cortisol and corticosterone by 11 beta-dehydrogenase. Desoxycorticosterone 165-187 proopiomelanocortin Homo sapiens 11-15