PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24580729-6 2014 The substrate (progesterone) and the product (deoxycorticosterone) of 21-hydroxylase are substrates of 20alpha-HSD, thus 20alpha-HSD (Akr1c18) gene expression was investigated. Desoxycorticosterone 46-65 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 70-84 24580729-11 2014 CONCLUSION: Progesterone is present at high levels during gestation and the product of 21-hydroxylase, deoxycorticosterone, can bind the glucocorticoid receptor with an affinity close to that of corticosterone. Desoxycorticosterone 103-122 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 87-101 27432820-7 2016 In vitro assays demonstrated that Cyp21a1-expressing fibroblasts can uptake progesterone from the culture media, convert it to deoxycorticosterone (DOC), and subsequently release DOC back into the media. Desoxycorticosterone 127-146 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 34-41 7925109-4 1994 21-OHase catalyzes the conversion of progesterone to deoxycorticosterone during adrenal steroidogenesis in mice; therefore, H-2aw18 homozygous mice are unable to synthesize corticosteroids. Desoxycorticosterone 53-72 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 0-8 27432820-7 2016 In vitro assays demonstrated that Cyp21a1-expressing fibroblasts can uptake progesterone from the culture media, convert it to deoxycorticosterone (DOC), and subsequently release DOC back into the media. Desoxycorticosterone 148-151 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 34-41 27432820-7 2016 In vitro assays demonstrated that Cyp21a1-expressing fibroblasts can uptake progesterone from the culture media, convert it to deoxycorticosterone (DOC), and subsequently release DOC back into the media. Desoxycorticosterone 179-182 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 34-41 27432820-8 2016 Autotransplantation of Cyp21a1-expressing fibroblasts into the subcutaneous tissues of the back resulted in a significant reduction in the serum progesterone/DOC ratio in four of six 21-OHD mice at 4 weeks after injection. Desoxycorticosterone 158-161 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 23-30