PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28487303-4 2017 The consequent cortisol deficiency results in a compensatory increase in adrenocorticotropic hormone (ACTH) drive, which stimulates the production of deoxycorticosterone and corticosterone leading to hypertension and hypokalaemia. Corticosterone 155-169 proopiomelanocortin Homo sapiens 73-100 28487303-4 2017 The consequent cortisol deficiency results in a compensatory increase in adrenocorticotropic hormone (ACTH) drive, which stimulates the production of deoxycorticosterone and corticosterone leading to hypertension and hypokalaemia. Corticosterone 155-169 proopiomelanocortin Homo sapiens 102-106 27535620-10 2016 To test the hypothesis that corticosterone effectively suppresses adrenocorticotropic hormone (ACTH) without the metabolic adverse effects of cortisol, we infused cortisol or corticosterone in patients with Addison"s disease. Corticosterone 28-42 proopiomelanocortin Homo sapiens 66-93 27535620-10 2016 To test the hypothesis that corticosterone effectively suppresses adrenocorticotropic hormone (ACTH) without the metabolic adverse effects of cortisol, we infused cortisol or corticosterone in patients with Addison"s disease. Corticosterone 28-42 proopiomelanocortin Homo sapiens 95-99 27535620-12 2016 These data indicate that corticosterone may be a metabolically favorable alternative to cortisol for glucocorticoid replacement therapy when ACTH suppression is desirable, as in congenital adrenal hyperplasia, and justify development of a pharmaceutical preparation. Corticosterone 25-39 proopiomelanocortin Homo sapiens 141-145 27358119-10 2016 Moreover, the release of ACTH binds the receptor MC2-R and stimulates the generation of glucocorticoids such as corticosterone and cortisol, which interact with the transcription factors AP-1 and NF-kB. Corticosterone 112-126 proopiomelanocortin Homo sapiens 25-29 25744413-5 2015 In contrast, administration of the NO donor sodium nitroprusside (SNP) led to mitochondrial oxidative stress and dysfunction in adrenal glands, which resulted in a blunted corticosterone response to ACTH. Corticosterone 172-186 proopiomelanocortin Homo sapiens 199-203 24702258-5 2014 Using a combination of both in vivo and in vitro approaches, we demonstrated that either CBS/CSE inhibitors or small interfering RNAs led to mitochondrial oxidative stress and dysfunction, which meanwhile resulted in blunted corticosterone responses to adrenocorticotropic hormone (ACTH). Corticosterone 225-239 proopiomelanocortin Homo sapiens 253-280 18637557-2 2008 ACTH stimulated corticosterone output in the breeding season. Corticosterone 16-30 proopiomelanocortin Homo sapiens 0-4 23276607-8 2013 Altered plasma corticosterone responses to ACTH injections were observed over the treatment course. Corticosterone 15-29 proopiomelanocortin Homo sapiens 43-47 23276607-10 2013 ACTH administration initially enhanced plasma corticosterone levels, however, these normalised to levels consistent with control animals by day 14. Corticosterone 46-60 proopiomelanocortin Homo sapiens 0-4 21242794-0 2011 Endotoxin tolerance of adrenal gland: attenuation of corticosterone production in response to lipopolysaccharide and adrenocorticotropic hormone. Corticosterone 53-67 proopiomelanocortin Homo sapiens 117-144 21242794-10 2011 Plasma corticosterone response to ACTH was decreased in rats receiving preinjection of lipopolysaccharide. Corticosterone 7-21 proopiomelanocortin Homo sapiens 34-38 21242794-11 2011 Lipopolysaccharide pretreatment caused a significant decrease in corticosterone production in response to subsequent ACTH and lipopolysaccharide stimulation in primary fasciculata-reticularis cells. Corticosterone 65-79 proopiomelanocortin Homo sapiens 117-121 21242794-15 2011 In vitro, lipopolysaccharide pretreatment impaired corticosterone production of fasciculata-reticularis cells in response to ACTH and lipopolysaccharide, which was associated with decreased expression of synthetic enzymes required for corticosterone production. Corticosterone 51-65 proopiomelanocortin Homo sapiens 125-129 21242794-15 2011 In vitro, lipopolysaccharide pretreatment impaired corticosterone production of fasciculata-reticularis cells in response to ACTH and lipopolysaccharide, which was associated with decreased expression of synthetic enzymes required for corticosterone production. Corticosterone 235-249 proopiomelanocortin Homo sapiens 125-129 19508587-9 2010 Compared with normal controls, carriers showed lower basal and ACTH-stimulated cortisol levels but higher ACTH-stimulated corticosterone levels. Corticosterone 122-136 proopiomelanocortin Homo sapiens 106-110 17537461-6 2007 It was found that infusion of rats with ACTH for 1 h caused an increase of adrenal ALA-s mRNA and activity accompanied by an increase in plasma corticosterone. Corticosterone 144-158 proopiomelanocortin Homo sapiens 40-44 18088360-4 2008 beta-MSH injection on food and water intake, plasma corticosterone concentration, ingestive and non-ingestive behaviours, and hypothalamic neuronal activation using Cobb-500 chicks. Corticosterone 52-66 proopiomelanocortin Homo sapiens 0-8 18088360-6 2008 beta-MSH-treated chicks also had increased plasma corticosterone concentrations and increased c-Fos reactivity in the periventricular, paraventricular and infundibular nuclei, and the ventromedial hypothalamus; however, the lateral hypothalamus was not affected. Corticosterone 50-64 proopiomelanocortin Homo sapiens 0-8 17332532-10 2007 We confirmed that ACTH increased adrenal weight and corticosterone levels when compared with control or dexamethasone-treated animals. Corticosterone 52-66 proopiomelanocortin Homo sapiens 18-22 17332532-12 2007 When ERKs activation was blocked by the use of a specific MEK inhibitor (PD98059), there was a decrease in ACTH-induced corticosterone release and PCNA expression. Corticosterone 120-134 proopiomelanocortin Homo sapiens 107-111 12047726-10 2002 In contrast, testosterone and corticosterone interact on stress-induced ACTH release and drive to the PVN motor neurones. Corticosterone 30-44 proopiomelanocortin Homo sapiens 72-76 17197073-4 2007 Melanocytes respond with enhanced production of cortisol and corticosterone, which is dependent on POMC activity. Corticosterone 61-75 proopiomelanocortin Homo sapiens 99-103 17197073-5 2007 Fibroblasts respond to CRH and ACTH with enhanced production of corticosterone, but not cortisol, which is produced constitutively. Corticosterone 64-78 proopiomelanocortin Homo sapiens 31-35 16174719-9 2005 After ACTH injection, PA females exhibited higher circulating levels of DHEA, androstenedione, and corticosterone but comparable levels of 17alpha-hydroxyprogesterone, cortisol, the sulfoconjugate of DHEA, and testosterone compared with controls. Corticosterone 99-113 proopiomelanocortin Homo sapiens 6-10 15837925-0 2005 The rapid release of corticosterone from the adrenal induced by ACTH is mediated by nitric oxide acting by prostaglandin E2. Corticosterone 21-35 proopiomelanocortin Homo sapiens 64-68 15837925-4 2005 We demonstrated that both sodium nitroprusside (NP), a nitric oxide (NO) donor, and ACTH stimulate corticosterone release. Corticosterone 99-113 proopiomelanocortin Homo sapiens 84-88 15837925-5 2005 NO mediated the acute response to ACTH because Nomega-nitro-l-arginine methyl ester, a NO synthase inhibitor, and hemoglobin, a NO scavenger, blocked the stimulation of corticosterone release induced by ACTH. Corticosterone 169-183 proopiomelanocortin Homo sapiens 34-38 15837925-5 2005 NO mediated the acute response to ACTH because Nomega-nitro-l-arginine methyl ester, a NO synthase inhibitor, and hemoglobin, a NO scavenger, blocked the stimulation of corticosterone release induced by ACTH. Corticosterone 169-183 proopiomelanocortin Homo sapiens 203-207 15837925-7 2005 Additionally, indomethacin, which inhibits cyclooxygenase, and thereby, prostaglandin release, prevented corticosterone release from the adrenal induced by both NP and ACTH, demonstrating that prostaglandins mediate acute corticosterone release. Corticosterone 105-119 proopiomelanocortin Homo sapiens 168-172 15837925-8 2005 Corticosterone content in adrenals after incubation with ACTH or NP was lower than in control glands, indicating that any de novo synthesis of corticosterone during this period was not sufficient to keep up with the release of the stored hormone. Corticosterone 0-14 proopiomelanocortin Homo sapiens 57-61 15837925-9 2005 The release induced by ACTH or NP depleted the corticosterone content in the adrenal by approximately 40% compared with the content of glands incubated in buffer. Corticosterone 47-61 proopiomelanocortin Homo sapiens 23-27 15837925-10 2005 The mechanism of rapid release is as follows: NO produced by NO synthase activation by ACTH activates cyclooxygenase, which generates PGE(2), which in turn releases corticosterone stored in microvesicles and other organelles. Corticosterone 165-179 proopiomelanocortin Homo sapiens 87-91 15572653-4 2005 CRH and ACTH also enhanced production of cortisol and corticosterone, and cortisol production was also stimulated by progesterone. Corticosterone 54-68 proopiomelanocortin Homo sapiens 8-12 15491790-6 2004 The treatment with gamma-MSH (1 microg), an MC3 receptor agonist, resulted in significant reduction of the IL-1beta-induced plasma corticosterone levels. Corticosterone 131-145 proopiomelanocortin Homo sapiens 19-28 15491790-8 2004 Besides, treatment with a high dose of alpha-MSH (1 microg) increased plasma corticosterone. Corticosterone 77-91 proopiomelanocortin Homo sapiens 39-48 15491790-9 2004 When alpha-MSH was given at a lower dose (0.1 microg), it did not modify corticosterone levels but caused an inhibitory effect on the corticosterone release induced by IL-1beta. Corticosterone 134-148 proopiomelanocortin Homo sapiens 5-14 12169769-8 2002 Splanchnic nerve transection also attenuated plasma corticosterone responses to submaximal doses of ACTH in dexamethasone-blocked, dehydrated rats, suggesting a decreased adrenal sensitivity to ACTH. Corticosterone 52-66 proopiomelanocortin Homo sapiens 100-104 15833364-4 2005 Furthermore, CRH and ACTH stimulate production of corticosterone in fibroblasts, with ACTH being more potent. Corticosterone 50-64 proopiomelanocortin Homo sapiens 21-25 15833364-8 2005 However, it diverges from the HPA organization in its distal step, where CRH and ACTH stimulate production of corticosterone, instead of cortisol. Corticosterone 110-124 proopiomelanocortin Homo sapiens 81-85 15742969-9 2005 At 60 min after ACTH injection, corticosterone levels were lower at d 12 than at d 15 and 18. Corticosterone 32-46 proopiomelanocortin Homo sapiens 16-20 15742969-10 2005 At 150 min after ACTH injection, corticosterone levels followed different trends according to incubation stage and turning duration. Corticosterone 33-47 proopiomelanocortin Homo sapiens 17-21 15742969-12 2005 Also at d 18, corticosterone levels in the T15 group were the highest at 150 min after ACTH injection. Corticosterone 14-28 proopiomelanocortin Homo sapiens 87-91 15588378-2 2004 Inhibition of thyrotropin (TSH) and MSH secretion by pituitary preparations by adding exogenous TSH or MSH to the medium was already observed in the 1960s, as was the phenomenon that adrenocorticotropic hormone (ACTH) injected in the hypothalamus lowered plasma corticosterone levels. Corticosterone 262-276 proopiomelanocortin Homo sapiens 183-210 14711894-5 2004 injection of ACTH for 7 consecutive days (postnatal days 3-9) elevated serum corticosterone levels 20-fold measured on postnatal day 10, indicating systemic absorption and circulation of the ACTH. Corticosterone 77-91 proopiomelanocortin Homo sapiens 13-17 14711894-5 2004 injection of ACTH for 7 consecutive days (postnatal days 3-9) elevated serum corticosterone levels 20-fold measured on postnatal day 10, indicating systemic absorption and circulation of the ACTH. Corticosterone 77-91 proopiomelanocortin Homo sapiens 191-195 11993792-0 2002 Preclinical Cushing"s syndrome due to ACTH-independent bilateral macronodular adrenocortical hyperplasia with excessive secretion of 18-hydroxydeoxycorticosterone and corticosterone. Corticosterone 148-162 proopiomelanocortin Homo sapiens 38-42 11993792-1 2002 A 64-year-old woman developed hypertension and hypokalemia, due to ACTH-independent bilateral macronodular adrenocortical hyperplasia (AIMAH) with excessive secretion of 18-hydroxydeoxycorticosterone and corticosterone. Corticosterone 185-199 proopiomelanocortin Homo sapiens 67-71 9516715-2 1998 This IPG is also able to inhibit the stimulation by ACTH of the production of the main glucocorticoid, corticosterone and the main mineralocorticoid, aldosterone, in rat adrenocortical cells. Corticosterone 103-117 proopiomelanocortin Homo sapiens 52-56 11260660-10 2001 Swimming stress also resulted in marked elevation in both ACTH and corticosterone levels, which were 10-20 fold higher (541.8 compared to 27.2-59.1 pg/dl for ACTH) and 2-5 fold higher (45.7 compared to 8.4- 20.0 microg/dl for corticosteroids) than the cage control animals. Corticosterone 67-81 proopiomelanocortin Homo sapiens 158-162 11403102-5 2001 The bioactivity of the high molecular weight ACTH in patient plasma was lower than the reference range of 1-39 ACTH, which is determined by the ability of dispersed rat adrenocortical cells to secrete corticosterone. Corticosterone 201-215 proopiomelanocortin Homo sapiens 45-49 11403102-5 2001 The bioactivity of the high molecular weight ACTH in patient plasma was lower than the reference range of 1-39 ACTH, which is determined by the ability of dispersed rat adrenocortical cells to secrete corticosterone. Corticosterone 201-215 proopiomelanocortin Homo sapiens 111-115 9619376-3 1998 However, there is one previous study which reported that such an inhibitory action of indomethacin on ACTH secretion is mediated principally by a fast, rate-sensitive negative feedback effect of corticosterone which increases after indomethacin injection, rather than by a decrease in PG production. Corticosterone 195-209 proopiomelanocortin Homo sapiens 102-106 12058538-2 2002 The defensins are known to display corticostatic activity by means of suppression of stress- and ACTH-induced rise in corticosterone level in the blood. Corticosterone 118-132 proopiomelanocortin Homo sapiens 97-101 11422117-10 2001 Basal concentrations of DOC, corticosterone, 11-deoxycortisol and cortisol and responses of corticosterone and cortisol to ACTH were not affected by genotype. Corticosterone 92-106 proopiomelanocortin Homo sapiens 123-127 11457663-6 2001 In contrast, SNP significantly inhibited the stimulatory effects of ACTH, AII and ET-1 on corticosterone and aldosterone secretion. Corticosterone 90-104 proopiomelanocortin Homo sapiens 68-72 9516715-7 1998 These data suggest that ACTH activates a GPI-PLC in rat adrenal cortex, which is in agreement with our previous data in calf adrenocortical cells; thus, the hydrolysis of GPI provoked by ACTH takes place in different mammals and the IPG released could inhibit ACTH-mediated synthesis of aldosterone, corticosterone and cortisol. Corticosterone 300-314 proopiomelanocortin Homo sapiens 24-28 9516715-7 1998 These data suggest that ACTH activates a GPI-PLC in rat adrenal cortex, which is in agreement with our previous data in calf adrenocortical cells; thus, the hydrolysis of GPI provoked by ACTH takes place in different mammals and the IPG released could inhibit ACTH-mediated synthesis of aldosterone, corticosterone and cortisol. Corticosterone 300-314 proopiomelanocortin Homo sapiens 187-191 9516715-7 1998 These data suggest that ACTH activates a GPI-PLC in rat adrenal cortex, which is in agreement with our previous data in calf adrenocortical cells; thus, the hydrolysis of GPI provoked by ACTH takes place in different mammals and the IPG released could inhibit ACTH-mediated synthesis of aldosterone, corticosterone and cortisol. Corticosterone 300-314 proopiomelanocortin Homo sapiens 187-191 9203553-1 1997 Basal plasma ACTH and corticosterone levels are controlled by the suprachiasmatic nucleus (SCN), the site of the circadian pacemaker, resulting in a daily peak in plasma corticosterone and ACTH. Corticosterone 22-36 proopiomelanocortin Homo sapiens 189-193 9787255-0 1997 Maintenance of Basal ACTH Levels by Corticosterone and RU28362, but not Aldosterone: Relationship to Available Type I and Type II Corticosteroid Receptor Levels in Brain and Pituitary. Corticosterone 36-50 proopiomelanocortin Homo sapiens 21-25 9787255-1 1997 This study examined the ability of three replacement doses of corticosterone, aldosterone, or RU28362 to prevent the increase in morning basal plasma ACTH levels that occurs after adrenalectomy. Corticosterone 62-76 proopiomelanocortin Homo sapiens 150-154 9787255-5 1997 The lowest dose of corticosterone partially prevented, and the middle and high doses of corticosterone completely prevented the adrenalectomy-induced increase in ACTH. Corticosterone 88-102 proopiomelanocortin Homo sapiens 162-166 9203553-1 1997 Basal plasma ACTH and corticosterone levels are controlled by the suprachiasmatic nucleus (SCN), the site of the circadian pacemaker, resulting in a daily peak in plasma corticosterone and ACTH. Corticosterone 170-184 proopiomelanocortin Homo sapiens 13-17 9203553-8 1997 Regression analysis of the relation ACTH-corticosterone before and after stress shows a changed pattern at ZT2, although at that time still no significant correlation between ACTH and corticosterone was detected. Corticosterone 41-55 proopiomelanocortin Homo sapiens 36-40 9203553-12 1997 (4) The present results therefore demonstrate SCN modulating corticosterone secretion by affecting ACTH secretion and changing the sensitivity of the adrenal cortex by means of a neuronal input. Corticosterone 61-75 proopiomelanocortin Homo sapiens 99-103 7770636-3 1995 Using isolated rat adrenal fasciculata-reticularis and glomerulosa cell bioassays, guinea pig ACTH was found to have similar activity to that of human ACTH with respect to corticosterone- and aldosterone-stimulating activity, in terms of maximal steroid output but was slightly more potent in terms of the concentration which elicited half-maximal steroid secretion. Corticosterone 172-186 proopiomelanocortin Homo sapiens 94-98 9068053-1 1997 The effects of exogenous naloxone and adrenocorticotropin (ACTH) on circulating concentrations of corticosterone and glucose in broilers were determined. Corticosterone 98-112 proopiomelanocortin Homo sapiens 59-63 9068053-7 1997 Intramuscular injections of naloxone significantly reduced subsequent ACTH-stimulated increases in serum corticosterone; however, when followed by saline, naloxone elevated corticosterone by 90 min after the final injection of saline. Corticosterone 105-119 proopiomelanocortin Homo sapiens 70-74 7724457-4 1995 This finding supports the conclusion that the substance produced by leukocytes previously shown in our laboratory to stimulate adrenal cells to secrete corticosterone is immunoreactive ACTH. Corticosterone 152-166 proopiomelanocortin Homo sapiens 185-189 7883855-9 1995 Basal and ACTH-stimulated concentrations of cortisol, corticosterone, and 18-hydroxycorticosterone were unchanged by the concomitant infusion of endothelin-1. Corticosterone 54-68 proopiomelanocortin Homo sapiens 10-14 7871163-7 1995 The ACTH response may be inhibited by elevated corticosterone levels after whole-body irradiation, or by other radiation-induced effects on the pituitary gland and hypothalamus. Corticosterone 47-61 proopiomelanocortin Homo sapiens 4-8 8165156-6 1994 Corticosterone concentrations in response to both 10(-6) and 10(-5) ACTH were significantly lower for BSX than for sham ACC. Corticosterone 0-14 proopiomelanocortin Homo sapiens 68-72 8077359-5 1994 The ratios of both corticosterone/11-deoxycorticosterone and cortisol/11-deoxycortisol were abnormally low, and decreased further 60 min after administration of ACTH-(1-24) (250 micrograms) as an i.v. Corticosterone 19-33 proopiomelanocortin Homo sapiens 161-165 1334002-13 1992 Inhibition of ACTH secretion by ion channel blockers or corticosterone has potent inhibitory effects on percentages of CRH-bound cells. Corticosterone 56-70 proopiomelanocortin Homo sapiens 14-18 1335552-6 1992 In addition, LEW/N corticotrophs were more sensitive to dexamethasone and to corticosterone suppression of CRH-stimulated ACTH secretion compared to F344/N. Corticosterone 77-91 proopiomelanocortin Homo sapiens 122-126 8312138-5 1993 For example, 0.1 nM ACTH stimulates steroid secretion by three-fold in isolated cells while 1 pM ACTH already induces a 25 and nine-fold increase, respectively, in corticosterone and aldosterone output in cultured cells. Corticosterone 164-178 proopiomelanocortin Homo sapiens 20-24 8312138-5 1993 For example, 0.1 nM ACTH stimulates steroid secretion by three-fold in isolated cells while 1 pM ACTH already induces a 25 and nine-fold increase, respectively, in corticosterone and aldosterone output in cultured cells. Corticosterone 164-178 proopiomelanocortin Homo sapiens 97-101 8482733-2 1993 Although these peptides are best known for their broad spectrum antimicrobial properties, they also inhibit ACTH (corticotropin) stimulated corticosterone production, chemoattract monocytes, and lyse mammalian cells. Corticosterone 140-154 proopiomelanocortin Homo sapiens 108-112 1482145-4 1992 Next, the corticosterone peak induced by a protective dose of IL-1 (800 ng) was simulated by administration of synthetic human adrenocorticotropic hormone 1-24 (ACTH) in normal and neutropenic mice. Corticosterone 10-24 proopiomelanocortin Homo sapiens 127-159 1482145-4 1992 Next, the corticosterone peak induced by a protective dose of IL-1 (800 ng) was simulated by administration of synthetic human adrenocorticotropic hormone 1-24 (ACTH) in normal and neutropenic mice. Corticosterone 10-24 proopiomelanocortin Homo sapiens 161-165 1482145-5 1992 Although corticosterone levels induced by pretreatment with IL-1 or ACTH were virtually identical, the ACTH-induced corticosterone peak was not associated with protection against Klebsiella pneumoniae infection in normal mice and Pseudomonas aeruginosa infection in neutropenic mice. Corticosterone 116-130 proopiomelanocortin Homo sapiens 103-107 1482145-7 1992 In addition, we found that plasma corticosterone concentrations during K. pneumoniae infection were significantly lower after pretreatment with IL-1 than after pretreatment with ACTH or vehicle, probably reflecting the better physical condition of IL-1-treated mice. Corticosterone 34-48 proopiomelanocortin Homo sapiens 178-182 1337504-13 1992 In ectopic ACTH syndrome the characteristic mineralocorticoid excess can be accounted for by a combination of increased secretion of cortisol, corticosterone and of 11-deoxycorticosterone and decreased inactivation of cortisol and corticosterone by 11 beta-dehydrogenase. Corticosterone 143-157 proopiomelanocortin Homo sapiens 11-15 1337504-13 1992 In ectopic ACTH syndrome the characteristic mineralocorticoid excess can be accounted for by a combination of increased secretion of cortisol, corticosterone and of 11-deoxycorticosterone and decreased inactivation of cortisol and corticosterone by 11 beta-dehydrogenase. Corticosterone 173-187 proopiomelanocortin Homo sapiens 11-15 1851181-5 1991 ACTH injection produced significant increases in plasma cortisol, plasma corticosterone, plasma 18-OHB, and PA (P less than 0.005 or P less than 0.001), and graded AII infusions produced significant increases in plasma 18-OHB and PA (P less than 0.05 or P less than 0.01) during both 170- and 100-mmol sodium intakes in the two groups. Corticosterone 73-87 proopiomelanocortin Homo sapiens 0-4 2157438-3 1990 The total cells from the inner portion of the adrenals metabolized [14C]7,12-dimethylbenz(a)anthracene at a rate of 4.04 pmol/min 10(6) cells and synthesized corticosterone in response to ACTH stimulation at a rate of 1.07 micrograms/hr/10(6) cells. Corticosterone 158-172 proopiomelanocortin Homo sapiens 188-192 1645674-2 1991 alpha-Melanocyte-stimulating hormone (alpha-MSH) introduced into the ventricular system simultaneously with IL-1 blocked these effects of IL-1 in a dose-dependent manner, with 10 ng of alpha-MSH totally blocking the elevation of plasma ACTH and corticosterone and suppression of Natural Killer (NK) cell activity produced by a dose of IL-1 (100 pg) that otherwise causes maximal effects. Corticosterone 245-259 proopiomelanocortin Homo sapiens 0-36 1645674-2 1991 alpha-Melanocyte-stimulating hormone (alpha-MSH) introduced into the ventricular system simultaneously with IL-1 blocked these effects of IL-1 in a dose-dependent manner, with 10 ng of alpha-MSH totally blocking the elevation of plasma ACTH and corticosterone and suppression of Natural Killer (NK) cell activity produced by a dose of IL-1 (100 pg) that otherwise causes maximal effects. Corticosterone 245-259 proopiomelanocortin Homo sapiens 38-47 1645674-2 1991 alpha-Melanocyte-stimulating hormone (alpha-MSH) introduced into the ventricular system simultaneously with IL-1 blocked these effects of IL-1 in a dose-dependent manner, with 10 ng of alpha-MSH totally blocking the elevation of plasma ACTH and corticosterone and suppression of Natural Killer (NK) cell activity produced by a dose of IL-1 (100 pg) that otherwise causes maximal effects. Corticosterone 245-259 proopiomelanocortin Homo sapiens 185-194 2162451-4 1990 In contrast, the (11-24)2Lys conjugate (10(-6)M) significantly decreased ACTH-induced stimulation of corticosterone and aldosterone (-63 and -62%, respectively). Corticosterone 101-115 proopiomelanocortin Homo sapiens 73-77 2162451-5 1990 The dimeric conjugate of the fragment ACTH(7-24), linked through the C-terminal ends, (7-24)2Lys (10(-6)M), was also completely devoid of effect on basal steroidogenesis but caused a marked decrease of ACTH-evoked corticosterone and aldosterone release (-72 and -80%, respectively). Corticosterone 214-228 proopiomelanocortin Homo sapiens 38-42 1719873-0 1991 Substance P afferents regulate ACTH-corticosterone release. Corticosterone 36-50 proopiomelanocortin Homo sapiens 31-35 2598356-6 1989 The response of the cultured adrenocortical cells to secret corticosterone to the stimulation of ACTH analogue was also significantly lower in the aged rats than that in the young rats, which suggests that the reserve power of the adrenal cortex was also decreased with aging. Corticosterone 60-74 proopiomelanocortin Homo sapiens 97-101 8070360-1 1994 Centrally administered histamine (HA) stimulates the secretion of adenohypophysial POMC-derived peptides, which subsequently cause release of corticosterone. Corticosterone 142-156 proopiomelanocortin Homo sapiens 83-87 2160651-2 1990 ACTH/MSH(4-10)-NH2, Ac-ACTH/MSH(4-10) and Ac-ACTH/MSH(4-10)-NH2 (10 microM to 1 mM) stimulated the aldosterone production of zona glomerulosa cells, whereas these peptides did not stimulate the corticosterone production of zona fasciculata cells, even at 1 mM concentration. Corticosterone 194-208 proopiomelanocortin Homo sapiens 0-4 2160651-3 1990 As ACTH/MSH(4-10) has been shown to have a steroidogenic effect on both types of adrenocortical cells, both charged chain termini seem to be essential for triggering of the corticosterone production of zona fasciculata cells, but for aldosterone production their presence appears not to be important. Corticosterone 173-187 proopiomelanocortin Homo sapiens 3-7 34483146-10 2022 Rapid ACTH injection resulted in elevations in the deoxycorticosterone, corticosterone, aldosterone, and 17-hydroxypregnenolone levels, but not in the cortisol level. Corticosterone 72-86 proopiomelanocortin Homo sapiens 6-10 35263051-3 2022 We highlight the presence of a "mineralocorticoid (MC) pathway of zona fasciculata (ZF)", where most circulating corticosterone and deoxycorticosterone (DOC) originate together with 18OHDOC, under ACTH control, a claim based on functional studies in normal subjects and in patients with 11beta-, and 17alpha-hydroxylase deficiencies. Corticosterone 113-127 proopiomelanocortin Homo sapiens 197-201 2828010-6 1988 In a pharmacological approach, we measured the influence of the complete, competitive antagonist, human (h) ACTH-(7-38) on hACTH-(7-39)-induced corticosterone production by adrenocortical cells from L and N cockerels. Corticosterone 144-158 proopiomelanocortin Homo sapiens 108-112 2547012-2 1989 Both desacetyl-alpha-MSH, thought to be the major form of the peptide in the human pituitary and in circulating plasma, and alpha-MSH caused a significant stimulation of aldosterone, corticosterone and cortisol secretion. Corticosterone 183-197 proopiomelanocortin Homo sapiens 15-24 2547012-2 1989 Both desacetyl-alpha-MSH, thought to be the major form of the peptide in the human pituitary and in circulating plasma, and alpha-MSH caused a significant stimulation of aldosterone, corticosterone and cortisol secretion. Corticosterone 183-197 proopiomelanocortin Homo sapiens 124-133 2547012-6 1989 Yields of steroid obtained under conditions of maximal stimulation by ACTH(1-24), alpha-MSH and desacetyl-alpha-MSH were at least three to five times the basal output of aldosterone, four to eight times that for corticosterone and more than seven to sixteen times that for cortisol. Corticosterone 212-226 proopiomelanocortin Homo sapiens 106-115 2543538-4 1989 Human ACTH-(1-24) was the most efficacious and potent ACTH analogue for stimulating corticosterone and cAMP production, whereas turkey ACTH-(1-39) was among the least efficacious and least potent analogues. Corticosterone 84-98 proopiomelanocortin Homo sapiens 54-58 2543538-4 1989 Human ACTH-(1-24) was the most efficacious and potent ACTH analogue for stimulating corticosterone and cAMP production, whereas turkey ACTH-(1-39) was among the least efficacious and least potent analogues. Corticosterone 84-98 proopiomelanocortin Homo sapiens 54-58 2543538-8 1989 Basal corticosterone production of female cells was 19% greater than that of male cells, albeit maximal ACTH analogue-induced corticosterone production was not different between male and female cells. Corticosterone 126-140 proopiomelanocortin Homo sapiens 104-108 2543538-11 1989 In addition, there were sex-dependent differences in sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity of male cells was 1.2-3.2 times that of female cells. Corticosterone 89-103 proopiomelanocortin Homo sapiens 68-72 2543538-11 1989 In addition, there were sex-dependent differences in sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity of male cells was 1.2-3.2 times that of female cells. Corticosterone 89-103 proopiomelanocortin Homo sapiens 126-130 2543538-11 1989 In addition, there were sex-dependent differences in sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity of male cells was 1.2-3.2 times that of female cells. Corticosterone 89-103 proopiomelanocortin Homo sapiens 126-130 2543538-11 1989 In addition, there were sex-dependent differences in sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity of male cells was 1.2-3.2 times that of female cells. Corticosterone 89-103 proopiomelanocortin Homo sapiens 126-130 2538536-0 1989 Effects of insulin, glucose and ACTH on corticosterone production by fetal adrenal cells from diabetic rats. Corticosterone 40-54 proopiomelanocortin Homo sapiens 32-36 2538536-10 1989 Human ACTH (0.02-20 nmol/l) caused a concentration-dependent increase in corticosterone output of comparable magnitude by cells from all three groups of animals. Corticosterone 73-87 proopiomelanocortin Homo sapiens 6-10 2537913-2 1989 ACTH-(11-24) stimulated the corticosterone production of zona fasciculata cells and the aldosterone production of zona glomerulosa cells; in addition, it potentiated the effects of ACTH-(1-39) on both cell systems. Corticosterone 28-42 proopiomelanocortin Homo sapiens 0-4 2843716-3 1988 Following infusion of 0.0084 microgram/kg of ACTH, plasma levels of corticosterone (P less than 0.02) and cortisol (P less than 0.01) were significantly increased; with chronic verapamil treatment plasma levels of corticosterone (P less than 0.05) and cortisol (P less than 0.02) were significantly lower than those without verapamil. Corticosterone 68-82 proopiomelanocortin Homo sapiens 45-49 2843716-3 1988 Following infusion of 0.0084 microgram/kg of ACTH, plasma levels of corticosterone (P less than 0.02) and cortisol (P less than 0.01) were significantly increased; with chronic verapamil treatment plasma levels of corticosterone (P less than 0.05) and cortisol (P less than 0.02) were significantly lower than those without verapamil. Corticosterone 214-228 proopiomelanocortin Homo sapiens 45-49 2843187-1 1988 We report the purification, structure and biological properties of a peptide of novel sequence from human granulocytes that inhibits ACTH stimulated synthesis of corticosterone in rat adrenal cell suspensions. Corticosterone 162-176 proopiomelanocortin Homo sapiens 133-137 2855412-3 1988 After ACTH-stimulation, plasma levels of corticosterone were elevated in five obligate heterozygotes and 18-hydroxydeoxycorticosterone levels were increased in four of them. Corticosterone 41-55 proopiomelanocortin Homo sapiens 6-10 2549116-2 1989 The present study has been designed in order to see if A II could modify in vitro spontaneous and ACTH-induced corticosterone (B) release from both fasciculata-reticularis enriched and total adrenal cells. Corticosterone 111-125 proopiomelanocortin Homo sapiens 98-102 2832501-10 1988 ACTH did not augment mitotic activity in enucleated-hypophysectomized rats but significantly increased plasma concentrations of corticosterone in s.c. injection experiments. Corticosterone 128-142 proopiomelanocortin Homo sapiens 0-4 2837755-11 1988 Donor CS was significantly lower in birds that received ACTH. Corticosterone 6-8 proopiomelanocortin Homo sapiens 56-60 2837755-12 1988 These results indicate that, when washed and reconstituted blood cells are injected into recipients and donor plasma CS is decreased, GVHR capacity is suppressed in ACTH-treated donors. Corticosterone 117-119 proopiomelanocortin Homo sapiens 165-169 2826112-9 1988 Plasma immunoreactive ACTH and corticosterone levels were decreased in the group treated with anti-hACTH (P less than 0.0001 and P less than 0.01, respectively). Corticosterone 31-45 proopiomelanocortin Homo sapiens 99-104 3351363-5 1988 It has been known that adrenal secretion of corticosterone in response to exogenous ACTH occurs prior to that of cortisol. Corticosterone 44-58 proopiomelanocortin Homo sapiens 84-88 3039518-8 1987 In another experiment, markedly greater changes, at similar time intervals, in plasma corticosterone were effected by multiple subcutaneous injections of adrenocorticotropic hormone (ACTH) (either 5 IU ACTH or 20 IU ACTH/kg). Corticosterone 86-100 proopiomelanocortin Homo sapiens 154-181 3039518-8 1987 In another experiment, markedly greater changes, at similar time intervals, in plasma corticosterone were effected by multiple subcutaneous injections of adrenocorticotropic hormone (ACTH) (either 5 IU ACTH or 20 IU ACTH/kg). Corticosterone 86-100 proopiomelanocortin Homo sapiens 183-187 2826568-10 1987 In addition to these effects on short-term regulators of glycemia, intracisternal beta-endorphin increased plasma concentrations of corticosterone and growth hormone. Corticosterone 132-146 proopiomelanocortin Homo sapiens 82-96 2822295-4 1987 Corticosterone, 18-hydroxycorticosterone and aldosterone concentrations were abnormally sensitive to infusions of ACTH and angiotensin II. Corticosterone 0-14 proopiomelanocortin Homo sapiens 114-137 3023203-3 1986 Cimetidine and ranitidine at 320 and 1000 micrograms/ml inhibited ACTH-stimulated corticosterone and cortisol synthesis and cimetidine decreased basal cortisol synthesis. Corticosterone 82-96 proopiomelanocortin Homo sapiens 66-70 2876827-1 1986 Treatment with long acting ACTH (20 IU kg-1) produces a large and sustained elevation of plasma corticosterone in the domestic fowl. Corticosterone 96-110 proopiomelanocortin Homo sapiens 27-31 3013598-6 1986 The biological potencies of the two ACTH preparations were identical with respect to corticosterone (B) release in the short term bioassay, with an ED50 value of 1.67 X 10(-10) M. The ED50 value for cortisol (F) release for rACTH and hACTH were 1.1 X 10(-10) M and 1.67 X 10(-10) M, respectively, which were not statistically different. Corticosterone 85-99 proopiomelanocortin Homo sapiens 36-40 3021558-3 1986 Daily ACTH injections of 0.1 IU/kg on 3 successive days showed a good reproducibility in response in plasma corticosterone levels. Corticosterone 108-122 proopiomelanocortin Homo sapiens 6-10 3021558-6 1986 A rather low correlation (r = 0.49) existed between individual baseline levels of plasma corticosterone and adrenal sensitivity for ACTH. Corticosterone 89-103 proopiomelanocortin Homo sapiens 132-136 2422455-7 1986 At the higher dose (10(-4) M), verapamil totally inhibited the stimulation of corticosterone and aldosterone production induced by ACTH. Corticosterone 78-92 proopiomelanocortin Homo sapiens 131-135 3008140-2 1986 Adrenocortical response, as indicated by corticosterone concentrations, was greater early in the photoperiod in cockerels exposed to HS or injected with ACTH. Corticosterone 41-55 proopiomelanocortin Homo sapiens 153-157 2997858-2 1985 ACTH-(4-7), ACTH-(6-10), ACTH-(4-10) and ACTH-(11-13) stimulated corticosterone production of the zona fasciculata and aldosterone production of the zona glomerulosa cells. Corticosterone 65-79 proopiomelanocortin Homo sapiens 0-4 2997858-2 1985 ACTH-(4-7), ACTH-(6-10), ACTH-(4-10) and ACTH-(11-13) stimulated corticosterone production of the zona fasciculata and aldosterone production of the zona glomerulosa cells. Corticosterone 65-79 proopiomelanocortin Homo sapiens 12-16 2997858-2 1985 ACTH-(4-7), ACTH-(6-10), ACTH-(4-10) and ACTH-(11-13) stimulated corticosterone production of the zona fasciculata and aldosterone production of the zona glomerulosa cells. Corticosterone 65-79 proopiomelanocortin Homo sapiens 12-16 2997858-2 1985 ACTH-(4-7), ACTH-(6-10), ACTH-(4-10) and ACTH-(11-13) stimulated corticosterone production of the zona fasciculata and aldosterone production of the zona glomerulosa cells. Corticosterone 65-79 proopiomelanocortin Homo sapiens 12-16 3018821-5 1986 Cortisol and corticosterone responses after syn-ACTH tended to be higher during depression. Corticosterone 13-27 proopiomelanocortin Homo sapiens 48-52 3000997-2 1985 Plasma corticosterone significantly increased (P less than 0.01) from a mean (+/- SD) basal concentration of 3.25 +/ 3.6 ng/ml to 26.47 +/- 9.25 (one hour after ACTH administration) and 25.69 +/- 13.23 ng/ml (2 hours after ACTH administration). Corticosterone 7-21 proopiomelanocortin Homo sapiens 161-165 3000997-2 1985 Plasma corticosterone significantly increased (P less than 0.01) from a mean (+/- SD) basal concentration of 3.25 +/ 3.6 ng/ml to 26.47 +/- 9.25 (one hour after ACTH administration) and 25.69 +/- 13.23 ng/ml (2 hours after ACTH administration). Corticosterone 7-21 proopiomelanocortin Homo sapiens 223-227 3000997-6 1985 Plasma corticosterone concentrations in cockatoos, macaws, Amazon parrots, conures, and lorikeets before and after ACTH administration indicated that the ACTH stimulation test could be used to evaluate adrenal secretory capacity in psittacine birds. Corticosterone 7-21 proopiomelanocortin Homo sapiens 154-158 2989323-3 1985 During ACTH stimulation, plasma corticosterone concentrations remained low and cortisol remained high, suggesting the cortisol was of exogenous origin. Corticosterone 32-46 proopiomelanocortin Homo sapiens 7-11 2993990-5 1985 In 13 GH-deficient children, GH treatment caused a significant decrease in the corticosterone response to ACTH (2.2 +/- 0.2 micrograms/dl before GH to 1.6 +/- 0.2 micrograms/dl; t = 5.22, p less than 0.001; paired t test) despite the fact that there was no significant change in the cortisol response to ACTH (18 +/- 2 micrograms/dl before and 16 +/- 2 micrograms/dl after). Corticosterone 79-93 proopiomelanocortin Homo sapiens 106-110 2993990-7 1985 Again, the stimulated levels of cortisol were not affected by GH treatment (19 +/- 4 versus 18 +/- 3 micrograms/dl) These results indicate that GH modulates the adrenal response to ACTH by suppressing corticosterone secretion without affecting cortisol secretion. Corticosterone 201-215 proopiomelanocortin Homo sapiens 181-185 2982239-7 1985 The fasciculata steroids cortisol, 11-deoxycorticosterone and corticosterone were continuously stimulated by ACTH. Corticosterone 43-57 proopiomelanocortin Homo sapiens 109-113 2986736-9 1985 The perfusion of fetal adrenal glands with the same immunological quantities of "big", "intermediate" and "little" ACTH showed that the "little" and "intermediate" forms have greater biological potency in eliciting corticosterone secretion than the "big" ACTH form. Corticosterone 215-229 proopiomelanocortin Homo sapiens 115-119 6099814-5 1984 Activation of ACTH secretion in response to hypoglycaemia may involve a cholinergic mechanism at the hypothalamic level, with a consequent reduction in the increments of plasma cortisol and corticosterone after atropine administration. Corticosterone 190-204 proopiomelanocortin Homo sapiens 14-18 6274570-12 1981 ACTH produced increases in plasma cortisol, 11-deoxycortisol, corticosterone, deoxycorticosterone, aldosterone, 17 alpha-hydroxyprogesterone and 17 alpha,20 alpha-dihydroxyprogesterone. Corticosterone 62-76 proopiomelanocortin Homo sapiens 0-4 6087372-6 1984 It is concluded that the prolonged exposure to ACTH presumably causes a corticosterone-mediated loss of responsiveness of functionally restricted opiate sensitive mechanisms in the central nervous system. Corticosterone 72-86 proopiomelanocortin Homo sapiens 47-51 6328122-0 1984 ACTH sensitivity of isolated human pathological adrenocortical cells: variability of responses in aldosterone, corticosterone, deoxycorticosterone and cortisol production. Corticosterone 111-125 proopiomelanocortin Homo sapiens 0-4 6328122-3 1984 Adrenocortical cells derived from micronodular hyperplasia causing Cushing"s syndrome and cells from cortisol producing adenoma displayed predominantly cortisol and corticosterone secretion both under basal conditions and following stimulation with ACTH. Corticosterone 165-179 proopiomelanocortin Homo sapiens 249-253 6327457-4 1984 A single injection of 8 IU of mammalian ACTH into juvenile alligators resulted in a significant increase in corticosterone levels by 1 hr; hormone levels remained elevated for 24 hr, returning to baseline by 48 hr. Corticosterone 108-122 proopiomelanocortin Homo sapiens 40-44 6281486-5 1982 ASF increased the conversion of corticosterone to aldosterone like ACTH and beta-LPH. Corticosterone 32-46 proopiomelanocortin Homo sapiens 67-71 6281486-5 1982 ASF increased the conversion of corticosterone to aldosterone like ACTH and beta-LPH. Corticosterone 32-46 proopiomelanocortin Homo sapiens 76-84 7056844-1 1982 Stimulation of aldosterone and corticosterone production by pituitary peptides structurally or biosynthetically related to ACTH was investigated in suspensions of isolated rat adrenal glomerulosa and fasciculata cells, respectively. Corticosterone 31-45 proopiomelanocortin Homo sapiens 123-127 7056844-4 1982 Stimulation of corticosterone production by beta LPH preparations generally paralleled their aldosterone-stimulating activity, and most steroidogenic activity could be accounted for by immunoreactive ACTH, as determined in two ACTH RIAs. Corticosterone 15-29 proopiomelanocortin Homo sapiens 44-52 7056844-5 1982 Synthetic human beta LPH-(37-58), which contains the 47-53 heptapeptide sequence common to beta LPH and ACTH, had aldosterone- and corticosterone-stimulating activities similar to those of equimolar concentrations of beta LPH, whereas synthetic fragments of the COOH-terminal (61-91) portion of beta LPH had no steroidogenic activity. Corticosterone 131-145 proopiomelanocortin Homo sapiens 16-24 7056849-3 1982 The blocking effect of met-enkephalin on the rate of aldosterone, deoxycorticosterone, and corticosterone release was significant at a concentration as low as 10(-11) M (P less than 0.001, P less than 0.01, and P less than 0.001, respectively). Corticosterone 71-85 proopiomelanocortin Homo sapiens 23-37 7056849-4 1982 Dose-dependent inhibition of steroid biosynthesis became more apparent with increasing amounts of met-enkephalin in the incubation medium (10(-11)-10(-5) M); at a concentration of 10(-5) M, met-enkephalin decreased the production of aldosterone by 45%, that of deoxycorticosterone by 51%, and that of corticosterone by 44%. Corticosterone 266-280 proopiomelanocortin Homo sapiens 98-112 7056849-6 1982 In a concentration of 10(-5) M, met-enkephalin produced significant decreases in aldosterone (P less than 0.001), deoxycorticosterone (P less than 0.05), and corticosterone (P less than 0.001) production compared to the peak values obtained after stimulation with 0.85 X 10(-10) M ACTH-(1-24). Corticosterone 119-133 proopiomelanocortin Homo sapiens 32-46 6263579-4 1981 [125I]Tyr23,Phe2,Nle4-ACTH-(1-38) was as potent as ACTH in stimulating corticosterone production in isolated rat adrenocortical cells. Corticosterone 71-85 proopiomelanocortin Homo sapiens 22-26 6263579-4 1981 [125I]Tyr23,Phe2,Nle4-ACTH-(1-38) was as potent as ACTH in stimulating corticosterone production in isolated rat adrenocortical cells. Corticosterone 71-85 proopiomelanocortin Homo sapiens 51-55 6263593-3 1981 Phe2,Nle4-ACTH-(1-38) was found to be indistinguishable from synthetic human ACTH in its ability to stimulate corticosterone production in isolated rat adrenocortical cells. Corticosterone 110-124 proopiomelanocortin Homo sapiens 10-14 6318854-1 1983 It has been disclosed that beta-endorphin exerts marked effect on the secretion of ACTH, prolactin, corticosterone, aldosterone and somatotrophin formation in the pituitary but does not produce any effect on blood thyrotropin. Corticosterone 100-114 proopiomelanocortin Homo sapiens 27-41 6318854-3 1983 At the 60th minute after beta-endorphin injection the content of prolactin, corticosterone and aldosterone in the blood dropped to the control level, while ACTH content remained significantly higher than in intact animals. Corticosterone 76-90 proopiomelanocortin Homo sapiens 25-39 232023-2 1979 Adrenocorticotropin (ACTH)-induced steroidogenesis, obtained by continuous administration of ACTH for 3 days, produces in man (a) sustained elevations of plasma deoxycorticosterone and cortisol concentrations, (b) transient elevations of plasma aldosterone and 18-hydroxycorticosterone concentrations that return to near-control values, and (c) brisk initial increases in plasma 18-hydroxydeoxycorticosterone and corticosterone concentrations that fall to 20-68% of peak values 30 h thereafter. Corticosterone 166-180 proopiomelanocortin Homo sapiens 21-25 6116178-0 1981 [Dynamics of cortisol, cortisone, and corticosterone following administration of ACTH in premature and mature newborn infants (author"s transl)]. Corticosterone 38-52 proopiomelanocortin Homo sapiens 81-85 6250679-6 1980 The increase elicited by ACTH was smaller in LS but, since it was maintained for longer, the plasma corticosterone response was at least 18% larger than that in RIR birds. Corticosterone 100-114 proopiomelanocortin Homo sapiens 25-29 6250679-13 1980 It is concluded that ACTH-induced depression of plasma GH and growth is mediated by corticosterone. Corticosterone 84-98 proopiomelanocortin Homo sapiens 21-25 6281421-3 1981 Experiments are presented that compare feedback inhibition of ACTH affected by corticosterone and by adrenal mass. Corticosterone 79-93 proopiomelanocortin Homo sapiens 62-66 232023-2 1979 Adrenocorticotropin (ACTH)-induced steroidogenesis, obtained by continuous administration of ACTH for 3 days, produces in man (a) sustained elevations of plasma deoxycorticosterone and cortisol concentrations, (b) transient elevations of plasma aldosterone and 18-hydroxycorticosterone concentrations that return to near-control values, and (c) brisk initial increases in plasma 18-hydroxydeoxycorticosterone and corticosterone concentrations that fall to 20-68% of peak values 30 h thereafter. Corticosterone 166-180 proopiomelanocortin Homo sapiens 93-97 35343-7 1979 These results indicate that the release of ACTH is controlled specifically by HY-CRF and corticosterone, and modified slightly by some other substances such as vasopressin and prostaglandins, and that the effect of most other neurogenic peptides and neurotransmitter substances is negligible or non-physiological at the pituitary level. Corticosterone 89-103 proopiomelanocortin Homo sapiens 43-47 223358-1 1979 The effects of corticosterone and cortisol in concentrations attainable in the adrenal gland were studied on ACTH-induced steroidogenesis in cultured cortical cells of foetal human and rat adrenals. Corticosterone 15-29 proopiomelanocortin Homo sapiens 109-113 223504-4 1979 ACTH in the presence of corticosterone produced a coincident peak in tyrosinase activity and cAMP levels followed by a depression of enzymatic activity. Corticosterone 24-38 proopiomelanocortin Homo sapiens 0-4 232360-2 1979 ACTH content of the incubation medium was measured by radioimmunoassay or by the corticosterone production of trypsinisolated adrenocortical cells. Corticosterone 81-95 proopiomelanocortin Homo sapiens 0-4 218133-2 1979 It was shown that corticosterone (CORT) inhibited ACTH output provoked by either corticotropin-releasing factor (CRF) extracts or dbcAMP, in a manner which was both dose- and time-dependent. Corticosterone 18-32 proopiomelanocortin Homo sapiens 50-54 212744-5 1978 It is devoid of corticosteroidogenic activity but is able to inhibit ACTH-stimulated corticosterone production in isolated rat adrenal cells. Corticosterone 85-99 proopiomelanocortin Homo sapiens 69-73 213826-0 1978 [Relationship between plasma levels of cortisol and corticosterone in subjects with different ACTH activity (author"s transl)]. Corticosterone 52-66 proopiomelanocortin Homo sapiens 94-98 634292-1 1978 Evaluating plasma levels of cortisol and corticosterone after ACTH-stimulation, and the urinary metabolites tetrahydrocortisone and tetrahydrocortisol in asthmatic children it could be demonstrated, that in most cases there was no suppression of adrenal function following treatment over 6 to 18 months with a daily dose of 200 to 300 microgram beclomethasone dipropionate. Corticosterone 41-55 proopiomelanocortin Homo sapiens 62-66 189465-3 1976 Tests of adrenal function showed that stimulation of the adrenal with exogenous ACTH and with dexamethasone caused an increase and decrease, respectively, in plasma concentrations of corticosterone. Corticosterone 183-197 proopiomelanocortin Homo sapiens 80-84 192977-0 1977 The effects of pineal indoles and a crude aqueous pineal extract on ACTH mediated corticosterone release by isolated adrenal cells. Corticosterone 82-96 proopiomelanocortin Homo sapiens 68-72 188965-7 1977 infusion of synthetic ACTH increased the plasma concentrations of both steroids to maximal values of 0-42 +/- 0-23 mug cortisol/100 ml and 1-06 +/- 0-56 mug corticosterone/100 ml at infusion rates of 1 i.u. Corticosterone 157-171 proopiomelanocortin Homo sapiens 22-26 188965-13 1977 The metabolic clearance rate of cortisol was greater than that of corticosterone and both were depressed by ACTH. Corticosterone 66-80 proopiomelanocortin Homo sapiens 108-112 198428-0 1977 The variations of plasma corticosterone/cortisol ratios following ACTH stimulation or dexamethasone administration in normal men. Corticosterone 25-39 proopiomelanocortin Homo sapiens 66-70 198428-2 1977 Plasma corticosterone increased 4.83 times as much as basal value at 60 min after an im injection of 0.25 mg synthetic beta1-24 ACTH (Cortrosyn) in normal subjects, whereas plasma cortisol increased 2.12 times as much at 60 min. Corticosterone 7-21 proopiomelanocortin Homo sapiens 128-132 198428-3 1977 And basal corticosterone/cortisol ratio of 0.053 +/- 0.017 increased to 0.116 +/- 0.022 (P less than 0.001) after ACTH. Corticosterone 10-24 proopiomelanocortin Homo sapiens 114-118 181223-7 1976 The hormonal form of ACTH appears to be an important factor regulating the cortisol/corticosterone ratio in mammalian adrenal corticoid secretion because administration of porcine ACTH to rabbits alters the adrenal secretory pattern so as to decrease corticosterone production and increase cortisol production. Corticosterone 84-98 proopiomelanocortin Homo sapiens 21-25 190605-1 1976 It was shown in vitro that ACTH influenced the progesterone transformation increasing corticosterone production only in those fetuses whose adrenal glands, in the absence of ACTH, transformed progesterone chiefly into hydrocortisone (8--12-week fetuses). Corticosterone 86-100 proopiomelanocortin Homo sapiens 27-31 4364642-0 1974 Secretion of ACTH by isolated anterior pituitary cells: kinetics of stimulation of corticotropin-releasing factor and of inhibition by corticosterone. Corticosterone 135-149 proopiomelanocortin Homo sapiens 13-17 4335082-0 1971 Effects of theophylline on corticosterone secretory and adrenal growth response to ACTH in vivo. Corticosterone 27-41 proopiomelanocortin Homo sapiens 83-87 4294247-2 1966 Secretory rate of corticosterone and cortisol during stimulation of the adrenal cortex with ACTH]. Corticosterone 18-32 proopiomelanocortin Homo sapiens 92-96 4286686-2 1966 The role of ACTH on the regulation of corticosterone secretion]. Corticosterone 38-52 proopiomelanocortin Homo sapiens 12-16 4285998-0 1965 Studies on the role of protein synthesis in the regulation of corticosterone production by adrenocorticotropic hormone in vivo. Corticosterone 62-76 proopiomelanocortin Homo sapiens 91-118 13941688-0 1963 [Forms of urinary elimination of hormones of the cortisol group and corticosterone after administration of ACTH]. Corticosterone 68-82 proopiomelanocortin Homo sapiens 107-111 13489950-2 1957 Action of ACTH on elimination of cortisol and corticosterone catabolites]. Corticosterone 46-60 proopiomelanocortin Homo sapiens 10-14 190553-6 1976 It is concluded that: (1) the greater ether-induced rise in plasma ACTH in the a.m. than in the p.m. is probably due to the lower plasma (and probably tissue) corticosterone concentration at that time; (2) the plasma ACTH concentration for inducing maximal adrenal activation is relatively low; and (3) the higher basal levels of plasma corticosterone in the p.m. than in the a.m. are due to a slight increase in basal ACTH secretion in the p.m. Corticosterone 159-173 proopiomelanocortin Homo sapiens 67-71 190553-6 1976 It is concluded that: (1) the greater ether-induced rise in plasma ACTH in the a.m. than in the p.m. is probably due to the lower plasma (and probably tissue) corticosterone concentration at that time; (2) the plasma ACTH concentration for inducing maximal adrenal activation is relatively low; and (3) the higher basal levels of plasma corticosterone in the p.m. than in the a.m. are due to a slight increase in basal ACTH secretion in the p.m. Corticosterone 337-351 proopiomelanocortin Homo sapiens 67-71 1173303-1 1975 The effect of acute administration of human growth hormone (HGH) and of alpha-melanocyte stimulating hormone (alpha-MSH) on plasma aldosterone, cortisol, corticosterone and growth hormone has been studied in normal man and in patients with panhypopituitarism. Corticosterone 154-168 proopiomelanocortin Homo sapiens 72-108 1173303-1 1975 The effect of acute administration of human growth hormone (HGH) and of alpha-melanocyte stimulating hormone (alpha-MSH) on plasma aldosterone, cortisol, corticosterone and growth hormone has been studied in normal man and in patients with panhypopituitarism. Corticosterone 154-168 proopiomelanocortin Homo sapiens 110-119 4363642-0 1974 Corticosterone suppression of ACTH secretion: actinomycin D sensitive and insensitive components of the response. Corticosterone 0-14 proopiomelanocortin Homo sapiens 30-34 4355827-0 1973 Influence of plasma on ACTH stimulated corticosterone production of isolated adrenal cells. Corticosterone 39-53 proopiomelanocortin Homo sapiens 23-27 4357103-0 1973 [On the existence of a fast-acting negative feedback control of ACTH-corticosterone secretion (author"s transl)]. Corticosterone 69-83 proopiomelanocortin Homo sapiens 64-68 4348818-0 1972 Studies of the potency of polypeptides with ACTH action by a new method based on continuous measurement of plasma corticosterone. Corticosterone 114-128 proopiomelanocortin Homo sapiens 44-48 4331036-0 1971 Evidence for another factor in the regulation of corticosterone biosynthesis by ACTH. Corticosterone 49-63 proopiomelanocortin Homo sapiens 80-84 4326999-0 1971 Evidence in favour of a fast feed-back control of ACTH secretion by corticosterone. Corticosterone 68-82 proopiomelanocortin Homo sapiens 50-54 4316573-0 1970 Suppression of ACTH release from adenophypophysis by corticosterone: an in vitro study. Corticosterone 53-67 proopiomelanocortin Homo sapiens 15-19 4310487-0 1969 In vitro release of ACTH: effects of potassium, calcium and corticosterone. Corticosterone 60-74 proopiomelanocortin Homo sapiens 20-24 4305503-0 1969 Sensitivity of the adrenal corticosterone response to ACTH as a function of time after hypophysectomy. Corticosterone 27-41 proopiomelanocortin Homo sapiens 54-58 4303907-0 1969 Influence of cycling, pregnancy, labor, and suckling on corticosterone-ACTH levels. Corticosterone 56-70 proopiomelanocortin Homo sapiens 71-75 181223-7 1976 The hormonal form of ACTH appears to be an important factor regulating the cortisol/corticosterone ratio in mammalian adrenal corticoid secretion because administration of porcine ACTH to rabbits alters the adrenal secretory pattern so as to decrease corticosterone production and increase cortisol production. Corticosterone 84-98 proopiomelanocortin Homo sapiens 180-184 181223-7 1976 The hormonal form of ACTH appears to be an important factor regulating the cortisol/corticosterone ratio in mammalian adrenal corticoid secretion because administration of porcine ACTH to rabbits alters the adrenal secretory pattern so as to decrease corticosterone production and increase cortisol production. Corticosterone 251-265 proopiomelanocortin Homo sapiens 21-25 181223-7 1976 The hormonal form of ACTH appears to be an important factor regulating the cortisol/corticosterone ratio in mammalian adrenal corticoid secretion because administration of porcine ACTH to rabbits alters the adrenal secretory pattern so as to decrease corticosterone production and increase cortisol production. Corticosterone 251-265 proopiomelanocortin Homo sapiens 180-184 32156515-4 2020 We have found that 5-days treatment with methylprednisolone suppresses basal ACTH and corticosterone secretion, as well as corticosterone secretion in response to a high dose of ACTH, and down-regulates key genes in the adrenal steroidogenic pathway, including StAR, MRAP, CYP11a1 and CYP11b1. Corticosterone 123-137 proopiomelanocortin Homo sapiens 178-182