PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30550932-11 2019 Despite showing no pro-inflammatory changes to hippocampal mRNA, male CAS rats displayed lower plasma corticosterone response to LPS at 2 h after injection followed by an exaggerated plasma IL-1beta response at 4 h. This potentially blunted corticosterone response coupled with excessive innate immune signaling in the periphery is consistent with possible glucocorticoid resistance in males. Corticosterone 241-255 interleukin 1 alpha Rattus norvegicus 190-198 15380328-5 2004 Corticosterone (CORT) or dexamethasone (DEX) supplementation not only cancelled effects of ADX, but also partially reversed TMT-induced enhancement of IL-1alpha/beta expressions. Corticosterone 0-14 interleukin 1 alpha Rattus norvegicus 151-160 15773051-5 2005 Corticosterone (CORT) or dexamethasone (DEX) supplementation not only cancelled effects of ADX, but also partially reversed TMT-induced enhancement of IL-1alpha/beta expressions. Corticosterone 0-14 interleukin 1 alpha Rattus norvegicus 151-160 15773051-5 2005 Corticosterone (CORT) or dexamethasone (DEX) supplementation not only cancelled effects of ADX, but also partially reversed TMT-induced enhancement of IL-1alpha/beta expressions. Corticosterone 16-20 interleukin 1 alpha Rattus norvegicus 151-160 15380328-5 2004 Corticosterone (CORT) or dexamethasone (DEX) supplementation not only cancelled effects of ADX, but also partially reversed TMT-induced enhancement of IL-1alpha/beta expressions. Corticosterone 16-20 interleukin 1 alpha Rattus norvegicus 151-160 12542666-1 2003 Single administration of the cytokine interleukin-1 alpha (IL-1), or the psychostimulant amphetamine, enhanced adrenocorticotropin hormone and corticosterone responses to a stress challenge weeks later. Corticosterone 143-157 interleukin 1 alpha Rattus norvegicus 38-57 9831177-6 1998 In vivo, recombinant rat IL-1alpha and IL-1beta enhanced body temperature, increased plasma levels of corticosterone and ACTH, and depressed social behaviour. Corticosterone 102-116 interleukin 1 alpha Rattus norvegicus 25-34 8833038-2 1996 CS treatment reduced the basal mRNA levels of IL-1 alpha and IL-1 beta, but elevated the mRNA levels of IL-6 in the hypothalamus and hippocampus as shown by RT-PCR. Corticosterone 0-2 interleukin 1 alpha Rattus norvegicus 46-56 8833038-7 1996 These results suggest that altered and clamped hypothalamic IL-1 alpha, IL-1 beta and IL-6 mRNA levels may be involved in the antipyretic effects of a pretreatment with high doses of CS and that these CS effects are rapidly reversible. Corticosterone 183-185 interleukin 1 alpha Rattus norvegicus 60-70 7588387-4 1995 Dose-dependent increases (P < 0.05) in corticosterone concentration were observed when primary adrenal cells were incubated with different doses (10(-10) to 10(-8) M) of IL-1 alpha. Corticosterone 42-56 interleukin 1 alpha Rattus norvegicus 173-183 8778170-0 1996 Bicuculline enhances the corticosterone secretion induced by lipopolysaccharide and interleukin-1 alpha in male rats. Corticosterone 25-39 interleukin 1 alpha Rattus norvegicus 84-103 8778170-12 1996 The present study provides evidence that GABA is involved, at least in part, in the neuroendocrine regulation of LPS/interleukin-1a-induced corticosterone secretion via GABA-A receptor in rats. Corticosterone 140-154 interleukin 1 alpha Rattus norvegicus 117-131 7665003-0 1995 Possible involvement of prostaglandins in increases in rat plasma adrenocorticotropic hormone and corticosterone levels induced by radiation and interleukin-1 alpha alone or combined. Corticosterone 98-112 interleukin 1 alpha Rattus norvegicus 145-164 7588387-5 1995 IL-1 alpha and IL-1 beta elevated corticosterone release after a 24 hr incubation period. Corticosterone 34-48 interleukin 1 alpha Rattus norvegicus 0-10 7588387-13 1995 Although IL-1 alpha significantly increased (P < 0.05) prostaglandin E2 (PGE2) levels from primary adrenal cells, the presence of the cyclooxygenase inhibitor, indomethacin (10 microM) significantly inhibited IL-1 alpha-induced PGE2 secretion without altering the effect of IL-1 alpha on corticosterone release. Corticosterone 291-305 interleukin 1 alpha Rattus norvegicus 9-19 8474317-5 1993 Plasma corticosterone levels were markedly elevated following rIL-1 alpha injection, with a maximal level occurring at 30 minutes. Corticosterone 7-21 interleukin 1 alpha Rattus norvegicus 62-73 8048512-7 1994 In these rats, the elevated plasma levels of insulin, glucagon, and corticosterone produced by intracerebroventricular injection of IL-1 alpha were still present. Corticosterone 68-82 interleukin 1 alpha Rattus norvegicus 132-142 8033416-8 1994 Administration of IL-1 alpha induced identical corticosterone responses in both CV and GF F344 rats. Corticosterone 47-61 interleukin 1 alpha Rattus norvegicus 18-28 8013385-1 1994 Studies from this and other laboratories have shown that interleukin-1 alpha (IL-1 alpha) stimulates corticosterone and prostaglandin (PG) release from primary cultures of rat adrenal cells. Corticosterone 101-115 interleukin 1 alpha Rattus norvegicus 57-76 8013385-1 1994 Studies from this and other laboratories have shown that interleukin-1 alpha (IL-1 alpha) stimulates corticosterone and prostaglandin (PG) release from primary cultures of rat adrenal cells. Corticosterone 101-115 interleukin 1 alpha Rattus norvegicus 78-88 8013385-2 1994 A previous report from our laboratory (1) indicated involvement of the alpha-adrenergic system in IL-1 alpha-stimulated corticosterone secretion from primary cultures of rat adrenal cells. Corticosterone 120-134 interleukin 1 alpha Rattus norvegicus 98-108 8013385-9 1994 IL-1 alpha significantly increased (P < 0.05) epinephrine, PGE2, and corticosterone levels above those in medium-treated controls from primary adrenal cells. Corticosterone 72-86 interleukin 1 alpha Rattus norvegicus 0-10 8013385-10 1994 In the presence of the alpha-adrenergic antagonist phentolamine (10 microM), IL-1 alpha-stimulated (P < 0.05) corticosterone release was inhibited, whereas IL-1 alpha-induced PGE2 release was not affected. Corticosterone 113-127 interleukin 1 alpha Rattus norvegicus 77-87 8013385-13 1994 These observations indicate that IL-1 alpha stimulates corticosterone release through an alpha-adrenergic mechanism that is independent of PGE2 release from primary rat adrenal cells. Corticosterone 55-69 interleukin 1 alpha Rattus norvegicus 33-43 8403498-5 1993 To examine further mechanisms responsible for suppression, we determined the level of plasma corticosterone in response to IL-1 alpha in Lewis, F344 and GF F344 rats. Corticosterone 93-107 interleukin 1 alpha Rattus norvegicus 123-133 8403498-6 1993 IL-1 alpha induced only low amounts of corticosterone in Lewis rats, but high amounts in both F344 and GF F344 rats. Corticosterone 39-53 interleukin 1 alpha Rattus norvegicus 0-10 8491087-4 1993 Acute peripheral injection of IL-1 alpha or beta causes dose-dependent increases in plasma adrenocorticotropic hormone (ACTH) and corticosterone secretion. Corticosterone 130-144 interleukin 1 alpha Rattus norvegicus 30-40 1329524-5 1992 Corticosterone release stimulated by 10(-8) M doses of ACTH and IL-1 beta began to rise 30 min after incubation and peaked at 2 h. In primary cultures of adrenal cells, IL-1 alpha and IL-1 beta elevated corticosterone release after a 24-h incubation period. Corticosterone 0-14 interleukin 1 alpha Rattus norvegicus 169-179 1329524-5 1992 Corticosterone release stimulated by 10(-8) M doses of ACTH and IL-1 beta began to rise 30 min after incubation and peaked at 2 h. In primary cultures of adrenal cells, IL-1 alpha and IL-1 beta elevated corticosterone release after a 24-h incubation period. Corticosterone 203-217 interleukin 1 alpha Rattus norvegicus 169-179 1846109-2 1991 The addition of rat interleukin-1 alpha (IL-1 alpha) or rat IL-2 increased corticosterone levels in the medium in a concentration-dependent manner during 24 h of incubation. Corticosterone 75-89 interleukin 1 alpha Rattus norvegicus 20-39 1846109-2 1991 The addition of rat interleukin-1 alpha (IL-1 alpha) or rat IL-2 increased corticosterone levels in the medium in a concentration-dependent manner during 24 h of incubation. Corticosterone 75-89 interleukin 1 alpha Rattus norvegicus 41-51 1846109-7 1991 Corticosterone production stimulated by IL-1 alpha or IL-2 was accompanied by intracellular and extracellular cAMP and PGE2 accumulation. Corticosterone 0-14 interleukin 1 alpha Rattus norvegicus 40-50