PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23872451-11 2013 These data indicate that, in the experimental model of adrenalectomised rats implanted with corticosterone pellets, nicotine increases the function of 5-HT1A receptors of 5-HT DRN neurons. Corticosterone 92-106 5-hydroxytryptamine receptor 1A Rattus norvegicus 151-157 24130987-1 2013 We studied the effects of injections of 5-HT1A-agonist buspirone to pregnant rats before stress exposure on corticosterone level in the dynamics of stress response to inflammatory-induced pain in 7-day-old offspring. Corticosterone 108-122 5-hydroxytryptamine receptor 1A Rattus norvegicus 40-46 22591911-0 2013 Chronic effects of corticosterone on GIRK1-3 subunits and 5-HT1A receptor expression in rat brain and their reversal by concurrent fluoxetine treatment. Corticosterone 19-33 5-hydroxytryptamine receptor 1A Rattus norvegicus 58-64 22591911-2 2013 Animal studies indicate that 5-HT1A receptor expression may be reduced by long-term administration of corticosterone. Corticosterone 102-116 5-hydroxytryptamine receptor 1A Rattus norvegicus 29-35 22591911-13 2013 These data are relevant for a better understanding of the differential regulation of pre- and postsynaptic 5-HT1A receptors by corticosterone flattened rhythm. Corticosterone 127-141 5-hydroxytryptamine receptor 1A Rattus norvegicus 107-113 18640111-3 2008 However, 5-HT1A receptor agonists increase plasma corticosterone and many antipsychotics disturb the regulation of glucose. Corticosterone 50-64 5-hydroxytryptamine receptor 1A Rattus norvegicus 9-15 18547240-4 2008 5HT1A mRNA in the dentate gyrus was increased on both sides of the brain by unilateral BDNF infusions, but this was also prevented by subcutaneous corticosterone pellets. Corticosterone 147-161 5-hydroxytryptamine receptor 1A Rattus norvegicus 0-5 17033092-0 2006 Imipramine and citalopram reverse corticosterone-induced alterations in the effects of the activation of 5-HT(1A) and 5-HT(2) receptors in rat frontal cortex. Corticosterone 34-48 5-hydroxytryptamine receptor 1A Rattus norvegicus 105-112 17033092-3 2006 Repetitive, but not single, corticosterone administration resulted in an attenuation of the effect of the activation of 5-HT(1A) receptors and in an enhancement of the effect related to 5-HT(2) receptors. Corticosterone 28-42 5-hydroxytryptamine receptor 1A Rattus norvegicus 120-127 17060050-1 2006 Acute stress and corticosterone enhance 5-HT1A receptor-mediated responses in rat hippocampal CA1 cells within 1-2 h, through a process involving transcriptional regulation of unknown genes. Corticosterone 17-31 5-hydroxytryptamine receptor 1A Rattus norvegicus 40-46 17060050-3 2006 We here tested the hypothesis that corticosterone targets genes encoding RGS4 or SGK1, which can both affect the 5-HT1A receptor associated Kir channel, thus affecting 5-HT1A receptor function. Corticosterone 35-49 5-hydroxytryptamine receptor 1A Rattus norvegicus 113-119 17060050-3 2006 We here tested the hypothesis that corticosterone targets genes encoding RGS4 or SGK1, which can both affect the 5-HT1A receptor associated Kir channel, thus affecting 5-HT1A receptor function. Corticosterone 35-49 5-hydroxytryptamine receptor 1A Rattus norvegicus 168-174 17060050-7 2006 We reject, however, the hypothesis that the effect of corticosterone on 5-HT1A responsiveness is mediated via altered RGS4 or SGK1 mRNA expression. Corticosterone 54-68 5-hydroxytryptamine receptor 1A Rattus norvegicus 72-78 16380238-0 2006 Imipramine treatment ameliorates corticosterone-induced alterations in the effects of 5-HT1A and 5-HT4 receptor activation in the CA1 area of rat hippocampus. Corticosterone 33-47 5-hydroxytryptamine receptor 1A Rattus norvegicus 86-92 16380238-1 2006 This study tested whether imipramine reverses adaptive modifications in the function of hippocampal 5-HT1A and 5-HT4 receptors induced by repetitive administration of corticosterone. Corticosterone 167-181 5-hydroxytryptamine receptor 1A Rattus norvegicus 100-106 16380238-7 2006 In the corticosterone plus imipramine group, the effect of 8-OH-DPAT and zacopride were not different from control, indicating that corticosterone-induced adaptive changes in the reactivity of 5-HT1A and 5-HT4 receptors were reversed by imipramine treatment. Corticosterone 7-21 5-hydroxytryptamine receptor 1A Rattus norvegicus 193-199 16380238-7 2006 In the corticosterone plus imipramine group, the effect of 8-OH-DPAT and zacopride were not different from control, indicating that corticosterone-induced adaptive changes in the reactivity of 5-HT1A and 5-HT4 receptors were reversed by imipramine treatment. Corticosterone 132-146 5-hydroxytryptamine receptor 1A Rattus norvegicus 193-199 15194873-0 2004 Corticosterone strongly increases the affinity of dorsal raphe 5-HT1A receptors. Corticosterone 0-14 5-hydroxytryptamine receptor 1A Rattus norvegicus 63-69 15194873-3 2004 Corticosterone increases 5-HT1A autoreceptor agonist affinity (+90%, p<0.001) in adrenalectomized rats. Corticosterone 0-14 5-hydroxytryptamine receptor 1A Rattus norvegicus 25-31 15194873-5 2004 Dorsal raphe glucocorticoid receptors activation by corticosterone may therefore lead to an increased signalling of 5-HT1A autoreceptors that may become counteracted by galanin receptor activation. Corticosterone 52-66 5-hydroxytryptamine receptor 1A Rattus norvegicus 116-122 15240353-2 2004 Activation of 5-HT(1A) and 5-HT(2A) receptors increases plasma corticosterone levels, and it is likely that these receptor subtypes are central to mediating the effects of SSRIs. Corticosterone 63-77 5-hydroxytryptamine receptor 1A Rattus norvegicus 14-21 14573385-2 2003 To examine this modulation, the effects of acute and chronic corticosterone administration on 5-HT(1A) autoreceptor function were investigated using in vitro electrophysiology in the rat dorsal raphe nucleus (DRN). Corticosterone 61-75 5-hydroxytryptamine receptor 1A Rattus norvegicus 94-101 12496947-0 2003 Flattening the corticosterone rhythm attenuates 5-HT1A autoreceptor function in the rat: relevance for depression. Corticosterone 15-29 5-hydroxytryptamine receptor 1A Rattus norvegicus 48-54 12496947-7 2003 Corticosterone treatment was found to induce a significant attenuation in the response to 8-OHDPAT, indicating functional desensitization of somatodendritic 5-HT(1A) autoreceptors. Corticosterone 0-14 5-hydroxytryptamine receptor 1A Rattus norvegicus 157-164 12237750-0 2002 Prolonged corticosterone treatment alters the responsiveness of 5-HT1A receptors to 8-OH-DPAT in rat CA1 hippocampal neurons. Corticosterone 10-24 5-hydroxytryptamine receptor 1A Rattus norvegicus 64-70 11804612-1 2002 Direct-acting serotonin (5-HT) receptor agonists increase serum corticosterone in rats by activating receptors of the 5-HT(1A) or the 5-HT(2A/2C) subtypes. Corticosterone 64-78 5-hydroxytryptamine receptor 1A Rattus norvegicus 118-125 11383709-0 2001 Opposite effects of antidepressants and corticosterone on the sensitivity of hippocampal CA1 neurons to 5-HT1A and 5-HT4 receptor activation. Corticosterone 40-54 5-hydroxytryptamine receptor 1A Rattus norvegicus 104-110 11383709-9 2001 These findings indicate that antidepressant treatments and repeated corticosterone have opposite effects on hippocampal responsiveness to 5-HT1A and 5-HT4 receptor activation. Corticosterone 68-82 5-hydroxytryptamine receptor 1A Rattus norvegicus 138-144 11137865-0 2001 Functional effects of corticosterone on 5-HT(1A) and 5-HT(1B) receptor activity in rat brain: in vivo microdialysis studies. Corticosterone 22-36 5-hydroxytryptamine receptor 1A Rattus norvegicus 40-47 9862759-5 1999 Fluoxetine produced a dose-dependent reduction in the oxytocin, ACTH, and corticosterone responses to the 5-HT1A agonist 8-hydroxy-2-(dipropylamino)tetralin (8-OH-DPAT, 50 micrograms/kg, s.c.). Corticosterone 74-88 5-hydroxytryptamine receptor 1A Rattus norvegicus 106-112 9726650-2 1998 5-HT1A receptor agonists, including flesinoxan, increase corticosterone (B) levels in the blood and reduces 5-HT1A receptor mRNA expression in the hippocampus. Corticosterone 57-71 5-hydroxytryptamine receptor 1A Rattus norvegicus 0-6 9726650-3 1998 In this study, we examined whether the 5-HT1A receptor downregulation induced by flesinoxan involves corticosterone control of 5-HT1A receptor gene transcription. Corticosterone 101-115 5-hydroxytryptamine receptor 1A Rattus norvegicus 39-45 9726650-3 1998 In this study, we examined whether the 5-HT1A receptor downregulation induced by flesinoxan involves corticosterone control of 5-HT1A receptor gene transcription. Corticosterone 101-115 5-hydroxytryptamine receptor 1A Rattus norvegicus 127-133 9726650-7 1998 Flesinoxan injection also caused a dose-dependent decrease of 5-HT1A mRNA in the dentate gyrus of adrenalectomized animals with corticosterone replacement. Corticosterone 128-142 5-hydroxytryptamine receptor 1A Rattus norvegicus 62-68 9670995-0 1998 Age-dependent loss of corticosterone modulation of central serotonin 5-HT1A receptor binding sites. Corticosterone 22-36 5-hydroxytryptamine receptor 1A Rattus norvegicus 59-84 9670995-1 1998 A loss of endocrine and neurotransmitter system interactions, including corticosterone regulation of 5-HT1A receptors, may underlie the age-related deficits in the hypothalamic-pituitary-adrenal (HPA) axis including adapting to stress. Corticosterone 72-86 5-hydroxytryptamine receptor 1A Rattus norvegicus 101-107 9670995-8 1998 The present study has identified an age-associated deficit in the regulation of hippocampal 5-HT1A receptors by corticosterone which may underly the diminished capacity of the aging HPA axis to cope with stress. Corticosterone 112-126 5-hydroxytryptamine receptor 1A Rattus norvegicus 92-98 9372553-1 1997 Previous in vitro studies showed that glucocorticoid receptor activation (notably by corticosterone) could induce a functional desensitization of somatodendritic 5-HT1A autoreceptors in the dorsal raphe nucleus [Laaris et al. Corticosterone 85-99 5-hydroxytryptamine receptor 1A Rattus norvegicus 162-168 9314024-2 1997 Binding of [3H]8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) to 5-HT1A receptors in the hippocampus decreased 24 h after both acute and chronic (14 day) administration of CORT (50 mg/kg, s.c.). Corticosterone 177-181 5-hydroxytryptamine receptor 1A Rattus norvegicus 70-76 9048755-12 1997 The present data show that MDMA may affect 5-HT1A receptors in a regionally dependent manner, notably through a drug effect on corticosterone release, which attenuates 5-HT1A receptor gene transcription selectively in the hippocampus. Corticosterone 127-141 5-hydroxytryptamine receptor 1A Rattus norvegicus 43-49 9048755-12 1997 The present data show that MDMA may affect 5-HT1A receptors in a regionally dependent manner, notably through a drug effect on corticosterone release, which attenuates 5-HT1A receptor gene transcription selectively in the hippocampus. Corticosterone 127-141 5-hydroxytryptamine receptor 1A Rattus norvegicus 168-174 8864491-2 1996 Corticosterone treatment significantly decreased the number of 5-HT1A receptor sites (Bmax = 108 +/- 8.20 fmol/mg protein and 152.31 +/- 13.36 fmol/mg protein in corticosterone- and vehicle-treated rats, respectively). Corticosterone 0-14 5-hydroxytryptamine receptor 1A Rattus norvegicus 63-69 8864491-2 1996 Corticosterone treatment significantly decreased the number of 5-HT1A receptor sites (Bmax = 108 +/- 8.20 fmol/mg protein and 152.31 +/- 13.36 fmol/mg protein in corticosterone- and vehicle-treated rats, respectively). Corticosterone 162-176 5-hydroxytryptamine receptor 1A Rattus norvegicus 63-69 8840120-7 1996 The results suggest that 5-HT2A, 5-HT2C and postsynaptic 5-HT1A receptor-mediated behaviour can be modulated by repeated treatment with a high dose of corticosterone. Corticosterone 151-165 5-hydroxytryptamine receptor 1A Rattus norvegicus 57-63 8809673-2 1996 In the first series of experiments, adrenalectomized (ADX) rats were injected with corticosterone one hour prior to decapitation (1-1000 micrograms/100 g body weight) after which 5HT1A induced hyperpolarizations were determined in vitro by means of intracellular recordings. Corticosterone 83-97 5-hydroxytryptamine receptor 1A Rattus norvegicus 179-184 8788518-0 1996 Role of the hypothalamic paraventricular nucleus in 5-HT1A, 5-HT2A and 5-HT2C receptor-mediated oxytocin, prolactin and ACTH/corticosterone responses. Corticosterone 125-139 5-hydroxytryptamine receptor 1A Rattus norvegicus 52-58 8719027-0 1996 Corticosterone alters 5-HT1A receptor-mediated hyperpolarization in area CA1 hippocampal pyramidal neurons. Corticosterone 0-14 5-hydroxytryptamine receptor 1A Rattus norvegicus 22-28 8719027-9 1996 Administration of high concentrations of CT in vitro to neurons from chronically treated ADX rats decreased the magnitude of the 5-HT1A receptor-mediated hyperpolarization. Corticosterone 41-43 5-hydroxytryptamine receptor 1A Rattus norvegicus 129-135 8532191-0 1995 Glucocorticoid receptor-mediated inhibition by corticosterone of 5-HT1A autoreceptor functioning in the rat dorsal raphe nucleus. Corticosterone 47-61 5-hydroxytryptamine receptor 1A Rattus norvegicus 65-71 8532191-8 1995 Complementary autoradiographic experiments showed that [3H]8-OH-DPAT specific binding to 5-HT1A sites in the dorsal raphe nucleus (and the hippocampus) was not significantly altered following adrenalectomy and exposure of brain stem slices to corticosterone. Corticosterone 243-257 5-hydroxytryptamine receptor 1A Rattus norvegicus 89-95 8532191-9 1995 These data suggest that GR are involved in the suppressive effects of high levels of corticosterone on the 5-HT1A receptor-dependent regulation of 5-HT neuronal activity in the rat dorsal raphe nucleus. Corticosterone 85-99 5-hydroxytryptamine receptor 1A Rattus norvegicus 107-113 8704740-0 1995 A role for the mineralocorticoid receptor in a rapid and transient suppression of hippocampal 5-HT1A receptor mRNA by corticosterone. Corticosterone 118-132 5-hydroxytryptamine receptor 1A Rattus norvegicus 94-100 8704740-3 1995 Injection of corticosterone led to a significant dose-dependent and transient suppression of 5-HT1A receptor mRNA. Corticosterone 13-27 5-hydroxytryptamine receptor 1A Rattus norvegicus 93-99 8704740-6 1995 These results point to a stringent regulation of hippocampal 5-HT1A receptors by corticosterone that is predominantly mediated by the mineralocorticoid receptor. Corticosterone 81-95 5-hydroxytryptamine receptor 1A Rattus norvegicus 61-67 7557817-5 1995 The results that are reviewed herein indicate that hippocampal 5-HT1A receptors are under the tonic inhibitory control of corticosterone. Corticosterone 122-136 5-hydroxytryptamine receptor 1A Rattus norvegicus 63-69 7708935-15 1995 These findings demonstrate that chronic treatment of some antidepressants potentiates 8-OH-DPAT-induced increase in plasma corticosterone, by actions at 5-HT-1A receptors located postsynaptically on 5-HT neurones. Corticosterone 123-137 5-hydroxytryptamine receptor 1A Rattus norvegicus 153-160 7996433-1 1994 Treatment of rats with the serotonin 5-HT1A agonist 8-hydroxy-2-(di-n- propylamino)tetralin (8-OH-DPAT, 1 mg/kg s.c.) markedly elevated plasma levels of corticosterone (CORT), adrenocorticotropic hormone (ACTH) and prolactin (PRL); the levels of growth hormone were unaffected. Corticosterone 153-167 5-hydroxytryptamine receptor 1A Rattus norvegicus 37-43 7825906-0 1994 Social defeat impairs plasma corticosterone response to the 5-HT1A agonist 8-OH-DPAT in the rat. Corticosterone 29-43 5-hydroxytryptamine receptor 1A Rattus norvegicus 60-66 7862863-0 1994 Time course of the effects of adrenalectomy and corticosterone replacement on 5-HT1A receptors and 5-HT uptake sites in the hippocampus and dorsal raphe nucleus of the rat brain: an autoradiographic analysis. Corticosterone 48-62 5-hydroxytryptamine receptor 1A Rattus norvegicus 78-84 7862863-1 1994 Previous studies have shown that adrenalectomy (ADX) increases the binding of 3H-DPAT to 5-HT1A receptors in the hippocampus (HIP) and this effect is partially overcome by corticosterone (CORT) replacement. Corticosterone 172-186 5-hydroxytryptamine receptor 1A Rattus norvegicus 89-95 8450471-4 1993 Similarly, 8-OH-DPAT was more efficacious than BMY 7378 in eliciting corticosterone secretion, a response mediated by postsynaptic 5-HT1A receptors, whereas BMY 7378 was as efficacious as 8-OH-DPAT in inhibiting striatal accumulation of 5-hydroxytryptophan, a response mediated by presynaptic 5-HT1A receptors. Corticosterone 69-83 5-hydroxytryptamine receptor 1A Rattus norvegicus 131-137 8510803-2 1993 Numerous studies have shown that administration of 5-HT1A receptor agonists increases plasma corticosterone (CS) concentrations in rats; however, the mechanism has not been established. Corticosterone 93-107 5-hydroxytryptamine receptor 1A Rattus norvegicus 51-57 8510803-2 1993 Numerous studies have shown that administration of 5-HT1A receptor agonists increases plasma corticosterone (CS) concentrations in rats; however, the mechanism has not been established. Corticosterone 109-111 5-hydroxytryptamine receptor 1A Rattus norvegicus 51-57 8510803-5 1993 Under pentobarbital anesthesia, central administration of the selective 5-HT1A agonists, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and ipsapirone decreased plasma CS levels, relative to saline-treated control rats, at all doses tested (0.001-20 nmol). Corticosterone 172-174 5-hydroxytryptamine receptor 1A Rattus norvegicus 72-78 1369598-0 1992 Quantitative autoradiographic analyses of the time course and reversibility of corticosterone-induced decreases in binding at 5-HT1A receptors in rat forebrain. Corticosterone 79-93 5-hydroxytryptamine receptor 1A Rattus norvegicus 126-132 1369598-1 1992 Quantitative autoradiography was used to evaluate the time course and reversibility of corticosterone (CORT)-induced decreases in binding at 5-HT1A receptors in the dorsal hippocampus, cortex and septum of the male rat. Corticosterone 87-101 5-hydroxytryptamine receptor 1A Rattus norvegicus 141-147 1448177-0 1992 Long lasting attenuation of 8-OH-DPAT-induced corticosterone secretion after a single injection of a 5-HT1A receptor agonist. Corticosterone 46-60 5-hydroxytryptamine receptor 1A Rattus norvegicus 101-107 1448177-2 1992 The 5-HT1A receptors mediating the corticosterone secretion appear to be postsynaptic to the 5-HT neurons, since the response to 8-OH-DPAT was not decreased but potentiated by depletion of 5-HT with p-chlorophenylalanine pretreatment of the animals. Corticosterone 35-49 5-hydroxytryptamine receptor 1A Rattus norvegicus 4-10 1448177-6 1992 The subsensitivity development was specific for the 5-HT1A receptor-mediated corticosterone secretion, since the increase in serum corticosterone produced by stimulation of other receptor systems, e.g. alpha 2-adrenoreceptors (clonidine) or 5-HT2 receptors [1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, (DOI)] was not affected. Corticosterone 77-91 5-hydroxytryptamine receptor 1A Rattus norvegicus 52-58 1448177-6 1992 The subsensitivity development was specific for the 5-HT1A receptor-mediated corticosterone secretion, since the increase in serum corticosterone produced by stimulation of other receptor systems, e.g. alpha 2-adrenoreceptors (clonidine) or 5-HT2 receptors [1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, (DOI)] was not affected. Corticosterone 131-145 5-hydroxytryptamine receptor 1A Rattus norvegicus 52-58 1353629-7 1992 Rats receiving an inescapable footshock 1 day earlier showed a further elevated corticosterone response to the 5-HT1A receptor agonist ipsapirone even before exposing them to the conditioned stress situation. Corticosterone 80-94 5-hydroxytryptamine receptor 1A Rattus norvegicus 111-117 1533016-0 1992 Autoradiographic analyses of the effects of adrenalectomy and corticosterone on 5-HT1A and 5-HT1B receptors in the dorsal hippocampus and cortex of the rat. Corticosterone 62-76 5-hydroxytryptamine receptor 1A Rattus norvegicus 80-97 1533016-1 1992 Quantitative autoradiography was used to evaluate the effects of adrenalectomy (ADX) and corticosterone (CORT) on binding at 5-HT1A and 5-HT1B receptors in the dorsal hippocampus and cortex of the rat. Corticosterone 89-103 5-hydroxytryptamine receptor 1A Rattus norvegicus 125-142 1435084-1 1992 The effects of 5 day corticosterone treatment (50 mg/kg s.c.; 2 x daily) are investigated on the behavioural and neuroendocrine responses to a 5-HT-1A selective agonist, 8-hydroxy -2-(di-n-propylamino) tetralin (8-OH-DPAT) in rats. Corticosterone 21-35 5-hydroxytryptamine receptor 1A Rattus norvegicus 143-150 1981046-9 1990 The presence of high corticosterone levels in the home cage after postdefeat ipsapirone treatment leads to the hypothesis that postsynaptic 5-HT 1A receptor hypersensitivity develops after the social stress of defeat. Corticosterone 21-35 5-hydroxytryptamine receptor 1A Rattus norvegicus 140-147 1963847-4 1990 Administration of the 5-HT1A agonists, 8-OH-DPAT (1 mg/kg) and ipsapirone (4 mg/kg), to rats resulted in activation of the HPA axis as evidenced by increased plasma ACTH and corticosterone concentrations in acutely treated rats and increased plasma corticosterone concentrations in both acutely and chronically treated rats. Corticosterone 174-188 5-hydroxytryptamine receptor 1A Rattus norvegicus 22-28 1963847-4 1990 Administration of the 5-HT1A agonists, 8-OH-DPAT (1 mg/kg) and ipsapirone (4 mg/kg), to rats resulted in activation of the HPA axis as evidenced by increased plasma ACTH and corticosterone concentrations in acutely treated rats and increased plasma corticosterone concentrations in both acutely and chronically treated rats. Corticosterone 249-263 5-hydroxytryptamine receptor 1A Rattus norvegicus 22-28 2148812-1 1990 The serum corticosterone concentration in rats was increased by injection of quipazine, a relatively nonselective serotonin (5-hydroxytryptamine; 5-HT) agonist, or 8-hydroxy-2-(di-n- propylamino)tetralin (8-OH-DPAT), a serotonin agonist selective for the 5-HT1A subtype of receptor. Corticosterone 10-24 5-hydroxytryptamine receptor 1A Rattus norvegicus 255-261 2148812-3 1990 The 8-OH-DPAT-induced increase in serum corticosterone was not antagonized by metergoline, the most potent antagonist of the quipazine effect, but was antagonized by pindolol or penbutolol, 5-HT1A receptor antagonists. Corticosterone 40-54 5-hydroxytryptamine receptor 1A Rattus norvegicus 190-196 2148812-5 1990 The results support earlier evidence that serum corticosterone concentration in rats can be increased by activation of either 5-HT1A or 5-HT2 receptors. Corticosterone 48-62 5-hydroxytryptamine receptor 1A Rattus norvegicus 126-132 2530590-0 1989 Stimulation of corticosterone secretion by the selective 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the rat. Corticosterone 15-29 5-hydroxytryptamine receptor 1A Rattus norvegicus 57-63 2530590-1 1989 The selective 5-HT1A receptor agonist 8-OH-DPAT increased serum corticosterone concentration in rats in a dose-dependent manner. Corticosterone 64-78 5-hydroxytryptamine receptor 1A Rattus norvegicus 14-20 2530590-3 1989 The corticosterone response to 8-OH-DPAT was also antagonized by spiperone, (+/-)- and (-)-pindolol and (+/-)-propranolol, all of which have been shown to have a high affinity for 5-HT1A receptors, though in most cases no complete blockade was found. Corticosterone 4-18 5-hydroxytryptamine receptor 1A Rattus norvegicus 180-186 2530590-7 1989 It is concluded that 8-OH-DPAT-induced increase in serum corticosterone concentration results from its action at a site different than the adrenal cortex and is mediated by postsynaptic 5-HT1A receptors, whereas other subtypes (5-HT1B, 5-HT2, 5-HT3) of 5-HT receptors do not participate in this response. Corticosterone 57-71 5-hydroxytryptamine receptor 1A Rattus norvegicus 186-192 2901112-9 1988 It is concluded that buspirone, gepirone and ipsapirone produce hypothermia and increase plasma concentrations of corticosterone by activating 5-HT1A receptor mechanisms. Corticosterone 114-128 5-hydroxytryptamine receptor 1A Rattus norvegicus 143-149 2956114-3 1987 The corticosterone and beta-END responses to 8-OH-DPAT were antagonized by spiperone and (-)-pindolol, both of which have been shown to have high affinity for the 5-HT1A binding site. Corticosterone 4-18 5-hydroxytryptamine receptor 1A Rattus norvegicus 163-169 29555828-8 2018 The obtained results indicated that 5-HT1A but not the 5-HT1B/D or 5-HT2 receptors in the PVN are engaged in the negative neuroendocrine regulation of cytochrome P450 via the stimulation of hypothalamic somatostatin secretion and in the decreases in the serum growth hormone and corticosterone concentrations. Corticosterone 279-293 5-hydroxytryptamine receptor 1A Rattus norvegicus 36-42