PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17700577-6 2008 The blunting of the adrenocortical activation in IL-1rKO mice may play a causal role in their resistance to depression, because removal of endogenous glucocorticoids by adrenalectomy also abolished the depressive-like effects of CMS, whereas chronic administration of corticosterone for 4 weeks produced depressive symptoms and reduced neurogenesis in both WT and IL-1rKO mice. Corticosterone 268-282 interleukin 1 complex Mus musculus 49-53 9629243-5 1998 We have also compared the magnitude of the increase in corticosterone levels induced by IL-1 in 3-day-old and adult mice to that caused by acute stress. Corticosterone 55-69 interleukin 1 complex Mus musculus 88-92 17047394-12 2006 The time courses of the IL-1- and LPS-induced increases in plasma corticosterone paralleled those in the reduction in milk drinking, however, the changes in body temperature appeared later. Corticosterone 66-80 interleukin 1 complex Mus musculus 24-28 10500198-10 1999 In mice, it induces serum amyloid A, potentiates the induction by IL-1 of corticosterone and IL-6, and causes body weight loss and B cell hyperplasia with serum IgG and IgM increase. Corticosterone 74-88 interleukin 1 complex Mus musculus 66-70 9878816-7 1999 Pretreatment of mice with anti-IL-6 significantly attenuated the IL-1-induced increases of plasma ACTH and corticosterone at 2 h, but not at 4 h. The IL-1-induced increases of MHPG, tryptophan and 5-HIAA in hypothalamus and brain stem were not significantly altered. Corticosterone 107-121 interleukin 1 complex Mus musculus 65-69 9878816-7 1999 Pretreatment of mice with anti-IL-6 significantly attenuated the IL-1-induced increases of plasma ACTH and corticosterone at 2 h, but not at 4 h. The IL-1-induced increases of MHPG, tryptophan and 5-HIAA in hypothalamus and brain stem were not significantly altered. Corticosterone 107-121 interleukin 1 complex Mus musculus 150-154 9728091-3 1998 At a dose of 5 mg/kg, which also caused body weight loss, leptin potentiated the induction by IL-1 of serum corticosterone and IL-6 but did not show any other activity. Corticosterone 108-122 interleukin 1 complex Mus musculus 94-98 8883917-7 1996 By contrast with previous experiments is rats, the IL-1-induced increase in plasma corticosterone was not significantly altered by the 6-OHDA pretreatment in mice. Corticosterone 83-97 interleukin 1 complex Mus musculus 51-55 8954596-3 1996 In 5-day-old mice, corticosterone blood levels were markedly elevated 2 h following the last injection of IL-1. Corticosterone 19-33 interleukin 1 complex Mus musculus 106-110 8954596-6 1996 Furthermore, an inverse correlation between ACTH and corticosterone levels in blood and between ACTH content in the pituitary gland and corticosterone levels was observed in IL-1-treated mice. Corticosterone 53-67 interleukin 1 complex Mus musculus 174-178 8954596-6 1996 Furthermore, an inverse correlation between ACTH and corticosterone levels in blood and between ACTH content in the pituitary gland and corticosterone levels was observed in IL-1-treated mice. Corticosterone 136-150 interleukin 1 complex Mus musculus 174-178 8634432-1 1996 Ciliary neurotrophic factor (CNTF) and interleukin-6 (IL-6) potentiate the elevation of serum corticosterone induced by suboptimal doses of interleukin-1 (IL-1). Corticosterone 94-108 interleukin 1 complex Mus musculus 140-153 8634432-1 1996 Ciliary neurotrophic factor (CNTF) and interleukin-6 (IL-6) potentiate the elevation of serum corticosterone induced by suboptimal doses of interleukin-1 (IL-1). Corticosterone 94-108 interleukin 1 complex Mus musculus 155-159 8634432-3 1996 Here, we report that four other cytokines (leukemia inhibitory factor [LIF], oncostatin M [OSM], interleukin-11 and cardiotrophin-1) also potentiated the elevation of serum corticosterone and IL-6 levels induced by IL-1. Corticosterone 173-187 interleukin 1 complex Mus musculus 215-219 8634432-6 1996 The potentiation of IL-1-induced serum corticosterone levels is not a consequence of the increased serum IL-6 observed after IL-1 administration. Corticosterone 39-53 interleukin 1 complex Mus musculus 20-24 8634432-7 1996 In fact, in IL-6 deficient mice, IL-1 increased serum corticosterone to a level comparable to that observed in wild-type mice. Corticosterone 54-68 interleukin 1 complex Mus musculus 33-37 7780034-0 1995 Ciliary neurotrophic factor (CNTF) induces serum amyloid A, hypoglycaemia and anorexia, and potentiates IL-1 induced corticosterone and IL-6 production in mice. Corticosterone 117-131 interleukin 1 complex Mus musculus 104-108 7780034-4 1995 A single intravenous injection of CNTF induced hypoglycaemia and SAA and potentiated IL-1-induced CS and IL-6. Corticosterone 98-100 interleukin 1 complex Mus musculus 85-89 1826128-11 1991 In addition, IL-1ra and 35F5 significantly blocked the ability of IL-1 to stimulate egress of PMN from bone marrow, to induce a transient neutrophilia, and to elevate serum levels of hepatic acute phase proteins, IL-6, and corticosterone. Corticosterone 223-237 interleukin 1 complex Mus musculus 13-17 7518332-8 1994 In addition to the neurochemical changes, plasma corticosterone concentrations were profoundly enhanced in IL-1-treated animals, but not significantly altered by IL-2 or IL-6 treatment. Corticosterone 49-63 interleukin 1 complex Mus musculus 107-111 7518332-9 1994 The IL-1-induced corticosterone elevations did not significantly correlate with alterations of hypothalamic NE activity. Corticosterone 17-31 interleukin 1 complex Mus musculus 4-8 8219776-5 1993 Recombinant IL-1 also induced a drastic increase in plasma corticosterone levels in various strains of normal mice. Corticosterone 59-73 interleukin 1 complex Mus musculus 12-16 8219776-7 1993 However, in young lupus-prone (NZB/W)F1 and MRL/MP-lpr mice, a significantly lower increase in plasma corticosterone levels was observed after injection of recombinant IL-1, suggesting a deficient immuno-endocrine communication via the HPA loop in this instance as well. Corticosterone 102-116 interleukin 1 complex Mus musculus 168-172 1482145-3 1992 IL-1 induced a dose-dependent increase in corticosterone levels in plasma. Corticosterone 42-56 interleukin 1 complex Mus musculus 0-4 1482145-5 1992 Although corticosterone levels induced by pretreatment with IL-1 or ACTH were virtually identical, the ACTH-induced corticosterone peak was not associated with protection against Klebsiella pneumoniae infection in normal mice and Pseudomonas aeruginosa infection in neutropenic mice. Corticosterone 9-23 interleukin 1 complex Mus musculus 60-64 1482145-7 1992 In addition, we found that plasma corticosterone concentrations during K. pneumoniae infection were significantly lower after pretreatment with IL-1 than after pretreatment with ACTH or vehicle, probably reflecting the better physical condition of IL-1-treated mice. Corticosterone 34-48 interleukin 1 complex Mus musculus 144-148 1482145-7 1992 In addition, we found that plasma corticosterone concentrations during K. pneumoniae infection were significantly lower after pretreatment with IL-1 than after pretreatment with ACTH or vehicle, probably reflecting the better physical condition of IL-1-treated mice. Corticosterone 34-48 interleukin 1 complex Mus musculus 248-252 1490727-6 1992 In the absence of a direct and lasting effect on TNF-producing cells, the host reaction responsible for the inhibitory effect of IL-1 could be related to the overproduction of corticosterone that occurred after IL-1 injection, since it was not observed in adrenalectomized animals. Corticosterone 176-190 interleukin 1 complex Mus musculus 129-133 1490727-6 1992 In the absence of a direct and lasting effect on TNF-producing cells, the host reaction responsible for the inhibitory effect of IL-1 could be related to the overproduction of corticosterone that occurred after IL-1 injection, since it was not observed in adrenalectomized animals. Corticosterone 176-190 interleukin 1 complex Mus musculus 211-215 1614286-6 1992 However, the cyclo-oxygenase inhibitor, diclofenac, did attenuate the IL-1-induced elevation of plasma corticosterone and the neurochemical changes. Corticosterone 103-117 interleukin 1 complex Mus musculus 70-74 1614286-10 1992 Forty min following IP IL-1, the corticosterone response to IL-1 was markedly attenuated. Corticosterone 33-47 interleukin 1 complex Mus musculus 23-27 1614286-10 1992 Forty min following IP IL-1, the corticosterone response to IL-1 was markedly attenuated. Corticosterone 33-47 interleukin 1 complex Mus musculus 60-64 1837482-5 1991 IL-1ra at 20 micrograms/mouse completely blocked induction of IL-6 and markedly inhibited hypoglycemia and increase in serum corticosterone induced by 0.1 micrograms of IL-1. Corticosterone 125-139 interleukin 1 complex Mus musculus 0-4 1999179-5 1991 We investigated the possible roles of changes in serum corticosterone and glucose in the effects of LPS, TNF and IL-1. Corticosterone 55-69 interleukin 1 complex Mus musculus 113-117 1999179-6 1991 A single injection of LPS, TNF, or IL-1 markedly increased serum corticosterone levels after 2 h. After only 2 days of chronic treatment, mice given LPS or TNF were refractory to induction of serum corticosterone by a subsequent injection of LPS or TNF, but mice given IL-1 for 2 days were still fully responsive to IL-1. Corticosterone 65-79 interleukin 1 complex Mus musculus 35-39 1999179-6 1991 A single injection of LPS, TNF, or IL-1 markedly increased serum corticosterone levels after 2 h. After only 2 days of chronic treatment, mice given LPS or TNF were refractory to induction of serum corticosterone by a subsequent injection of LPS or TNF, but mice given IL-1 for 2 days were still fully responsive to IL-1. Corticosterone 198-212 interleukin 1 complex Mus musculus 35-39 1999179-9 1991 This lack of adaptation to the increase of serum corticosterone and hypoglycemia was also observed when IL-1 was given at lower, nonlethal doses (0.25-1.0 microgram) and for a longer period (up to 8 days). Corticosterone 49-63 interleukin 1 complex Mus musculus 104-108 2681261-5 1989 Exogenous administration of either IL-1 or TNF could induce increases in serum corticosterone in sham-operated mice. Corticosterone 79-93 interleukin 1 complex Mus musculus 35-39 1992764-15 1991 In contrast, IL-1 levels rose concurrently with corticosterone. Corticosterone 48-62 interleukin 1 complex Mus musculus 13-17 2168227-2 1990 Among mice receiving paired delivery of cues and IL-1, subsequent re-exposure to cues elicited corticosterone production. Corticosterone 95-109 interleukin 1 complex Mus musculus 49-53 2558326-3 1989 Rats chronically cannulated in the right jugular veins showed a time-related increase in plasma corticosterone concentrations in response to intraperitoneal administration of IL-1 that lasted up to 4 h. In the same rats, plasma epinephrine (E) and norepinephrine (NE) concentrations were only slightly elevated (2-fold increase) at 30 min and at 1 h after IL-1 administration. Corticosterone 96-110 interleukin 1 complex Mus musculus 175-179 2681261-6 1989 Finally, treatment of adrenalectomized mice with corticosterone or dexamethasone could inhibit the induction of serum IL-1 and TNF and modified the pattern of these cytokine-induced deaths. Corticosterone 49-63 interleukin 1 complex Mus musculus 118-122 2824799-4 1987 In extending our studies to rats, we showed that increased ACTH and blood corticosterone levels are also induced by IL-1 in this species. Corticosterone 74-88 interleukin 1 complex Mus musculus 116-120 3261749-0 1988 In vivo administration of IL-1 induces thymic hypoplasia and increased levels of serum corticosterone. Corticosterone 87-101 interleukin 1 complex Mus musculus 26-30 3261749-10 1988 injection of IL-1 caused a three-fold increase in serum corticosterone levels, which peaked approximately 3 h after IL-1 administration. Corticosterone 56-70 interleukin 1 complex Mus musculus 13-17 3261749-10 1988 injection of IL-1 caused a three-fold increase in serum corticosterone levels, which peaked approximately 3 h after IL-1 administration. Corticosterone 56-70 interleukin 1 complex Mus musculus 116-120 3261749-11 1988 Thus, an IL-1-dependent increase in serum corticosterone levels may be responsible for the observed thymic hypoplasia. Corticosterone 42-56 interleukin 1 complex Mus musculus 9-13 3264009-5 1988 In response to mitogen stimulation, however, splenocytes from athymic mice produced a factor (not IL-1), which, upon injection, increased corticosterone levels and suppressed inflammation. Corticosterone 138-152 interleukin 1 complex Mus musculus 98-102 3260987-0 1988 Systemic interleukin-1 administration stimulates hypothalamic norepinephrine metabolism parallelling the increased plasma corticosterone. Corticosterone 122-136 interleukin 1 complex Mus musculus 9-22 3318508-6 1987 A moderate hypoglycemia, paralleled by increased glucagon and corticosterone blood levels, was also observed in IL 1-injected rats, but no increase in insulin levels was detected. Corticosterone 62-76 interleukin 1 complex Mus musculus 112-116