PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8071432-4 1994 The effect of restraint and of corticosterone on macrophage function was abrogated by either treating mice with the glucocorticoid receptor antagonist RU486 or the addition of the drug to cultures of macrophages. Corticosterone 31-45 nuclear receptor subfamily 3, group C, member 1 Mus musculus 116-139 8229762-11 1993 The glucocorticoid receptor antagonist RU 486 was used to block the actions of corticosterone and investigate its possible role in morphine sulfate-induced suppression of phagocytosis. Corticosterone 79-93 nuclear receptor subfamily 3, group C, member 1 Mus musculus 4-27 1656771-5 1991 Cytosolic glucocorticoid receptor numbers were similar in liver and brain of 4-wk-old lean and ob/ob mice is likely secondary to elevated plasma corticosterone concentrations in these older mice. Corticosterone 145-159 nuclear receptor subfamily 3, group C, member 1 Mus musculus 10-33 33941859-6 2021 Thus, CPEB3-KO neurons with elevated GR expression exhibited increased corticosterone-induced calcium influx and decreased mRNA and protein levels of brain-derived neurotrophic factor (Bdnf). Corticosterone 71-85 nuclear receptor subfamily 3, group C, member 1 Mus musculus 37-39 34401204-6 2021 Fetal corticosterone exposure was measured by placental Abca1, Hsd11beta1, Hsd11beta2, and brain Nr3c1 (GR); Pomc expression measured by RT-qPCR. Corticosterone 6-20 nuclear receptor subfamily 3, group C, member 1 Mus musculus 97-102 34265317-8 2021 Furthermore, CORT injections decreased the expression of hippocampal synapse-related proteins, cell density and dendritic spine density in the hippocampus, accompanied by increased protein expression in the MAPK signaling pathway and decreased expression of the GR. Corticosterone 13-17 nuclear receptor subfamily 3, group C, member 1 Mus musculus 262-264 34215821-4 2021 Female AgRP-GR KO mice had delayed onset of Cort-induced hyperphagia. Corticosterone 44-48 nuclear receptor subfamily 3, group C, member 1 Mus musculus 12-14 34215821-7 2021 Additionally, Cort treatment led to hyperinsulinaemia, but compared to controls, Cort-treated AgRP-GR KO mice had both lower fasting insulin levels and lower insulin levels during a glucose tolerance test. Corticosterone 81-85 nuclear receptor subfamily 3, group C, member 1 Mus musculus 99-101 34401204-6 2021 Fetal corticosterone exposure was measured by placental Abca1, Hsd11beta1, Hsd11beta2, and brain Nr3c1 (GR); Pomc expression measured by RT-qPCR. Corticosterone 6-20 nuclear receptor subfamily 3, group C, member 1 Mus musculus 104-106 35218705-6 2022 Moreover, FMN reduced the serum corticosterone levels, upregulated the protein expression levels of the glucocorticoid receptor (GR), and brain-derived neurotrophic factor (BDNF) in the hippocampus, protected against the CORT-induced neuronal impairment, and promoted the neurogenesis in the hippocampus. Corticosterone 221-225 nuclear receptor subfamily 3, group C, member 1 Mus musculus 129-131 35433692-4 2022 This study showed that both mouse embryculture with corticosterone (ECC) and maternal preimplantation restraint stress (PIRS) increased anxiety-like behavior (ALB) while decreasing hippocampal expression of glucocorticoid receptor (GR) and brain-derived neurotrophic factor (BDNF) in offspring. Corticosterone 52-66 nuclear receptor subfamily 3, group C, member 1 Mus musculus 207-230 35433692-4 2022 This study showed that both mouse embryculture with corticosterone (ECC) and maternal preimplantation restraint stress (PIRS) increased anxiety-like behavior (ALB) while decreasing hippocampal expression of glucocorticoid receptor (GR) and brain-derived neurotrophic factor (BDNF) in offspring. Corticosterone 52-66 nuclear receptor subfamily 3, group C, member 1 Mus musculus 232-234 34861075-0 2022 Central role of intestinal epithelial glucocorticoid receptor in alcohol- and corticosterone-induced gut permeability and systemic response. Corticosterone 78-92 nuclear receptor subfamily 3, group C, member 1 Mus musculus 38-61 35091292-6 2022 Here, using a combination of endogenous knockout and viral rescue, we show that male mice lacking FKBP51 in Pomc-expressing cells exhibit enhanced GR-mediated negative feedback and are protected from age-related disruption of their diurnal corticosterone (CORT) rhythm. Corticosterone 256-260 nuclear receptor subfamily 3, group C, member 1 Mus musculus 147-149 34983931-12 2022 Cinnamaldehyde administration reversed CORT-induced GR reduction in testis, miR-190b upregulation in testis and sperm, pre-miR-190b upregulation in testis, and the amount of GR on miR-190b promoter regions of F0 males. Corticosterone 39-43 nuclear receptor subfamily 3, group C, member 1 Mus musculus 52-54 34983931-12 2022 Cinnamaldehyde administration reversed CORT-induced GR reduction in testis, miR-190b upregulation in testis and sperm, pre-miR-190b upregulation in testis, and the amount of GR on miR-190b promoter regions of F0 males. Corticosterone 39-43 nuclear receptor subfamily 3, group C, member 1 Mus musculus 174-176 3420111-1 1988 The effect of exogenous corticosterone on the level of mouse hepatic glucocorticoid receptor was monitored to ascertain whether agonist-induced glucocorticoid receptor regulation takes place in living animals as it does in isolated cell systems. Corticosterone 24-38 nuclear receptor subfamily 3, group C, member 1 Mus musculus 69-92 4079382-1 1985 The biopotencies of dexamethasone and corticosterone in causing glucocorticoid receptor downregulation in the AtT-20 cell were assessed and compared to their affinity for the isolated, cytosolic glucocorticoid receptor. Corticosterone 38-52 nuclear receptor subfamily 3, group C, member 1 Mus musculus 64-87 3015230-1 1986 Treatment of mice with ACTH not only increased plasma corticosterone levels, but also reduced the ligand-binding capacity of the glucocorticoid receptor in skeletal muscle cytosol. Corticosterone 54-68 nuclear receptor subfamily 3, group C, member 1 Mus musculus 129-152 4079382-0 1985 Biopotency of corticosterone and dexamethasone in causing glucocorticoid receptor downregulation. Corticosterone 14-28 nuclear receptor subfamily 3, group C, member 1 Mus musculus 58-81 6958493-5 1982 The radioactivity bound to the cytosolic glucocorticoid receptor protein also appeared to consist of unmetabolised corticosterone and 5 alpha-dihydrocorticosterone. Corticosterone 115-129 nuclear receptor subfamily 3, group C, member 1 Mus musculus 41-64 33950381-0 2021 Ketamine, but not fluoxetine, rapidly rescues corticosterone-induced impairments on glucocorticoid receptor and dendritic branching in the hippocampus of mice. Corticosterone 46-60 nuclear receptor subfamily 3, group C, member 1 Mus musculus 84-107 164467-5 1975 Other glucocorticoids appear to stimulate murine mammary tumor virus production by a mechanism similar to that of dexamethasone; for example, corticosterone competes with dexamethasone for binding to the glucocorticoid receptor and blocks the uptake of dexamethasone into cells. Corticosterone 142-156 nuclear receptor subfamily 3, group C, member 1 Mus musculus 204-227 33684964-12 2021 CONCLUSIONS AND IMPLICATIONS: The intestinal epithelial glucocorticoid receptor has deleterious effects in experimental colitis induced by DSS, probably related to inhibition of epithelial proliferative responses leading to impaired wound healing and reduced endogenous corticosterone production. Corticosterone 270-284 nuclear receptor subfamily 3, group C, member 1 Mus musculus 56-79 33950381-6 2021 Chronic CORT administration downregulated hippocampal GR immunocontent, but this alteration was completely reversed by a single administration of ketamine, but not fluoxetine. Corticosterone 8-12 nuclear receptor subfamily 3, group C, member 1 Mus musculus 54-56 33950381-9 2021 This study provides novel evidence that a single administration of ketamine, but not fluoxetine, rescued the impairments on GR and dendritic branching in the hippocampus of mice subjected to chronic CORT administration, effects that may be associated with its rapid antidepressant response. Corticosterone 199-203 nuclear receptor subfamily 3, group C, member 1 Mus musculus 124-126 33957303-11 2021 Akin to the gene expression pattern, gluconeogenesis from AAs was synergistically induced by glucagon and corticosterone in a CREB- and GR-dependent manner. Corticosterone 106-120 nuclear receptor subfamily 3, group C, member 1 Mus musculus 136-138 33957303-12 2021 CONCLUSIONS: Transcriptional regulation of AA catabolism genes during fasting is widespread and is driven by glucagon (via CREB) and corticosterone (via GR). Corticosterone 133-147 nuclear receptor subfamily 3, group C, member 1 Mus musculus 153-155 33519376-8 2020 Moreover, the glucocorticoid receptor (GR) mediated the effects of CORT on the stimulation of the expression of BACE-1 and PS1 via the PKA and CREB pathways in neuroblastoma N2a cells. Corticosterone 67-71 nuclear receptor subfamily 3, group C, member 1 Mus musculus 14-37 33152342-0 2021 Responses to chronic corticosterone on brain glucocorticoid receptors, adrenal gland, and gut microbiota in mice lacking neuronal serotonin. Corticosterone 21-35 nuclear receptor subfamily 3, group C, member 1 Mus musculus 45-69 33519376-8 2020 Moreover, the glucocorticoid receptor (GR) mediated the effects of CORT on the stimulation of the expression of BACE-1 and PS1 via the PKA and CREB pathways in neuroblastoma N2a cells. Corticosterone 67-71 nuclear receptor subfamily 3, group C, member 1 Mus musculus 39-41 33025573-7 2021 Similar results were obtained in mice, in which administrated CORT in drinking water for 21 days significantly impaired the GR levels in the mitochondria, while Bag-1 overexpression rescued this reduction. Corticosterone 62-66 nuclear receptor subfamily 3, group C, member 1 Mus musculus 124-126 33267881-10 2020 CONCLUSION: Carotid sinus nerve electrostimulation attenuates inflammation and protects against lipopolysaccharide-induced endotoxaemic shock via increased corticosterone acting on the glucocorticoid receptor of myeloid immune cells. Corticosterone 156-170 nuclear receptor subfamily 3, group C, member 1 Mus musculus 185-208 31888678-1 2019 Chronic corticosterone (CORT) stress is an anxiety and depression inducing factor that involves the dysfunction of glucocorticoid receptor (GR), brain-derived neurotrophic factor (BDNF), and neuronal plasticity. Corticosterone 8-22 nuclear receptor subfamily 3, group C, member 1 Mus musculus 115-138 32585162-0 2020 Cholecalciferol abolishes depressive-like behavior and hippocampal glucocorticoid receptor impairment induced by chronic corticosterone administration in mice. Corticosterone 121-135 nuclear receptor subfamily 3, group C, member 1 Mus musculus 67-90 33005133-8 2020 Third, these opposite effects of CORT on fear memory are both mediated by glucocorticoid receptor (GR) activation, and reproduced by post-conditioning stress or systemic CORT injection. Corticosterone 33-37 nuclear receptor subfamily 3, group C, member 1 Mus musculus 74-97 33005133-8 2020 Third, these opposite effects of CORT on fear memory are both mediated by glucocorticoid receptor (GR) activation, and reproduced by post-conditioning stress or systemic CORT injection. Corticosterone 33-37 nuclear receptor subfamily 3, group C, member 1 Mus musculus 99-101 32348866-0 2020 Combined neurodevelopmental exposure to deltamethrin and corticosterone is associated with Nr3c1 hypermethylation in the midbrain of male mice. Corticosterone 57-71 nuclear receptor subfamily 3, group C, member 1 Mus musculus 91-96 32348866-4 2020 Through targeted next-generation sequencing of a panel of cortisol and dopamine pathway genes, we observed hypermethylation of the glucocorticoid receptor gene, Nr3c1, in the midbrain of C57/BL6N males in response to dual deltamethrin and corticosterone exposures during development. Corticosterone 239-253 nuclear receptor subfamily 3, group C, member 1 Mus musculus 131-154 32348866-4 2020 Through targeted next-generation sequencing of a panel of cortisol and dopamine pathway genes, we observed hypermethylation of the glucocorticoid receptor gene, Nr3c1, in the midbrain of C57/BL6N males in response to dual deltamethrin and corticosterone exposures during development. Corticosterone 239-253 nuclear receptor subfamily 3, group C, member 1 Mus musculus 161-166 32348866-5 2020 This is the first description of DNA methylation studies of Nr3c1 and key dopaminergic genes within the midbrain in response to a pyrethroid insecticide, corticosterone, and these two exposures together. Corticosterone 154-168 nuclear receptor subfamily 3, group C, member 1 Mus musculus 60-65 31888678-1 2019 Chronic corticosterone (CORT) stress is an anxiety and depression inducing factor that involves the dysfunction of glucocorticoid receptor (GR), brain-derived neurotrophic factor (BDNF), and neuronal plasticity. Corticosterone 8-22 nuclear receptor subfamily 3, group C, member 1 Mus musculus 140-142 31588796-7 2019 In adrenal-intact mice, chronic blockade of glucocorticoid receptor (GR) with RU486 did not change total NCC but prevented corticosterone-induced NCC phosphorylation and activation of clock genes. Corticosterone 123-137 nuclear receptor subfamily 3, group C, member 1 Mus musculus 44-67 31588796-7 2019 In adrenal-intact mice, chronic blockade of glucocorticoid receptor (GR) with RU486 did not change total NCC but prevented corticosterone-induced NCC phosphorylation and activation of clock genes. Corticosterone 123-137 nuclear receptor subfamily 3, group C, member 1 Mus musculus 69-71 31370004-9 2019 Additionally, serum corticosterone levels were selectively elevated in GR-CKO mice with CR, suggesting the possibility of bone-hypothalamus-pituitary-adrenal crosstalk during metabolic stress. Corticosterone 20-34 nuclear receptor subfamily 3, group C, member 1 Mus musculus 71-77 30455377-0 2019 Adipocyte Glucocorticoid Receptor Deficiency Promotes Adipose Tissue Expandability and Improves the Metabolic Profile Under Corticosterone Exposure. Corticosterone 124-138 nuclear receptor subfamily 3, group C, member 1 Mus musculus 10-33 30627088-4 2018 Our data indicate that GR deletion in GABAergic neurons causes elevated corticosterone stress responsiveness and decreased cross-over latencies in a passive avoidance task in females, but not males. Corticosterone 72-86 nuclear receptor subfamily 3, group C, member 1 Mus musculus 23-25 29533388-7 2018 Interestingly, these 3 pain states were associated with changes in glucocorticoid signalling, as indicated by the increased expression, at spinal cord level, of the glucocorticoid receptor isoform associated with glucocorticoid resistance, GRbeta, and increased levels of plasma corticosterone. Corticosterone 279-293 nuclear receptor subfamily 3, group C, member 1 Mus musculus 165-188 29230949-10 2018 Furthermore, pre-incubation with 0.1 muM corticosterone increased C2C12 cell viability during heat exposure and mitochondrial and nuclear GR expression. Corticosterone 41-55 nuclear receptor subfamily 3, group C, member 1 Mus musculus 138-140 28515473-0 2017 Placental O-GlcNAc-transferase expression and interactions with the glucocorticoid receptor are sex specific and regulated by maternal corticosterone exposure in mice. Corticosterone 135-149 nuclear receptor subfamily 3, group C, member 1 Mus musculus 68-91 29125184-9 2018 Serum samples were obtained to assay corticosterone levels, a GR activator. Corticosterone 37-51 nuclear receptor subfamily 3, group C, member 1 Mus musculus 62-64 29125184-15 2018 Corticosterone levels, a GR ligand, were increased in the blood post-SE. Corticosterone 0-14 nuclear receptor subfamily 3, group C, member 1 Mus musculus 25-27 27240530-3 2017 The glucocorticoid receptor (GR) is the major receptor for the stress hormone cortisol (corticosterone in rodents) and is widely expressed in excitatory and inhibitory neurons, as well as in glial cells. Corticosterone 88-102 nuclear receptor subfamily 3, group C, member 1 Mus musculus 4-27 28196601-7 2017 Physiological levels of corticosterone promote HSC migration via the GC receptor Nr3c1-dependent signaling and upregulation of actin-organizing molecules. Corticosterone 24-38 nuclear receptor subfamily 3, group C, member 1 Mus musculus 81-86 28137450-10 2017 Full rescue of wild-type-like corticosterone and GR circadian rhythm and level in CRF1-/- mice by exogenous corticosterone does not affect CRF1 receptor-dependent cocaine reward but induces stereotypy responses to cocaine. Corticosterone 108-122 nuclear receptor subfamily 3, group C, member 1 Mus musculus 49-51 28131845-5 2017 Pre-treatment with the glucocorticoid receptor antagonist RU486 attenuated the effect of corticosterone on swelling at 24h, but not that of 5alphaTHB. Corticosterone 89-103 nuclear receptor subfamily 3, group C, member 1 Mus musculus 23-46 27240530-3 2017 The glucocorticoid receptor (GR) is the major receptor for the stress hormone cortisol (corticosterone in rodents) and is widely expressed in excitatory and inhibitory neurons, as well as in glial cells. Corticosterone 88-102 nuclear receptor subfamily 3, group C, member 1 Mus musculus 29-31 26121342-7 2015 In hypothalamic-derived 4B cells, 10 nM corticosterone increased immunoreactive glucocorticoid receptor content in membrane fractions, with association and clearance rates paralleling the effects on ACTH secretion from corticotrophs. Corticosterone 40-54 nuclear receptor subfamily 3, group C, member 1 Mus musculus 80-103 27502757-3 2016 In this study, we used the chronic corticosterone (CORT)-induced mouse model of anxiety/depression to assess antidepressant-like effects of baicalin and illuminate possible molecular mechanisms by which baicalin affects GR-mediated hippocampal neurogenesis. Corticosterone 35-49 nuclear receptor subfamily 3, group C, member 1 Mus musculus 220-222 25447936-7 2015 The effect of corticosterone on CSD frequency was normalised by pre-administration of the glucocorticoid receptor (GR) antagonist mifepristone. Corticosterone 14-28 nuclear receptor subfamily 3, group C, member 1 Mus musculus 90-113 25447936-7 2015 The effect of corticosterone on CSD frequency was normalised by pre-administration of the glucocorticoid receptor (GR) antagonist mifepristone. Corticosterone 14-28 nuclear receptor subfamily 3, group C, member 1 Mus musculus 115-117 25405735-2 2014 Stress increases the secretion of glucocorticoid (corticosterone, CORT; in rats), which decreases circulating testosterone levels in part through a direct action by binding to the glucocorticoid receptors (NR3C1) in Leydig cells. Corticosterone 50-64 nuclear receptor subfamily 3, group C, member 1 Mus musculus 206-211 23089634-4 2013 GR(dim)-LPS mice exhibited elevated and prolonged levels of plasma corticosterone (CORT), interleukin (IL)-6 and IL-10 (but not plasma tumor necrosis factor-alpha (TNFalpha)), enhanced early expression of brain TNFalpha, IL-1beta and IL-6 mRNA levels, and impaired later central TNFalpha mRNA expression. Corticosterone 67-81 nuclear receptor subfamily 3, group C, member 1 Mus musculus 0-2 24565565-0 2014 The selective glucocorticoid receptor modulator CORT108297 restores faulty hippocampal parameters in Wobbler and corticosterone-treated mice. Corticosterone 113-127 nuclear receptor subfamily 3, group C, member 1 Mus musculus 14-37 24845182-6 2014 Acute corticosterone-induced increase in TrkB protein levels was dependent on glucocorticoid receptor (GR). Corticosterone 6-20 nuclear receptor subfamily 3, group C, member 1 Mus musculus 78-101 24845182-6 2014 Acute corticosterone-induced increase in TrkB protein levels was dependent on glucocorticoid receptor (GR). Corticosterone 6-20 nuclear receptor subfamily 3, group C, member 1 Mus musculus 103-105 24636513-4 2014 Synaptic deficits evoked by exposure to elevated corticosterone levels in db/db mice are attributable to glucocorticoid receptor-mediated transrepression of AP-1 actions at BDNF promoters I and IV. Corticosterone 49-63 nuclear receptor subfamily 3, group C, member 1 Mus musculus 105-128 24567706-2 2014 This process of discrimination and decision-making is stressful and triggers secretion of corticosterone activating mineralocorticoid receptor (MR) and glucocorticoid receptor (GR). Corticosterone 90-104 nuclear receptor subfamily 3, group C, member 1 Mus musculus 152-175 24567706-2 2014 This process of discrimination and decision-making is stressful and triggers secretion of corticosterone activating mineralocorticoid receptor (MR) and glucocorticoid receptor (GR). Corticosterone 90-104 nuclear receptor subfamily 3, group C, member 1 Mus musculus 177-179 21860595-6 2011 In addition, in brain slices incubated with corticosterone together with RU486 (MR-dominant group), the proportion of neurons showing a burst firing pattern was significantly higher than those in the slices incubated with vehicle, corticosterone, or corticosterone with spironolactone (GR-dominant group; 64 vs. 11~14%, p< 0.01 by chi(2)-test). Corticosterone 44-58 nuclear receptor subfamily 3, group C, member 1 Mus musculus 286-288 23044404-4 2013 The aim of this study is to explore if chronic corticosterone administration would induce depression-like behavior and affect the expression and function of hippocampal MR and GR, in addition to assess whether manipulation of corticosteroid receptors would modulate depressive behaviors. Corticosterone 47-61 nuclear receptor subfamily 3, group C, member 1 Mus musculus 176-178 23110767-6 2012 Numerous mRNAs regulated by dexamethasone were also regulated by the natural ligand corticosterone; all of the mRNAs regulated >=twofold by corticosterone were substantially attenuated by cotreatment with the glucocorticoid receptor antagonist RU486. Corticosterone 84-98 nuclear receptor subfamily 3, group C, member 1 Mus musculus 212-235 23110767-6 2012 Numerous mRNAs regulated by dexamethasone were also regulated by the natural ligand corticosterone; all of the mRNAs regulated >=twofold by corticosterone were substantially attenuated by cotreatment with the glucocorticoid receptor antagonist RU486. Corticosterone 143-157 nuclear receptor subfamily 3, group C, member 1 Mus musculus 212-235 20940090-10 2011 In light of the previously reported high corticosterone levels during postnatal development in GR(POMCCre) mice, our findings suggest that adverse early life events may have beneficial developmental effects on the organism to improve stress coping later in life. Corticosterone 41-55 nuclear receptor subfamily 3, group C, member 1 Mus musculus 95-97 20717994-6 2011 Molecular analysis revealed corticosterone-induced increase in expression of stromal growth factor Fgf10 which, together with prominent stromal GR expression, suggest that glucocorticoid modify stromal-to-epithelial signaling in the mouse prostate. Corticosterone 28-42 nuclear receptor subfamily 3, group C, member 1 Mus musculus 144-146 20717994-7 2011 The mitogenic effects were prostate specific and not mediated by systemic effects on testosterone production suggesting that corticosterone effects were primarily mediated via prostate GR expression. Corticosterone 125-139 nuclear receptor subfamily 3, group C, member 1 Mus musculus 185-187 18615595-6 2008 Both cell types expressed the GR and treatment with dexamethasone or corticosterone downregulated total cellular GR levels while increasing nuclear translocation of the GR in both L6 and C2C12 myotubes. Corticosterone 69-83 nuclear receptor subfamily 3, group C, member 1 Mus musculus 30-32 21092068-1 2011 Corticosterone activates two types of intracellular receptors in the rodent brain: the high affinity mineralocorticoid receptor (MR) and lower affinity glucocorticoid receptor (GR). Corticosterone 0-14 nuclear receptor subfamily 3, group C, member 1 Mus musculus 152-175 21092068-1 2011 Corticosterone activates two types of intracellular receptors in the rodent brain: the high affinity mineralocorticoid receptor (MR) and lower affinity glucocorticoid receptor (GR). Corticosterone 0-14 nuclear receptor subfamily 3, group C, member 1 Mus musculus 177-179 20127047-11 2010 These results suggest that the GR gene polymorphism has a significant impact on the stress-induced output, including the gastric lesion index, corticosterone, cytokines, and Hsp70 levels in serum. Corticosterone 143-157 nuclear receptor subfamily 3, group C, member 1 Mus musculus 31-33 20098621-5 2010 Caveolin-1 was strongly responsive in several organs, and the HRE pair in its upstream region showed increased occupancy by glucocorticoid receptor in response to corticosterone. Corticosterone 163-177 nuclear receptor subfamily 3, group C, member 1 Mus musculus 124-147 19799583-2 2010 Corticosterone is proposed to modulate cocaine intravenous self-administration (SA) and cocaine-induced locomotion through distinct receptors, the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR), respectively. Corticosterone 0-14 nuclear receptor subfamily 3, group C, member 1 Mus musculus 147-170 19799583-2 2010 Corticosterone is proposed to modulate cocaine intravenous self-administration (SA) and cocaine-induced locomotion through distinct receptors, the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR), respectively. Corticosterone 0-14 nuclear receptor subfamily 3, group C, member 1 Mus musculus 172-174 19447109-1 2009 The stress hormone corticosterone acts via two receptor types in the brain: the mineralocorticoid (MR) and the glucocorticoid receptor (GR). Corticosterone 19-33 nuclear receptor subfamily 3, group C, member 1 Mus musculus 111-134 19447109-1 2009 The stress hormone corticosterone acts via two receptor types in the brain: the mineralocorticoid (MR) and the glucocorticoid receptor (GR). Corticosterone 19-33 nuclear receptor subfamily 3, group C, member 1 Mus musculus 136-138 19379741-9 2009 An effect of GR activation on 5-HT2A receptor levels was further corroborated by the culture studies as long-term exposure of 3 microM corticosterone to organotypic hippocampal cultures increased 5-HT2A receptor levels (p < 0.05). Corticosterone 135-149 nuclear receptor subfamily 3, group C, member 1 Mus musculus 13-15 19494313-4 2009 The effects of corticosterone were assessed on cytokine profile and glucocorticoid receptor activation in LPS-stimulated spleen cell cultures in vitro. Corticosterone 15-29 nuclear receptor subfamily 3, group C, member 1 Mus musculus 68-91 19213843-5 2009 Conditional knockout mice with a deletion of the GR at the pituitary (GR(POMCCre)) show excessive basal corticosterone levels during postnatal development, but not in adulthood. Corticosterone 104-118 nuclear receptor subfamily 3, group C, member 1 Mus musculus 49-51 19213843-5 2009 Conditional knockout mice with a deletion of the GR at the pituitary (GR(POMCCre)) show excessive basal corticosterone levels during postnatal development, but not in adulthood. Corticosterone 104-118 nuclear receptor subfamily 3, group C, member 1 Mus musculus 70-72 18796307-5 2008 Chronic corticosterone decreased the levels of cortical glucocorticoid receptors and stress-induced increases in plasma corticosterone levels, and blocked the response of plasma corticosterone to dexamethasone, while isolation rearing did not cause any changes in the glucocorticoid receptor system. Corticosterone 8-22 nuclear receptor subfamily 3, group C, member 1 Mus musculus 56-79 18796307-8 2008 These results suggest that chronic corticosterone and isolation rearing increase the depressive-like behavior in glucocorticoid receptor-dependent and independent manners, respectively, and that RU-43044 shows an antidepressant-like effect, probably via an inhibition of enhanced prefrontal dopaminergic neurotransmission in these mouse models. Corticosterone 35-49 nuclear receptor subfamily 3, group C, member 1 Mus musculus 113-136 18617609-3 2008 The data indicate that the forebrain GR is necessary for maintaining basal regulation of corticosterone secretion in the morning, confirming its role in HPA axis regulation. Corticosterone 89-103 nuclear receptor subfamily 3, group C, member 1 Mus musculus 37-39 18650268-7 2008 The glucocorticoid receptor (GR) antagonist mifepristone (MF) prevented CT from inducing COX-2 gene, suggesting a GR-dependent induction in cardiomyocytes. Corticosterone 72-74 nuclear receptor subfamily 3, group C, member 1 Mus musculus 4-27 18650268-7 2008 The glucocorticoid receptor (GR) antagonist mifepristone (MF) prevented CT from inducing COX-2 gene, suggesting a GR-dependent induction in cardiomyocytes. Corticosterone 72-74 nuclear receptor subfamily 3, group C, member 1 Mus musculus 29-31 18650268-7 2008 The glucocorticoid receptor (GR) antagonist mifepristone (MF) prevented CT from inducing COX-2 gene, suggesting a GR-dependent induction in cardiomyocytes. Corticosterone 72-74 nuclear receptor subfamily 3, group C, member 1 Mus musculus 114-116 18615595-6 2008 Both cell types expressed the GR and treatment with dexamethasone or corticosterone downregulated total cellular GR levels while increasing nuclear translocation of the GR in both L6 and C2C12 myotubes. Corticosterone 69-83 nuclear receptor subfamily 3, group C, member 1 Mus musculus 113-115 18615595-6 2008 Both cell types expressed the GR and treatment with dexamethasone or corticosterone downregulated total cellular GR levels while increasing nuclear translocation of the GR in both L6 and C2C12 myotubes. Corticosterone 69-83 nuclear receptor subfamily 3, group C, member 1 Mus musculus 113-115 18615595-7 2008 The GR antagonist RU38486 inhibited the dexamethasone- and corticosterone-induced increases in atrogin-1 and MuRF1 expression in L6 myotubes but not in C2C12 myotubes. Corticosterone 59-73 nuclear receptor subfamily 3, group C, member 1 Mus musculus 4-6 18308401-9 2008 Application of the glucocorticoid receptor antagonist RU38486 (200 mg/kg) elevated plasma corticosterone for at least 8h. Corticosterone 90-104 nuclear receptor subfamily 3, group C, member 1 Mus musculus 19-42 18372328-3 2008 The GR mutants die about 1 wk after birth and display a fulminant increase in plasma corticosterone as well as a severe histopathological phenotype. Corticosterone 85-99 nuclear receptor subfamily 3, group C, member 1 Mus musculus 4-6 17699665-7 2007 Transgenic mice with GR overexpression in forebrain (GRov) display normal basal circulating adrenocorticotropic hormone and corticosterone levels. Corticosterone 124-138 nuclear receptor subfamily 3, group C, member 1 Mus musculus 21-23 17869410-14 2007 The findings indicate that both corticosterone and progesterone could affect intracellular insulin degradation and crinophagy solely via the glucocorticoid receptor, and that prostaglandins may have a regulatory role in intracellular turnover of secretory material in pancreatic islet beta-cells. Corticosterone 32-46 nuclear receptor subfamily 3, group C, member 1 Mus musculus 141-164 17021021-1 2007 Previous studies have shown that corticosterone enhances whole cell calcium currents in CA1 pyramidal neurons, through a pathway involving binding of glucocorticoid receptor homodimers to the DNA. Corticosterone 33-47 nuclear receptor subfamily 3, group C, member 1 Mus musculus 150-173 17710249-5 2007 Progressive corticosterone concentrations with predominant action via GR induced strong emotional arousal at the expense of cognitive performance. Corticosterone 12-26 nuclear receptor subfamily 3, group C, member 1 Mus musculus 70-72 16453979-9 2006 CONCLUSIONS: These data suggest that glucocorticoid-receptor activation by corticosterone participates in the antidepressant-like adaptive changes in 5-HT1A autoreceptors in sleep-deprived mice. Corticosterone 75-89 nuclear receptor subfamily 3, group C, member 1 Mus musculus 37-60 16873540-5 2006 Suppression of hepatic GR expression was correlated with reduced levels of glucose and corresponded to the inhibition of phosphoenolpyruvate carboxykinase mRNA and 11beta-hydroxysteroid dehydrogenase type 1-mediated synthesis of active corticosterone from inactive 11-dehydrocorticosterone in liver. Corticosterone 236-250 nuclear receptor subfamily 3, group C, member 1 Mus musculus 23-25 16278020-7 2006 This proliferation was a function of corticosterone-induced activation of the N-methyl-D-aspartate (NMDA) receptor within the CNS since blockade of corticosterone synthesis, the glucocorticoid receptor, or the NMDA receptor each prevented stress-induced increases in microglia number. Corticosterone 37-51 nuclear receptor subfamily 3, group C, member 1 Mus musculus 178-201 15616008-2 2005 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts inactive 11-dehydrocorticosterone into active corticosterone, thus amplifying glucocorticoid receptor-mediated tissue glucocorticoid action, particularly in the liver. Corticosterone 85-99 nuclear receptor subfamily 3, group C, member 1 Mus musculus 144-167 15616008-5 2005 Increased expression of glucocorticoid receptor and 11beta-HSD1 in the liver of db/db mice was correlated with elevated circulating levels of corticosterone, insulin, and blood glu-cose. Corticosterone 142-156 nuclear receptor subfamily 3, group C, member 1 Mus musculus 24-47 15616008-7 2005 Addition of corticosterone to db/db mouse primary hepatocytes activated expression of glucocorticoid receptor, 11beta-HSD1, and PEPCK, and these effects were abolished by RU486. Corticosterone 12-26 nuclear receptor subfamily 3, group C, member 1 Mus musculus 86-109 15013364-14 2004 mRNA for these inflammatory mediators was induced 6 h after the corticosterone pretreatment, and was associated with activation of nuclear factor-kappaB in the presence of activated glucocorticoid receptor. Corticosterone 64-78 nuclear receptor subfamily 3, group C, member 1 Mus musculus 182-205 15959917-7 2005 The glucocorticoid-receptor (GR) antagonist RU 38486 blocked both the effects of corticosterone. Corticosterone 81-95 nuclear receptor subfamily 3, group C, member 1 Mus musculus 4-27 15959917-7 2005 The glucocorticoid-receptor (GR) antagonist RU 38486 blocked both the effects of corticosterone. Corticosterone 81-95 nuclear receptor subfamily 3, group C, member 1 Mus musculus 29-31 16125856-5 2005 Second, these latter effects were prevented by treating slices with the glucocorticoid receptor antagonist mifepristone prior to and during corticosterone administration. Corticosterone 140-154 nuclear receptor subfamily 3, group C, member 1 Mus musculus 72-95 16125856-8 2005 These results indicate that corticosterone, via glucocorticoid receptor activation, selectively hampers N-methyl-D-aspartate receptor dependent synaptic plasticity in vitro and leaves more complex forms of long term potentiation unaffected. Corticosterone 28-42 nuclear receptor subfamily 3, group C, member 1 Mus musculus 48-71 12234997-10 2002 Treatment of cells with RU 486, a glucocorticoid receptor blocker, reversed the effects of corticosterone on cell growth and KIP/P27 protein levels suggesting the involvement of the glucocorticoid receptor in accounting for these effects. Corticosterone 91-105 nuclear receptor subfamily 3, group C, member 1 Mus musculus 34-57 12234997-10 2002 Treatment of cells with RU 486, a glucocorticoid receptor blocker, reversed the effects of corticosterone on cell growth and KIP/P27 protein levels suggesting the involvement of the glucocorticoid receptor in accounting for these effects. Corticosterone 91-105 nuclear receptor subfamily 3, group C, member 1 Mus musculus 182-205 11606764-10 2001 These findings suggest that task-related facilitating effects of corticosterone on spatial memory indeed depend on DNA binding of the glucocorticoid receptor rather than on protein-protein interactions of the receptor with other transcription factors. Corticosterone 65-79 nuclear receptor subfamily 3, group C, member 1 Mus musculus 134-157 11277981-5 2001 We hypothesized that dexamethasone, corticosterone and serotonin exposure modify GR and MR mRNA levels in fetal mouse hippocampal cultures, and that these effects are confined to neurons. Corticosterone 36-50 nuclear receptor subfamily 3, group C, member 1 Mus musculus 81-83 11579225-0 2001 Homology modelling of the ligand-binding domain of glucocorticoid receptor: binding site interactions with cortisol and corticosterone. Corticosterone 120-134 nuclear receptor subfamily 3, group C, member 1 Mus musculus 51-74 11277981-10 2001 Four days exposure to dexamethasone or corticosterone (10 or 100 nM) decreased levels of GR mRNA within neurons. Corticosterone 39-53 nuclear receptor subfamily 3, group C, member 1 Mus musculus 89-91 11223190-7 2001 Despite the evidence for expression of a ligand-binding domain fragment of the glucocorticoid receptor these mice are profoundly glucocorticoid resistant, with elevated levels of plasma ACTH and corticosterone. Corticosterone 195-209 nuclear receptor subfamily 3, group C, member 1 Mus musculus 79-102 11258486-3 2000 Furthermore, adult MR-/- mice exhibited a significant reduction of granule cell neurogenesis to 65% of control levels, possibly mediated by GR due to elevated corticosterone plasma levels. Corticosterone 159-173 nuclear receptor subfamily 3, group C, member 1 Mus musculus 140-142 10666137-6 2000 Finally, we demonstrated that pretreatment with the glucocorticoid receptor antagonist RU-486 blocks the delay in barrier recovery produced by systemic corticosterone, change of cage, or immobilization. Corticosterone 152-166 nuclear receptor subfamily 3, group C, member 1 Mus musculus 52-75 10509797-2 1999 GR-/- mice show impaired negative feedback in the hypothalamic-pituitary-adrenal axis, resulting in elevated circulating levels of ACTH and corticosterone. Corticosterone 140-154 nuclear receptor subfamily 3, group C, member 1 Mus musculus 0-2 9705523-3 1998 In contrast, no recombinase activity was detected in the absence of ligand or in the presence of the natural GR ligands corticosterone, cortisol or aldosterone. Corticosterone 120-134 nuclear receptor subfamily 3, group C, member 1 Mus musculus 109-111 9191104-5 1997 We hypothesized that if the glucocorticoid receptor is important as a mediator of the suppressive effect of corticosterone, this would be revealed by changed (enhanced) expression of 5-HT(1A) receptor mRNA in mice with a genetically changed glucocorticoid receptor status. Corticosterone 108-122 nuclear receptor subfamily 3, group C, member 1 Mus musculus 28-51 9191104-5 1997 We hypothesized that if the glucocorticoid receptor is important as a mediator of the suppressive effect of corticosterone, this would be revealed by changed (enhanced) expression of 5-HT(1A) receptor mRNA in mice with a genetically changed glucocorticoid receptor status. Corticosterone 108-122 nuclear receptor subfamily 3, group C, member 1 Mus musculus 241-264