PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32931865-16 2021 CONCLUSIONS: Simultaneous targeting of RSK and AKT might be an efficient approach to block the repair of DSBs after irradiation and to induce radiosensitization of breast cancer cells. dsbs 105-109 AKT serine/threonine kinase 1 Homo sapiens 47-50 29090098-13 2017 Together, these data indicate that Akt1 and Akt3, but not Akt2, physically interact with DNA-PKcs, thus stimulating the repair of DSBs and therefore protecting K-RASmut cells against IR. dsbs 130-134 AKT serine/threonine kinase 1 Homo sapiens 35-39 24179529-8 2013 Treatment with U20126, a mitogen-activated protein kinase kinase (MEK) inhibitor, resulted in attenuated induction of DSBs and apoptosis through activation of protein kinase B (Akt), suggesting that LB-mediated actin dysfunction induces DSBs via the MEK/extracellular signal-regulated kinase (Erk) pathway in cells. dsbs 237-241 AKT serine/threonine kinase 1 Homo sapiens 177-180 21263216-9 2011 Altogether, our results show that low levels of DSBs trigger ATM- and AKT-dependent ERK pro-survival signaling and increased cell proliferation whereas higher levels result in ERK dephosphorylation consistent with a dose-dependent switch from pro-survival to anti-survival signaling. dsbs 48-52 AKT serine/threonine kinase 1 Homo sapiens 70-73 20956948-3 2011 In this report, our results showed that inhibition of Akt activity impaired the repair of DSBs in CNE2 cells, whereas activated Akt promoted the repair of DSBs in HeLa cells. dsbs 90-94 AKT serine/threonine kinase 1 Homo sapiens 54-57 20956948-3 2011 In this report, our results showed that inhibition of Akt activity impaired the repair of DSBs in CNE2 cells, whereas activated Akt promoted the repair of DSBs in HeLa cells. dsbs 155-159 AKT serine/threonine kinase 1 Homo sapiens 54-57 20956948-3 2011 In this report, our results showed that inhibition of Akt activity impaired the repair of DSBs in CNE2 cells, whereas activated Akt promoted the repair of DSBs in HeLa cells. dsbs 155-159 AKT serine/threonine kinase 1 Homo sapiens 128-131