PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24090735-8 2013 Pre-treatment with antioxidant n-acetyl-l-cysteine (NAC) reduced ROS generation and DNA DSBs, inhibited apoptosis, and increased cell viability in AFG1-treated cells. dsbs 88-92 X-linked Kx blood group Homo sapiens 52-55 16628006-3 2006 We recently reported that this constitutive H2AX phosphorylation (CHP) is markedly reduced by the antioxidant N-acetyl-L-cysteine (NAC), and postulated that it reflects the oxidative DNA damage ("endogenous DSBs") induced by reactive oxygen species (ROS) generated by metabolic activity during progression through the cell cycle. dsbs 207-211 X-linked Kx blood group Homo sapiens 131-134 16685450-5 2006 In the present study, we show that N-acetyl L-cysteine (NAC) and glutathione, both effective scavengers of free radicals, prevented induction of DSBs by CS in these cells. dsbs 145-149 X-linked Kx blood group Homo sapiens 56-59 16685450-7 2006 The observed reduction of DSBs by NAC correlated with protection of the reproductive capability (clonogenicity) of A549 cells treated with CS. dsbs 26-30 X-linked Kx blood group Homo sapiens 34-37