PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18805512-9	2008	However, in wrn-kd but not wrn-wt cells they were converted into DNA double-strand breaks (DSBs) at high frequency, as shown by neutral comet assay and phosphorylation of H2AX.	dsbs	91-95	WRN RecQ like helicase	Homo sapiens	12-15	
24429382-6	2014	Accumulation of the mutant WRN at the site of laser-induced DSBs occurred with the same kinetics as wild type WRN in live HeLa cells.	dsbs	60-64	WRN RecQ like helicase	Homo sapiens	27-30	
24429382-7	2014	While the wild type WRN relocalized to the nucleoli after 24 hours recovery from etoposide-induced DSBs, the mutant WRN remained mostly in the nucleoplasm.	dsbs	99-103	WRN RecQ like helicase	Homo sapiens	20-23	
18852298-5	2008	Thus, we provide novel evidence that WRN is required to avoid accumulation of DSBs and fork collapse after replication perturbation, and that prompt MUS81-dependent generation of DSBs is instrumental for recovery from hydroxyurea-mediated replication arrest under such pathological conditions.	dsbs	78-82	WRN RecQ like helicase	Homo sapiens	37-40	
18524993-6	2008	Furthermore, "knockdown" of either DNA ligase IIIalpha or WRN leads to increased accumulation of unrepaired DSBs, demonstrating that they contribute to the repair of DSBs.	dsbs	108-112	WRN RecQ like helicase	Homo sapiens	58-61	
18658245-5	2008	The presence of the 70/86 Ku heterodimer (Ku), participating in the repair of double-strand breaks (DSBs), alleviates WRN exonuclease blockage imposed by the oxidatively induced DNA lesions.	dsbs	100-104	WRN RecQ like helicase	Homo sapiens	118-121	
18524993-6	2008	Furthermore, "knockdown" of either DNA ligase IIIalpha or WRN leads to increased accumulation of unrepaired DSBs, demonstrating that they contribute to the repair of DSBs.	dsbs	166-170	WRN RecQ like helicase	Homo sapiens	58-61	
17449919-7	2007	These results indicate that WS cells are prone to accumulate DSBs spontaneously due to a defect of WRN, which leads to increased chromosome instability that could activate checkpoints, resulting in accelerated senescence.	dsbs	61-65	WRN RecQ like helicase	Homo sapiens	99-102